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Total Cleanse Liver

Solaray
4.8
★ ★ ★ ★ ★
(2393 ratings)
Selenium 100 mcg
Gluthathione 25 mg
Product Image
Score60
A modest NAC and antioxidant formula whose large hidden liver blend makes the product difficult to evaluate or use confidently.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Immunity
General Health

Score 60

A modest NAC and antioxidant formula whose large hidden liver blend makes the product difficult to evaluate or use confidently.
How scoring works
$23.19($0.77 per serving)
Amazon
$ 28.09
Vitacost
$ 23.19
iHerb
$ 23.19
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Analysis

N-acetyl cysteine supplies a glutathione precursor, while vitamin C and selenium support related antioxidant systems. Selenomethionine is a favorable form and all three disclosed amounts are easy to assess.

The 25 mg glutathione amount is too small to provide strong direct depth. More importantly, the 635 mg liver blend does not reveal its ingredients or individual doses, preventing a reliable evaluation of effectiveness, safety, or medication interactions.

The capsule is more relevant to targeted antioxidant support than to broad general health or immunity. Its cleanse framing should not substitute for transparent formulation or evidence-based care for liver concerns.

Who is it for
  • Adults seeking modest NAC support
  • Users who understand the limitations of proprietary blends
  • People not taking interacting medicines
Best for
  • Antioxidant pathway support
  • Glutathione precursor intake
  • Short-term targeted supplementation

Pros

  • Uses selenomethionine
  • Includes NAC
  • Provides vitamin C
  • Discloses the main non-blend amounts

Cons

  • Large proprietary blend
  • Glutathione is very low
  • NAC amount is modest
  • Weak fit for broad immunity or general health

Warnings

  • The proprietary liver blend hides its ingredients, so medication, allergy, pregnancy, and liver-condition risks cannot be fully assessed from the supplied label.
  • NAC can cause nausea or other digestive upset and may intensify headache or low blood pressure when combined with nitroglycerin.

Nutrient quality

67 High impact

Selenomethionine and vitamin C are useful forms, while the glutathione form is unspecified. The very small glutathione amount and modest N-acetyl cysteine dose limit the formula's direct antioxidant support.

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Ingredient transparency

53 Moderate impact

The main active amounts are mostly visible, making the core formula possible to assess. Serving directions and non-active ingredients are missing, and any named blend further limits clarity.

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Customer satisfaction

71 High impact

The supplied average is very strong and the response volume is large. No detailed feedback is provided to assess recurring complaints or fit with the intended purpose.

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Value for money

52 Moderate impact

Several useful cofactors provide some formula value. The tiny glutathione amount and undisclosed botanical blend weaken cost efficiency.

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Report analysis

Goals

Immunity
Immunity
Impact
Moderate effect
C Goal FitD Strength of SupportD+ CoverageD+ Formula Quality
Vitamin C · 120 mgSelenium · 100 mcg

Vitamin C, selenium, N-acetyl cysteine, and glutathione provide antioxidant support that can help normal immune defenses. Selenomethionine is a favorable selenium form, but the product is built mainly around a liver-cleanse theme.

The 635 mg blend hides its individual ingredients, while the 200 mg N-acetyl cysteine and 25 mg glutathione amounts are modest. Limited vitamin C and opaque blending make it less convincing as a dedicated immunity formula.

Study evidence
Selenium Mixed 37 studies
Vitamin C Supportive 53 studies
General Health
General Health
Impact
Moderate effect
C- Goal FitF Strength of SupportC- CoverageC Formula Quality
Selenium · 100 mcgVitamin C · 120 mg

The antioxidant nutrients and NAC offer some systemic support, but the liver-cleanse focus is narrower than general nutritional maintenance. The formula touches antioxidant and glutathione pathways but does not cover multiple foundational nutrient systems.

The 25 mg glutathione amount is unlikely to provide meaningful direct support, while NAC and the basic nutrients contribute more substantially. Several active amounts are disclosed, but the 635 mg proprietary blend hides the amounts of its individual components.

Study evidence
Gluthathione Supportive 7 studies
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid, Natural)
 120 mg
Selenium (Selenomethionine)
 100 mcg
Total Cleanse Liver Blend
635 mg
N-Acetyl Cysteine
200 mg
L-Glutathione
25 mg
Adults 18–50
Report overview
Selenium (Selenomethionine) · 100 mcg OverallScore72
A- Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
Selenomethionine provides a highly bioavailable organic source, though the label does not specify its bioactive isomer. The dose supports daily maintenance and remains comfortably below the daily upper limit. Cost efficiency is poor when standardized to a full selenium amount. Value from the broader botanical formula may still matter beyond selenium alone.
View ingredientView products
Gluthathione · 25 mg OverallScore20
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The very small glutathione amount is unlikely to provide meaningful direct systemic support. Vitamin C, selenium, and NAC may support antioxidant pathways, but they do not replace an effective direct glutathione dose. The above-median serving cost represents poor value for this collection.

View ingredientView products
Loading alternative details
84 Performance

L-Glutathione (Reduced) 500 mg

California Gold Nutrition
<p>A substantial amount of clearly identified reduced glutathione offers much deeper direct glutathione support than the original small serving. Standard oral delivery remains a limitation, but the clean formula removes the uncertainty created by the undisclosed liver blend.</p>
87 Performance

Se-Methyl L-Selenocysteine 200 mcg

Life Extension
<p>Se-methyl L-selenocysteine provides a precisely identified organic selenium form with excellent general-health and immunity alignment. It strengthens selenium quality and transparency, although it does not retain the original glutathione pathway ingredients.</p>
79 Performance

Mega-Liposomal Glutathione+ 750 mg Organic Fruit Flavor

Aurora NutraScience
<p>A high glutathione amount paired with vitamin C creates a more focused antioxidant formula than the original low-dose glutathione blend. The supplied details do not verify reduced glutathione or liposomal delivery, so the claimed absorption advantage remains uncertain.</p>
76 Budget

L-Glutathione 500 mg

AN Amazing Nutrition Amazing Formulas
<p>A substantial direct glutathione amount provides far more nominal glutathione at a lower recurring cost. Its exact delivery form is not identified, but the focused formula avoids the original undisclosed liver blend and very small direct glutathione amount.</p>
85 Budget

Selenium 100 mcg

NOW
<p>L-selenomethionine supplies the same maintenance-oriented selenium amount in a precise, inexpensive single-mineral formula. It improves selenium value and transparency, though it does not replace N-acetyl cysteine, vitamin C, or glutathione.</p>
72 Budget

L-Glutathione 100 mg

Bluebonnet
<p>Clearly identified reduced glutathione supplies more direct glutathione with lower serving cost and fewer opaque ingredients. The amount remains modest and no enhanced delivery is stated, but it is easier to assess than the original hidden liver blend.</p>
79 Value

Glutathione 500 mg

Nutricost
<p>A substantial direct glutathione amount offers strong nominal antioxidant value in an economical large format. The form and delivery method are not identified, but the product still provides much more glutathione for the cost than the original.</p>
87 Value

Selenium 100 mcg

Swanson
<p>Trademarked L-selenomethionine supplies the same practical selenium amount with precise sourcing and exceptional serving economy. It is a focused selenium option rather than a full replacement for the original vitamin C, N-acetyl cysteine, and glutathione combination.</p>
76 Value

Reduced Glutathione 250 mg

Source Naturals
<p>Clearly identified reduced glutathione provides a meaningful maintenance amount at favorable recurring value. Basic tablet delivery and the absence of a named purity source limit form quality, yet the formula is more transparent and more substantial than the original direct glutathione serving.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Selenium supplementation for the primary prevention of cardiovascular disease.
    Rees K; Hartley L; Day C; Flowers N; Clarke A; Stranges S · The Cochrane database of systematic reviews · 2013
    Meta-analysis19,715 participants12 studies pooledGeneral Health forSelenium
  2. Effect of long-term selenium supplementation on mortality: Results from a multiple-dose, randomised controlled trial.
    Rayman MP; Winther KH; Pastor-Barriuso R; Cold F; Thvilum M; Stranges S; Guallar E; Cold S · Free radical biology & medicine · 2019
    Randomized trial491 participantsGeneral Health forSelenium
  3. Glutathione reduces the toxicity and improves quality of life of women diagnosed with ovarian cancer treated with cisplatin: results of a double-blind, randomised trial.
    Smyth JF; Bowman A; Perren T; Wilkinson P; Prescott RJ; Quinn KJ; Tedeschi M · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trial151 participantsGeneral Health forGluthathione
  4. Influence of Long-Term Fasting on Blood Redox Status in Humans.
    Wilhelmi de Toledo F; Grundler F; Goutzourelas N; Tekos F; Vassi E; Mesnage R; Kouretas D · Antioxidants (Basel, Switzerland) · 2020
    Single-arm trial109 participantsGeneral Health forGluthathione
  5. Glutathione and morbidity in a community-based sample of elderly.
    Julius M; Lang CA; Gleiberman L; Harburg E; DiFranceisco W; Schork A · Journal of clinical epidemiology · 1995
    Cross-sectional study33 participantsGeneral Health forGluthathione
  6. The role of zinc, copper, plasma glutathione peroxidase enzyme, and vitamins in the development of allergic diseases in early childhood: The Polish mother and child cohort study.
    Stelmach I; Grzelewski T; Bobrowska-Korzeniowska M; Kopka M; Majak P; Jerzynska J; Stelmach W; Polańska K; Sobala W; Gromadzińska J; Wąsowicz W; Hanke W · Allergy and asthma proceedings · 2014
    Cohort study240 participantsGeneral Health forGluthathione
  7. Status of glutathione and other thiols and disulfides in human plasma.
    Kleinman WA; Richie JP · Biochemical pharmacology · 2000
    Cross-sectional studyGeneral Health forGluthathione
  8. Impact of a tailored exercise regimen on physical capacity and plasma proteome profile in post-COVID-19 condition.
    Chowdhury MMH; Fontaine MN; Lord SE; Quenum AJI; Limoges MA; Rioux-Perreault C; Lucier JF; Cliche DO; Levesque D; Boisvert FM; Cantin AM; Allard-Chamard H; Menendez A; Ilangumaran S; Piché A; Dionne IJ; Ramanathan S · Frontiers in physiology · 2024
    Single-arm trialGeneral Health forGluthathione
  9. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  10. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  11. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  12. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  13. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledGeneral Health forSelenium
  14. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  15. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  16. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  17. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  18. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  19. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  20. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  21. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  22. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  23. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  24. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  25. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  26. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  27. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  28. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C