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Natural E-400

Protocol For Life Balance
4.9
★ ★ ★ ★ ★
(238 ratings)
Vitamin E 400 IU
Selenium 100 mcg
Product Image
Score81
A focused natural vitamin E formula with mixed tocopherols and selenium in a convenient softgel. The high potency requires attention to bleeding risk and total vitamin E intake.
How scoring works
Quantity:120 Softgel(s) • (120 servings)
Goals:
Vision Support
Anti-Inflammatory Support
Immunity
General Health
Cardiovascular Support

Score 81

A focused natural vitamin E formula with mixed tocopherols and selenium in a convenient softgel. The high potency requires attention to bleeding risk and total vitamin E intake.
How scoring works
$37.00($0.30 per serving)
iHerb
$ 37.00
Pure Formulas
$ 39.00
iHerb
$ 37.00
Report prices

Analysis

The formula combines natural d-alpha-tocopherol with beta, delta, and gamma tocopherols rather than relying on alpha-tocopherol alone. Selenium yeast adds a complementary antioxidant nutrient at a moderate amount.

One softgel provides a convenient and fat-compatible delivery format. The high vitamin E amount is better suited to deliberate supplementation than casual stacking with other vitamin E products.

Vision, antioxidant, and general immune support are the clearest uses, while nail support is weak because the formula lacks core nail nutrients. Good serving value and focused composition make it attractive for users who specifically need vitamin E and selenium.

Who is it for
  • Adults specifically seeking natural vitamin E
  • Users who want mixed tocopherols
  • People seeking vitamin E with selenium
Best for
  • Antioxidant support
  • Vision-related nutrient support
  • General immune support

Pros

  • Uses natural d-alpha-tocopherol
  • Includes beta, delta, and gamma tocopherols
  • Adds selenium yeast
  • One-softgel serving

Cons

  • Vitamin E amount is high for casual use
  • Not a broad multivitamin
  • Little relevance to nail health
  • May be unnecessary when diet and other supplements already supply vitamin E

Warnings

  • High-dose vitamin E can increase bleeding risk with warfarin, other anticoagulants, or antiplatelet medicines.
  • Supplementation should be stopped or reviewed before surgery because of the vitamin E amount.
  • Combining it with other selenium products may push total selenium intake unnecessarily high.

Nutrient quality

84 Highest impact

Several nutrients use well-regarded natural, methylated, or chelated forms. Vitamin E, selenium, and mixed tocopherols are supplied at meaningful amounts.

.

Ingredient transparency

82 Highest impact

Every listed active has a specific amount. A complete excipient list is not available in the supplied data.

.

Customer satisfaction

72 High impact

The average rating is very strong. The rating volume is adequate for a useful satisfaction signal.

.

Value for money

84 Highest impact

The supply provides moderate value per effective serving. The formula is not inflated by low-value extras.

.
Report analysis

Goals

Vision Support
Vision Support
Impact
Highest effect
A- Goal FitA+ Strength of SupportB- CoverageA Formula Quality
Vitamin E · 48 mg

Natural vitamin E supplies a core AREDS antioxidant for protecting retinal cell membranes, while selenium supports endogenous antioxidant enzymes. The combination has strong ocular relevance but does not provide macular pigments, zinc, or omega-3 fats.

Natural alpha-tocopherol and individually quantified mixed tocopherols offer excellent form quality, and selenium yeast provides a useful maintenance amount. The high vitamin E serving may increase bleeding tendency when combined with anticoagulant or antiplatelet medicines.

Study evidence
Selenium Supportive 15 studies
Vitamin E Disputed 35 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Highest effect
B Goal FitA Strength of SupportB CoverageA+ Formula Quality
Vitamin E · 48 mg

Natural vitamin E, mixed tocopherols, and selenium provide broad antioxidant support for cell membranes and selenium-dependent protective enzymes. The disclosed amounts are substantial, and the tocopherol profile is unusually complete.

The formula is coherent and avoids token amounts of its main actives. The 400 IU vitamin E amount may increase bleeding tendency with anticoagulant or antiplatelet medicines, so regular combined use deserves clinical guidance.

Study evidence
Selenium Supportive 34 studies
Vitamin E Supportive 20 studies
Immunity
Immunity
Impact
Highest effect
B+ Goal FitA- Strength of SupportB- CoverageA Formula Quality
Selenium · 100 mcg

Natural vitamin E, mixed tocopherols, and selenium provide complementary antioxidant support for normal immune-cell integrity. Detailed tocopherol disclosure is a notable strength.

Selenium source standardization is limited, and the formula lacks direct zinc, vitamin D, or vitamin C coverage. High-dose vitamin E may increase bleeding risk when combined with anticoagulant or antiplatelet medicines.

Study evidence
Selenium Mixed 37 studies
Vitamin E Supportive 21 studies
General Health
General Health
Impact
Highest effect
A- Goal FitB+ Strength of SupportB- CoverageA Formula Quality
Selenium · 100 mcg

Natural vitamin E, mixed tocopherols, and selenium provide complementary antioxidant support with some breadth across vitamin E forms. Selenium yeast supplies a meaningful 100 mcg maintenance amount and contributes to thyroid-related enzyme function.

The selenium source is not standardized, and the 400 IU vitamin E amount is high for routine general wellness. People using anticoagulant or antiplatelet medicines should discuss the vitamin E amount with a clinician because it may increase bleeding risk.

Study evidence
Selenium Supportive 70 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
C Goal FitA- Strength of SupportC- CoverageA Formula Quality
Selenium · 100 mcgVitamin E · 48 mg

Natural vitamin E, mixed tocopherols, and selenium provide broad lipid and antioxidant protection. Their biochemical roles are relevant, but high-dose vitamin E supplementation has not consistently improved cardiovascular outcomes in well-nourished adults.

The forms and amounts are clearly disclosed, with a diverse tocopherol profile and a reasonable selenium amount. The 400 IU vitamin E serving may increase bleeding risk when combined with warfarin, direct oral anticoagulants, aspirin, or other antiplatelet medicines.

Study evidence
Selenium Supportive 107 studies
Vitamin E Mixed 79 studies

Ingredients

IngredientAmount per serving
Vitamin E (D-Alpha-Tocopherol)
 400 IU
Selenium (Selenium Yeast)
 100 mcg
natural Mixed Tocopherols (D-Beta Tocopherol, D-Delta-Tocopherol, D-Gamma-Tocopherol)
 48 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Vitamin E (D-Alpha-Tocopherol) · 400 IU OverallScore91
B Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The natural d-alpha form is paired with individually quantified beta, delta, and gamma tocopherols for a broad vitamin E profile. Its 400 IU dose reaches the upper end of the preferred support range without exceeding it. The natural forms, detailed disclosure, and low serving cost make it well aligned with this collection.

View ingredientView products
Selenium (Selenium Yeast) · 100 mcg OverallScore74
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value

Selenium yeast supplies a food-form matrix, but the label does not identify a branded or standardized yeast source. The 100 mcg amount fits daily maintenance and allows ample room for dietary intake. Natural vitamin E and mixed tocopherols broaden the formula, though selenium cost efficiency is limited.

View ingredientView products
Loading alternative details
88 Performance

Vitamin E Complete

OL Olympian Labs
<p>Natural d-alpha-tocopherol and mixed tocotrienols provide broader vitamin E-family coverage than the original’s tocopherol-focused formula. Individual tocotrienol isomers are not quantified, but the practical amount improves balance.</p>
84 Performance

Natural E-Complex With Mixed Tocopherols 400 IU

Country Life
<p>Several natural tocopherol isomers provide broader vitamin E coverage than alpha alone. Repeated equal amount entries make the true total uncertain, so the substantial exposure still warrants medication-related bleeding caution.</p>
82 Performance

Gamma E 400

Source Naturals
<p>Natural alpha-tocopherol, a broad tocopherol blend, and tocotrienols diversify vitamin E forms beyond the original. Individual blend amounts are hidden, and sesame oil makes it unsuitable for anyone with a sesame allergy.</p>
86 Budget

Mixed Vitamin E 400 IU

Natural Factors
<p>Natural d-alpha vitamin E with mixed tocopherols provides broader vitamin E-family coverage at a lower serving cost. The amount is still substantial, so people using anticoagulant or antiplatelet medicines should consider the added bleeding risk.</p>
85 Budget

Natural E-400

NOW
<p>Natural d-alpha-tocopheryl acetate preserves the original’s core vitamin E amount at a lower serving cost. Mixed tocopherols and selenium are absent, and the substantial dose may add bleeding risk with anticoagulant or antiplatelet medicines.</p>
80 Budget

Kyolic Vitamin E Cayenne Hawthorn

Kyolic
<p>Natural-form vitamin E and aged garlic add antioxidant and cardiovascular relevance at a lower serving cost. Hawthorn and cayenne are modest, while vitamin E, garlic, and cayenne may increase bleeding tendency with anticoagulant or antiplatelet medicines.</p>
88 Value

Se-Methyl L-Selenocysteine 200 mcg

Life Extension
<p>Clearly identified organic selenium provides a focused, economical way to retain the original’s selenium component. Vitamin E is absent, and total selenium from other supplements and food still deserves attention.</p>
88 Value

Selenium 200 mcg

Nature's Way
<p>L-selenomethionine provides a clearly disclosed organic selenium form with strong serving value. It does not replace the original’s vitamin E or mixed tocopherols, and combined selenium intake should be monitored.</p>
85 Value

Natural E-Oil

NOW
<p>Natural d-alpha-tocopherol offers an economical, practical vitamin E amount in liquid form. Selenium and mixed vitamin E isomers are absent, while daily intake directions are missing from the supplied data.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2018
    Meta-analysis55,614 participants4 studies pooledVision Support forVitamin E
  2. Vitamin E and beta-carotene supplementation and hospital-treated pneumonia incidence in male smokers.
    Hemilä H; Virtamo J; Albanes D; Kaprio J · Chest · 2004
    Randomized trial29,133 participantsImmunity forVitamin E
  3. Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults.
    Ivory K; Prieto E; Spinks C; Armah CN; Goldson AJ; Dainty JR; Nicoletti C · Clinical nutrition (Edinburgh, Scotland) · 2018
    Randomized trial117 participantsImmunity forSelenium
  4. Efficacy of Selenium Supplementation in Graves' Orbitopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis.
    Kostadinov N; Kirovakov Z; Penchev P · Journal of clinical medicine · 2026
    Meta-analysis303 participants5 studies pooledVision Support forSelenium
  5. Acute selenium toxicity associated with a dietary supplement.
    MacFarquhar JK; Broussard DL; Melstrom P; Hutchinson R; Wolkin A; Martin C; Burk RF; Dunn JR; Green AL; Hammond R; Schaffner W; Jones TF · Archives of internal medicine · 2010
    Observational study201 participantsNail Health forSelenium
  6. Why don't we use vitamin E in dermatology?
    Pehr K; Forsey RR · CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1993
    Systematic reviewNail Health forVitamin E
  7. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa.
    Berson EL; Rosner B; Sandberg MA; Hayes KC; Nicholson BW; Weigel-DiFranco C; Willett W · Archives of ophthalmology (Chicago, Ill. : 1960) · 1993
    Randomized trial601 participantsVision Support forVitamin E
  8. Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: a randomized controlled trial.
    Graat JM; Schouten EG; Kok FJ · JAMA · 2002
    Randomized trial652 participantsImmunity forVitamin E
  9. Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency.
    Mao J; Pop VJ; Bath SC; Vader HL; Redman CW; Rayman MP · European journal of nutrition · 2016
    Randomized trial230 participantsImmunity forSelenium
  10. Association between late age-related macular degeneration and dietary intake of copper, iron, zinc and selenium: a 2005-2008 NHANES cross-sectional observational study.
    Lu Y; Li C; Liu Y; Wu T; Lu P · BMC ophthalmology · 2025
    Observational study4,996 participantsVision Support forSelenium
  11. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forVitamin E
  12. Age-related cataract in men in the selenium and vitamin e cancer prevention trial eye endpoints study: a randomized clinical trial.
    Christen WG; Glynn RJ; Gaziano JM; Darke AK; Crowley JJ; Goodman PJ; Lippman SM; Lad TE; Bearden JD; Goodman GE; Minasian LM; Thompson IM; Blanke CD; Klein EA · JAMA ophthalmology · 2015
    Randomized trial11,267 participantsVision Support forVitamin E
  13. Effect of 3 months vitamin E supplementation on indices of the cellular and humoral immune response in elderly subjects.
    De Waart FG; Portengen L; Doekes G; Verwaal CJ; Kok FJ · The British journal of nutrition · 1997
    Randomized trialImmunity forVitamin E
  14. Association of daily selenium intake and glaucoma: A cross-sectional study.
    Zhao R; Liu T; Zhao B · Medicine · 2024
    Cross-sectional studyVision Support forSelenium
  15. Selenium supplementation for critically ill adults.
    Allingstrup M; Afshari A · The Cochrane database of systematic reviews · 2016
    Meta-analysis2,084 participants16 studies pooledImmunity forSelenium
  16. Dermatologic signs in patients with eating disorders.
    Strumia R · American journal of clinical dermatology · 2005
    Narrative reviewNail Health forVitamin E
  17. Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial.
    Meydani SN; Leka LS; Fine BC; Dallal GE; Keusch GT; Singh MF; Hamer DH · JAMA · 2004
    Randomized trial617 participantsImmunity forVitamin E
  18. Selenium and immune function: a systematic review and meta-analysis of experimental human studies.
    Filippini T; Fairweather-Tait S; Vinceti M · The American journal of clinical nutrition · 2023
    Meta-analysis9 studies pooledImmunity forSelenium
  19. Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract.
    Mathew MC; Ervin AM; Tao J; Davis RM · The Cochrane database of systematic reviews · 2012
    Meta-analysis117,272 participants9 studies pooledVision Support forVitamin E
  20. Toxic risks and nutritional benefits of traditional diet on near visual contrast sensitivity and color vision in the Brazilian Amazon.
    Fillion M; Lemire M; Philibert A; Frenette B; Weiler HA; Deguire JR; Guimarães JR; Larribe F; Barbosa F; Mergler D · Neurotoxicology · 2014
    Cross-sectional study228 participantsVision Support forSelenium
  21. Yellow nail syndrome: clinical experience in a series of 21 patients.
    Piraccini BM; Urciuoli B; Starace M; Tosti A; Balestri R · Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2014
    Case series20 participantsNail Health forVitamin E
  22. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects.
    Meydani SN; Barklund MP; Liu S; Meydani M; Miller RA; Cannon JG; Morrow FD; Rocklin R; Blumberg JB · The American journal of clinical nutrition · 1990
    Randomized trial32 participantsImmunity forVitamin E
  23. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  24. Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study.
    Christen WG; Liu S; Glynn RJ; Gaziano JM; Buring JE · Archives of ophthalmology (Chicago, Ill. : 1960) · 2008
    Cohort study35,551 participantsVision Support forVitamin E
  25. Evaluation of clinical and ocular surface changes in thyroid eye disease: impact of treatment and risk factors.
    Barman Kakil Ş; Arslan N · Therapeutic advances in ophthalmology · 2025
    Cohort study365 participantsVision Support forSelenium
  26. Immunomodulatory effects of palm-derived tocotrienol-rich fraction in healthy volunteers following influenza vaccination: A randomised clinical trial.
    Chen S; Ahmad B; Palanisamy UD; Hafid SRA; Selvaduray KR; Radhakrishnan AK · Nutrition research (New York, N.Y.) · 2026
    Randomized trial150 participantsImmunity forVitamin E
  27. Humoral immune response to COVID-19 mRNA vaccination in relation to selenium status.
    Demircan K; Chillon TS; Sun Q; Heller RA; Klingenberg GJ; Hirschbil-Bremer IM; Seemann P; Diegmann J; Bachmann M; Moghaddam A; Schomburg L · Redox biology · 2022
    Cohort study126 participantsImmunity forSelenium
  28. Prospective cohort study of antioxidant vitamin supplement use and the risk of age-related maculopathy.
    Christen WG; Ajani UA; Glynn RJ; Manson JE; Schaumberg DA; Chew EC; Buring JE; Hennekens CH · American journal of epidemiology · 1999
    Cohort study21,120 participantsVision Support forVitamin E
  29. Selenium Supplementation in Graves' Orbitopathy: Effects on Blood Concentrations and Clinical Outcomes.
    Lumyongsatien M; Vejsitthangkul K; Treebuppachatsakul T; Sintuwong S; Nimitwongsakul O; Pongpirul K · Clinical ophthalmology (Auckland, N.Z.) · 2026
    Observational study48 participantsVision Support forSelenium
  30. Selenium and immune functions in humans.
    Arvilommi H; Poikonen K; Jokinen I; Muukkonen O; Räsänen L; Foreman J; Huttunen JK · Infection and immunity · 1983
    Randomized trial40 participantsImmunity forSelenium
  31. Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers.
    Mahalingam D; Radhakrishnan AK; Amom Z; Ibrahim N; Nesaretnam K · European journal of clinical nutrition · 2011
    Randomized trialImmunity forVitamin E
  32. Vitamin E in the treatment of uveitis-associated macular edema.
    Nussenblatt RB; Kim J; Thompson DJ; Davis MD; Chew E; Ferris FL; Buggage R · American journal of ophthalmology · 2006
    Randomized trialVision Support forVitamin E
  33. Selenium, selenoproteins and vision.
    Flohé L · Developments in ophthalmology · 2005
    Narrative reviewVision Support forSelenium
  34. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  35. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin E
  36. Effect of conjugated linoleic Acid, vitamin e, alone or combined on immunity and inflammatory parameters in adults with active rheumatoid arthritis: a randomized controlled trial.
    Aryaeian N; Djalali M; Shahram F; Djazayery A; Eshragian MR · International journal of preventive medicine · 2015
    Randomized trial78 participantsImmunity forVitamin E
  37. Thyroid eye disease: towards an evidence base for treatment in the 21st century.
    Gillespie EF; Smith TJ; Douglas RS · Current neurology and neuroscience reports · 2012
    Narrative reviewVision Support forSelenium
  38. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities.
    Huang Z; Rose AH; Hoffmann PR · Antioxidants & redox signaling · 2012
    Narrative reviewImmunity forSelenium
  39. Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons.
    Pallast EG; Schouten EG; de Waart FG; Fonk HC; Doekes G; von Blomberg BM; Kok FJ · The American journal of clinical nutrition · 1999
    Randomized trial161 participantsImmunity forVitamin E
  40. Long-term nutrient intake and 5-year change in nuclear lens opacities.
    Jacques PF; Taylor A; Moeller S; Hankinson SE; Rogers G; Tung W; Ludovico J; Willett WC; Chylack LT · Archives of ophthalmology (Chicago, Ill. : 1960) · 2005
    Cohort study408 participantsVision Support forVitamin E
  41. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  42. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study.
    Tan JS; Wang JJ; Flood V; Rochtchina E; Smith W; Mitchell P · Ophthalmology · 2008
    Cohort study3,654 participantsVision Support forVitamin E
  43. Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention.
    Wu D; Meydani SN · Journal of leukocyte biology · 2008
    Narrative reviewImmunity forVitamin E
  44. Selenium and the course of mild Graves' orbitopathy.
    Marcocci C; Kahaly GJ; Krassas GE; Bartalena L; Prummel M; Stahl M; Altea MA; Nardi M; Pitz S; Boboridis K; Sivelli P; von Arx G; Mourits MP; Baldeschi L; Bencivelli W; Wiersinga W; European Group on Graves' Orbitopathy · The New England journal of medicine · 2011
    Randomized trial159 participantsAnti-Inflammatory Support forSelenium
  45. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial.
    Asemi Z; Jamilian M; Mesdaghinia E; Esmaillzadeh A · Nutrition (Burbank, Los Angeles County, Calif.) · 2016
    Randomized trial70 participantsAnti-Inflammatory Support forSelenium
  46. Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease.
    Farrokhian A; Bahmani F; Taghizadeh M; Mirhashemi SM; Aarabi MH; Raygan F; Aghadavod E; Asemi Z · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2017
    Randomized trial60 participantsAnti-Inflammatory Support forSelenium
  47. The effects of selenium supplementation on cardiovascular risk factors in patients with metabolic diseases ‒ A systematic review and meta-analysis of randomized controlled trials.
    Qiu W; Huang N; Zhang K; Qiu H; Guo Z; Han F; Sun X; Hou N; Kan C · Nutricion hospitalaria · 2026
    Meta-analysis656 participants11 studies pooledAnti-Inflammatory Support forSelenium
  48. Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Kamali A; Amirani E; Asemi Z · Biological trace element research · 2020
    Randomized trial33 participantsAnti-Inflammatory Support forSelenium
  49. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  50. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  51. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  52. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  53. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  54. Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial.
    Rayman MP; Stranges S; Griffin BA; Pastor-Barriuso R; Guallar E · Annals of internal medicine · 2011
    Randomized trial501 participantsCardiovascular Support forSelenium
  55. Association of selenium and cadmium with heart failure and mortality based on the National Health and Nutrition Examination Survey.
    Xing X; Xu M; Yang L; Shao C; Wang Y; Qi M; Niu X; Gao D · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2023
    Cohort study15,689 participantsCardiovascular Support forSelenium
  56. Higher serum selenium concentration is associated with lower risk of all-cause and cardiovascular mortality among individuals with chronic kidney disease: A population-based cohort study of NHANES.
    Zhu D; Zhong Q; Lin T; Song T · Frontiers in nutrition · 2023
    Cohort study3,063 participantsCardiovascular Support forSelenium
  57. Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis.
    Kuria A; Tian H; Li M; Wang Y; Aaseth JO; Zang J; Cao Y · Critical reviews in food science and nutrition · 2021
    Meta-analysis13 studies pooledCardiovascular Support forSelenium
  58. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledCardiovascular Support General Health forSelenium
  59. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis.
    Loffredo L; Perri L; Di Castelnuovo A; Iacoviello L; De Gaetano G; Violi F · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Meta-analysis16 studies pooledCardiovascular Support forVitamin E
  60. Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
    Chen B; Li Y; Li Z; Hu X; Zhen H; Chen H; Nie C; Hou Y; Zhu S; Xiao L; Li T · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025
    Randomized trial90 participantsCardiovascular Support forVitamin E
  61. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.
    Lonn E; Bosch J; Yusuf S; Sheridan P; Pogue J; Arnold JM; Ross C; Arnold A; Sleight P; Probstfield J; Dagenais GR; HOPE and HOPE-TOO Trial Investigators · JAMA · 2005
    Randomized trial9,541 participantsCardiovascular Support forVitamin E
  62. Independent and combined associations of dietary antioxidant exposure with all-cause and cause-specific mortality in the general population.
    Liu Z; He Z; Xing Y · Journal of nutritional science · 2026
    Cohort study34,955 participantsCardiovascular Support forVitamin E
  63. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study.
    Chin SF; Ibahim J; Makpol S; Abdul Hamid NA; Abdul Latiff A; Zakaria Z; Mazlan M; Mohd Yusof YA; Abdul Karim A; Wan Ngah WZ · Nutrition & metabolism · 2011
    Randomized trial62 participantsCardiovascular Support forVitamin E
  64. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  65. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health Vision Support forSelenium
  66. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  67. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
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