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Supreme C Complex

Swanson Premium Brand
4.8
★ ★ ★ ★ ★
(329 ratings)
Vitamin C 500 mg
Rutin 50 mg
Flavonoid (mixture) 500 mg
Product Image
Score80
A good-value vitamin C and bioflavonoid formula with clear amounts, but the unbuffered form may be uncomfortable and the rutin lacks quality detail.
How scoring works
Quantity:250 Tablet(s) • (250 servings)
Goals:
Immunity
Skin Health
General Health
Anti-Inflammatory Support
Vision Support

Score 80

A good-value vitamin C and bioflavonoid formula with clear amounts, but the unbuffered form may be uncomfortable and the rutin lacks quality detail.
How scoring works
$22.09($0.08 per serving)
iHerb
$ 22.09
iHerb
$ 22.09
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Analysis

Vitamin C provides focused antioxidant, collagen, and immune support at a meaningful amount. A substantial citrus bioflavonoid complex and added rutin give the tablet more depth than a basic single-ingredient product.

All active amounts are clearly listed, so the relative roles are easy to understand. Standard ascorbic acid is not buffered, and the label does not identify a source or purity for rutin.

The low serving cost makes this a practical option for people who tolerate ordinary vitamin C well. It remains an antioxidant formula rather than a complete product for skin, vision, or broader immune nutrition.

Who is it for
  • Value-focused vitamin C users
  • Adults wanting a substantial bioflavonoid addition
  • People who tolerate standard ascorbic acid
Best for
  • Focused antioxidant support
  • Normal collagen synthesis
  • Daily immune nutrition

Pros

  • Meaningful vitamin C amount
  • Substantial citrus bioflavonoid complex
  • Clear active-ingredient amounts

Cons

  • Unbuffered ascorbic acid
  • Rutin source and purity are not stated
  • Does not cover broader vision or skin pathways

Warnings

  • Plain ascorbic acid may irritate a sensitive stomach
  • Rutin is below a typical targeted-support amount
  • Check total vitamin C intake when using other supplements

Nutrient quality

86 Highest impact

Standard ascorbic acid is effective but lacks buffering or enhanced delivery. Vitamin C and citrus bioflavonoids are substantial, while rutin provides useful support.

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Ingredient transparency

77 High impact

Every listed active has a specific amount. The supplied data does not include a complete inactive ingredient list.

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Customer satisfaction

68 High impact

The aggregate satisfaction measure is strong enough to support a favorable first impression. Missing feedback themes leave repeat complaints and purpose fit uncertain despite adequate volume.

.

Value for money

90 Highest impact

The low price is appropriate for basic ascorbic acid with meaningful flavonoid support. Each serving is exceptionally inexpensive for the active amounts provided.

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Goals

Immunity
Immunity
Impact
Highest effect
A+ Goal FitA Strength of SupportB CoverageA Formula Quality
Vitamin C · 500 mg

A meaningful vitamin C amount directly supports antioxidant protection and immune-cell function. Bioflavonoids and rutin add related antioxidant support around the main nutrient.

Plain ascorbic acid lacks buffering or an advanced delivery system for sensitive users. The formula is deeper than a single vitamin but still does not address vitamin D, zinc, or barrier-specific immune pathways.

Study evidence
Vitamin C Supportive 53 studies
Skin Health
Skin Health
Impact
Highest effect
B+ Goal FitA Strength of SupportB- CoverageA Formula Quality
Vitamin C · 500 mg

Vitamin C directly supports collagen synthesis and antioxidant protection in skin. The 500 mg amount gives this focused pathway meaningful depth.

Ascorbic acid is fully disclosed, while bioflavonoids and rutin add complementary antioxidant support. The formula does not add hydration lipids, collagen peptides, or a separate photoprotection pathway.

Study evidence
Vitamin C Supportive 53 studies
General Health
General Health
Impact
Highest effect
A- Goal FitB+ Strength of SupportC+ CoverageA- Formula Quality
Vitamin C · 500 mg

Vitamin C provides well-established antioxidant, collagen, and immune support at a useful daily amount. Citrus bioflavonoids and rutin add complementary plant compounds, although their incremental general-health benefit is less certain.

Standard ascorbic acid is fully disclosed but lacks buffered or enhanced delivery for people with a sensitive stomach. The streamlined combination offers meaningful antioxidant depth without trying to cover every general-wellness pathway.

Study evidence
Vitamin C Supportive 56 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
D+ Goal FitB Strength of SupportC- CoverageA Formula Quality
Vitamin C · 500 mg

Vitamin C provides antioxidant support and may help regulate inflammatory stress, but it is not a targeted inflammation-modulating active. Bioflavonoids broaden antioxidant coverage without adding a strong direct pathway.

Standard ascorbic acid is clearly identified but has no enhanced-delivery advantage. The focused formula is better suited to basic antioxidant nutrition than pronounced inflammatory support.

Study evidence
Vitamin C Supportive 50 studies
Vision Support
Vision Support
Impact
High effect
C Goal FitC+ Strength of SupportD+ CoverageB Formula Quality
Vitamin C · 500 mg

Vitamin C supplies meaningful antioxidant support for the lens and other ocular tissues. Rutin and citrus bioflavonoids may add vascular and antioxidant support, with all active amounts clearly stated.

The formula is not a complete vision product because it lacks macular carotenoids, omega-3s, vitamin E, zinc, and copper. Rutin is also not standardized, so its active quality is harder to judge.

Study evidence
Rutin Not classified 1 study
Vitamin C Disputed 24 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 500 mg
Citrus Bioflavonoid Complex
500 mg
Rutin
50 mg
Adults 18–50
Report overview
Vitamin C (Ascorbic Acid) · 500 mg OverallScore64
F Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyB+ Value
The 500 mg serving provides a well-targeted amount of standard ascorbic acid. Bioflavonoids and rutin broaden the formula but do not replace a buffered or advanced vitamin C delivery system. Cost per gram is favorable, while stomach comfort and complete excipient disclosure remain limitations.
View ingredientView products
Rutin · 50 mg OverallScore45
F Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyB Value

The 50 mg standalone rutin amount is clearly disclosed but remains below a targeted-support dose. Its botanical source, chemical form, and purity are not identified. The low cost per serving provides good value relative to the stated rutin amount.

View ingredientView products
Loading alternative details
86 Performance

Ester-C Plus 1000 mg Vitamin C

Solgar
<p>A substantial buffered vitamin C dose and citrus bioflavonoids provide a simpler, more stomach-friendly option than the original’s unbuffered formula. Separate rutin is absent, but the core nutrient and delivery form are stronger.</p>
87 Performance

Ester-C with Citrus Bioflavonoids

American Health
<p>Buffered vitamin C and a substantial citrus bioflavonoid amount create a concentrated, well-aligned antioxidant formula. It improves form quality over standard ascorbic acid, although rutin is not separately disclosed.</p>
86 Performance

C

Swanson
<p>Fully buffered calcium ascorbate provides twice the vitamin C with a clearly disclosed citrus bioflavonoid amount. The focused formula improves stomach-comfort potential, though it omits the original’s separately measured rutin.</p>
84 Budget

Ester-C 500 mg With Citrus Bioflavoinds

American Health
<p>Buffered calcium ascorbate improves expected stomach comfort while retaining substantial citrus bioflavonoid support at lower serving cost. The label repeats the bioflavonoid complex under many forms, so the actual component breakdown is less clear than the original.</p>
84 Budget

Ester-C 24 Hour Immune Support 1000 mg

NatureSmart
<p>A buffered vitamin C form doubles the core nutrient amount and adds citrus bioflavonoids with near-budget serving economics. Rutin is not separately quantified, but the formula may be gentler than the original’s unbuffered ascorbic acid.</p>
82 Budget

Ester-C Plus 1000 mg Vitamin C

Solgar
<p>Buffered calcium ascorbate supplies twice the vitamin C with citrus bioflavonoids, acerola, rose hips, and rutin at efficient long-term value. Supporting plant amounts are modest, but the delivery form is more stomach-friendly than the original.</p>
80 Value

AlphaSorb-C 500

NOW
<p>Buffered calcium ascorbate matches the original’s vitamin C amount while adding bioflavonoids, rutin, acerola, and rose hips at favorable value. Several supporting ingredients are small or incompletely characterized, but the delivery form may be easier on sensitive stomachs.</p>
79 Value

Buffered Vitamin C 500 mg

Bluebonnet
<p>Calcium ascorbate matches the original’s vitamin C amount and adds a meaningful citrus bioflavonoid portion with better expected stomach comfort. Rutin is much lighter than in the original, but the long supply supports practical value.</p>
81 Value

Ester-C Plus 1000 mg Vitamin C

Solgar
<p>A large buffered vitamin C serving with bioflavonoids, acerola, rose hips, and rutin provides strong ingredient depth for the cost. Its supporting amounts are smaller than the original’s bioflavonoid dose, but the core form is more refined.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis.
    Bjelakovic G; Nikolova D; Gluud LL; Simonetti RG; Gluud C · JAMA · 2007
    Meta-analysis232,606 participants68 studies pooledGeneral Health forVitamin C
  2. Vitamin C intake and multiple health outcomes: an umbrella review of systematic reviews and meta-analyses.
    Xu K; Peng R; Zou Y; Jiang X; Sun Q; Song C · International journal of food sciences and nutrition · 2022
    Meta-analysis76 studies pooledGeneral Health forVitamin C
  3. Vitamin C supplementation in kidney failure: effect on uraemic symptoms.
    Singer RF · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2011
    Randomized trial99 participantsGeneral Health forVitamin C
  4. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  5. Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic Review and Meta-Analysis.
    Keya TA; Leela A; Fernandez K; Habib N; Rashid M · Current reviews in clinical and experimental pharmacology · 2022
    Meta-analysis10 studies pooledImmunity forVitamin C
  6. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  7. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  8. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage.
    Fitzpatrick RE; Rostan EF · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2002
    Non-randomized trial10 participantsSkin Health forVitamin C
  9. Vitamin C and postoperative outcomes following mandibular third molar extraction: a randomized split-mouth study.
    Demirel M; Aktas A; Kizil M; Yalcin N · Oral surgery, oral medicine, oral pathology and oral radiology · 2026
    Randomized trial56 participantsSkin Health forVitamin C
  10. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  11. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  12. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  13. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  14. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  15. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  16. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  17. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  18. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  19. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  20. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  21. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  22. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  23. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  24. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  25. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  26. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  27. A randomized, double-masked study on the treatment of retinal vein occlusion with troxerutin
    Glacet-Bernard A, Coscas G, Chabanel A, Zourdani A, Lelong F, Samama MM · American Journal of Ophthalmology · 1994
    Randomized trial53 participantsVision Support forRutin
  28. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  29. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  30. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  31. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  32. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C