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Liver Refresh

NOW
4.8
★ ★ ★ ★ ★
(21941 ratings)
Methionine
L-Carnitine 50 mg
Gluthathione 100 mg
Milk Thistle 300 mg
Turmeric 30 mg
Product Image
Score62
A broad milk-thistle formula with a credible core, but too many light additions and an opaque enzyme blend.
How scoring works
Quantity:90 Capsule(s) • (30 servings)
Goals:
Detoxification

Score 62

A broad milk-thistle formula with a credible core, but too many light additions and an opaque enzyme blend.
How scoring works

Also available as

1 option
180 servings 3 Veg Capsule(s) • 180 Capsule(s) • 60 servings $25.21 ($0.42 per serving)
$15.10($0.50 per serving)
Vitacost
$ 17.33
Daily Vita
$ 15.10
iHerb
$ 15.91
Amazon
$ 15.10
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Analysis

Milk thistle is the main active and is identified by its silymarin flavonoids. NAC, glutathione, grape polyphenols, and alpha-lipoic acid broaden antioxidant support.

Several botanical and amino-acid additions are present at relatively modest amounts. The 90 mg herbal-enzyme blend lacks component names and activity units, preventing a useful assessment.

The smaller bottle offers less practical value than the larger version of the same formula. Its complexity may not suit users who want a clear, focused supplement.

Who is it for
  • Adults seeking broad liver-support nutrients
  • People wanting to try a smaller supply
  • Users comfortable with multi-botanical formulas
Best for
  • Milk-thistle supplementation
  • Antioxidant support
  • Shorter trial use

Pros

  • Standardized milk-thistle amount
  • Includes NAC and glutathione
  • Broad antioxidant coverage

Cons

  • Hidden enzyme-blend contents
  • Several ingredients are lightly dosed
  • Small supply has weaker value

Warnings

  • Alpha-lipoic acid can lower blood glucose and may interact with diabetes medicine
  • Barberry makes the formula unsuitable during pregnancy
  • Unknown enzyme-blend contents limit allergy screening

Nutrient quality

66 High impact

Standardized milk thistle anchors a coherent liver-support formula. Most supporting actives are modest and an opaque enzyme blend weakens focus.

.

Ingredient transparency

54 Moderate impact

Most core active amounts are visible. An undisclosed blend and missing non-active ingredients reduce transparency.

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Customer satisfaction

73 High impact

The supplied average rating is very strong. No specific review comments were supplied, so repeated negative experiences cannot be assessed.

.

Value for money

56 Moderate impact

Standardized milk thistle provides some practical value. Many modest additions and a hidden blend reduce competitiveness.

.
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Goals

Detoxification
Detoxification
Impact
High effect
A- Goal FitC- Strength of SupportB- CoverageB Formula Quality
Milk Thistle · 300 mg

A liver-focused combination of milk thistle, glutathione, NAC, alpha-lipoic acid, and supporting botanicals aligns directly with detoxification. The ingredients target liver protection, glutathione status, and antioxidant recycling through complementary mechanisms.

Milk thistle has a substantial extract weight, but its silymarin yield is not stated. NAC, glutathione, turmeric, and methionine are modest, and the undisclosed herbal-enzyme blend makes potency harder to judge.

Study evidence
Milk Thistle Supportive 46 studies

Ingredients

IngredientAmount per serving
Calories
10 Calorie(s)
Total Carbohydrates
1 Gram(s)
Milk Thistle extract (Silymarin Flavonoids)
 300 mg
Herbal-Enzyme Blend
90 mg
L-Glutathione
100 mg
N-Acetyl Cysteine
100 mg
Grape (Polyphenols)
 100 mg
Alpha Lipoic Acid
100 mg
L-Carnitine (L-Carnitine Tartrate)
 50 mg
Scute
50 mg
Schisandra
100 mg
Barberry
30 mg
organic Turmeric
30 mg
L-Methionine
20 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Methionine · 20 mg OverallScore55
B- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyC- Value

The formula identifies L-Methionine and discloses its amount, but the very small dose is unlikely to suit focused supplementation. Standardized botanical compounds and several complementary antioxidants make the product primarily a broader liver-support blend. Its typical serving cost offers fair formula-level value, while the absence of a methionine purity grade limits source confidence.

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L-Carnitine (L-Carnitine Tartrate) · 50 mg OverallScore44
B- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

L-carnitine tartrate offers a suitable fitness-oriented form but only as a minor part of this liver-support blend. The listed compound yields a very small elemental dose and is unlikely to meet typical carnitine needs alone. Its low serving cost does not offset the poor value per gram of active carnitine.

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Gluthathione · 100 mg OverallScore26
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyD- Value

Direct L-glutathione is disclosed alongside antioxidant precursors, but the label does not confirm a reduced or enhanced-delivery form. The amount is only a low maintenance contribution, and no branded purity source is identified. A near-median serving cost provides modest value within the broader combination formula.

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Loading alternative details
69 Performance

Liver Detox & Blood Refresh

Irwin Naturals
<p>It is a stronger formulation match because 270 mg of silymarin is paired with vitamin C, selenium, burdock, and dandelion. Compared with the original’s broad but mostly modestly dosed milk-thistle and antioxidant blend, many additional herbs, algae, and powders are too lightly dosed to contribute much, and cayenne may aggravate reflux.</p>
74 Performance

Active Liver

New Nordic
<p>It is a stronger formulation match because 250 mg of milk-thistle extract is paired with 222 mg of artichoke and 150 mg of turmeric. Compared with the original’s broad but mostly modestly dosed milk-thistle and antioxidant blend, the extract weights are useful, but active-marker yields are not supplied.</p>
77 Performance

Liver Support Factors

Country Life
<p>It is a stronger formulation match because 400 mg of methionine is paired with choline, milk thistle, artichoke, and turmeric. Compared with the original’s broad but mostly modestly dosed milk-thistle and antioxidant blend, most botanical extracts lack active-marker standardization and several companion amounts are modest.</p>
66 Budget

Advanced Liver Support

Super Nutrition
<p>It is a more economical option because paired milk-thistle fruit and seed extracts are supported by 100 mg each of glutathione, NAC, grape polyphenols, and alpha-lipoic acid. Compared with the original’s broad but mostly modestly dosed milk-thistle and antioxidant blend, the enzyme blend is hidden and many secondary additions are modestly dosed.</p>
80 Budget

Silymarin Complex

California Gold Nutrition
<p>It is a more economical option because 300 mg of milk thistle is paired with dandelion, artichoke, turmeric, ginger, and piperine. Compared with the original’s broad but mostly modestly dosed milk-thistle and antioxidant blend, the active silymarin yield is not supplied and the supporting botanicals remain modest.</p>
81 Budget

Milk Thistle Phytosome 150 mg

Natural Factors HerbalFactors
<p>It is a more economical option because a 150 mg milk-thistle phytosome is paired with dandelion, turmeric, and artichoke. Compared with the original’s broad but mostly modestly dosed milk-thistle and antioxidant blend, the phytosome improves the absorption case, although the active silymarin yield is not supplied.</p>
65 Value

Super Thisilyn

Nature's Way
<p>It offers a useful quality-to-cost balance because 175 mg of milk thistle is paired with artichoke, NAC, methionine, turmeric, and alpha-lipoic acid. Compared with Liver Refresh, milk-thistle potency is unclear and the proprietary vegetable blend reduces transparency.</p>
63 Value

Liver Refresh

NOW
<p>It offers a useful quality-to-cost balance because 300 mg of milk-thistle flavonoids is paired with 100 mg each of glutathione, NAC, grape polyphenols, and alpha-lipoic acid. Compared with Liver Refresh, the enzyme blend is hidden and many additional herbs and amino acids are modestly dosed.</p>
79 Value

Silymarin Complex

California Gold Nutrition
<p>It offers a useful quality-to-cost balance because 300 mg of milk thistle is paired with dandelion, artichoke, turmeric, ginger, and piperine. Compared with Liver Refresh, the active silymarin yield is not supplied and the smaller herbs add breadth rather than verified potency.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  2. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  3. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  4. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  5. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  6. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  7. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  8. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle