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Cal-Mag Citrate 2:1 Ratio

4.7
★ ★ ★ ★ ★
(2009 ratings)
Calcium 1000 mg
Magnesium 500 mg
Product Image
Score73
A focused citrate-based calcium-magnesium formula with vitamin D3, offset by oxide content, label ambiguity, and a large capsule serving.
How scoring works
Capsule
Quantity:180 Capsule(s) • (30 servings)
Goals:
Bone Health
General Health
Energy
Heart Health
Testosterone Support

Score 73

A focused citrate-based calcium-magnesium formula with vitamin D3, offset by oxide content, label ambiguity, and a large capsule serving.
How scoring works

Also available as

1 option
360 servings Calcium 1000 mg, Magnesium 500 mg • 360 VegCap(s) • 60 servings $39.60 ($0.66 per serving)
$20.69($0.68 per serving)
iHerb
$ 21.69
Vitacost
$ 21.69
Amazon
$ 20.69
iHerb
$ 21.69
Pure Formulas
$ 21.69
Report prices

Analysis

The two-to-one calcium-to-magnesium design is easy to understand and aligns with bone and muscle support. Vitamin D3 complements the calcium and makes the formula more complete than a mineral-only product.

Calcium citrate and magnesium citrate are useful forms, while magnesium oxide is a weaker addition. The repeated vitamin D and magnesium declarations also create some uncertainty about whether the stated amounts are totals or duplicated entries.

Six capsules per serving is a substantial daily burden, and the high magnesium listing may cause digestive effects. The product fits users who value citrate forms and a defined ratio, but convenience and dose clarity are meaningful trade-offs.

Who is it for
  • Adults seeking a defined calcium-to-magnesium ratio
  • People focused on bone support with vitamin D3
Best for
  • Bone mineral intake
  • Citrate-form supplementation
  • Users comfortable dividing a large capsule serving

Pros

  • Uses calcium citrate
  • Includes magnesium citrate
  • Adds vitamin D3
  • Provides a clear two-to-one mineral concept

Cons

  • Also contains magnesium oxide
  • Requires six capsules per serving
  • Repeated entries create dose ambiguity
  • Serving value is moderate

Warnings

  • The high magnesium declaration may cause diarrhea or abdominal cramping
  • A large calcium serving may cause constipation in sensitive users
  • Substantial calcium and magnesium intake requires care with kidney impairment

Nutrient quality

84 Highest impact

Useful citrate forms and relevant doses make the mineral profile capable. Magnesium oxide and relatively large doses are the main compromises.

.

Ingredient transparency

72 High impact

Named actives have amounts, but totals repeated across several forms leave each form’s contribution unclear. Non-active ingredients are not supplied, so excipient disclosure cannot be verified.

.

Customer satisfaction

69 High impact

The average customer rating is very strong. No specific review comments were supplied, so repeated negative experiences cannot be ruled out.

.

Value for money

64 Moderate impact

Solid mineral dosing does not fully offset the relatively high cost. The product is not especially competitive on serving value.

.
Report analysis

Goals

Bone Health
Bone Health
Impact
Highest effect
A+ Goal FitB- Strength of SupportB+ CoverageA Formula Quality
Magnesium · 500 mgCalcium · 1000 mgVitamin D · 25 mcg

Calcium citrate, magnesium, and vitamin D3 create a coherent mineralization formula for bone health. Calcium citrate is a favorable form, but magnesium oxide lowers the quality of the magnesium blend.

The calcium and magnesium amounts are high for one serving, so divided intake may improve absorption and reduce digestive effects. Vitamin K is absent, leaving calcium-placement support less complete than the most comprehensive bone formulas.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Vitamin D Supportive 202 studies
General Health
General Health
Impact
Highest effect
A Goal FitB Strength of SupportB CoverageA- Formula Quality
Vitamin D · 25 mcgMagnesium · 500 mg

Calcium, magnesium, and vitamin D3 support bone structure, muscle function, nerve signaling, and calcium absorption. The two-to-one mineral ratio gives the formula a clear structural-health purpose.

Magnesium oxide lowers expected absorption, and the amount is slightly above common supplemental targets. A six-capsule serving also makes the otherwise focused design less convenient.

Study evidence
Magnesium Supportive 114 studies
Energy
Energy
Impact
High effect
B Goal FitB Strength of SupportB- CoverageB Formula Quality
Vitamin D · 25 mcgMagnesium · 500 mg

Magnesium supports ATP-dependent metabolism, while vitamin D3 may help muscle function when vitamin D status is low. The magnesium amount is substantial, but oxide lowers absorption quality and the calcium-heavy design is not a direct energy formula.

The 500 mg supplemental magnesium amount, partly from oxide, can cause diarrhea or abdominal cramping. The substantial calcium amount may also cause constipation in sensitive users.

Study evidence
Magnesium Supportive 4 studies
Vitamin D Supportive 32 studies
Heart Health
Heart Health
Impact
High effect
B Goal FitB- Strength of SupportC+ CoverageB Formula Quality
Magnesium · 500 mgVitamin D · 25 mcg

Magnesium provides the clearest heart-relevant contribution through vascular tone and normal electrical signaling. Vitamin D3 adds mineral-regulation support but no direct lipid or cardiac antioxidant pathway.

The 500 mg magnesium amount is substantial, but the oxide portion lowers expected absorption and the calcium-heavy design limits cardiovascular focus. The high mineral serving may cause diarrhea from magnesium or constipation from calcium in sensitive users.

Study evidence
Magnesium Supportive 158 studies
Vitamin D Mixed 164 studies
Testosterone Support
Testosterone Support
Impact
High effect
B Goal FitC Strength of SupportD+ CoverageB Formula Quality
Magnesium · 500 mgVitamin D · 25 mcg

Magnesium provides a relevant route to testosterone support. The disclosed amount appears meaningful for that focused role.

The formula remains narrow rather than comprehensive. The large magnesium amount may cause diarrhea, cramping, and fluid loss, especially because an oxide form is present.

Study evidence
Magnesium Disputed 5 studies
Stress Relief
Stress Relief
Impact
Moderate effect
C- Goal FitC Strength of SupportC- CoverageC- Formula Quality
Vitamin D · 25 mcgMagnesium · 500 mg

Magnesium may support nervous-system regulation and muscle relaxation when intake is inadequate. The 500 mg total is substantial, while vitamin D adds general nutritional context.

The split between citrate and poorly absorbed oxide is not disclosed, and calcium dominates a formula built mainly for bone health. The high magnesium amount may cause diarrhea or stomach cramping in sensitive users.

Study evidence
Magnesium Supportive 13 studies
Vitamin D Supportive 41 studies

Ingredients

IngredientAmount per serving
Total Carbohydrates
1 Gram(s)
Vitamin D (Cholecalciferol, Vitamin D3)
 25 mcg
Calcium (Calcium Citrate)
 1000 mg
Magnesium (Magnesium Citrate, Magnesium Oxide)
 500 mg
Adults 18–50
Report overview
Calcium (Calcium Citrate) · 1000 mg OverallScore70
A- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyD+ Value

Calcium citrate offers reliable absorption across a broad range of stomach-acid levels. The 1000 mg serving is larger than the amount usually absorbed most efficiently at once, so dividing it may improve use. Vitamin D3 adds a useful cofactor, while the cost is only moderate rather than especially low.

View ingredientView products
Magnesium (Magnesium Citrate, Magnesium Oxide) · 500 mg OverallScore54
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value

A citrate-and-oxide blend offers some absorbable magnesium, but the oxide portion lowers expected uptake. The clearly stated amount is somewhat above the preferred range and may be harder to tolerate. Relevant vitamins or boron add useful formulation support. The above-median serving cost is difficult to justify for the form quality.

View ingredientView products
Loading alternative details
88 Performance

Calcium Citrate Pure Powder

NOW
<p>Pure calcium citrate provides a substantial, well-absorbed amount with simple active disclosure. The focused powder improves calcium form quality but does not include magnesium, vitamin D, or vitamin K.</p>
85 Performance

Magnesium Bisglycinate Chelate

Healthy Origins
<p>TRAACS magnesium bisglycinate provides stronger absorption quality than oxide-containing blends and a useful elemental amount. The clean powder is limited to magnesium, so it does not replace the original calcium component.</p>
83 Performance

Albion Chelated Calcium 180 mg

Swanson Ultra
<p>Calcium glycinate chelate offers favorable form quality with a small vitamin D3 addition. The product name and supplied serving amount conflict, and the focused formula contains no magnesium.</p>
85 Budget

600+D3

21st Century
<p>Calcium carbonate and vitamin D3 provide focused bone support at a much lower serving cost. The formula omits magnesium, and carbonate is better suited to use with food than citrate-based calcium.</p>
88 Budget

Magnesium Bisglycinate Powder

NOW
<p>Magnesium bisglycinate provides a well-absorbed form at a lower serving cost than the original. The adjustable powder is clearly labeled but supplies no calcium or vitamin D.</p>
91 Budget

Krebs Magnesium Potassium Complex

Nature's Way
<p>Magnesium lysinate and malate provide favorable forms at a lower serving cost, with potassium adding another useful electrolyte. The focused formula does not replace the original product's calcium contribution.</p>
84 Value

Calcium Citrate +D3 Petites

21st Century
<p>Calcium citrate and vitamin D3 deliver practical bone support with strong serving efficiency. The active amounts are clear, although missing excipient details and the absence of magnesium narrow the formula.</p>
82 Value

Calcium Citrate

Nature's Way
<p>Citrate and malate provide useful calcium forms at an economical serving cost. The formula supplies no magnesium, while missing excipient and full-use details limit transparency.</p>
84 Value

Magnesium Bisglycinate Chelate

Healthy Origins
<p>TRAACS magnesium bisglycinate offers favorable absorption and a useful amount with solid serving value. The tablet remains a single-mineral option and therefore does not replace calcium coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Treatment with alendronate plus calcium, alendronate alone, or calcium alone for postmenopausal low bone mineral density.
    Bonnick S; Broy S; Kaiser F; Teutsch C; Rosenberg E; DeLucca P; Melton M · Current medical research and opinion · 2007
    Randomized trial701 participantsBone Health forCalcium
  2. Associations of dietary calcium intake with metabolic syndrome and bone mineral density among the Korean population: KNHANES 2008-2011.
    Kim MK; Chon SJ; Noe EB; Roh YH; Yun BH; Cho S; Choi YS; Lee BS; Seo SK · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Cross-sectional study14,705 participantsBone Health forCalcium
  3. Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta-analysis.
    Tihtonen K; Korhonen P; Isojärvi J; Ojala R; Ashorn U; Ashorn P; Tammela O · Annals of the New York Academy of Sciences · 2022
    Meta-analysis1,566 participants7 studies pooledBone Health forCalcium
  4. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  5. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.
    Orchard TS; Larson JC; Alghothani N; Bout-Tabaku S; Cauley JA; Chen Z; LaCroix AZ; Wactawski-Wende J; Jackson RD · The American journal of clinical nutrition · 2014
    Cohort study73,684 participantsBone Health forMagnesium
  6. Dialysate Magnesium and Coronary Artery Calcification, Bone Mineral Density, and Cramping in Maintenance Hemodialysis: A Quasi-experimental Study.
    Srisuwarn P; Sethakarun S; Nongnuch A; Jongjirasiri S; Sritara C; Klyprayong P; Disthabanchong S · Kidney medicine · 2022
    Non-randomized trial40 participantsBone Health forMagnesium
  7. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  8. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  9. Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
    Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012
    Randomized trial49 participantsDigestive Health forMagnesium
  10. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  11. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  12. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  13. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  14. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  15. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  16. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  17. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  18. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  19. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  20. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  21. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  22. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  23. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  24. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  25. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  26. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  27. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium Heart Health forVitamin D
  28. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  29. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  30. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  31. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  32. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  33. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  34. Effect of Vitamin D Supplementation on Human Gut Microbiota: A Systematic Review of Randomized Controlled Trials.
    Zeb F; Osaili T; Hashim M; Alkalbani N; Papandreou D; Cheikh Ismail L; Naja F; Radwan H; Hasan H; Obaid RS; Savvaidis I; AlBlooshi S; Alam I · Nutrition reviews · 2026
    Systematic review1,458 participants14 studies pooledDigestive Health forVitamin D
  35. Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome.
    Amani R; Abbasnezhad A; Hajiani E; Cheraghian B; Abdoli Z; Choghakhori R · Iranian journal of immunology : IJI · 2018
    Randomized trial90 participantsDigestive Health forVitamin D
  36. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsDigestive Health forVitamin D
  37. Maternal vitamin D intakes during pregnancy and child health outcome.
    Nasantogtokh E; Ganmaa D; Altantuya S; Amgalan B; Enkhmaa D · The Journal of steroid biochemistry and molecular biology · 2023
    Randomized trial311 participantsDigestive Health forVitamin D
  38. Vitamin D metabolites and the gut microbiome in older men.
    Thomas RL; Jiang L; Adams JS; Xu ZZ; Shen J; Janssen S; Ackermann G; Vanderschueren D; Pauwels S; Knight R; Orwoll ES; Kado DM · Nature communications · 2020
    Cross-sectional study567 participantsDigestive Health forVitamin D
  39. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  40. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  41. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  42. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  43. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  44. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  45. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  46. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  47. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  48. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  49. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  50. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  51. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  52. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  53. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  54. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  55. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  56. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  57. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsHeart Health forVitamin D
  58. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  59. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  60. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  61. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  62. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  63. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  64. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  65. Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study.
    Zaromytidou E; Koufakis T; Dimakopoulos G; Drivakou D; Konstantinidou S; Rakitzi P; Grammatiki M; Manthou E; Notopoulos A; Iakovou I; Gotzamani-Psarrakou A; Kotsa K · Metabolites · 2023
    Randomized trial90 participantsStress Relief forVitamin D
  66. Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial.
    Charoenporn V; Tungsukruthai P; Teacharushatakit P; Hanvivattanakul S; Sriyakul K; Sukprasert S; Kamalashiran C; Tungsukruthai S; Charernboon T · Psychiatry and clinical neurosciences · 2024
    Randomized trial80 participantsStress Relief forVitamin D
  67. The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review.
    Głąbska D; Kołota A; Lachowicz K; Skolmowska D; Stachoń M; Guzek D · Nutrients · 2021
    Systematic review24 studies pooledStress Relief forVitamin D
  68. Vitamin D3 enhances mood in healthy subjects during winter.
    Lansdowne AT; Provost SC · Psychopharmacology · 1998
    Randomized trial44 participantsStress Relief forVitamin D
  69. Comparative Effects of Etelcalcetide and Maxacalcitol on Serum Calcification Propensity in Secondary Hyperparathyroidism: A Randomized Clinical Trial.
    Shoji T; Nakatani S; Kabata D; Mori K; Shintani A; Yoshida H; Takahashi K; Ota K; Fujii H; Ueda S; Nishi S; Nakatani T; Yoshiyama M; Goto K; Hamada T; Imanishi M; Ishimura E; Kagitani S; Kato Y; Kumeda Y; Maekawa K; Matsumura T; Nagayama H; Obi Y; Ohno Y; Sai Y; Sakurai M; Sasaki S; Shidara K; Shoji S; Tsujimoto Y; Yamakawa K; Yasuda H; Yodoi S; Inaba M; Emoto M · Clinical journal of the American Society of Nephrology : CJASN · 2021
    Randomized trial326 participantsStress Relief forVitamin D
  70. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  71. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  72. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  73. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  74. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium