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B12 Methylcobalamin 1000 mcg

Natural Factors
4.8
★ ★ ★ ★ ★
(10260 ratings)
Vitamin B12 1000 mcg
Product Image
Score87
A transparent 1,000 mcg methylcobalamin tablet with a large supply. It delivers focused B12 support with few formulation drawbacks.
How scoring works
Quantity:180 Tablet(s) • (180 servings)
Goals:
General Health
Energy
Productivity Boost
Hair Health

Score 87

A transparent 1,000 mcg methylcobalamin tablet with a large supply. It delivers focused B12 support with few formulation drawbacks.
How scoring works

Also available as

2 options
90 servings 1 Tablet(s) • 90 Tablet(s) • 90 servings $10.47 ($0.11 per serving) 10000.00mcg • 30 Tablet(s) servings • Cherry Flavor 10000.00mcg • 30 Tablet(s) • 30 servings $13.27 ($0.44 per serving)
$17.47($0.09 per serving)
Vitacost
$ 17.47
Amazon
$ 17.47
iHerb
$ 17.47
Report prices

Analysis

Methylcobalamin offers a directly usable B12 form that supports normal nerves, red blood cells, and energy metabolism. A 1,000 mcg amount is substantial enough for common oral supplementation plans.

The large tablet count provides convenient long-term use without a proprietary blend. A single-active design also reduces unnecessary overlap for people already using a multivitamin.

The product will be most useful when B12 intake or absorption is inadequate. It does not address iron, thyroid, sleep, or other non-B12 reasons for low energy.

Who is it for
  • Adults wanting active-form B12
  • People with low animal-food intake
  • Regular users seeking a large supply
Best for
  • Long-term B12 supplementation
  • Supporting normal nerve and blood-cell function
  • Simple daily use

Pros

  • Active methylcobalamin form
  • Substantial but not extreme amount
  • Large serving count

Cons

  • No companion nutrients
  • Only useful when B12 is relevant
  • Fixed-dose tablet

Nutrient quality

93 Highest impact

A well-regarded vitamin form supports good ingredient quality. The amount is meaningful without a major safety imbalance.

Ingredient transparency

85 Highest impact

Active amounts are clearly disclosed and no proprietary blend is shown. Inactive ingredients and full daily-use directions are missing from the supplied data.

Customer satisfaction

73 High impact

The average rating is strong and supported by a large evidence base. No specific feedback is supplied to judge repeated complaints or whether experience matches the intended use.

Value for money

97 Highest impact

The supply provides strong cost efficiency for the active amount. A focused formula avoids unnecessary nutrient extras.

Report analysis

Goals

General Health
General Health
Impact
Highest effect
A Goal FitA Strength of SupportC- CoverageA Formula Quality
Vitamin B12 · 1000 mcg

Methylcobalamin provides a bioactive B12 form for red blood cell formation, nerve function, and cellular energy metabolism. The 1,000 mcg chewable serving is substantial and fully disclosed.

The focused formula is useful for people with higher B12 needs, including some older adults and people eating little or no animal food. It does not provide broad nutrient coverage, and the amount is far above ordinary daily requirements.

Study evidence
Vitamin B12 Adverse 66 studies
Energy
Energy
Impact
Highest effect
A- Goal FitA+ Strength of SupportC- CoverageA Formula Quality
Vitamin B12 · 1000 mcg

Vitamin B12 supports normal red-blood-cell formation and cellular energy metabolism. The substantial serving is most relevant for users with low intake, impaired absorption, or deficiency.

Methylcobalamin is a preferred bioactive B12 form with clear amount disclosure. People with adequate B12 status should not expect a stimulant-like energy effect from the high serving.

Study evidence
Vitamin B12 Disputed 14 studies
Productivity Boost
Productivity Boost
Impact
High effect
C+ Goal FitA+ Strength of SupportD CoverageA Formula Quality
Vitamin B12 · 1000 mcgVitamin B12 · 1000 mcg

The 1,000 mcg serving of vitamin B12 may support energy metabolism and mental clarity when low B12 status contributes to fatigue. People with adequate B12 status should not expect a direct stimulant-like productivity effect.

Methylcobalamin is clearly named, allowing the active form to be judged. The single-active formula is focused but covers only a foundational nutrient pathway.

Study evidence
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies
Hair Health
Hair Health
Impact
Moderate effect
F Goal FitA+ Strength of SupportF CoverageB+ Formula Quality

Vitamin B12 may support hair health when a deficiency disrupts normal cell turnover, but it is not a direct hair-growth active. People with adequate B12 status are unlikely to gain a meaningful hair benefit.

Methylcobalamin and the 1,000 mcg amount are clearly disclosed. The single-nutrient formula does not support structural protein, hormonal, or scalp pathways.

Study evidence
Vitamin B12 Disputed 17 studies

Ingredients

IngredientAmount per serving
Vitamin B12 (Methylcobalamin)
 1000 mcg
Gluten Free Adults 18–50 Vegetarian
Report overview
Vitamin B12 (Methylcobalamin) · 1000 mcg OverallScore95
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

A substantial methylcobalamin dose provides preferred form quality with clear labeling. The chewable format is practical even though it lacks a specific sublingual claim. The larger package delivers excellent cost efficiency.

View ingredientView products
Loading alternative details
89 Performance

Methyl B-12 1000 mcg & Methyl Folate 400 mcg plus P-5-P Lemon Flavor

Jarrow Formulas
<p>Methylcobalamin, folate, and active vitamin B6 support linked energy and methylation pathways with clearly stated amounts. The 1,000 mcg amount matches the original dose while using methylcobalamin in a focused formula.</p>
87 Performance

Fully Active B12 1500 mcg

Doctor's Best
<p>1,500 mcg of bioactive methylcobalamin provides a focused, easy-to-assess vitamin B12 option. The 1,500 mcg amount exceeds the original 1,000 mcg serving, so it fits a defined higher-intake need better than routine maintenance.</p>
87 Performance

B12 Energizer+ Natural Cherry Flavor

Advanced Nutrition by Zahler
<p>5,000 mcg of bioactive methylcobalamin provides a focused, easy-to-assess vitamin B12 option. The 5,000 mcg amount exceeds the original 1,000 mcg serving, so it fits a defined higher-intake need better than routine maintenance.</p>
86 Budget

Vitamin B12 2000 mcg

Nutricost
<p>A lower serving cost provides 2,000 mcg of methylcobalamin in a clearly disclosed formula. The 2,000 mcg amount exceeds the original 1,000 mcg serving, so it fits a defined higher-intake need better than routine maintenance.</p>
86 Budget

Quick Dissolve B-12 Methylcobalamin 2500 mcg

Nature's Bounty
<p>A lower serving cost provides 2,500 mcg of methylcobalamin in a clearly disclosed formula. The 2,500 mcg amount exceeds the original 1,000 mcg serving, so it fits a defined higher-intake need better than routine maintenance.</p>
86 Budget

Fully Active B12 1500 mcg

Doctor's Best
<p>One of the lowest-cost eligible options provides 1,500 mcg of methylcobalamin in a clearly disclosed formula. The 1,500 mcg amount exceeds the original 1,000 mcg serving, so it fits a defined higher-intake need better than routine maintenance.</p>
87 Value

Chewable Fully Active B12 Chocolate Mint Flavor 1000 mcg

Doctor's Best
<p>1,000 mcg of methylcobalamin supplies a bioactive form without low-value nutrient extras. The favorable serving cost strengthens value, and the 1,000 mcg amount matches the original dose while using methylcobalamin in a focused formula.</p>
85 Value

Vegan B12 2500 mcg

DEVA
<p>2,500 mcg of methylcobalamin supplies a bioactive form without low-value nutrient extras. The focused formula supports reasonable value, and the 2,500 mcg amount exceeds the original 1,000 mcg serving, so it fits a defined higher-intake need better than routine maintenance.</p>
83 Value

Sublingual Methylcobalamin 1000 mcg

Solgar
<p>1,000 mcg of methylcobalamin supplies a bioactive form without low-value nutrient extras. The focused formula supports reasonable value, and the 1,000 mcg amount matches the original dose while using methylcobalamin in a focused formula.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  2. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  3. Vitamin B12 Supplementation: Is More Always Better?
    Yepes-Calderón M; Doorenbos CSE; Stegmann ME; Touw DJ; Harmsen HJM; Heiner-Fokkema MR; van Spronsen FJ; Corpeleijn E; Bakker SJL · Nutrients · 2026
    Narrative reviewEnergy forVitamin B12
  4. Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients With Fibromyalgia.
    Munipalli B; Strothers S; Rivera F; Malavet P; Mitri G; Abu Dabrh AM; Dawson NL · Mayo Clinic proceedings. Innovations, quality & outcomes · 2022
    Observational study2,142 participantsEnergy forVitamin B12
  5. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  6. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  7. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  8. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  9. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  10. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  11. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  12. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  13. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forVitamin B12
  14. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  15. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  16. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  17. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  18. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsProductivity Boost forVitamin B12
  19. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  20. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  21. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  22. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  23. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  24. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsProductivity Boost forVitamin B12
  25. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  26. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12