Product Image

Liver Refresh

NOW
4.8
★ ★ ★ ★ ★
(21972 ratings)
Methionine
L-Carnitine 50 mg
Glutathione 100 mg
Milk Thistle 300 mg
Turmeric 30 mg
Product Image
Score63
A credible milk-thistle and antioxidant formula whose many light additions and hidden enzyme blend reduce clarity.
How scoring works
Quantity:180 Capsule(s) • (60 servings)
Goals:
Detoxification

Score 63

A credible milk-thistle and antioxidant formula whose many light additions and hidden enzyme blend reduce clarity.
How scoring works

Also available as

1 option
90 servings 3 Veg Capsule(s) • 90 Capsule(s) • 30 servings $15.10 ($0.50 per serving)
$25.21($0.42 per serving)
Pure Formulas
$ 28.56
Vitacost
$ 30.47
Daily Vita
$ 27.80
iHerb
$ 29.39
Amazon
$ 25.21
Report prices

Analysis

Milk thistle standardized to silymarin provides the clearest liver-support rationale in the formula. NAC, glutathione, grape-seed extract, and alpha-lipoic acid add overlapping antioxidant pathways.

Schisandra contributes another relevant botanical, but carnitine, turmeric, methionine, and barberry appear at light amounts. The herbal-enzyme blend is not broken down, so its practical contribution cannot be judged.

The large bottle offers reasonable value for a broad formula. Users seeking a simpler product may prefer a focused milk-thistle or NAC supplement with fewer underdosed additions.

Who is it for
  • Adults seeking broad nutritional liver support
  • Users who prefer multi-ingredient antioxidant formulas
  • People comfortable with a three-capsule serving
Best for
  • Milk-thistle-based support
  • Antioxidant nutrient intake
  • Broad detoxification-oriented routines

Pros

  • Substantial standardized milk thistle
  • Includes NAC and reduced glutathione
  • Several complementary antioxidant ingredients

Cons

  • Many supporting ingredients are lightly dosed
  • Herbal-enzyme blend contents are hidden
  • Crowded formula makes individual effects hard to assess

Warnings

  • Alpha-lipoic acid may lower blood glucose and interact with diabetes medicines
  • Barberry-containing products are generally unsuitable during pregnancy
  • The undisclosed enzyme blend makes allergy and tolerance assessment incomplete

Nutrient quality

66 High impact

Standardized milk thistle anchors a coherent liver-support formula. Most supporting actives are modest and an opaque enzyme blend weakens focus.

.

Ingredient transparency

54 Moderate impact

Most core active amounts are visible. An undisclosed blend and missing non-active ingredients reduce transparency.

.

Customer satisfaction

73 High impact

The supplied average rating is very strong. No specific review comments were supplied, so repeated negative experiences cannot be assessed.

.

Value for money

61 Moderate impact

Standardized milk thistle and moderate cost provide fair value. Many modest additions and a hidden blend reduce competitiveness.

.
Report analysis

Goals

Detoxification
Detoxification
Impact
High effect
A- Goal FitC Strength of SupportB CoverageB- Formula Quality
Milk Thistle · 300 mg

Milk thistle, NAC, glutathione, alpha-lipoic acid, schisandra, and antioxidant botanicals create direct liver and glutathione support. The combination addresses hepatocyte protection and antioxidant recycling more clearly than the general multivitamins in this set.

Several important actives are present at modest amounts, and the label does not state the milk-thistle extract concentration. Barberry can lower blood glucose and may add to the effects of diabetes medicines.

Study evidence
Milk Thistle Supportive 46 studies

Ingredients

IngredientAmount per serving
Calories
10 Calorie(s)
Total Carbohydrates
1 Gram(s)
Milk Thistle extract (Silymarin Flavonoids)
 300 mg
Herbal-Enzyme Blend
90 mg
L-Glutathione
100 mg
N-Acetyl Cysteine
100 mg
Grape seed standardized extract (Polyphenols)
 100 mg
Alpha Lipoic Acid
100 mg
L-Carnitine (L-Carnitine Tartrate)
 50 mg
Scute
50 mg
Schisandra
100 mg
Barberry
30 mg
organic Turmeric
30 mg
L-Methionine
20 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Methionine · 20 mg OverallScore60
A- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyD+ Value

L-methionine is clearly named, but its very small amount offers little focused structural support. Milk thistle, N-acetyl cysteine, glutathione, and other actives make the formula more relevant to liver support than to methionine supplementation. The serving is affordable, yet value remains limited when methionine is the main goal.

View ingredientView products
L-Carnitine (L-Carnitine Tartrate) · 50 mg OverallScore44
B- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

L-carnitine tartrate is a useful fitness-oriented form, but it appears here as a minor supporting ingredient. The compound amount yields very little elemental carnitine and is unlikely to serve as a stand-alone maintenance dose. Its cost is reasonable for the broader blend yet poor when judged only by delivered carnitine.

View ingredientView products
Glutathione · 100 mg OverallScore39
F Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB- Value

The glutathione form is not identified as reduced or paired with an absorption-focused delivery system, leaving its uptake uncertain. The clearly disclosed 100 mg amount is at the lower end of a practical standard-form serving and requires three capsules. The serving is affordable, but the modest glutathione amount limits its value for someone specifically seeking glutathione.

View ingredientView products
Loading alternative details
85 Performance

Glutathione 500 mg

NOW
<p>Reduced glutathione is supplied at a much larger dose, with milk thistle and alpha-lipoic acid providing a compact antioxidant-focused alternative. The narrower formula improves focus and disclosure but does not reproduce the original's NAC, methionine, carnitine, or turmeric.</p>
77 Performance

Liver Support Factors

Country Life
<p>A substantial methionine dose, choline, milk thistle, artichoke, and turmeric create a more focused lipotropic and botanical formula. Its ingredient quality and transparency are stronger, though it omits glutathione and NAC.</p>
74 Performance

Active Liver

New Nordic
<p>Artichoke, standardized milk thistle, and turmeric provide a concise botanical option with strong alignment to the stated detoxification goal. It is easier to interpret than the original blend, but it lacks the original antioxidant amino acids.</p>
74 Budget

Liv-Gall Cleanse

Natural Factors HerbalFactors
<p>Milk thistle, artichoke, turmeric, and dandelion retain a practical liver-support profile at a markedly lower serving cost. The formula is simpler than the original and omits glutathione, NAC, and alpha-lipoic acid.</p>
78 Budget

Silymarin Milk Thistle Extract 150 mg

NOW
<p>A large turmeric amount alongside milk thistle keeps the main botanical focus while reducing serving cost. It is less comprehensive than the original because it leaves out glutathione, NAC, methionine, and alpha-lipoic acid.</p>
66 Budget

Advanced Liver Support

Super Nutrition
<p>The ingredient profile closely mirrors the original and supplies two listed milk-thistle extracts while costing less per serving. It still uses an undisclosed herbal-enzyme blend, so the transparency concern remains.</p>
81 Value

Milk Thistle Phytosome 150 mg

Natural Factors HerbalFactors
<p>Milk-thistle phytosome, artichoke, turmeric, and dandelion provide a concise botanical approach at a lower serving cost. The phytosome format may improve practical delivery, while the narrow formula omits glutathione, NAC, and methionine.</p>
65 Value

Super Thisilyn

Nature's Way
<p>Standardized milk thistle, artichoke, dandelion, methionine, NAC, turmeric, and alpha-lipoic acid retain several of the original's useful components at lower cost. Smaller doses and a partly defined vegetable blend limit the advantage.</p>
80 Value

Glutathione 500 mg

NOW
<p>A large glutathione dose plus milk thistle and alpha-lipoic acid offers a focused antioxidant alternative with favorable value. The trade-off is a much narrower formula without NAC, methionine, carnitine, or turmeric.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  3. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  4. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  5. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  6. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  7. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  8. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  9. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  10. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle