Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Markers of Hypoxia and Oxidative Stress in Aging Volunteers Ingesting Lycosomal Formulation of Dark Chocolate Containing Astaxanthin.
Petyaev IM; Klochkov VA; Chalyk NE; Pristensky DV; Chernyshova MP; Kyle NH; Bashmakov YK · The journal of nutrition, health & aging · 2019
Randomized trial32 participantsflagAnti-Aging forscienceAstaxanthin
- The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity.
Phetcharat L; Wongsuphasawat K; Winther K · Clinical interventions in aging · 2016
Randomized trial34 participantsflagAnti-Aging flagSkin Health forscienceAstaxanthin
- Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential.
Kidd P · Alternative medicine review : a journal of clinical therapeutic · 2012
Narrative reviewflagAnti-Aging flagVision Support forscienceAstaxanthin
- Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing.
Zhou X; Cao Q; Orfila C; Zhao J; Zhang L · Nutrients · 2021
Meta-analysis11 studies pooledflagAnti-Aging forscienceAstaxanthin
- Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women.
Zhao X; Aldini G; Johnson EJ; Rasmussen H; Kraemer K; Woolf H; Musaeus N; Krinsky NI; Russell RM; Yeum KJ · The American journal of clinical nutrition · 2006
Randomized trial37 participantsflagAnti-Aging forscienceLycopene
- Associations of different isomeric forms of serum lycopene with cardiovascular disease and all-cause mortality.
Zhang Y; Zhai X; Chai H; Liu K; Ma W; Li S; Zeng J; Yang M; Zhou F; Zheng S; Wu X; Xiang B; Cao J; Eshak ES; Jiang C · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2024
Cohort study7,452 participantsflagAnti-Aging forscienceLycopene
- Associations between dietary carotenoid and biological age acceleration: insights from NHANES 2009-2018.
Chen X; He C; Yu W; Ma L; Gou S; Fu P · Biogerontology · 2024
Cross-sectional study19,280 participantsflagAnti-Aging forscienceLycopene
- Biological Aging Mediates the Associations Between Multiple Serum Micronutrients and All-Cause Mortality Among U.S. Adults.
Bian C; Wang W; Wu Z; Zhang H; Wen C; Zhong K; Yang R; Zhong Q · Biological trace element research · 2026
Cohort study6,387 participantsflagAnti-Aging forscienceLycopene
- Topical lycopene emulgel significantly improves biophysical parameters of human skin.
Sohail M; Muhammad Faran Ashraf Baig M; Akhtar N; Chen Y; Xie B; Li B · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2022
Clinical trialflagAnti-Aging flagSkin Health forscienceLycopene
- Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
Meta-analysis3,891 participants3 studies pooledflagAnti-Aging forscienceVitamin K
- Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
Randomized trial30 participantsflagAnti-Aging forscienceVitamin K
- Vitamin K status and cognitive function in healthy older adults.
Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
Cross-sectional study320 participantsflagAnti-Aging forscienceVitamin K
- High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
Cohort study644 participantsflagAnti-Aging forscienceVitamin K
- Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
Cross-sectional study85 participantsflagAnti-Aging forscienceVitamin K
- The anti-inflammatory and antioxidant effects of astaxanthin as an adjunctive therapy in community-acquired pneumonia: a randomized controlled trial.
Youssef FM; Ateyya H; Hanna Samy AE; Elmokadem EM · Frontiers in pharmacology · 2025
Randomized trial80 participantsflagAnti-Inflammatory Support forscienceAstaxanthin
- The Role of Astaxanthin as an Antioxidant and Anti-Inflammatory Agent in Human Health: A Systematic Review.
Malcangi G; Inchingolo AM; Casamassima L; Trilli I; Ferrante L; Longo M; Inchingolo F; Marinelli G; Palermo A; Dipalma G; Inchingolo AD · International journal of molecular sciences · 2026
Systematic review15 studies pooledflagAnti-Inflammatory Support forscienceAstaxanthin
- Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial.
Rostami S; Alyasin A; Saedi M; Nekoonam S; Khodarahmian M; Moeini A; Amidi F · Frontiers in endocrinology · 2023
Randomized trial50 participantsflagAnti-Inflammatory Support forscienceAstaxanthin
- Astaxanthin Modulates Inflammation in Type 2 Diabetes via Regulation of microRNAs, Lysophosphatidylcholine, and α-Hydroxybutyrate.
Sharifi-Rigi A; Zal F; Aarabi MH; Dehghani M; Roustaei Rad N; Taghiyar S · International journal of endocrinology · 2025
Randomized trial50 participantsflagAnti-Inflammatory Support forscienceAstaxanthin
- Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes.
Basereh A; Khoramipour K; Hosseini N; HajHosseini M; Khodabakhshi A; Amirkhosravi L; Khoramipour K · Scientific reports · 2025
Randomized trial90 participantsflagAnti-Inflammatory Support forscienceAstaxanthin
- Carotenoids supplementation and inflammation: a systematic review and meta-analysis of randomized clinical trials.
Hajizadeh-Sharafabad F; Zahabi ES; Malekahmadi M; Zarrin R; Alizadeh M · Critical reviews in food science and nutrition · 2022
Meta-analysis26 studies pooledflagAnti-Inflammatory Support forscienceLycopene
- Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men.
Kim JY; Paik JK; Kim OY; Park HW; Lee JH; Jang Y; Lee JH · Atherosclerosis · 2011
Randomized trial126 participantsflagAnti-Inflammatory Support forscienceLycopene
- Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals.
McEneny J; Wade L; Young IS; Masson L; Duthie G; McGinty A; McMaster C; Thies F · The Journal of nutritional biochemistry · 2013
Randomized trial54 participantsflagAnti-Inflammatory Support forscienceLycopene
- Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept.
Wood LG; Garg ML; Powell H; Gibson PG · Free radical research · 2008
Randomized trial32 participantsflagAnti-Inflammatory Support forscienceLycopene
- Locally delivered antioxidant gel as an adjunct to nonsurgical therapy improves measures of oxidative stress and periodontal disease.
Chandra RV; Srinivas G; Reddy AA; Reddy BH; Reddy C; Nagarajan S; Naveen A · Journal of periodontal & implant science · 2013
Randomized trial31 participantsflagAnti-Inflammatory Support forscienceLycopene
- Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study.
Katagiri M; Satoh A; Tsuji S; Shirasawa T · Journal of clinical biochemistry and nutrition · 2012
Randomized trial96 participantsflagCognitive Support forscienceAstaxanthin
- Effect of astaxanthin-rich extract derived from Paracoccus carotinifaciens on cognitive function in middle-aged and older individuals.
Hayashi M; Ishibashi T; Maoka T · Journal of clinical biochemistry and nutrition · 2020
Clinical trial54 participantsflagCognitive Support forscienceAstaxanthin
- The Effects of Astaxanthin on Cognitive Function and Neurodegeneration in Humans: A Critical Review.
Queen CJJ; Sparks SA; Marchant DC; McNaughton LR · Nutrients · 2024
Narrative reviewflagCognitive Support forscienceAstaxanthin
- Effects of Astaxanthin Supplementation on Fatigue, Motor Function and Cognition: A Meta-Analysis of Randomized Controlled Trials.
Liu C; Dong X; Jia J; Ha M · Biological research for nursing · 2024
Meta-analysis346 participants11 studies pooledflagCognitive Support forscienceAstaxanthin
- Astaxanthin and improvement of dementia: A systematic review of current clinical trials.
Utomo NP; Pinzon RT; Latumahina PK; Damayanti KRS · Cerebral circulation - cognition and behavior · 2024
Systematic reviewflagCognitive Support forscienceAstaxanthin
- The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial.
Ito N; Seki S; Ueda F · Nutrients · 2018
Randomized trial23 participantsflagSkin Health forscienceAstaxanthin
- Supplementating with dietary astaxanthin combined with collagen hydrolysate improves facial elasticity and decreases matrix metalloproteinase-1 and -12 expression: a comparative study with placebo.
Yoon HS; Cho HH; Cho S; Lee SR; Shin MH; Chung JH · Journal of medicinal food · 2015
Randomized trial44 participantsflagSkin Health forscienceAstaxanthin
- Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers.
Chalyk NE; Klochkov VA; Bandaletova TY; Kyle NH; Petyaev IM · Nutrition research (New York, N.Y.) · 2018
Single-arm trial31 participantsflagSkin Health forscienceAstaxanthin
- Cosmetic benefits of astaxanthin on humans subjects.
Tominaga K; Hongo N; Karato M; Yamashita E · Acta biochimica Polonica · 2012
Other66 participantsflagSkin Health forscienceAstaxanthin
- Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study.
Chernyshova MP; Pristenskiy DV; Lozbiakova MV; Chalyk NE; Bandaletova TY; Petyaev IM · Journal of dairy science · 2019
Randomized trialflagSkin Health forscienceLycopene
- Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema.
Aust O; Stahl W; Sies H; Tronnier H; Heinrich U · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2005
Randomized trialflagSkin Health forscienceLycopene
- Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States.
Kim J; Park MK; Li WQ; Qureshi AA; Cho E · JAMA dermatology · 2024
Cohort study123,570 participantsflagSkin Health forscienceLycopene
- β-Carotene and other carotenoids in protection from sunlight.
Stahl W; Sies H · The American journal of clinical nutrition · 2013
Narrative reviewflagSkin Health forscienceLycopene
- Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
Randomized trial23 participantsflagSkin Health forscienceVitamin C
- Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
Randomized trial149 participantsflagSkin Health forscienceVitamin C
- Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
Randomized trial25 participantsflagSkin Health forscienceVitamin C
- Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
Randomized trial16 participantsflagSkin Health forscienceVitamin C
- Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
Cross-sectional study4,025 participantsflagSkin Health forscienceVitamin C
- Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
Randomized trial45 participantsflagSkin Health forscienceVitamin E
- Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
Meta-analysis20 studies pooledflagSkin Health forscienceVitamin E
- Evidence-Based Nutritional Interventions in Wound Care.
Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
Systematic review2,339 participants36 studies pooledflagSkin Health forscienceVitamin E
- Effects of tocotrienol on aging skin: A systematic review.
Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
Systematic reviewflagSkin Health forscienceVitamin E
- Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
Randomized trialflagSkin Health forscienceVitamin E
- Benefits and Safety of Astaxanthin in the Treatment of Mild-To-Moderate Dry Eye Disease.
Tian L; Wen Y; Li S; Zhang P; Wang Y; Wang J; Cao K; Du L; Wang N; Jie Y · Frontiers in nutrition · 2022
Single-arm trial60 participantsflagVision Support forscienceAstaxanthin
- Astaxanthin (AstaReal®) Improved Acute and Chronic Digital Eye Strain in Children: A Randomized Double-Blind Placebo-Controlled Trial.
Hecht KA; Marwah M; Wood V; Nishida Y; Bach AE; Gerson J; Hom MM; Schnackenberg J; Raote S; Srivastava S; Negi P; Caston E · Advances in therapy · 2025
Randomized trial64 participantsflagVision Support forscienceAstaxanthin
- Effects of diet containing astaxanthin on visual function in healthy individuals: a randomized, double-blind, placebo-controlled, parallel study.
Sekikawa T; Kizawa Y; Li Y; Miura N · Journal of clinical biochemistry and nutrition · 2023
Randomized trial60 participantsflagVision Support forscienceAstaxanthin
- Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
Martinez-Perez C; Oliveira AP · Nutrients · 2026
Systematic review9 studies pooledflagVision Support forscienceAstaxanthin
- The Associations of Plasma Carotenoids and Vitamins With Risk of Age-Related Macular Degeneration: Results From a Matched Case-Control Study in China and Meta-Analysis.
Jiang H; Fan Y; Li J; Wang J; Kong L; Wang L; Li Z; Ma M; Shi X; Liu S; Shi J; Zhu H; Liu X; Ma L · Frontiers in nutrition · 2022
Meta-analysis9 studies pooledflagVision Support forscienceLycopene
- Serum carotenoids and risk of age-related macular degeneration in a chinese population sample.
Zhou H; Zhao X; Johnson EJ; Lim A; Sun E; Yu J; Zhang Y; Liu X; Snellingen T; Shang F; Liu N · Investigative ophthalmology & visual science · 2011
Case-control study263 participantsflagVision Support forscienceLycopene
- Serum antioxidants and age-related macular degeneration in a population-based case-control study.
Mares-Perlman JA; Brady WE; Klein R; Klein BE; Bowen P; Stacewicz-Sapuntzakis M; Palta M · Archives of ophthalmology (Chicago, Ill. : 1960) · 1995
Case-control study334 participantsflagVision Support forscienceLycopene
- Association between serum carotenoid concentrations and risk of major age-related eye diseases among middle-aged and older adults.
Che S; Ma Y; Cao J · Frontiers in medicine · 2025
Cross-sectional study1,478 participantsflagVision Support forscienceLycopene
- Plasma antioxidant vitamins and carotenoids and age-related cataract
Gale CR, Hall NF, Phillips DI, Martyn CN · Ophthalmology · 2001
Cross-sectional study372 participantsflagVision Support forscienceLycopene