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B12 1000 mcg

Nature Made
4.7
★ ★ ★ ★ ★
(29559 ratings)
Vitamin B12 1000 mcg
Product Image
Score81
A straightforward, long-supply B12 tablet with useful potency. Its conventional cyanocobalamin form and standard delivery trail stronger methylcobalamin options.
How scoring works
Quantity:160 Tablet(s) • (160 servings)
Goals:
General Health
Energy
Productivity Boost
Hair Health

Score 81

A straightforward, long-supply B12 tablet with useful potency. Its conventional cyanocobalamin form and standard delivery trail stronger methylcobalamin options.
How scoring works
$18.25($0.11 per serving)
Vitacost
$ 18.25
iHerb
$ 18.49
iHerb
$ 18.49
Vitacost
$ 18.35
Amazon
$ 18.49
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Analysis

The 1,000 mcg cyanocobalamin serving supports normal red blood cell formation, nerve function, and energy metabolism. The form and amount are clearly disclosed.

Cyanocobalamin is a conventional form that requires conversion before use in B12-dependent pathways. The added calcium does not materially broaden the purpose, and the swallowed tablet offers no mucosal delivery advantage.

The product may suit users who value a familiar tablet and long serving supply. People prioritizing an active B12 form or absorption-focused delivery have more suitable options.

Who is it for
  • Adults seeking a basic B12 tablet
  • Users comfortable with cyanocobalamin
  • People prioritizing many servings
Best for
  • Basic B12 intake
  • Normal energy metabolism
  • Nerve and blood support

Pros

  • Clearly disclosed B12 form and amount
  • Long serving supply
  • Simple tablet format
  • Focused purpose

Cons

  • Cyanocobalamin is not a bioactive coenzyme form
  • No mouth-based delivery
  • Added calcium adds little to the goal
  • Narrow formula

Warnings

  • The 1,000 mcg amount may be more than needed for routine maintenance.
  • The tablet should not be expected to provide stimulant-like energy.
  • People with significant absorption problems may need a purpose-designed or clinician-directed B12 approach.

Nutrient quality

80 High impact

Cyanocobalamin is stable and useful but requires conversion to active B12 forms. Vitamin B12 has low known toxicity and the listed amount raises no clear safety limit issue.

.

Ingredient transparency

88 Highest impact

A specific amount is supplied for every listed active ingredient. No proprietary blend hides the active doses.

.

Customer satisfaction

72 High impact

The supplied aggregate rating is very strong. No complaint themes or purpose-specific experience details are supplied.

.

Value for money

79 High impact

The formula offers reasonable value, though its form or dose is not ideal. Added calcium contributes little to the core B12 purpose.

.
Report analysis

Goals

General Health
General Health
Impact
Highest effect
A Goal FitA- Strength of SupportC- CoverageA Formula Quality
Vitamin B12 · 1000 mcg

The substantial vitamin B12 amount supports cellular energy processes, nerve function, and red blood cell formation. Exact cyanocobalamin disclosure makes the dose easy to assess.

Cyanocobalamin is less preferred than bioactive coenzyme forms, and the swallowed tablet offers no specialized mucosal delivery. Added calcium is modest and does not materially broaden the formula.

Study evidence
Vitamin B12 Adverse 66 studies
Energy
Energy
Impact
High effect
A- Goal FitB Strength of SupportC- CoverageB Formula Quality
Vitamin B12 · 1000 mcg

The high B12 amount can support energy metabolism and blood formation, especially when intake or absorption is inadequate. B12 does not act like a stimulant, so people with adequate status may not feel an energy increase.

Cyanocobalamin is clearly identified but is less preferred than bioactive methylcobalamin or adenosylcobalamin. The standard swallowed tablet also lacks a mucosal-delivery advantage, while the added calcium does not materially broaden the energy strategy.

Study evidence
Vitamin B12 Disputed 14 studies
Productivity Boost
Productivity Boost
Impact
High effect
C+ Goal FitB Strength of SupportD CoverageB- Formula Quality
Vitamin B12 · 1000 mcgVitamin B12 · 1000 mcg

Vitamin B12 supports neurological energy and may reduce brain fog when low status is present. The high amount is clearly disclosed, but cyanocobalamin is less direct than active coenzyme forms.

People with adequate B12 should not expect a stimulant-like improvement in focus or output. The product also lacks other pathways for acute alertness, neurotransmitter support, or stress resilience.

Study evidence
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies
Hair Health
Hair Health
Impact
Moderate effect
D+ Goal FitC+ Strength of SupportF CoverageB+ Formula Quality

Vitamin B12 may support normal hair growth when deficiency contributes to shedding. Extra B12 is unlikely to improve hair in people with adequate status.

Cyanocobalamin is a basic form, and the swallowed tablet offers no absorption advantage. Calcium adds little to the hair purpose.

Study evidence
Vitamin B12 Disputed 17 studies

Ingredients

IngredientAmount per serving
Vitamin B12 (Cyanocobalamin)
 1000 mcg
Calcium (Dibasic Calcium Phosphate)
 120 mg
Gluten Free Adults 18–50
Report overview
Vitamin B12 (Cyanocobalamin) · 1000 mcg OverallScore64
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

The 1,000 mcg dose provides substantial B12, but cyanocobalamin is not a bioactive coenzyme form. The swallowed tablet offers standard delivery rather than a format designed for absorption through the mouth. Clear form and dose disclosure combine with favorable cost efficiency.

View ingredientView products
Loading alternative details
94 Performance

Methyl B-12 1000 mcg & Methyl Folate 400 mcg plus P-5-P Lemon Flavor

Jarrow Formulas
<p>Methylcobalamin, methyl folate, and active B6 provide related support for energy and methylation pathways. Compared with the original cyanocobalamin tablet, the companion nutrients are purposeful and clearly dosed rather than being an opaque or unrelated blend.</p>
91 Performance

B12 Energizer+ Natural Cherry Flavor

Advanced Nutrition by Zahler
<p>A bioactive B12 form and substantial serving provide focused support for higher intake needs. The simple formula is easy to assess alongside the original cyanocobalamin tablet, though the amount may exceed routine maintenance needs.</p>
90 Performance

B12 2500 mcg Red Cherry

EZ Melts
<p>Fast-melting methylcobalamin provides a bioactive form and delivery suited to use in the mouth. Compared with the original cyanocobalamin tablet, clear high-dose disclosure and convenient delivery strengthen practical absorption-oriented use.</p>
94 Budget

Quick Dissolve B-12 Methylcobalamin 2500 mcg

Nature's Bounty
<p>Serving cost is lower than the original cyanocobalamin tablet, while the active B12 amount remains meaningful. Quick-dissolve methylcobalamin supplies a bioactive form and substantial amount, though the amount may exceed routine maintenance needs.</p>
91 Budget

Vitamin B12 2000 mcg

Nutricost
<p>Serving cost is lower than the original cyanocobalamin tablet, while the active B12 amount remains meaningful. A simple methylcobalamin formula provides a substantial amount, while people with adequate B12 status may gain little from routine high-dose use.</p>
93 Budget

B12 Methylcobalamin 1000 mcg

Natural Factors
<p>Serving cost is lower than the original cyanocobalamin tablet, while the active B12 amount remains meaningful. Methylcobalamin provides a bioactive form at a meaningful amount without unrelated nutrient extras, though inactive ingredients and full directions are missing.</p>
91 Value

Sublingual Methylcobalamin 1000 mcg

Solgar
<p>Sublingual methylcobalamin combines a bioactive B12 form, mouth-based delivery, and strong serving value. Compared with the original cyanocobalamin tablet, the focused amount is practical for higher intake needs without using unrelated extras.</p>
92 Value

Fully Active B12 1500 mcg

Doctor's Best
<p>A simple methylcobalamin formula provides a substantial amount with excellent serving value. Compared with the original cyanocobalamin tablet, it is easier to assess, although people with adequate B12 status may gain little from routine supplementation.</p>
91 Value

Methyl B-12 Natural Cherry Flavor

ZHOU
<p>A bioactive B12 form and substantial serving combine high nutrient quality with excellent practical value. The focused design is straightforward beside the original cyanocobalamin tablet, though the amount may exceed maintenance needs.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  2. Holo-transcobalamin is not associated with the risk of all-cause mortality in the general population.
    Stürmer P; Strathmann EA; Rimbach G; Weber KS; Lieb W · Clinical nutrition ESPEN · 2024
    Cohort study862 participantsGeneral Health forVitamin B12
  3. The origin of vitamin B12 levels and risk of all-cause, cardiovascular and cancer specific mortality: A systematic review and dose-response meta-analysis.
    Liu K; Yang Z; Lu X; Zheng B; Wu S; Kang J; Sun S; Zhao J · Archives of gerontology and geriatrics · 2024
    Meta-analysis92,346 participants22 studies pooledGeneral Health forVitamin B12
  4. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  5. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  6. Vitamin B12 Supplementation: Is More Always Better?
    Yepes-Calderón M; Doorenbos CSE; Stegmann ME; Touw DJ; Harmsen HJM; Heiner-Fokkema MR; van Spronsen FJ; Corpeleijn E; Bakker SJL · Nutrients · 2026
    Narrative reviewEnergy forVitamin B12
  7. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  8. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  9. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  10. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  11. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  12. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  13. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  14. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forVitamin B12
  15. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  16. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  17. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  18. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  19. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsProductivity Boost forVitamin B12
  20. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  21. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  22. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  23. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  24. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  25. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsProductivity Boost forVitamin B12
  26. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  27. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12