Rutin

botanical
Browse products

Rutin is a potent bioflavonoid and flavonol glycoside found in a variety of plants. It is recognized for its antioxidant capabilities, which help protect cells from oxidative stress. This protective action contributes to overall cellular health and helps reduce free-radical damage associated with aging and disease. Beyond its antioxidant role, Rutin is used for its anti-inflammatory effects and its ability to support the integrity of capillaries and blood vessels. By helping to maintain capillary strength and reducing permeability, Rutin supports healthy blood circulation and can be beneficial for managing issues related to fragile vessels, such as bruising, spider veins, and swelling. Furthermore, Rutin may contribute to cardiovascular health by supporting healthy blood pressure and reducing cholesterol levels. Researchers also study its potential to work synergistically with other nutrients, particularly vitamin C.

Natural sources
BuckwheatApples (especially the peel)Citrus fruits (oranges, grapefruits, lemons)Berries (cranberries, mulberries)AsparagusBlack and green teaFigs

No public comparison lists found.

Timing & Intake
AnytimeWith foodTake with Vitamin C
Rutin can be taken with or without food, though taking it with a meal may help minimize potential stomach discomfort. It is frequently paired with Vitamin C for synergistic effects.
Optimal Dosage
Minimum300 mg
Maximum600 mg
Safety & Toxicity
4 safety notes
  • Pregnant or nursing women should consult a healthcare professional before use.
  • Individuals taking blood-thinning medications should consult a doctor due to potential interaction.
  • Discontinue use and consult a healthcare professional if adverse reactions occur.
  • Not recommended for individuals with a known allergy to rutin or any plant sources of rutin.
Goals
Vision Support
Vision Support
Impact
Moderate effect
Typical dose:250–1000 mg
Rutin helps strengthen the small blood vessels in the eye. This supports overall eye health and may be relevant to conditions involving vascular fragility, such as diabetic retinopathy. Its role is supportive compared with foundational nutrients such as lutein and zinc.

Study evidence

1 study

The supplied research does not establish a vision benefit from Rutin supplements. It concerns troxerutin used as a medical treatment for retinal vein occlusion, where preliminary improvements cannot be generalized to Rutin itself or to routine vision support.

View goal
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Situational effect
Typical dose:250–1000 mg
Rutin's primary benefits are related to vascular health, where it reduces capillary permeability and fragility, which can help with swelling and bruising. Its antioxidant and enzyme-inhibiting properties provide moderate anti-inflammatory effects, making it a strong situational choice, especially when combined with Vitamin C.

Study evidence

6 studies

Rutin shows early potential to reduce inflammatory activity, but direct human evidence for the ingredient alone is limited. Improvements in pain and inflammation with enzyme combinations containing rutin cannot establish how much rutin contributes, and laboratory findings do not confirm a general supplement benefit.

View goal
Cardiovascular Support
Cardiovascular Support
Impact
Situational effect
Typical dose:250–1000 mg
Rutin helps maintain the structural integrity of small blood vessels (capillaries), reducing their fragility and permeability. This action supports healthy circulation and can be beneficial for conditions related to venous insufficiency. Its antioxidant properties also contribute to protecting the vascular system from oxidative stress.

Study evidence

4 studies

Rutin may improve blood pressure and some cardiovascular risk markers in people with type 2 diabetes, but the evidence is preliminary. Research on related rutoside medicines concerns venous symptoms and cannot establish that rutin supplements prevent heart attacks or other cardiovascular events.

View goal

Studies

Research connections will load here.
Sources

Up to five highest-ranked published examples per goal. Study counts and charts include all published studies for the connection.

  1. A randomized, double-masked study on the treatment of retinal vein occlusion with troxerutin
    Glacet-Bernard A, Coscas G, Chabanel A, Zourdani A, Lelong F, Samama MM · American Journal of Ophthalmology · 1994
    Randomized trial53 participantsVision Support
  2. The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial.
    Bazyar H; Moradi L; Zaman F; Zare Javid A · Phytotherapy research : PTR · 2023
    Randomized trial50 participantsCardiovascular SupportAnti-Inflammatory Support
  3. Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature.
    Muvhulawa N; Dludla PV; Ziqubu K; Mthembu SXH; Mthiyane F; Nkambule BB; Mazibuko-Mbeje SE · Pharmacological research · 2022
    Systematic reviewAnti-Inflammatory Support
  4. Rutin-loaded chitosan microspheres: Characterization and evaluation of the anti-inflammatory activity.
    Cosco D; Failla P; Costa N; Pullano S; Fiorillo A; Mollace V; Fresta M; Paolino D · Carbohydrate polymers · 2018
    OtherAnti-Inflammatory Support
  5. Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial.
    Henrotin Y; Pap T; Lieten S; Badot V; Dubuc JE; Urbin-Choffray D; von Eynatten M; Johansen OE; Rau S; Brabants K · RMD open · 2025
    Randomized trial45 participantsAnti-Inflammatory Support
  6. The Impact of the Combination of Proteolytic Enzyme and Rutin on the Post-operative Management of Inflammation: A Randomized, Controlled, Double-Blind, Comparative Clinical Trial
    Rathi PC, Rathi CL, Risbud SP, Ganu GP · Cureus · 2024
    Randomized trial65 participantsAnti-Inflammatory Support
  7. The effects of rutin supplement on blood pressure markers, some serum antioxidant enzymes, and quality of life in patients with type 2 diabetes mellitus compared with placebo.
    Bazyar H; Zare Javid A; Ahangarpour A; Zaman F; Hosseini SA; Zohoori V; Aghamohammadi V; Yazdanfar S; Ghasemi Deh Cheshmeh M · Frontiers in nutrition · 2023
    Randomized trial50 participantsCardiovascular Support
  8. Interventions for varicosities and leg oedema in pregnancy.
    Young GL; Jewell D · The Cochrane database of systematic reviews · 2000
    Systematic review115 participants3 studies pooledCardiovascular Support
  9. HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides) in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial
    Incandela L, Belcaro G, Renton S, DeSanctis MT, Cesarone MR, Bavera P, Ippolito E, Bucci M, Griffin M, Geroulakos G, Dugall M, Golden G, Acerbi G · Journal of Cardiovascular Pharmacology and Therapeutics · 2002
    Randomized trial60 participantsCardiovascular Support