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DopaPlus

Pure Encapsulations
4.0
★ ★ ★ ★ ★
(14 ratings)
Rhodiola
Tyrosine 1000 mg
Product Image
Score72

A substantial tyrosine-and-mucuna core offers focused cognitive support, but its potency and interaction profile demand careful use.

How scoring works
Quantity:180 Capsule(s) • (60 servings)
Goals:
Cognitive Support
Brain Health
Energy
Mental Focus

Score 72

A substantial tyrosine-and-mucuna core offers focused cognitive support, but its potency and interaction profile demand careful use.

How scoring works
$66.50($1.10 per serving)
Pure Formulas
$ 66.50
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Analysis

L-tyrosine at 1,000 mg provides a substantial precursor amount, while mucuna supplies an L-Dopa-marked extract. P5P, methylfolate, and zinc support the formula's nutrient foundation.

Rhodiola is identified by salidroside and rosavins, with grape and green tea polyphenols adding antioxidant support. The 100 mg entries do not state standardization percentages, so exact active amounts remain unclear.

The formula fits adults seeking targeted energy and cognitive support more than a simple focus aid. Three capsules and several monoamine-active ingredients increase the need to review medications and sensitivity.

Who is it for
  • Adults seeking targeted dopamine-pathway support
  • Users wanting tyrosine with standardized rhodiola
  • People who can review medication interactions
Best for
  • Demanding mental-work periods
  • Energy support without a simple caffeine formula
  • Cognitive routines guided by professional advice

Pros

  • Provides 1,000 mg L-tyrosine
  • Includes L-Dopa-marked mucuna
  • Uses active B6 and folate forms
  • Identifies rhodiola marker compounds

Cons

  • Three capsules per serving
  • Marker percentages are not shown
  • Complex monoamine-active formula
  • Not suited to casual daily use

Warnings

  • Mucuna-derived L-Dopa can interact with Parkinson's medicines, antipsychotics, and other dopamine-active drugs
  • Tyrosine and rhodiola may be overstimulating for sensitive users
  • Green tea extract is present, but caffeine content is not disclosed

Nutrient quality

86 Highest impact

Methylated nutrients, zinc picolinate, and standardized botanicals provide strong form quality. Meaningful tyrosine and mucuna amounts suit focused use, though L-Dopa raises medication concerns.

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Ingredient transparency

81 Highest impact

Active forms and amounts are disclosed individually without hidden blends. Full intake directions and inactive ingredients are not supplied.

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Customer satisfaction

51 Moderate impact

The supplied average rating is comparatively mixed. The small rating base limits confidence in the average, but no detailed experience evidence was supplied.

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Value for money

63 Moderate impact

Serving economics are weak. Formula limitations keep practical value moderate.

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Report analysis

Goals

Cognitive Support
Cognitive Support
Impact
Highest effect
A- Goal FitA- Strength of SupportA- CoverageB+ Formula Quality
Vitamin B6 · 6.7 mgFolate · 833 mcg DFEGreen Tea · 100 mg

Tyrosine, mucuna-derived L-DOPA, rhodiola, P5P, and folate directly support catecholamine production and stress resilience. The stack provides substantial amounts across several related pathways.

Active vitamin forms and disclosed botanical markers improve quality, though marker percentages remain incomplete. Mucuna-derived L-DOPA can interact with levodopa, MAO inhibitors, and dopamine-active medicines, so this formula is not suitable for casual combination with those treatments.

Study evidence
Folate Supportive 68 studies
Rhodiola Supportive 7 studies
Brain Health
Brain Health
Impact
High effect
A- Goal FitB- Strength of SupportB+ CoverageB- Formula Quality
Folate · 833 mcg DFEVitamin B6 · 6.7 mg

The blend strongly targets neurotransmitter production and mental performance under stress. A substantial tyrosine amount is joined by Rhodiola markers, L-Dopa from mucuna, active folate, and supporting antioxidants.

Several botanical marker percentages are absent, so their true active yields remain uncertain. Mucuna-derived L-Dopa can materially affect dopaminergic signaling and may be unsuitable with dopamine-related medicines or certain psychiatric conditions.

Study evidence
Folate Supportive 90 studies
Rhodiola Supportive 8 studies
Tyrosine Supportive 7 studies
Energy
Energy
Impact
High effect
B+ Goal FitB+ Strength of SupportB- CoverageB Formula Quality

Tyrosine, mucuna-derived L-Dopa, and rhodiola target neurotransmitter support, focus, and stress-related fatigue. Rhodiola and tyrosine have useful human evidence in demanding conditions, while routine energy benefit from the full dopamine-oriented stack is less certain.

Tyrosine reaches 1000 mg, while rhodiola and the standardized extracts provide moderate rather than maximal amounts. Active folate, P5P, zinc picolinate, and named botanical markers improve disclosure, but marker percentages are not shown.

Study evidence
Rhodiola Supportive 18 studies
Mental Focus
Mental Focus
Impact
Moderate effect
B- Goal FitC- Strength of SupportC CoverageC Formula Quality
Folate · 833 mcg DFEVitamin B6 · 6.7 mg

Rhodiola offers credible support for mental fatigue and alertness during demanding periods. The broader dopamine-oriented blend may extend the focus rationale, but the supplied Rhodiola amount appears modest.

Rosavins and salidroside are named, yet their percentages are missing. Without that standardization, the extract strength and preferred active balance cannot be confirmed.

Study evidence
Rhodiola Supportive 15 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxal 5-Phosphate)
 6.7 mg
Folate (Metafolin)
 833 mcg DFE
Zinc (Zinc Picolinate)
 10 mg
L-Tyrosine
1000 mg
Velvet Bean (Mucuna pruriens) extract (L-Dopa)
 200 mg
Rhodiola (Rhodiola rosea) extract (Salidroside, total Rosavins)
 100 mg
Grape (Vitis vinifera) extract (Polyphenols)
 100 mg
Green Tea (Camellia sinensis) extract (EGCG, total Tea Catechins)
 100 mg
Gluten Free Adults 18–50
Report overview
Rhodiola (Salidroside, total Rosavins) · 100 mg OverallScore70
A- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Rhodiola rosea extract identifies both rosavins and salidroside, which supports a relevant active profile. Marker percentages are missing, so the preferred natural balance cannot be confirmed. The serving is modest and works better as part of a blend than as a focused Rhodiola dose.

View ingredientView products
Tyrosine · 1000 mg OverallScore70
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Standard L-Tyrosine is supplied at a well-aligned 1,000 mg amount with full dose disclosure. No tyrosine-specific source, purity grade, or testing information is provided. The complex botanical and nutrient formula makes the cost per gram of tyrosine unfavorable.

View ingredientView products
Loading alternative details
81 Performance

Super Rhodiola Root Extract 500 mg

Solaray
A high-strength rhodiola extract identifies both salidrosides and rosavins for focused energy and stress support. Compared with DopaPlus, the stronger rhodiola emphasis provides clearer adaptogen coverage, though it gives up the original formula’s tyrosine and nutrient breadth.
83 Performance

Rhodiola Extract 500 mg

California Gold Nutrition
A substantial rhodiola root extract identifies both major marker groups and aligns well with energy and cognitive goals. Compared with DopaPlus, the stronger rhodiola emphasis provides clearer adaptogen coverage, though it gives up the original formula’s tyrosine and nutrient breadth.
80 Performance

Full Spectrum Rhodiola Rosea Extract 327 mg

Planetary Herbals
A substantial Rhodiola rosea extract identifies both major marker groups and provides focused adaptogen support. Compared with DopaPlus, the stronger rhodiola emphasis provides clearer adaptogen coverage, though it gives up the original formula’s tyrosine and nutrient breadth.
86 Budget

L-Tyrosine 750 mg - Extra Strength

NOW
A substantial free-form L-tyrosine serving offers focused support for mental demand through a simple, clearly quantified formula. Compared with DopaPlus, the focused formula lowers recurring cost and avoids mucuna-derived L-Dopa, although it does not reproduce the full tyrosine-and-adaptogen blend.
81 Budget

Rhodiola 250 mg

Nature's Way
A marker-defined rhodiola extract provides a practical middle-strength option for energy, focus, and stress support. Compared with DopaPlus, the focused formula lowers recurring cost and avoids mucuna-derived L-Dopa, although it does not reproduce the full tyrosine-and-adaptogen blend.
85 Budget

L-Tyrosine Powder

Source Naturals
Bulk L-tyrosine supplies a meaningful amount with flexible dosing and a very economical active yield. Compared with DopaPlus, the focused formula lowers recurring cost and avoids mucuna-derived L-Dopa, although it does not reproduce the full tyrosine-and-adaptogen blend.
86 Value

L-Tyrosine 500 mg

NOW
A practical L-tyrosine amount and a simple formula provide focused support for acute mental demand. Compared with DopaPlus, the simpler active profile offers more economical, easier-to-assess support for one of its main pathways, but it is not a full substitute for the combined formula.
85 Value

Best L-Tyrosine 500 mg

Doctor's Best
Free-form L-tyrosine is supplied at a practical amount in a streamlined capsule with favorable serving value. Compared with DopaPlus, the simpler active profile offers more economical, easier-to-assess support for one of its main pathways, but it is not a full substitute for the combined formula.
81 Value

Rhodiola Root Extract

Solgar
Standardized rhodiola extract plus root powder provides a well-specified approach to energy and stress support. Compared with DopaPlus, the simpler active profile offers more economical, easier-to-assess support for one of its main pathways, but it is not a full substitute for the combined formula.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of Rhodiola rosea on Physical and Decision-Making Performance in Football Players: A Randomised Controlled Trial.
    Dou Y; Wang Y; Zhang W; Jiang Y; Zhang J; Yang T; Han Z; Li Y; Liu C; Ren D · Nutrients · 2026
    Randomized trial24 participantsEnergy Mental Focus forRhodiola
  2. Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trial.
    Punja S; Shamseer L; Olson K; Vohra S · PloS one · 2015
    Randomized trial48 participantsEnergy forRhodiola
  3. Scientific Opinion on the substantiation of a health claim related to Rhodiola rosea L. extract and reduction of mental fatigue pursuant to Article 13(5) of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forRhodiola
  4. Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study.
    Koozehchian MS; Newton AT; Mabrey G; Bonness FM; Rafajlovska R; Naderi A · Nutrients · 2025
    Randomized trial27 participantsMental Focus Brain Health forRhodiola
  5. Acute Rhodiola rosea intake can improve endurance exercise performance.
    De Bock K; Eijnde BO; Ramaekers M; Hespel P · International journal of sport nutrition and exercise metabolism · 2004
    Randomized trial24 participantsMental Focus forRhodiola
  6. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.
    Wang Z; Zhu W; Xing Y; Jia J; Tang Y · Nutrition reviews · 2022
    Meta-analysis46,175 participants95 studies pooledBrain Health Cognitive Support forFolate
  7. Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial.
    Catena A; Muñoz-Machicao JA; Torres-Espínola FJ; Martínez-Zaldívar C; Diaz-Piedra C; Gil A; Haile G; Györei E; Molloy AM; Decsi T; Koletzko B; Campoy C · The American journal of clinical nutrition · 2016
    Randomized trial136 participantsBrain Health forFolate
  8. Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.
    Liu Y; Yu Z; Cai Z; Zhao L; Wang Y; Guo Y; Su X; Miao Y; Yi B; Wang Y; Zhang X · The journal of prevention of Alzheimer's disease · 2025
    Randomized trial220 participantsBrain Health forFolate
  9. Circulating folate concentrations and the risk of mild cognitive impairment: A prospective study on the older Chinese population without folic acid fortification.
    Fu J; Liu Q; Zhu Y; Sun C; Duan H; Huang L; Zhou D; Wang Z; Zhao J; Li Z; Ma F; Li W; Liu H; Zhang X; Chen Y; Wang G; Du Y; Huang G · European journal of neurology · 2022
    Cohort study3,974 participantsBrain Health forFolate
  10. Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment.
    Jang S; Han JW; Shin J; Kim TH; Kwak KP; Kim K; Kim BJ; Kim SG; Kim JL; Kim TH; Moon SW; Park JY; Park JH; Byun S; Suh SW; Seo J; So Y; Ryu SH; Youn JC; Lee KH; Lee DY; Lee DW; Lee SB; Lee JJ; Lee JR; Jeong H; Jeong HG; Jhoo JH; Han K; Hong JW; Kim KW · Psychiatry investigation · 2020
    Cohort study3,910 participantsBrain Health forFolate
  11. A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers.
    Boyle NB; Billington J; Lawton C; Quadt F; Dye L · Nutritional neuroscience · 2022
    Randomized trial100 participantsBrain Health forRhodiola
  12. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.
    Panossian A; Wikman G; Sarris J · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2010
    Narrative reviewBrain Health forRhodiola
  13. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
    Darbinyan V; Kteyan A; Panossian A; Gabrielian E; Wikman G; Wagner H · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2001
    Randomized trial56 participantsBrain Health forRhodiola
  14. Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study.
    Koop T; Dienel A; Heldmann M; Münte TF · Phytotherapy research : PTR · 2021
    Single-arm trial50 participantsBrain Health Cognitive Support forRhodiola
  15. Combined L-carnosine and L-tyrosine supplementation as an ergogenic strategy for physical and cognitive performance under fatigue in professional football players.
    Bilgin S; Bozyılan E; Buzdağlı Y; Karaç Öcal Y; Gürkan O; Toktaş S; İnan H; Egil İ; Yarayan YE · Frontiers in nutrition · 2026
    Randomized trial24 participantsBrain Health forTyrosine
  16. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review.
    Jongkees BJ; Hommel B; Kühn S; Colzato LS · Journal of psychiatric research · 2016
    Narrative reviewBrain Health forTyrosine
  17. Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans.
    Hensel C; Becker M; Düzel S; Demuth I; Norman K; Steinhagen-Thiessen E; Gallinat J; Lindenberger U; Kühn S · NeuroImage · 2019
    Cross-sectional study286 participantsBrain Health forTyrosine
  18. Dietary Tyrosine Intake (FFQ) Is Associated with Locus Coeruleus, Attention and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II.
    Plini ERG; Melnychuk MC; Harkin A; Dahl MJ; McAuslan M; Kühn S; Boyle RT; Whelan R; Andrews R; Düzel S; Drewelies J; Wagner GG; Lindenberger U; Norman K; Robertson IH; Dockree PM · The journal of nutrition, health & aging · 2023
    Cross-sectional study398 participantsBrain Health forTyrosine
  19. Baseline-dependent effect of dopamine's precursor L-tyrosine on working memory gating but not updating.
    Jongkees BJ · Cognitive, affective & behavioral neuroscience · 2021
    Randomized trial45 participantsBrain Health forTyrosine
  20. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China.
    Ma F; Wu T; Zhao J; Han F; Marseglia A; Liu H; Huang G · The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Randomized trial180 participantsCognitive Support forFolate
  21. Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.
    Michelakos T; Kousoulis AA; Katsiardanis K; Dessypris N; Anastasiou A; Katsiardani KP; Kanavidis P; Stefanadis C; Papadopoulos FC; Petridou ET · Journal of aging and health · 2013
    Meta-analysis8,122 participants9 studies pooledCognitive Support forFolate
  22. Homocysteine and folate as risk factors for dementia and Alzheimer disease.
    Ravaglia G; Forti P; Maioli F; Martelli M; Servadei L; Brunetti N; Porcellini E; Licastro F · The American journal of clinical nutrition · 2005
    Cohort study816 participantsCognitive Support forFolate
  23. Folate mediates cognitive impairment of aged people with periodontitis.
    Liu F; Liu Y; Feng Y; Zhao J; Wang M; Ye M; Zhang Y; Gan X; Pan Q; Shen J · Nutritional neuroscience · 2025
    Cross-sectional study1,966 participantsCognitive Support forFolate
  24. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
    Panossian A; Wikman G · Current clinical pharmacology · 2009
    Narrative reviewCognitive Support Mental Focus forRhodiola
  25. Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy.
    Al-Kuraishy HM · Journal of intercultural ethnopharmacology · 2016
    Clinical trial112 participantsCognitive Support forRhodiola
  26. Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes.
    Łuszczak J; Kocki J · Annals of agricultural and environmental medicine : AAEM · 2026
    Systematic review19 studies pooledCognitive Support forRhodiola
  27. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
    Olsson EM; von Schéele B; Panossian AG · Planta medica · 2009
    Randomized trial60 participantsCognitive Support forRhodiola
  28. The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players.
    Wang J; Zhao H; Yu L; Zhao K; Jiang W; Liu S; Dai J; Xu L; Sun P; Yun H; Liu C · Nutrients · 2025
    Randomized trial48 participantsEnergy forRhodiola
  29. Combined Effects of Rhodiola Rosea and Caffeine Supplementation on Straight Punch Explosive Power in Untrained and Trained Boxing Volunteers: A Synergistic Approach.
    Tao B; Sun H; Li H; Xu Z; Xu Y; Chen L; Ma C; Zhang X; Yu L; Bao S; Liu C · Metabolites · 2025
    Randomized trial96 participantsEnergy forRhodiola
  30. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial.
    Lekomtseva Y; Zhukova I; Wacker A · Complementary medicine research · 2019
    Single-arm trial100 participantsEnergy forRhodiola
  31. Combined Rhodiola rosea and eccentric training boost endurance performance and lower-limb reactive strength in recreationally active women.
    Wang IL; Su Y; Zhang L; Tang M; Chen YM · Frontiers in physiology · 2025
    Randomized trial30 participantsEnergy forRhodiola
  32. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials.
    Hung SK; Perry R; Ernst E · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
    Systematic review11 studies pooledMental Focus forRhodiola
  33. Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men.
    Jówko E; Sadowski J; Długołęcka B; Gierczuk D; Opaszowski B; Cieśliński I · Journal of sport and health science · 2022
    Randomized trial26 participantsMental Focus forRhodiola