No-Flush Niacin (Inositol Hexanicotinate) 500 mg
Solgar
No-Flush Niacin (Inositol Hexanicotinate) 500 mg
Niacin 400 mg
Score 75.0
A reliable no-flush niacin option for general B3 benefits, energy, and skin health, though less potent for cholesterol management than traditional niacin.
Quantity: 100 Capsule(s) • (100 servings)
Goals:
Skin Health
Score 75.0
A reliable no-flush niacin option for general B3 benefits, energy, and skin health, though less potent for cholesterol management than traditional niacin.
Analysis
This product delivers niacin in the inositol hexanicotinate form, specifically chosen to mitigate the uncomfortable flushing sensation associated with standard niacin. It effectively supports general metabolic functions, energy production, and contributes to skin health as a vital B vitamin. However, nutritionists and research often indicate that this 'no-flush' form is less potent for significantly lowering LDL cholesterol or raising HDL cholesterol compared to nicotinic acid, a key reason many take niacin. Despite this, for broad B3 support without side effects, it remains a well-tolerated and reliable option from a reputable brand like Solgar.
Pros
- Effectively prevents the common 'niacin flush' side effect, ensuring comfortable use.
- Supports general Vitamin B3 functions, including energy production and skin health.
- Manufactured by Solgar, a brand recognized for quality and reliability.
Cons
- Its effectiveness for robust cholesterol lowering is generally considered less potent than traditional nicotinic acid.
- The price per serving is higher compared to many standard niacinamide or basic niacin options.
- The specific niacin content from the 500mg inositol hexanicotinate is 400mg, which is good but some competitors offer more for less.
$18.92($0.18 per serving)
 iHerb | $ 18.92 | |
 Vitacost | $ 20.19 | |
 Pure Formulas | $ 20.24 | |
 Daily Vita | $ 20.24 |
Effectiveness for goals
Niacin is known as one of the most effective agents for increasing high-density lipoprotein (HDL) cholesterol levels. It can significantly raise HDL, which is often considered beneficial for cardiovascular health. However, studies have shown that this increase in HDL does not always translate to a reduction in cardiovascular events.
While Niacin can contribute to lowering LDL cholesterol, its primary effect on lipids is typically a more significant reduction in triglycerides and an increase in HDL cholesterol. For LDL reduction, it is generally considered less potent than statins and often used in conjunction with other lipid-lowering therapies if prescribed.
Yes, Niacin is highly effective at reducing elevated triglyceride levels. It achieves this by decreasing the liver's production of very low-density lipoprotein (VLDL), which is a precursor to triglycerides and LDL cholesterol. This makes it a common consideration for individuals with hypertriglyceridemia.
Niacin, also known as vitamin B3, is primarily recognized for its role in preventing and treating pellagra, a deficiency disease. In supplement form, it has been extensively studied for its effects on cholesterol and triglyceride levels. Its physiological functions include energy metabolism and DNA repair.
Niacin can be used in combination with statins to further improve lipid profiles, particularly to increase HDL and lower triglycerides. However, some studies have shown that adding Niacin to statin therapy does not consistently provide additional cardiovascular benefits and may increase the risk of side effects such as myopathy (muscle pain) when taken with certain statins. Medical supervision is essential for this combination.
Dosage, timing & forms
Nicotinic acid is the form most commonly associated with the 'niacin flush' and is often used at higher doses for specific health support under medical supervision. Niacinamide (nicotinamide) generally does not cause flushing and is often preferred for general vitamin B3 supplementation, though it has different metabolic effects compared to nicotinic acid. Their applications can differ significantly.
'Flush-free' niacin, often inositol hexanicotinate, is a form where niacin is chemically bound to inositol, a sugar-like compound. This bond leads to a slow, gradual release of niacin in the body, significantly reducing or eliminating the rapid vasodilation that causes the common flushing sensation. It's often chosen by individuals sensitive to the flush.
To minimize the niacin flush from immediate-release nicotinic acid, individuals can start with a very low dose and gradually increase it over time. Taking it with a non-fatty meal, avoiding hot beverages or alcohol around the time of dosing, and potentially taking aspirin 30 minutes beforehand (if medically appropriate and advised) can also help. Slow and steady increases in dosage are key.
Immediate-release niacin (nicotinic acid) is absorbed quickly, leading to a rapid peak effect and often a pronounced, but temporary, flush. Extended-release forms are designed to release niacin slowly over several hours, which can help reduce the intensity and duration of the flush and may allow for less frequent dosing. The slower release aims to improve tolerance.
Niacin is available in several forms, including nicotinic acid (immediate-release and extended-release), niacinamide (nicotinamide), and inositol hexanicotinate (often marketed as 'no-flush' niacin). Each form has distinct properties and effects within the body. The choice of form can influence how it is absorbed and its potential side effects.
Safety & interactions
The niacin flush is a common side effect characterized by redness, itching, warmth, and tingling, primarily on the face, neck, and chest. It is caused by the release of prostaglandins, which dilate blood vessels. Taking niacin with food, starting with a low dose and gradually increasing it, or taking a low-dose aspirin before niacin may help reduce the flush.
High doses of niacin, particularly sustained-release forms, have been associated with elevated liver enzymes and, in rare cases, liver toxicity. Regular monitoring of liver function by a healthcare professional is often recommended when taking high-dose niacin. Individuals with pre-existing liver conditions should avoid niacin unless specifically advised by a doctor.
Yes, niacin can interact with several medications. It may enhance the effects of blood pressure-lowering drugs, potentially causing hypotension, and can increase the risk of myopathy when taken with statins. Niacin might also interact with blood thinners, antidiabetic medications, and gout medications. Consulting a healthcare provider about all current medications before starting niacin is important.
Individuals with active liver disease, severe hypotension, active peptic ulcer disease, or active bleeding should generally avoid niacin supplements. Those with a history of gout, diabetes, or gallbladder disease should also use niacin with caution and under medical supervision. Consultation with a healthcare provider is essential to determine suitability.
High doses of niacin, particularly nicotinic acid, can sometimes increase blood glucose levels. This effect is more pronounced in individuals with diabetes or prediabetes. People managing their blood sugar should monitor their levels closely if taking niacin and discuss its use with a healthcare provider.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Niacin | 400 mg |
Inositol | 100 mg |
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Vegetarian
Report overviewCategories
Niacin 75.0
As a Niacin product, it provides effective B3 in a well-tolerated 'no-flush' form. While it excels in comfort and general B3 benefits, it's not the top choice for specific, high-impact cholesterol management, which is a common use case for Niacin, hence a moderate score in its collection.
Goals
Skin Health 85.0
Niacin (Vitamin B3) in any form plays a vital role in skin health by supporting the skin barrier function, reducing inflammation, and potentially mitigating sun damage. The no-flush form ensures these benefits can be gained without the temporary redness and irritation associated with nicotinic acid, making it a comfortable option for consistent skin support.
Energy 80.0
As a precursor to NAD+ and NADH, niacin is crucial for energy metabolism at the cellular level, helping convert food into usable energy. This no-flush form effectively provides the necessary B3 to support these metabolic pathways without the distracting flush, contributing to overall energy production and vitality.
Metabolism Boost 80.0
Niacin is fundamental to hundreds of enzymatic reactions involved in metabolism, including the breakdown of carbohydrates, fats, and proteins for energy. This product provides a readily absorbable form of B3 that supports efficient metabolic processes throughout the body, assisting in nutrient utilization for overall metabolic health.
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