Gamma Linolenic Acid

Description

Gamma Linolenic Acid (GLA) is a type of omega-6 fatty acid, specifically a polyunsaturated fatty acid (PUFA). Unlike many other omega-6 fatty acids that can be pro-inflammatory, GLA is metabolized in the body into compounds like dihomo-gamma-linolenic acid (DGLA) and then further into series-1 prostaglandins and leukotrienes, which generally have anti-inflammatory or neutral effects. This makes GLA unique among omega-6 fatty acids, as it can help to balance the body's inflammatory responses. GLA is not an essential fatty acid as the body can synthesize it from linoleic acid (LA), another omega-6 fatty acid. However, this conversion can be impaired by various factors such as aging, stress, certain nutrient deficiencies, and health conditions. Supplementation with preformed GLA can bypass these conversion limitations, making it readily available for the body's metabolic pathways. Its primary uses revolve around supporting healthy skin, including managing conditions like eczema and dry skin, and alleviating symptoms associated with hormonal fluctuations, such as premenstrual syndrome (PMS) and menopausal discomfort. GLA also shows promise in supporting nerve function and bone health, contributing to overall physiological well-being.

Sources

Evening Primrose OilBorage Seed OilBlack Currant Seed OilHemp Seed Oil

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Optimal Dosage

Minimum240 mg

Maximum360 mg

Safety & Toxicity

Goals

Anti-Inflammatory Support

Anti-Inflammatory Support

Typical dose:240–500 mg

Unlike other omega-6s, GLA (from sources like borage or evening primrose oil) uniquely converts into anti-inflammatory prostaglandins. This makes it highly effective for conditions characterized by inflammation and immune dysregulation, such as rheumatoid arthritis and eczema. Its targeted mechanism places it in the high-impact tier.

Typical dose:500–1000 mg

Gamma Linolenic Acid (from sources like Borage or Evening Primrose oil) is converted into DGLA, a precursor to anti-inflammatory prostaglandins (PGE1). This helps to balance pro-inflammatory pathways and has shown significant benefit in reducing symptoms of rheumatoid arthritis.

Typical dose:240–500 mg

Gamma-Linolenic Acid (GLA), found in oils like borage and evening primrose, is converted into anti-inflammatory prostaglandins. It is highly effective for improving skin barrier integrity, increasing hydration, and reducing symptoms of inflammatory skin conditions like eczema and dermatitis.

Interactions

Positive Interactions

GLA (an Omega-6) can work synergistically with Omega-3 fatty acids to help maintain a balanced inflammatory response in the body.

EPA (Eicosapentaenoic Acid)

GLA complements EPA in modulating inflammatory pathways, contributing to overall anti-inflammatory effects.

Similar to EPA, DHA works alongside GLA to support a healthy balance of immune and inflammatory processes.

As an antioxidant, Vitamin E can help protect polyunsaturated fatty acids like GLA from oxidative damage, ensuring its stability and efficacy.

Zinc is a cofactor for enzymes involved in fatty acid metabolism, potentially supporting the beneficial conversion pathways of GLA in the body.

Vitamin B6 is a cofactor necessary for the proper metabolism of fatty acids, including the enzymatic conversion steps involving GLA.

Magnesium plays a role in enzyme activities related to lipid metabolism, which may indirectly support the optimal function of GLA.

Fish Oil, rich in EPA and DHA, can synergize with GLA to promote a balanced inflammatory response and overall cardiovascular health.

Negative Interactions

Both GLA and Turmeric (Curcumin) possess anti-inflammatory and antiplatelet properties. Combining them might theoretically enhance these effects, potentially increasing the risk of bleeding in susceptible individuals, although this interaction is generally considered mild for typical supplement doses.

Curcumin shares some anti-inflammatory and mild anticoagulant properties with GLA. Concurrent use could potentially heighten these effects, leading to a slightly increased risk of bruising or bleeding, particularly at high doses or in sensitive individuals.

Ginkgo is known for its blood-thinning effects. When combined with GLA, which also has mild antiplatelet activity, there could be an additive effect leading to an increased risk of bleeding, especially in individuals prone to such conditions.

Ginger possesses antiplatelet properties. Combining it with GLA might enhance these effects, potentially increasing the risk of bleeding or bruising, particularly at higher supplemental doses.

Product stats

Price per product

Average$22.11

Median$20.97

Price per serving

Average$0.44

Median$0.43

Price per 10 mg

Average$0.08

Median$0.04

Price distribution

Price per serving distribution

Price per 10 mg

Reference amount: 10 mg

Paired ingredients

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