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Cal/Mag 500 mg/250 mg

NaturesPlus
4.7
★ ★ ★ ★ ★
(683 ratings)
Calcium 500 mg
Magnesium 250 mg
Product Image
Score85
A high-value, one-tablet calcium-magnesium base with useful chelated forms, though it lacks complementary bone nutrients.
How scoring works
Quantity:180 Tablet(s) • (180 servings)
Goals:
Bone Health
General Health
Stress Relief
Heart Health
Energy
Cardiovascular Support

Score 85

A high-value, one-tablet calcium-magnesium base with useful chelated forms, though it lacks complementary bone nutrients.
How scoring works
$24.69($0.13 per serving)
Vitacost
$ 24.69
iHerb
$ 38.21
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Analysis

The product keeps its purpose clear with chelated calcium and magnesium in a practical two-to-one balance. Both amounts are suitable for building a basic mineral routine without an excessive ingredient list.

Amino acid chelates are a meaningful strength compared with carbonate or oxide formulas. The label does not specify the exact chelating amino acids, and no vitamin D is included to support calcium use.

One tablet per serving and strong qualitative value make the formula easy to use consistently. It fits users who already obtain complementary bone nutrients elsewhere, but it should not be mistaken for a complete skeletal-support formula.

Who is it for
  • Adults seeking a simple chelated calcium-magnesium supplement
  • Users who already obtain vitamin D and other bone nutrients elsewhere
Best for
  • Foundational mineral support
  • Simple one-tablet routines
  • Strong serving value

Pros

  • Uses amino acid chelates
  • Provides a sensible mineral ratio
  • Requires one tablet per serving
  • Offers strong qualitative value

Cons

  • Does not include vitamin D
  • Does not include vitamin K
  • Exact chelate composition is not specified
  • Provides no broader bone-matrix support

Warnings

  • Calcium may cause constipation in sensitive users
  • Magnesium may loosen stools depending on tolerance
  • Calcium and magnesium may need separation from medicines affected by mineral binding

Nutrient quality

93 Highest impact

Chelated forms, meaningful doses, and a balanced ratio create a strong mineral profile. No obvious dosing or ingredient-selection weakness is evident from the supplied facts.

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Ingredient transparency

84 Highest impact

All listed active ingredients include specific amounts, though amounts shared across multiple forms are not apportioned clearly. Non-active ingredients are not supplied, so excipient disclosure cannot be verified.

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Customer satisfaction

66 High impact

The average customer rating is very strong. No specific review comments were supplied, so repeated negative experiences cannot be ruled out.

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Value for money

96 Highest impact

The chelated forms provide strong quality for the cost. The price-to-quality balance is highly competitive.

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Report analysis

Goals

Bone Health
Bone Health
Impact
Highest effect
A Goal FitA Strength of SupportB+ CoverageA- Formula Quality
Magnesium · 250 mgCalcium · 500 mg

Chelated calcium and magnesium provide two important minerals in practical, clearly disclosed amounts. The amino acid complexes offer favorable absorption potential and maintain a sensible two-to-one balance.

The formula delivers strong depth for structural mineral support without unnecessary additions. It lacks vitamins D and K and offers no direct protein-matrix support, so broader skeletal coverage is limited.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
General Health
Stress Resilience
General Health
Impact
Highest effect
A Goal FitA- Strength of SupportB CoverageA Formula Quality
Magnesium · 250 mg

Calcium and magnesium directly support bone, muscle, nerve, and energy functions. Their amounts are substantial and well balanced for a combined mineral supplement.

Generic amino acid chelates offer reasonable absorption potential, though the exact amino acids and chelation quality are not disclosed. The two-ingredient design is focused, transparent, and free from decorative blends.

Study evidence
Magnesium Supportive 114 studies
Stress Relief
Stress Relief
Impact
High effect
B+ Goal FitB+ Strength of SupportC- CoverageA Formula Quality
Magnesium · 250 mg

Magnesium directly supports nervous-system regulation and relaxation. Magnesium has established evidence when inadequate status contributes to stress symptoms.

The magnesium amount reaches a useful supplemental range. The generic amino acid chelate is disclosed but lacks exact chelation detail.

Study evidence
Magnesium Supportive 13 studies
Heart Health
Healthy Blood Pressure
Heart Health
Impact
High effect
B+ Goal FitB+ Strength of SupportC- CoverageA- Formula Quality
Magnesium · 250 mg

A meaningful magnesium amount supports vascular tone, rhythm-related physiology, and cellular energy. The simple calcium-to-magnesium formula is fully quantified and avoids unrelated ingredients.

The generic amino-acid chelate does not identify a specific ligand or validated raw material, which limits absorption confidence. It provides focused mineral support rather than broad lipid, nitric-oxide, or homocysteine coverage.

Study evidence
Magnesium Supportive 158 studies
Energy
Energy
Impact
High effect
B- Goal FitB Strength of SupportD+ CoverageA- Formula Quality
Magnesium · 250 mg

Magnesium at 250 mg meets the stated energy-support threshold and may help when inadequate mineral intake contributes to fatigue. A generic amino-acid chelate suggests reasonable absorption, though the exact ligand and chelation quality are not shown.

Calcium is supplied at twice the magnesium amount, keeping the product focused on mineral support rather than direct stimulation. The formula does not add B vitamins, CoQ10, caffeine, or an adaptogen for a second energy pathway.

Study evidence
Magnesium Supportive 4 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
C+ Goal FitB Strength of SupportD CoverageB+ Formula Quality
Magnesium · 250 mg

A clearly labeled magnesium amount can support normal vascular tone and cardiac rhythm. The amino acid chelate should absorb better than magnesium oxide, although the exact chelation details are missing.

Calcium is included at the upper acceptable balance relative to magnesium, keeping the formula narrow and mineral-focused. The simple composition is practical for users who specifically want combined calcium and magnesium rather than broad heart support.

Study evidence
Magnesium Supportive 123 studies

Ingredients

IngredientAmount per serving
Calcium (Calcium Amino Acid Chelate)
 500 mg
Magnesium (Magnesium Amino Acid Chelate)
 250 mg
Gluten Free Adults 18–50 Vegetarian
Report overview
Calcium (Calcium Amino Acid Chelate) · 500 mg OverallScore100
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Chelated calcium offers strong absorption potential. The 500 mg serving is sized efficiently for a single dose. The very low cost and clean supplied ingredient profile support strong practical value.

View ingredientView products
Magnesium (Magnesium Amino Acid Chelate) · 250 mg OverallScore72
D Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyB+ Value

A generic amino acid chelate offers reasonable absorption potential, although the exact chelating amino acid and reaction quality are not disclosed. The elemental dose is clear and well aligned, and the calcium-to-magnesium ratio stays at the acceptable boundary. Low serving cost supports good practical value despite limited raw-material detail.

View ingredientView products
Loading alternative details
88 Performance

Calcium Citrate Pure Powder

NOW
The pure calcium citrate powder is adjustable, clearly labeled, and carries strong supplied quality measures. It improves calcium-form specificity but removes the original's magnesium component.
85 Performance

Magnesium Bisglycinate Chelate

Healthy Origins
TRAACS magnesium bisglycinate provides a clearly identified chelated form with stronger magnesium-specific quality. It omits calcium, so it is appropriate only when magnesium is the priority.
85 Performance

Cal/Mag Caps

NaturesPlus
The capsule supplies the same balanced calcium and magnesium amounts in related amino acid chelates, making it the closest functional alternative. Its main advantage is format flexibility rather than a clear ingredient upgrade.
83 Budget

Citracal Petites Calcium Citrate +D3

Bayer Citracal
Calcium with vitamin D3 offers a lower serving cost and adds a nutrient that supports calcium use. Magnesium is absent, so it does not preserve the original's balanced two-mineral design.
84 Budget

Calcium 600 with Vitamin D3

Nature's Bounty
The formula provides calcium plus vitamin D3 at a lower serving cost and has strong supplied bone-health alignment. It uses calcium carbonate and contains no magnesium, making it less balanced than the original.
85 Budget

600+D3

21st Century
A very economical calcium and vitamin D3 combination supports a focused bone-health routine. Calcium carbonate may be less flexible than a chelated form, and the formula omits magnesium.
91 Value

Krebs Magnesium Potassium Complex

Nature's Way
Well-defined magnesium lysinate and malate plus modest potassium provide strong quality and value for a magnesium-centered routine. It does not include calcium, so it cannot match the original's balanced mineral coverage.
84 Value

Calcium Citrate +D3 Petites

21st Century
Calcium citrate and vitamin D3 combine favorable form quality with a low serving cost. The formula improves calcium support per unit of cost but omits magnesium.
83 Value

Albion Chelated Calcium 180 mg

Swanson Ultra
TRAACS calcium glycinate and vitamin D provide a well-defined chelated calcium option with favorable supplied value. It is less comprehensive than the original because no magnesium is included.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  2. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  3. Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
    Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012
    Randomized trial49 participantsDigestive Health forMagnesium
  4. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  5. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  6. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  7. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  8. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  9. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  10. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  11. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  12. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  13. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  14. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  15. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  16. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  17. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  18. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  19. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  20. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  21. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  22. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  23. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  24. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  25. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  26. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  27. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  28. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  29. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  30. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  31. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  32. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  33. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  34. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  35. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  36. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  37. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  38. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  39. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  40. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  41. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  42. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  43. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  44. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  45. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium