Product Image

Glucosamine Chondroitin Complex plus MSM Advanced Triple Strength

21st Century
4.8
★ ★ ★ ★ ★
(21698 ratings)
Manganese 2 mg
Boron 3 mg
Boswellia 100 mg
Product Image
Score68
A full glucosamine amount and several joint-focused additions make the concept useful for mobility support. Hidden chondroitin and MSM amounts, unstandardized Boswellia, and basic mineral forms limit confidence.
How scoring works
Quantity:80 Tablet(s) • (40 servings)
Goals:
General Health
Bone Health
Testosterone Support

Score 68

A full glucosamine amount and several joint-focused additions make the concept useful for mobility support. Hidden chondroitin and MSM amounts, unstandardized Boswellia, and basic mineral forms limit confidence.
How scoring works

Also available as

1 option
1103.00mg Proprietary Blend • 120 servings Boswellia 100 mg, Boron 3 mg +1 more • 120 Tablet(s) • 60 servings $22.99 ($0.38 per serving)
$13.52($0.33 per serving)
iHerb
$ 15.99
iHerb
$ 15.99
Amazon
$ 13.52
Report prices

Analysis

Glucosamine hydrochloride is clearly listed at 1.5 g, while the 1.25 g proprietary blend appears to provide the chondroitin and MSM portion. The total blend weight is disclosed, but its internal amounts cannot be checked against targeted joint doses.

Boswellia extract is present at 100 mg without boswellic-acid or AKBA standardization. Boron reaches a useful 3 mg amount, while manganese covers basic maintenance but uses the less compelling sulfate form.

Vitamin C supports connective-tissue nutrition, yet the formula is much more relevant to joint comfort than to broad bone, general-health, or testosterone goals. The tablet format is practical, but the disclosure gap remains the deciding limitation.

Who is it for
  • Adults looking for a broad joint-support tablet
  • People who value a full disclosed glucosamine amount
  • Users comfortable with a partially proprietary formula
Best for
  • Daily joint-mobility support
  • Glucosamine-centered supplementation
  • Connective-tissue nutrient support

Pros

  • Provides 1.5 g glucosamine hydrochloride
  • Includes Boswellia, vitamin C, manganese, and boron
  • Clearly discloses the total proprietary-blend weight
  • Low serving cost supports good value for a broad joint formula.

Cons

  • Does not disclose individual chondroitin and MSM amounts
  • Boswellia lacks active-marker standardization
  • Manganese sulfate is a basic mineral form
  • The formula is not comprehensive for bone or testosterone support

Warnings

  • Glucosamine or the chondroitin-containing blend may cause digestive upset in sensitive users.
  • Chondroitin and Boswellia may add bleeding concern for people taking anticoagulant or antiplatelet medicines.
  • The ingredient source for glucosamine is not stated, so people with relevant source allergies should verify the package before use.

Nutrient quality

78 High impact

Glucosamine hydrochloride is recognizable, while manganese sulfate and sodium borate are basic forms and Boswellia lacks standardization, and glucosamine is meaningfully supplied, while Boswellia is modest and the proprietary joint blend hides chondroitin and MSM amounts. The listed nutrient and joint-support amounts are not obviously excessive, while glucosamine, a joint blend, Boswellia, manganese, boron, and vitamin C form a coherent joint-support formula.

.

Ingredient transparency

45 Lower impact

Several core ingredients have amounts, but a proprietary blend hides important component doses, and a proprietary blend hides the amounts of its individual components. Serving count is supplied, but complete daily-use directions are not provided, while inactive ingredients and excipients are not included in the supplied label details.

.

Customer satisfaction

76 High impact

The supplied average rating is strong, and extensive review volume makes the average rating more dependable. Specific review themes are unavailable, so repeated negatives and real-world fit remain uncertain.

.

Value for money

78 High impact

Uneven forms, dosing, or disclosure weaken formula value, and the low serving cost provides strong practical value. The core additions support joints, though the hidden blend prevents a full filler assessment, while the formula and serving value compare well with similar products.

.
Report analysis

Goals

General Health
General Health
Impact
Moderate effect
C+ Goal FitC Strength of SupportC- CoverageC Formula Quality
Boron · 3 mgVitamin C · 60 mg

Boron and a substantial joint-support base provide some relevance to structural health and daily mobility. Glucosamine, Boswellia, vitamin C, and manganese create a broader joint-focused formula.

The product is less aligned with general wellness than a balanced vitamin or mineral formula. A large proprietary blend also prevents a full assessment of chondroitin, MSM, and other hidden components.

Study evidence
Boron Supportive 6 studies
Vitamin C Supportive 56 studies
Bone Health
Bone Health
Impact
Moderate effect
C Goal FitD+ Strength of SupportC- CoverageC Formula Quality
Manganese · 2 mgBoron · 3 mgVitamin C · 60 mg

Boron and manganese provide relevant trace-mineral support, while glucosamine and vitamin C relate more to joints and connective tissue. The boron amount is useful, but manganese is only a maintenance dose and uses a basic sulfate form.

Calcium, magnesium, vitamin D, and vitamin K are absent, limiting direct support for mineralization. A proprietary joint blend also prevents full assessment of chondroitin or other possible contributors.

Study evidence
Boron Supportive 5 studies
Manganese Adverse 12 studies
Vitamin C Supportive 46 studies
Testosterone Support
Testosterone Support
Impact
Moderate effect
C Goal FitB Strength of SupportD CoverageF Formula Quality
Boron · 3 mg

Boron at 3 mg provides a relevant endocrine-support amount and is the formula’s only strong link to testosterone. Glucosamine, chondroitin, MSM, boswellia, and vitamin C are aimed at joint health rather than hormonal function.

The boron dose is clearly stated, though sodium borate is a basic inorganic form. A proprietary joint blend and many unrelated actives make the product inefficient for targeted testosterone support.

Study evidence
Boron Disputed 3 studies

Ingredients

IngredientAmount per serving
Calories
10 Calorie(s)
Total Carbohydrates
2 Gram(s)
Vitamin C (Ascorbic Acid)
 60 mg
Manganese (Manganese Sulfate)
 2 mg
Sodium
50 mg
Glucosamine HCl
1500 mg
Proprietary Blend
1250 mg
Boswellia serrata extract
100 mg
Boron (Sodium Borate)
 3 mg
Adults 18–50
Report overview
Manganese (Manganese Sulfate) · 2 mg OverallScore66
D- Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyB+ Value

Manganese sulfate is an inorganic form with lower absorption potential. The clearly stated 2 mg serving supports basic maintenance but remains below the targeted bone and joint range. A below-median serving cost is favorable, although the form quality is modest.

View ingredientView products
Boron (Sodium Borate) · 3 mg OverallScore58
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyC Value

The disclosed sodium borate provides a clinically relevant boron amount but uses a basic inorganic form. Labeling makes the dose assessable even though it is part of a larger joint-support formula. The serving cost yields fair value when normalized to the boron amount.

View ingredientView products
Boswellia · 100 mg OverallScore33
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyB- Value

The small Boswellia extract contribution has no stated boswellic-acid or AKBA standardization. Its tablet delivery offers no disclosed absorption support, making the amount less convincing for a Boswellia-focused use. The inexpensive serving helps affordability, but the broader joint blend rather than Boswellia drives the formula.

View ingredientView products
Loading alternative details
93 Performance

ArthroMax Advanced NT2 Collagen & ApresFlex

Life Extension
Glucosamine, branded Boswellia, standardized cartilage collagen, and fructoborate provide a more transparent and focused joint formula. Some marker details remain incomplete, but the key structural and botanical actives are easier to assess than the original proprietary blend.
85 Performance

Osteo Bi-Flex Triple Strength

Osteo Bi-Flex
Meaningful glucosamine and branded 5-Loxin Boswellia improve botanical identity and keep the formula closely aligned with joint support. Chondroitin and MSM remain combined rather than individually disclosed, and the shorter supply weakens value.
66 Performance

Bone Support with Strontium & Boron

Dr. Mercola
Strontium citrate, boron, manganese, and silica provide stronger bone-mineral support with clearly named core forms. It does not replace glucosamine-centered joint support, and strontium should be taken separately from calcium because they can compete for absorption.
88 Budget

Osteo Bi-Flex Triple Strength

Osteo Bi-Flex
Meaningful glucosamine and branded 5-Loxin Boswellia provide a more clearly characterized joint core at a lower serving cost. Chondroitin and MSM still share a combined amount, but the Boswellia identity is more specific than in the original.
58 Budget

Silica Complex

NOW
A substantial horsetail extract with calcium, zinc, manganese, and boron costs less and provides focused mineral support. It omits glucosamine, chondroitin, MSM, and Boswellia, so it is a bone-and-silica option rather than a direct joint-formula replacement.
72 Budget

Glucosamine Chondroitin Complex plus MSM

21st Century
The matched glucosamine, Boswellia, boron, manganese, and vitamin C profile is among the closest lower-cost or near-cost alternatives. Its proprietary blend still hides the chondroitin and MSM amounts, so transparency does not materially improve.
79 Value

Osteo Bi-Flex Triple Strength

Osteo Bi-Flex
Glucosamine and branded 5-Loxin Boswellia provide a recognizable joint-support core with strong customer acceptance. Chondroitin and MSM remain hidden within a combined amount, and the high recurring cost limits the value advantage.
70 Value

Calcium & Magnesium Orange Cream Flavor

Liquid Health
Citrate, lactate gluconate, and chelated minerals provide broad bone-support value with vitamin D, manganese, and boron. The product omits glucosamine, chondroitin, MSM, and Boswellia, so it fits bone nutrition better than direct joint support.
52 Value

Ultra Prostate Formula

Life Extension
Standardized saw palmetto, lycopene, boron, phytosterols, and Boswellia provide a well-constructed male-health formula. Its prostate focus and lack of glucosamine, chondroitin, and MSM make it a poor joint substitute despite shared boron and Boswellia.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
    Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
    Narrative reviewBone Health forManganese
  2. Correlation between bone mineral density and serum trace element contents of elderly males in Beijing urban area.
    Wang L; Yu H; Yang G; Zhang Y; Wang W; Su T; Ma W; Yang F; Chen L; He L; Ma Y; Zhang Y · International journal of clinical and experimental medicine · 2016
    Cross-sectional study91 participantsBone Health forManganese
  3. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
    Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
    Cross-sectional study9,732 participantsBone Health forManganese
  4. Association of per- and polyfluoroalkylated substances/heavy metals and bone health in children and adolescents.
    Wei Y; Zhang Y; Ji Q; Yang S; Yang F · Frontiers in public health · 2024
    Cross-sectional study622 participantsBone Health forManganese
  5. [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
    José Ramón V; Mora Mora M; Marino Alarcón O; Hernández G; Josefina Linares L; Urdaneta Romero H; Arévalo González E · Investigacion clinica · 2013
    Case-control study45 participantsBone Health forBoron
  6. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
    Nielsen FH; Hunt CD; Mullen LM; Hunt JR · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1987
    Single-arm trial12 participantsBone Health forBoron
  7. The relationship between boron and magnesium status and bone mineral density in the human: a review.
    Volpe SL; Taper LJ; Meacham S · Magnesium research · 1994
    Narrative reviewBone Health forBoron
  8. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
    Meacham SL; Taper LJ; Volpe SL · Environmental health perspectives · 1995
    Randomized trial28 participantsBone Health forBoron
  9. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
    C D Hunt, J L Herbel, F H Nielsen · The American Journal of Clinical Nutrition · 1997
    Non-randomized trial11 participantsBone Health forBoron
  10. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsBone Health forManganese
  11. Associations of multiple metals with bone mineral density: A population-based study in US adults.
    Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
    Cross-sectional studyBone Health forManganese
  12. Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
    Li H; Li G; Yi M; Zhou J; Deng Y; Huang Y; He S; Meng X; Liu L · Frontiers in public health · 2024
    Cross-sectional study31 participantsBone Health forManganese
  13. Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies.
    Zeng LF; Luo MH; Liang GH; Yang WY; Xiao X; Wei X; Yu J; Guo D; Chen HY; Pan JK; Huang HT; Liu Q; Guan ZT; Han YH; Zhao D; Zhao JL; Hou SR; Wu M; Lin JT; Li JH; Liang WX; Ou AH; Wang Q; Li ZP; Liu J · Frontiers in endocrinology · 2020
    Meta-analysis19,484 participants17 studies pooledBone Health forVitamin C
  14. Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis.
    Sun Y; Liu C; Bo Y; You J; Zhu Y; Duan D; Cui H; Lu Q · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Meta-analysis6 studies pooledBone Health forVitamin C
  15. Smoking, antioxidant vitamins, and the risk of hip fracture.
    Melhus H; Michaëlsson K; Holmberg L; Wolk A; Ljunghall S · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1999
    Cohort study66,651 participantsBone Health forVitamin C
  16. Micronutrients and the risk of hip fracture: Case-control study.
    Torbergsen AC; Watne LO; Wyller TB; Frihagen F; Strømsøe K; Bøhmer T; Mowe M · Clinical nutrition (Edinburgh, Scotland) · 2018
    Case-control study189 participantsBone Health forVitamin C
  17. Favorable effect of dietary vitamin C on bone mineral density in postmenopausal women (KNHANES IV, 2009): discrepancies regarding skeletal sites, age, and vitamin D status.
    Kim YA; Kim KM; Lim S; Choi SH; Moon JH; Kim JH; Kim SW; Jang HC; Shin CS · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Cross-sectional study1,196 participantsBone Health forVitamin C
  18. Effects of boron supplementation on the severity and duration of pain in primary dysmenorrhea.
    Nikkhah S; Dolatian M; Naghii MR; Zaeri F; Taheri SM · Complementary therapies in clinical practice · 2015
    Randomized trial113 participantsGeneral Health forBoron
  19. Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: Results from 2 randomized phase-III studies.
    Elewski BE; Aly R; Baldwin SL; González Soto RF; Rich P; Weisfeld M; Wiltz H; Zane LT; Pollak R · Journal of the American Academy of Dermatology · 2015
    Randomized trialGeneral Health forBoron
  20. The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis.
    Toledo-Bahena ME; Bucko A; Ocampo-Candiani J; Herz-Ruelas ME; Jones TM; Jarratt MT; Pollak RA; Zane LT · Journal of drugs in dermatology : JDD · 2015
    Clinical trial336 participantsGeneral Health forBoron
  21. Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA).
    Henriksson R; Capala J; Michanek A; Lindahl SA; Salford LG; Franzén L; Blomquist E; Westlin JE; Bergenheim AT; Swedish Brain Tumour Study Group · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2009
    Single-arm trial30 participantsGeneral Health forBoron
  22. Effects of Calcium Fructoborate on Levels of C-Reactive Protein, Total Cholesterol, Low-Density Lipoprotein, Triglycerides, IL-1β, IL-6, and MCP-1: a Double-blind, Placebo-controlled Clinical Study
    Otilia-Constantina Rogoveanu, George Dan Mogosanu, Cornelia Bejenaru, Ludovic Everard Bejenaru, Octavian Croitoru, Johny Neamtu, Zbigniew Pietrzkowski, Tania Reyes-Izquierdo, Andrei Bita, Iulia Daria Scorei, Romulus Ion Scorei · Biological Trace Element Research · 2015
    Randomized trial78 participantsGeneral Health forBoron
  23. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  24. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  25. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  26. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  27. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  28. Biochemical and physiologic consequences of boron deprivation in humans.
    Nielsen FH · Environmental health perspectives · 1995
    Single-arm trial12 participantsTestosterone Support forBoron
  29. Plasma boron and the effects of boron supplementation in males.
    Green NR; Ferrando AA · Environmental health perspectives · 1995
    Randomized trial19 participantsTestosterone Support forBoron
  30. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines
    Mohammad Reza Naghii, Mahmoud Mofid, Ali Reza Asgari, Mehdi Hedayati, Maryam-Saddat Daneshpour · Journal of Trace Elements in Medicine and Biology · 2011
    Non-randomized trial8 participantsTestosterone Support forBoron