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Calcium Magnesium & Vitamin D3 Orange Vanilla Flavor

4.6
★ ★ ★ ★ ★
(841 ratings)
Calcium 500 mg
Magnesium 250 mg
Product Image
Score77
A convenient chewable calcium-magnesium-D3 formula with some strong forms. Oxide, carbonate, carbohydrate, and ambiguous source totals limit precision.
How scoring works
Tablet
Quantity:90 Tablet(s) • (45 servings)
Goals:
Bone Health
General Health
Stress Relief
Energy
Heart Health
Digestive Health

Score 77

A convenient chewable calcium-magnesium-D3 formula with some strong forms. Oxide, carbonate, carbohydrate, and ambiguous source totals limit precision.
How scoring works
$17.56($0.39 per serving)
Vitacost
$ 17.56
iHerb
$ 17.56
Pure Formulas
$ 17.56
Daily Vita
$ 17.56
Vitacost
$ 17.56
Report prices

Analysis

The orange-vanilla chewable combines calcium carbonate, citrate, and citrate malate with magnesium bisglycinate and oxide. Vitamin D3 and sodium ascorbate add relevant supporting nutrients.

The mixed forms offer broader flexibility than carbonate and oxide alone. Repeated 500 mg calcium and 250 mg magnesium entries do not clearly show the elemental contribution of each source, while the chewable adds carbohydrate.

It fits adults who prioritize chewability and can verify the serving totals on the current label. Users with sensitive digestion may prefer a simpler citrate or bisglycinate capsule.

Who is it for
  • Adults who prefer chewable minerals
  • Users wanting vitamin D3 with calcium and magnesium
  • People comfortable with a mixed-form formula
Best for
  • Chewable bone-mineral support
  • Calcium and magnesium intake
  • Vitamin D-supported mineral use

Pros

  • Includes calcium citrate malate
  • Uses some magnesium bisglycinate
  • Provides vitamin D3 and vitamin C
  • Chewable format

Cons

  • Also uses calcium carbonate and magnesium oxide
  • Source totals are ambiguous
  • Adds carbohydrate

Warnings

  • Chewing exposes teeth to carbohydrate and acidity, so rinsing afterward is sensible
  • Magnesium oxide may cause diarrhea or cramping
  • Calcium and magnesium can reduce absorption of thyroid medicine and certain antibiotics

Nutrient quality

84 Highest impact

The mix combines useful and weaker mineral forms. The core ingredients remain coherent for the intended use.

.

Ingredient transparency

80 Highest impact

Active amounts are fully disclosed without a hidden blend. Missing full directions and inactive ingredients keep the supplied label information incomplete.

.

Customer satisfaction

63 Moderate impact

The supplied average is generally favorable and rests on an adequate review count. No review text was provided to assess repeated complaints or specific user experiences.

.

Value for money

77 High impact

Serving efficiency is reasonable for the disclosed mineral profile. Delivery ingredients create only a modest trade-off.

.
Report analysis

Goals

Bone Health
Bone Health
Impact
Highest effect
A Goal FitA- Strength of SupportB CoverageA Formula Quality
Magnesium · 250 mgCalcium · 500 mgVitamin D · 10 mcgVitamin C · 80 mg

Calcium, magnesium, and vitamin D3 form a strong foundation for mineralization and absorption. Citrate malate and bisglycinate improve the blend, while carbonate and magnesium oxide lower average form quality.

The amounts are well balanced for a combined serving. Vitamin K and collagen are absent, but the formula remains focused on skeletal support.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Vitamin C Supportive 46 studies
General Health
Stress Resilience
General Health
Impact
Highest effect
A Goal FitB+ Strength of SupportB CoverageA Formula Quality
Vitamin D · 10 mcgMagnesium · 250 mgVitamin C · 80 mg

Calcium, magnesium, vitamin D3, and vitamin C provide broad support for bone, muscle, immune, and antioxidant function. The core nutrient amounts are useful for routine coverage.

Magnesium bisglycinate and calcium citrate malate improve parts of the formula, but oxide and carbonate lower the overall absorption profile. The chewable format is convenient but does not add a specialized absorption advantage.

Study evidence
Magnesium Supportive 114 studies
Vitamin C Supportive 56 studies
Stress Relief
Calm and Tension Relief
Stress Relief
Impact
Highest effect
A- Goal FitB Strength of SupportB CoverageA- Formula Quality
Vitamin D · 10 mcgMagnesium · 250 mgVitamin C · 80 mg

Magnesium provides direct nervous-system and muscle support at a substantial daily amount. Its role in correcting inadequate magnesium intake is well established, though direct stress-relief effects vary by baseline status.

Bisglycinate supports absorption, while magnesium oxide and calcium carbonate weaken the overall form profile. Calcium, vitamin D, and vitamin C add broad nutrition but little direct calming breadth.

Study evidence
Magnesium Supportive 13 studies
Vitamin C Supportive 11 studies
Vitamin D Supportive 41 studies
Energy
Energy
Impact
High effect
B+ Goal FitB Strength of SupportC- CoverageB+ Formula Quality
Vitamin D · 10 mcgMagnesium · 250 mg

Magnesium reaches a useful 250 mg amount and supports ATP-dependent energy reactions. Vitamin D and calcium provide related mineral support in the chewable formula.

Magnesium oxide lowers absorption despite the presence of bisglycinate. The product covers a mineral pathway rather than alertness or stress resilience.

Study evidence
Magnesium Supportive 4 studies
Vitamin D Supportive 32 studies
Heart Health
Healthy Blood Pressure
Heart Health
Impact
High effect
B Goal FitB- Strength of SupportC CoverageB- Formula Quality
Magnesium · 250 mgVitamin D · 10 mcg

Magnesium provides a credible heart-relevant foundation for rhythm and vascular tone. Vitamin D3 adds some complementary support, while the calcium-heavy design is not a broad cardiovascular formula.

The disclosed amount is useful, but magnesium oxide lowers absorption quality beside bisglycinate. People prone to digestive upset may tolerate the oxide portion less well.

Study evidence
Magnesium Supportive 158 studies
Digestive Health
Digestive Health
Impact
High effect
C+ Goal FitB Strength of SupportD CoverageB- Formula Quality
Vitamin D · 10 mcgMagnesium · 250 mg

Buffered magnesium bisglycinate and oxide may support bowel motility and softer stool, giving the product a clear but narrow digestive role. The osmotic effect of magnesium is established, although response and tolerance vary with the form and the user's baseline intake.

The elemental magnesium serving is meaningful for motility support. Bisglycinate improves absorption, while oxide reduces overall form quality and may increase digestive upset. Calcium and vitamin D make this primarily a mineral formula rather than a comprehensive digestive product. The oxide component may produce loose stool or abdominal discomfort in sensitive users.

Study evidence
Magnesium Supportive 50 studies
Vitamin D Supportive 49 studies

Ingredients

IngredientAmount per serving
Calories
5 Calorie(s)
Total Carbohydrates
2 Gram(s)
Vitamin C (Sodium Ascorbate)
 80 mg
Vitamin D (Cholecalciferol)
 10 mcg
Calcium (Calcium Carbonate, Calcium Citrate, Calcium Citrate Malate)
 500 mg
Magnesium (Magnesium Bisglycinate Chelate, Magnesium Oxide)
 250 mg
Gluten Free Adults 18–50 Kosher Dairy Free No Allergies
Report overview
Calcium (Calcium Carbonate, Calcium Citrate, Calcium Citrate Malate) · 500 mg OverallScore84
A- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyB+ Value

The mixed calcium sources combine well-absorbed citrate and citrate malate with less absorbable carbonate. The disclosed calcium amount fits an absorption-friendly serving, while the chewables add a small amount of carbohydrate. A competitive serving cost and included vitamin D support practical value.

View ingredientView products
Magnesium (Magnesium Bisglycinate Chelate, Magnesium Oxide) · 250 mg OverallScore71
D- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value
+1

Bisglycinate supports absorption, but the added oxide lowers the blend’s systemic quality. Vitamin D3 adds bone-support logic, and the calcium-to-magnesium ratio does not exceed the competitive cutoff. A favorable serving cost supports reasonable value, though oxide may increase digestive upset.

View ingredientView products
Loading alternative details
94 Performance

Cal/Mag 500 mg/250 mg

NaturesPlus
<p>Chelated calcium and magnesium provide a balanced, focused mineral formula with stronger form quality than products relying heavily on carbonate or oxide. The simple serving is easy to assess, though vitamin D and vitamin K are not included.</p>
92 Performance

Magnesium Bisglycinate Chelate

Healthy Origins
<p>TRAACS magnesium bisglycinate provides a well-absorbed form at a useful amount and avoids the weaker oxide forms found in many combinations. The powder covers magnesium only, so a separate calcium source is needed when both minerals are intended.</p>
92 Performance

Calcium Citrate Pure Powder

NOW
<p>Calcium citrate provides a well-absorbed, clearly disclosed calcium source in an adjustable powder. The focused formula omits magnesium, vitamin D, and vitamin K, so it works better as a targeted calcium option than as a complete replacement.</p>
87 Budget

600 Calcium Supplement

21st Century
<p>A straightforward calcium carbonate tablet provides a much lower-cost source of calcium at a practical supplemental amount. Carbonate works best with food, and the formula omits magnesium, vitamin D, and other bone-supporting cofactors found in broader products.</p>
86 Budget

Calcium Carbonate

NOW
<p>A pure calcium carbonate powder offers substantial calcium with excellent serving value and no unrelated actives. Food and stomach acid aid carbonate absorption, while the calcium-only design leaves magnesium and vitamin D uncovered.</p>
85 Budget

Calcium 600 with Vitamin D3

Nature's Bounty
<p>Calcium with vitamin D3 provides an economical, meaningfully dosed bone-support pairing. Calcium carbonate is best taken with food, and the formula does not replace the original magnesium coverage.</p>
94 Value

Krebs Magnesium Potassium Complex

Nature's Way
<p>Magnesium lysinate and malate provide favorable forms at a useful amount, with modest potassium adding complementary mineral support. Serving value is strong, but the formula requires a separate calcium source when calcium is also needed.</p>
90 Value

Calcium Citrate +D3 Petites

21st Century
<p>Calcium citrate with vitamin D3 combines a practical amount, favorable absorption, and accessible serving value. The focused formula does not provide magnesium, and missing excipient details modestly limit transparency.</p>
88 Value

Albion Chelated Calcium 180 mg

Swanson Ultra
<p>Calcium glycinate chelate with a small vitamin D3 addition offers a useful balance of form quality and value. The supplied product name and serving amount conflict, so the current label should be checked, and magnesium still needs separate coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  2. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  3. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  4. Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation.
    Bu LN; Chang MH; Ni YH; Chen HL; Cheng CC · Pediatrics international : official journal of the Japan Pediatric Society · 2007
    Randomized trial45 participantsDigestive Health forMagnesium
  5. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial.
    Kubota M; Ito K; Tomimoto K; Kanazaki M; Tsukiyama K; Kubota A; Kuroki H; Fujita M; Vandenplas Y · Nutrients · 2020
    Randomized trial60 participantsDigestive Health forMagnesium
  6. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  7. Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial.
    Yoneda H; Tomita T; Kitano T; Morishita D; Kodani M; Nishii N; Sei H; Eda H; Sato T; Kawai M; Yokoyama Y; Igeta M; Okugawa T; Fukui H; Shinzaki S · Neurogastroenterology and motility · 2026
    Randomized trial40 participantsDigestive Health forMagnesium
  8. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  9. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  10. Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
    Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012
    Randomized trial49 participantsDigestive Health forMagnesium
  11. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  12. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  13. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  14. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  15. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  16. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  17. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  18. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  19. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  20. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  21. Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies.
    Zeng LF; Luo MH; Liang GH; Yang WY; Xiao X; Wei X; Yu J; Guo D; Chen HY; Pan JK; Huang HT; Liu Q; Guan ZT; Han YH; Zhao D; Zhao JL; Hou SR; Wu M; Lin JT; Li JH; Liang WX; Ou AH; Wang Q; Li ZP; Liu J · Frontiers in endocrinology · 2020
    Meta-analysis19,484 participants17 studies pooledBone Health forVitamin C
  22. Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis.
    Sun Y; Liu C; Bo Y; You J; Zhu Y; Duan D; Cui H; Lu Q · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Meta-analysis6 studies pooledBone Health forVitamin C
  23. Smoking, antioxidant vitamins, and the risk of hip fracture.
    Melhus H; Michaëlsson K; Holmberg L; Wolk A; Ljunghall S · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1999
    Cohort study66,651 participantsBone Health forVitamin C
  24. Micronutrients and the risk of hip fracture: Case-control study.
    Torbergsen AC; Watne LO; Wyller TB; Frihagen F; Strømsøe K; Bøhmer T; Mowe M · Clinical nutrition (Edinburgh, Scotland) · 2018
    Case-control study189 participantsBone Health forVitamin C
  25. Favorable effect of dietary vitamin C on bone mineral density in postmenopausal women (KNHANES IV, 2009): discrepancies regarding skeletal sites, age, and vitamin D status.
    Kim YA; Kim KM; Lim S; Choi SH; Moon JH; Kim JH; Kim SW; Jang HC; Shin CS · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Cross-sectional study1,196 participantsBone Health forVitamin C
  26. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  27. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  28. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  29. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  30. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  31. Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis.
    Rozemeijer S; Hemilä H; van Baaren M; de Man AME · BMC cardiovascular disorders · 2023
    Meta-analysis872 participants7 studies pooledCardiovascular Support forVitamin C
  32. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.
    Taddei S; Virdis A; Ghiadoni L; Magagna A; Salvetti A · Circulation · 1998
    Clinical trial49 participantsCardiovascular Support forVitamin C
  33. Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: A randomized, placebo-controlled, cross-over study.
    Boonthongkaew C; Tong-Un T; Kanpetta Y; Chaungchot N; Leelayuwat C; Leelayuwat N · The Chinese journal of physiology · 2021
    Randomized trial24 participantsCardiovascular Support forVitamin C
  34. Vascular benefits of vitamin C supplementation against fine particulate air pollution in healthy adults: A double-blind randomised crossover trial.
    Ren J; Liang J; Wang J; Yin B; Zhang F; Li X; Zhu S; Tian H; Cui Q; Song J; Liu G; Ling W; Ma Y · Ecotoxicology and environmental safety · 2022
    Randomized trial58 participantsCardiovascular Support forVitamin C
  35. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes.
    Mullan BA; Young IS; Fee H; McCance DR · Hypertension (Dallas, Tex. : 1979) · 2003
    Randomized trial30 participantsCardiovascular Support forVitamin C
  36. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  37. Effect of Vitamin D Supplementation on Human Gut Microbiota: A Systematic Review of Randomized Controlled Trials.
    Zeb F; Osaili T; Hashim M; Alkalbani N; Papandreou D; Cheikh Ismail L; Naja F; Radwan H; Hasan H; Obaid RS; Savvaidis I; AlBlooshi S; Alam I · Nutrition reviews · 2026
    Systematic review1,458 participants14 studies pooledDigestive Health forVitamin D
  38. Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome.
    Amani R; Abbasnezhad A; Hajiani E; Cheraghian B; Abdoli Z; Choghakhori R · Iranian journal of immunology : IJI · 2018
    Randomized trial90 participantsDigestive Health forVitamin D
  39. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsDigestive Health forVitamin D
  40. Maternal vitamin D intakes during pregnancy and child health outcome.
    Nasantogtokh E; Ganmaa D; Altantuya S; Amgalan B; Enkhmaa D · The Journal of steroid biochemistry and molecular biology · 2023
    Randomized trial311 participantsDigestive Health forVitamin D
  41. Vitamin D metabolites and the gut microbiome in older men.
    Thomas RL; Jiang L; Adams JS; Xu ZZ; Shen J; Janssen S; Ackermann G; Vanderschueren D; Pauwels S; Knight R; Orwoll ES; Kado DM · Nature communications · 2020
    Cross-sectional study567 participantsDigestive Health forVitamin D
  42. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  43. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  44. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  45. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  46. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  47. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  48. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  49. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  50. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  51. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  52. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  53. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  54. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  55. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  56. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  57. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  58. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
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  84. Comparative Effects of Etelcalcetide and Maxacalcitol on Serum Calcification Propensity in Secondary Hyperparathyroidism: A Randomized Clinical Trial.
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