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Niacinamide 500 mg

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4.7
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(11585 ratings)
Niacin 500 mg
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Score82
A high-value niacinamide capsule with good skin relevance and no typical flush. The large amount and duplicated label entries are the key drawbacks.
How scoring works
Quantity:100 Capsule(s) • (100 servings)
Goals:
Skin Health

Score 82

A high-value niacinamide capsule with good skin relevance and no typical flush. The large amount and duplicated label entries are the key drawbacks.
How scoring works
$7.60($0.07 per serving)
Pure Formulas
$ 7.73
Vitacost
$ 7.97
Daily Vita
$ 7.60
iHerb
$ 7.95
Report prices

Analysis

Niacinamide is clearly named and is better suited to nutritional and skin-barrier support than nicotinic acid. It avoids the classic flush, which improves immediate tolerance for many users.

The supplied label repeats the amount under niacinamide and vitamin B3. Those lines likely describe one active, but the presentation should not be interpreted as two separate servings without confirmation.

The amount is substantial enough to warrant caution during long-term daily use. Its fit for heart and cardiovascular goals is weak because niacinamide does not share nicotinic acid's lipid-focused role.

Who is it for
  • Adults seeking non-flushing vitamin B3
  • People focused on skin-barrier nutrition
  • Users wanting a low-cost niacinamide capsule
Best for
  • Niacinamide supplementation
  • Skin-supportive nutrition
  • Non-flushing B3 intake

Pros

  • Clearly named niacinamide
  • Strong value
  • No typical nicotinic-acid flush

Cons

  • Duplicate label lines cloud the total
  • Amount exceeds routine daily needs
  • Weak fit for lipid-focused goals

Warnings

  • The large niacinamide amount may cause nausea, headache, or digestive upset.
  • Prolonged high-dose use may affect liver markers or glucose control in susceptible users.
  • Do not add the duplicate ingredient lines together without confirming the serving total.

Nutrient quality

80 Highest impact

Niacinamide is a clear and well-understood non-flushing form. The amount is meaningful for skin-oriented use and high for routine nutrition.

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Ingredient transparency

79 High impact

The core amount is shown, but parts of the active labeling remain ambiguous. The supplied data does not include a complete inactive ingredient list.

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Customer satisfaction

71 High impact

The aggregate satisfaction measure is strong and supported by adequate volume. Missing feedback themes leave recurring complaints and purpose fit uncertain.

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Value for money

96 Highest impact

The price is very well matched to the formula quality and dose. Each serving provides excellent cost efficiency.

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Report analysis

Goals

Skin Health
Skin Health
Impact
Highest effect
B+ Goal FitA+ Strength of SupportC+ CoverageB+ Formula Quality

Niacinamide directly supports ceramide production and skin barrier function. The 500 mg amount is at the upper end of common oral use and is clearly distinguished from flush-producing nicotinic acid.

The streamlined formula gives useful depth to barrier support but does not address collagen building blocks, direct hydration, or antioxidant protection. Its role is more targeted than a general niacin product, though oral skin outcomes are less established than topical use.

Study evidence
Niacin Supportive 61 studies

Ingredients

IngredientAmount per serving
Niacin (Niacinamide, Vitamin B3)
 500 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Vegetarian
Report overview
Niacin (Niacinamide, Vitamin B3) · 500 mg OverallScore94
A Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value

The single-ingredient capsule provides niacinamide at the upper end of the established general and skin-oriented range. Its clearly stated form makes it easy to distinguish from flush-producing nicotinic acid. Basic capsule delivery is offset by a very favorable serving cost.

View ingredientView products
Loading alternative details
81 Performance

Niacinamide 500 mg

Nature's Way
<p>A focused niacinamide capsule provides transparent non-flushing vitamin B3 with useful skin-oriented coverage. Compared with the original, it keeps a non-flushing vitamin B3 emphasis while improving dose clarity or everyday practicality; however, the amount is high for routine nutrition and does not substitute for nicotinic acid in lipid-focused use.</p>
80 Performance

Niacinamide

Thorne
<p>Clearly identified niacinamide provides a simple non-flushing option with strong skin-purpose alignment. Compared with the original, it keeps a non-flushing vitamin B3 emphasis while improving dose clarity or everyday practicality; however, the amount is well above basic nutritional needs and is not a direct cardiovascular niacin substitute.</p>
85 Performance

Niacin 100 mg

Source Naturals
<p>A moderate niacinamide tablet provides clearly identified vitamin B3 without typical nicotinic-acid flushing. Compared with the original, it keeps a non-flushing vitamin B3 emphasis while improving dose clarity or everyday practicality; however, the form is intended for nutritional or skin support rather than lipid-focused effects.</p>
86 Budget

Niacinamide B-3 100 mg

Source Naturals
<p>A clearly identified moderate niacinamide tablet offers simple non-flushing vitamin B3 support with excellent serving economics. Serving cost is lower than the original, but it does not provide nicotinic acid’s lipid-focused effects and complete excipient details are missing.</p>
80 Budget

Niacinamide 500 mg

Best Naturals
<p>Clearly identified niacinamide provides a non-flushing option with useful skin and NAD-metabolism alignment. Serving cost is lower than the original, but the amount is well above basic nutritional needs and is not equivalent to nicotinic acid for lipid-focused use.</p>
82 Budget

Niacinamide 500 mg

Solaray
<p>Clearly named niacinamide offers a non-flushing form suited more to skin and NAD metabolism than lipid management. It is among the lowest-cost supplied choices, although it does not undercut the already inexpensive original, but the amount exceeds basic nutritional needs and long-term unsupervised use is less suitable.</p>
80 Value

Niacinamide 500 mg

21st Century
<p>A low-cost niacinamide tablet supplies non-flushing vitamin B3 with a simple active formula. Its lower serving cost and clearer active design support practical value compared with the original, although the high amount is poorly suited to casual long-term use and is not equivalent to nicotinic acid for lipid goals.</p>
82 Value

No Flush Niacin (Inositol Hexanicotinate) 800 mg

Life Extension
<p>Clearly named inositol hexanicotinate provides substantial flush-free niacin exposure with economical serving value. Its quality-adjusted serving economics and clearer active design support practical value compared with the original, although its cardiovascular effects may be less direct and reliable than those of nicotinic acid.</p>
81 Value

B-Complex with Folic Acid plus Vitamin C

Nature's Bounty
<p>A broad B-complex with vitamin C provides practical daily B-vitamin coverage at very low serving cost. Its lower serving cost and clearer active design support practical value compared with the original, although several forms are conventional, thiamine entries are duplicated, and it is not a dedicated niacin or performance formula.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Role of Niacin in Current Clinical Practice: A Systematic Review.
    Garg A; Sharma A; Krishnamoorthy P; Garg J; Virmani D; Sharma T; Stefanini G; Kostis JB; Mukherjee D; Sikorskaya E · The American journal of medicine · 2017
    Meta-analysis35,206 participants13 studies pooledHeart Health forNiacin
  2. Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes).
    Guyton JR; Slee AE; Anderson T; Fleg JL; Goldberg RB; Kashyap ML; Marcovina SM; Nash SD; O'Brien KD; Weintraub WS; Xu P; Zhao XQ; Boden WE · Journal of the American College of Cardiology · 2013
    Randomized trial3,414 participantsHeart Health Cardiovascular Support forNiacin
  3. Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis.
    Mainville L; Smilga AS; Fortin PR · Journal of cutaneous medicine and surgery · 2022
    Meta-analysis3,039 participants29 studies pooledSkin Health forNiacin
  4. Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.
    D'Andrea E; Hey SP; Ramirez CL; Kesselheim AS · JAMA network open · 2020
    Meta-analysis35,760 participants17 studies pooledHeart Health Cardiovascular Support forNiacin
  5. Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.
    Allen NC; Martin AJ; Snaidr VA; Eggins R; Chong AH; Fernandéz-Peñas P; Gin D; Sidhu S; Paddon VL; Banney LA; Lim A; Upjohn E; Schaider H; Ganhewa AD; Nguyen J; McKenzie CA; Prakash S; McLean C; Lochhead A; Ibbetson J; Dettrick A; Landgren A; Allnutt KJ; Allison C; Davenport RB; Mumford BP; Wong B; Stagg B; Tedman A; Gribbin H; Edwards HA; De Rosa N; Stewart T; Doolan BJ; Kok Y; Simpson K; Low ZM; Kovitwanichkanont T; Scolyer RA; Dhillon HM; Vardy JL; Chadban SJ; Bowen DG; Chen AC; Damian DL · The New England journal of medicine · 2023
    Randomized trial158 participantsSkin Health forNiacin
  6. Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar.
    Jenkins DJA; Spence JD; Giovannucci EL; Kim YI; Josse RG; Vieth R; Sahye-Pudaruth S; Paquette M; Patel D; Blanco Mejia S; Viguiliouk E; Nishi SK; Kavanagh M; Tsirakis T; Kendall CWC; Pichika SC; Sievenpiper JL · Journal of the American College of Cardiology · 2021
    Meta-analysisCardiovascular Support forNiacin
  7. A Foodborne Outbreak Traced to Niacin Overenrichment.
    Hudson PJ; Vogt RL · Journal of food protection · 2023
    Case-control study21 participantsSkin Health forNiacin
  8. Exploring the Cardiovascular Impacts of Oral Nicotinamide: A Comprehensive Narrative Review.
    Shoukfeh R; Tisack AM; Lim HW; Mohammad TF · Journal of drugs in dermatology : JDD · 2025
    Narrative reviewHeart Health forNiacin
  9. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  10. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  11. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.
    Chiu PC; Chan CC; Lin HM; Chiu HC · Journal of cosmetic dermatology · 2008
    Randomized trial52 participantsSkin Health forNiacin
  12. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  13. Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial.
    Elam MB; Hunninghake DB; Davis KB; Garg R; Johnson C; Egan D; Kostis JB; Sheps DS; Brinton EA · JAMA · 2000
    Randomized trial468 participantsHeart Health Cardiovascular Support forNiacin
  14. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
    Hakozaki T; Minwalla L; Zhuang J; Chhoa M; Matsubara A; Miyamoto K; Greatens A; Hillebrand GG; Bissett DL; Boissy RE · The British journal of dermatology · 2002
    Randomized trial138 participantsSkin Health forNiacin
  15. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group · Atherosclerosis · 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  16. Niacinamide: A B vitamin that improves aging facial skin appearance.
    Bissett DL; Oblong JE; Berge CA · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial50 participantsSkin Health forNiacin
  17. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  18. Effectiveness of niacin supplementation for patients with type 2 diabetes: A meta-analysis of randomized controlled trials.
    Xiang D; Zhang Q; Wang YT · Medicine · 2020
    Meta-analysis2,110 participants8 studies pooledCardiovascular Support forNiacin
  19. Nicotinamide for Skin Cancer Chemoprevention.
    Breglio KF; Knox KM; Hwang J; Weiss R; Maas K; Zhang S; Yao L; Madden C; Xu Y; Hartman RI; Wheless L · JAMA dermatology · 2025
    Cohort study33,822 participantsSkin Health forNiacin
  20. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
    Thoenes M; Oguchi A; Nagamia S; Vaccari CS; Hammoud R; Umpierrez GE; Khan BV · International journal of clinical practice · 2008
    Randomized trial50 participantsHeart Health forNiacin
  21. Niacin improves lipid profile but not endothelial function in patients with coronary artery disease on high dose statin therapy.
    Philpott AC; Hubacek J; Sun YC; Hillard D; Anderson TJ · Atherosclerosis · 2013
    Randomized trial66 participantsCardiovascular Support forNiacin
  22. Niacin intake and risk of skin cancer in US women and men.
    Park SM; Li T; Wu S; Li WQ; Weinstock M; Qureshi AA; Cho E · International journal of cancer · 2017
    Cohort study114,116 participantsSkin Health forNiacin
  23. Differential effect of two nicotinic acid preparations on low-density lipoprotein subclass distribution in patients classified as low-density lipoprotein pattern A, B, or I.
    Superko HR; McGovern ME; Raul E; Garrett B · The American journal of cardiology · 2004
    Randomized trial180 participantsHeart Health forNiacin
  24. Effects of HDL-modifiers on cardiovascular outcomes: a meta-analysis of randomized trials.
    Verdoia M; Schaffer A; Suryapranata H; De Luca G · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2015
    Meta-analysis69,515 participants18 studies pooledCardiovascular Support forNiacin
  25. Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide.
    Kawada A; Konishi N; Oiso N; Kawara S; Date A · The Journal of dermatology · 2008
    Randomized trial30 participantsSkin Health forNiacin
  26. Extended-release niacin therapy and risk of ischemic stroke in patients with cardiovascular disease: the Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) trial.
    Teo KK; Goldstein LB; Chaitman BR; Grant S; Weintraub WS; Anderson DC; Sila CA; Cruz-Flores S; Padley RJ; Kostuk WJ; Boden WE; AIM-HIGH Investigators · Stroke · 2013
    Randomized trial3,414 participantsHeart Health forNiacin
  27. Chemoprevention of keratinocyte carcinomas and actinic keratoses in adults who were immunocompetent: a systematic review.
    Susanto A; Morgan E; Lindsay D; Collins LG · Clinical and experimental dermatology · 2026
    Systematic review7,355 participants11 studies pooledSkin Health forNiacin
  28. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
    Chen AC; Martin AJ; Choy B; Fernández-Peñas P; Dalziell RA; McKenzie CA; Scolyer RA; Dhillon HM; Vardy JL; Kricker A; St George G; Chinniah N; Halliday GM; Damian DL · The New England journal of medicine · 2015
    Randomized trial386 participantsSkin Health forNiacin