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Mixed Vitamin E 400 IU

Natural Factors
4.8
★ ★ ★ ★ ★
(2313 ratings)
Vitamin E 400 IU
Product Image
Score84
Natural vitamin E, some isomer diversity, and a long supply create good value, though the companion tocopherol amount is limited.
How scoring works
Quantity:240 Softgel(s) • (240 servings)
Goals:
Anti-Inflammatory Support
Cardiovascular Support
Vision Support

Score 84

Natural vitamin E, some isomer diversity, and a long supply create good value, though the companion tocopherol amount is limited.
How scoring works
$37.07($0.15 per serving)
iHerb
$ 37.07
Vitacost
$ 37.07
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Analysis

Natural d-alpha-tocopherol delivers substantial vitamin E activity, while mixed tocopherols broaden the isomer profile. The softgel format also suits absorption of these fat-soluble compounds.

The secondary tocopherol amount is fairly small beside the alpha-tocopherol dose. Even so, its presence makes the antioxidant profile more complete than an alpha-only product.

The long one-softgel supply makes regular use convenient and economical. It remains a focused vitamin E supplement rather than a complete vision, heart, or anti-inflammatory formula.

Who is it for
  • Adults seeking natural vitamin E
  • Users who want some mixed-tocopherol coverage
  • People prioritizing a long supply
Best for
  • Routine antioxidant support
  • Broader vitamin E intake
  • Cell-membrane protection

Pros

  • Natural d-alpha form
  • Includes mixed tocopherols
  • Softgel delivery
  • Very long supply

Cons

  • Mixed-tocopherol amount is modest
  • No tocotrienols
  • Narrow single-nutrient design

Warnings

  • The substantial vitamin E amount may increase bleeding tendency with anticoagulant or antiplatelet medicines.

Nutrient quality

85 Highest impact

Natural tocopherol and tocotrienol forms provide broad, meaningful vitamin E support. The substantial amount remains generally balanced for targeted use.

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Ingredient transparency

82 Highest impact

Active ingredients and their amounts are mostly clear without a hidden proprietary total. Daily directions and a complete other-ingredients panel are not included in the supplied data.

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Customer satisfaction

71 High impact

The aggregate rating is favorable and supported by large feedback volume. Complaint-level experiences are unavailable, so repeated drawbacks and purpose fit remain uncertain.

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Value for money

95 Highest impact

Useful active amounts and a low serving cost provide strong practical value. Minor formula limitations do not outweigh the economy.

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Goals

Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Highest effect
B Goal FitA- Strength of SupportC CoverageA+ Formula Quality
Vitamin E · 10 mg

Natural vitamin E provides membrane-focused antioxidant protection that may help limit oxidative drivers of inflammation. The substantial amount and added mixed tocopherols make it stronger than a basic alpha-tocopherol formula.

The formula remains narrow because it does not address direct inflammatory enzymes, immune regulation, or resolution lipids. Anyone using anticoagulant or antiplatelet medicine should review the high vitamin E amount because it may increase bleeding risk.

Study evidence
Vitamin E Supportive 20 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
C Goal FitA- Strength of SupportD+ CoverageA+ Formula Quality
Vitamin E · 10 mg

Natural vitamin E and mixed tocopherols provide lipid-soluble antioxidant protection that may help limit oxidation of circulating lipids. The formula is relevant to vascular protection but does not directly address blood pressure, triglycerides, or cardiac energy.

The amount and natural form are clearly disclosed in one softgel. The high vitamin E amount may increase bleeding tendency, especially when combined with anticoagulant or antiplatelet medicines.

Study evidence
Vitamin E Mixed 79 studies
Vision Support
Vision Support
Impact
High effect
C+ Goal FitA- Strength of SupportD CoverageB+ Formula Quality
Vitamin E · 10 mg

Natural vitamin E supports retinal antioxidant defense but does not provide macular pigment or retinal lipids. Vitamin E is part of established eye-health nutrient frameworks, though evidence does not support using it as a complete standalone formula.

The vitamin E amount is substantial and falls within a commonly used antioxidant range. Natural d-alpha tocopherol is paired with mixed tocopherols, although the secondary isomer amounts are limited.

Study evidence
Vitamin E Disputed 35 studies

Ingredients

IngredientAmount per serving
Vitamin E (D-Alpha-Tocopherol)
 400 IU
Mixed Tocopherols
10 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Vitamin E (D-Alpha-Tocopherol) · 400 IU OverallScore79
C Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyA+ Value

Natural d-alpha vitamin E is paired with mixed tocopherols, broadening the formula beyond alpha alone. The amount falls within the established range for general antioxidant support. Cost efficiency is favorable for the natural form provided.

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Loading alternative details
81 Performance

Natural E-400

Protocol For Life Balance
<p>Natural vitamin E, three named mixed tocopherols, and selenium form a transparent antioxidant combination. Compared with Mixed Vitamin E 400 IU, its fully disclosed mixed tocopherols and selenium may address the original's limited mixed-tocopherol addition more directly, although the vitamin E amount is high for routine use.</p>
78 Performance

Natural E-Complex With Mixed Tocopherols 400 IU

Country Life
<p>Four named natural tocopherol isomers provide broader vitamin E family coverage than alpha-tocopherol alone. Compared with Mixed Vitamin E 400 IU, its broad tocopherol profile may address the original's limited mixed-tocopherol addition more directly, although the repeated equal amount entries make the true total uncertain.</p>
83 Performance

Vitamin E Complete

OL Olympian Labs
<p>Natural d-alpha-tocopherol and mixed tocotrienols create balanced vitamin E family coverage at a practical amount. Compared with Mixed Vitamin E 400 IU, its balanced tocopherol-and-tocotrienol design may address the original's limited mixed-tocopherol addition more directly, although the individual tocotrienol isomers are not quantified.</p>
83 Budget

Natural E Liquid

NOW
<p>A modest natural d-alpha-tocopherol amount offers a lower-intensity maintenance option in liquid form. Its lower recurring cost than Mixed Vitamin E 400 IU supports this category, although the formula is alpha-only and daily directions are absent.</p>
68 Budget

Collagen

Sanar Naturals
<p>Natural-form vitamin E is paired with vitamin C and hydrolyzed collagen in a concise formula. Its lower recurring cost than Mixed Vitamin E 400 IU supports this category, although the collagen blend is below common gram-level servings and is not a dedicated vitamin E formula.</p>
65 Budget

Water Dispersible E Supplement 1000 IU

Spring Valley
<p>A single-ingredient softgel keeps the vitamin E label easy to read. The supplied data does not show it costing less than Mixed Vitamin E 400 IU; it is included only because fewer than three eligible lower-cost candidates are available, and the chemical form is unidentified and the very large amount is poorly suited to routine use.</p>
79 Value

Kyolic Vitamin E Cayenne Hawthorn

Kyolic
<p>Natural-form vitamin E is paired with aged garlic, hawthorn, and cayenne for broader cardiovascular support. Compared with Mixed Vitamin E 400 IU, its ingredient advantages and its vitamin E and clearly stated cardiovascular botanicals create a more favorable quality-to-cost balance, although the combination may increase bleeding tendency with anticoagulant or antiplatelet medicines.</p>
85 Value

Natural E-Oil

NOW
<p>Natural d-alpha-tocopherol provides a practical antioxidant amount in a concentrated liquid. Compared with Mixed Vitamin E 400 IU, its lower recurring cost and its clearly stated natural vitamin E amount create a more favorable quality-to-cost balance, although the formula is alpha-only and daily intake directions are absent.</p>
84 Value

Coenzyme Q10 100 mg

Source Naturals
<p>Clearly identified ubiquinone is paired with a small natural vitamin E amount in a short formula. Compared with Mixed Vitamin E 400 IU, its ingredient advantages and its transparent coenzyme Q10 form and focused ingredient list create a more favorable quality-to-cost balance, although the vitamin E contribution is minor.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2018
    Meta-analysis55,614 participants4 studies pooledVision Support forVitamin E
  2. A systematic review and meta-analysis on the impact of oral vitamin E supplementation on apolipoproteins A1 and B100.
    Hamedi-Kalajahi F; Zarezadeh M; Dehghani A; Musazadeh V; Kolahi A; Shabbidar S; Djafarian K · Clinical nutrition ESPEN · 2022
    Meta-analysis1,284 participants7 studies pooledCardiovascular Support forVitamin E
  3. The effect of vitamin E supplementation on biomarkers of endothelial function and inflammation among hemodialysis patients: A double-blinded randomized clinical trial.
    Pirhadi-Tavandashti N; Imani H; Ebrahimpour-Koujan S; Samavat S; Hakemi MS · Complementary therapies in medicine · 2020
    Randomized trial49 participantsAnti-Inflammatory Support forVitamin E
  4. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa.
    Berson EL; Rosner B; Sandberg MA; Hayes KC; Nicholson BW; Weigel-DiFranco C; Willett W · Archives of ophthalmology (Chicago, Ill. : 1960) · 1993
    Randomized trial601 participantsVision Support forVitamin E
  5. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS).
    Hodis HN; Mack WJ; LaBree L; Mahrer PR; Sevanian A; Liu CR; Liu CH; Hwang J; Selzer RH; Azen SP; VEAPS Research Group · Circulation · 2002
    Randomized trialCardiovascular Support forVitamin E
  6. Vitamin E tocotrienol supplementation improves lipid profiles in chronic hemodialysis patients.
    Daud ZA; Tubie B; Sheyman M; Osia R; Adams J; Tubie S; Khosla P · Vascular health and risk management · 2014
    Randomized trial81 participantsAnti-Inflammatory Support forVitamin E
  7. Age-related cataract in men in the selenium and vitamin e cancer prevention trial eye endpoints study: a randomized clinical trial.
    Christen WG; Glynn RJ; Gaziano JM; Darke AK; Crowley JJ; Goodman PJ; Lippman SM; Lad TE; Bearden JD; Goodman GE; Minasian LM; Thompson IM; Blanke CD; Klein EA · JAMA ophthalmology · 2015
    Randomized trial11,267 participantsVision Support forVitamin E
  8. The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.
    Ward NC; Wu JH; Clarke MW; Puddey IB; Burke V; Croft KD; Hodgson JM · Journal of hypertension · 2007
    Randomized trial58 participantsCardiovascular Support forVitamin E
  9. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  10. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis.
    Loffredo L; Perri L; Di Castelnuovo A; Iacoviello L; De Gaetano G; Violi F · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Meta-analysis16 studies pooledCardiovascular Support forVitamin E
  11. Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract.
    Mathew MC; Ervin AM; Tao J; Davis RM · The Cochrane database of systematic reviews · 2012
    Meta-analysis117,272 participants9 studies pooledVision Support forVitamin E
  12. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  13. Effect of oral vitamin E (alpha-tocopherol) supplementation on vascular endothelial function in Type 2 diabetes mellitus.
    Gazis A; White DJ; Page SR; Cockcroft JR · Diabetic medicine : a journal of the British Diabetic Association · 1999
    Clinical trial69 participantsCardiovascular Support forVitamin E
  14. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  15. Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study.
    Christen WG; Liu S; Glynn RJ; Gaziano JM; Buring JE · Archives of ophthalmology (Chicago, Ill. : 1960) · 2008
    Cohort study35,551 participantsVision Support forVitamin E
  16. Effects of Vitamin C and/or E Supplementation on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes: A Systematic Review and Subgroup Meta-analysis.
    Aragón-Vela J; Huertas JR; Casuso RA · Nutrition reviews · 2026
    Meta-analysis1,425 participants52 studies pooledCardiovascular Support forVitamin E
  17. The Role of Vitamin E in the Treatment of NAFLD.
    Perumpail BJ; Li AA; John N; Sallam S; Shah ND; Kwong W; Cholankeril G; Kim D; Ahmed A · Diseases (Basel, Switzerland) · 2020
    Systematic reviewAnti-Inflammatory Support forVitamin E
  18. Prospective cohort study of antioxidant vitamin supplement use and the risk of age-related maculopathy.
    Christen WG; Ajani UA; Glynn RJ; Manson JE; Schaumberg DA; Chew EC; Buring JE; Hennekens CH · American journal of epidemiology · 1999
    Cohort study21,120 participantsVision Support forVitamin E
  19. Interventional study with vitamin E in cardiovascular disease and meta-analysis.
    Violi F; Nocella C; Loffredo L; Carnevale R; Pignatelli P · Free radical biology & medicine · 2022
    Meta-analysisCardiovascular Support forVitamin E
  20. Impact of vitamin E and C supplementation on serum adhesion molecules in chronic degenerative aortic stenosis: a randomized controlled trial.
    Tahir M; Foley B; Pate G; Crean P; Moore D; McCarroll N; Walsh M · American heart journal · 2005
    Randomized trial100 participantsAnti-Inflammatory Support forVitamin E
  21. Vitamin E in the treatment of uveitis-associated macular edema.
    Nussenblatt RB; Kim J; Thompson DJ; Davis MD; Chew E; Ferris FL; Buggage R · American journal of ophthalmology · 2006
    Randomized trialVision Support forVitamin E
  22. Effect of vitamin E on cardiometabolic factors in paediatric metabolic dysfunction-associated steatotic liver disease: a systematic review with meta-analysis.
    Pam P; Musazadeh V; Mahmoudinezhad M; Panahiyan P; Mansoori MA; Zarrin R; Faghfouri AH · The British journal of nutrition · 2026
    Meta-analysis665 participants11 studies pooledCardiovascular Support forVitamin E
  23. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  24. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin E
  25. The effects of tocotrienol supplementation on lipid profile: A meta-analysis of randomized controlled trials.
    Zuo S; Wang G; Han Q; Xiao H; O Santos H; Avelar Rodriguez D; Khani V; Tang J · Complementary therapies in medicine · 2021
    Meta-analysis15 studies pooledCardiovascular Support forVitamin E
  26. Vitamin E modulation of C-reactive protein in smokers with acute coronary syndromes.
    Murphy RT; Foley JB; Tome MT; Mulvihill NT; Murphy A; McCarroll N; Crean P; Walsh MJ · Free radical biology & medicine · 2004
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  27. Long-term nutrient intake and 5-year change in nuclear lens opacities.
    Jacques PF; Taylor A; Moeller S; Hankinson SE; Rogers G; Tung W; Ludovico J; Willett WC; Chylack LT · Archives of ophthalmology (Chicago, Ill. : 1960) · 2005
    Cohort study408 participantsVision Support forVitamin E
  28. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
    Chen B; Li Y; Li Z; Hu X; Zhen H; Chen H; Nie C; Hou Y; Zhu S; Xiao L; Li T · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
    Randomized trial90 participantsCardiovascular Support forVitamin E
  29. Vitamin E and Multiple Health Outcomes: An Umbrella Review of Meta-Analyses.
    Xiong Z; Liu L; Jian Z; Ma Y; Li H; Jin X; Liao B; Wang K · Nutrients · 2023
    Systematic review32 studies pooledAnti-Inflammatory Support forVitamin E
  30. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study.
    Tan JS; Wang JJ; Flood V; Rochtchina E; Smith W; Mitchell P · Ophthalmology · 2008
    Cohort study3,654 participantsVision Support forVitamin E
  31. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  32. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
    Lonn E; Bosch J; Yusuf S; Sheridan P; Pogue J; Arnold JM; Ross C; Arnold A; Sleight P; Probstfield J; Dagenais GR; HOPE and HOPE-TOO Trial Investigators · JAMA · 2005
    Randomized trial9,541 participantsCardiovascular Support forVitamin E
  33. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.
    Liu Z; He Z; Xing Y · Journal of nutritional science · 2026
    Cohort study34,955 participantsCardiovascular Support forVitamin E
  34. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
    Chin SF; Ibahim J; Makpol S; Abdul Hamid NA; Abdul Latiff A; Zakaria Z; Mazlan M; Mohd Yusof YA; Abdul Karim A; Wan Ngah WZ · Nutrition & metabolism · 2011
    Randomized trial62 participantsCardiovascular Support forVitamin E
  35. Dietary intake of antioxidants and risk of age-related macular degeneration.
    van Leeuwen R; Boekhoorn S; Vingerling JR; Witteman JC; Klaver CC; Hofman A; de Jong PT · JAMA · 2005
    Cohort study4,765 participantsVision Support forVitamin E