Natural E-400
NOW
Natural E-400
4.8
★ ★ ★ ★ ★
(10295 ratings)
Vitamin E 400 IU
Score 88.0
NOW Natural E-400 delivers 400 IU of natural D-Alpha-Tocopheryl Acetate, a highly bioavailable and widely studied form of Vitamin E. Its exceptional number of positive reviews highlights its popularity and perceived effectiveness among users. Priced very competitively per serving, it offers excellent value for foundational Vitamin E supplementation, though it doesn't provide the full spectrum of mixed tocopherols.
Quantity: 250 Softgel(s)Servings size: 1 Softgel(s) (250 servings)
Selected goals:
Other goals:
Anti-Aging
Skin Health
Heart Health
Cardiovascular Support
leaderboard Score 88.0
NOW Natural E-400 delivers 400 IU of natural D-Alpha-Tocopheryl Acetate, a highly bioavailable and widely studied form of Vitamin E. Its exceptional number of positive reviews highlights its popularity and perceived effectiveness among users. Priced very competitively per serving, it offers excellent value for foundational Vitamin E supplementation, though it doesn't provide the full spectrum of mixed tocopherols.
insights Analysis
This product provides 400 IU of Vitamin E in the form of D-Alpha-Tocopheryl Acetate, which is a natural and highly bioavailable form of Vitamin E. As the most active form, D-Alpha-Tocopherol is well-recognized by nutritionists for its antioxidant properties and benefits for skin, heart, and anti-aging goals. Its esterified form (acetate) ensures stability and good absorption. With nearly 9500 reviews and a very low price per serving, it's a testament to its widespread acceptance and value. While mixed tocopherols are often preferred for a broader spectrum of benefits, this product offers excellent focused support at a very accessible price point.
- Contains natural D-Alpha-Tocopheryl Acetate, a highly bioavailable form.
- Very affordable price per serving.
- Extremely high number of positive reviews indicates high customer satisfaction and trust.
- Standard and effective 400 IU dosage.
- Focuses solely on alpha-tocopherol, lacking other beneficial mixed tocopherols.
- Gelatin capsule may not be suitable for vegans/vegetarians.
$26.60($0.10 per serving)
 Daily Vita | $ 26.60 | |
 iHerb | $ 28.16 | |
 Vitacost | $ 43.99 |
bolt Effectiveness for goals
Vitamin E primarily acts as a powerful antioxidant, protecting cells from oxidative damage caused by free radicals. It is also involved in immune function and plays a role in cell signaling and gene expression. This fat-soluble vitamin contributes to maintaining overall cellular health.
Vitamin E, particularly alpha-tocopherol, neutralizes harmful free radicals by donating an electron, preventing them from damaging cell membranes, proteins, and DNA. This protective action helps mitigate oxidative stress throughout the body. Its fat-soluble nature allows it to protect cell membranes.
Vitamin E is a common ingredient in skincare products, with its antioxidant properties potentially helping to protect skin cells from environmental damage. It may contribute to maintaining skin integrity and moisture. However, scientific evidence for significant therapeutic effects from topical or oral supplements alone for specific skin conditions varies.
Vitamin E is known to play a role in supporting the immune system, particularly in older adults, by protecting immune cells from oxidative damage. Adequate intake is important for optimal immune responses and may enhance the body's natural defense mechanisms. Its impact on specific immune conditions continues to be studied.
Observational studies have linked higher Vitamin E intake from food with a lower risk of heart disease. However, large clinical trials evaluating Vitamin E supplements for heart disease prevention have yielded mixed results and generally do not support a protective effect in healthy individuals. Current evidence suggests that obtaining Vitamin E from dietary sources is preferable for cardiovascular benefits.
schedule Dosage, timing & forms
The recommended dietary allowance (RDA) for Vitamin E in adults is 15 mg (or 22.4 IU) of alpha-tocopherol per day. This amount is typically met through diet for healthy individuals. Supplement dosages can vary and should be considered based on individual needs.
Vitamin E exists in eight chemical forms, including alpha-, beta-, gamma-, and delta-tocopherol, and corresponding tocotrienols. Alpha-tocopherol is the only form recognized to meet human requirements and is most commonly found in supplements. Some products may offer mixed tocopherols or include tocotrienols.
Natural Vitamin E is typically labeled as 'd-alpha-tocopherol' and is derived from plant oils. Synthetic Vitamin E is labeled 'dl-alpha-tocopherol' and is produced chemically. Natural Vitamin E is generally considered to be more bioavailable and potent than synthetic forms.
Yes, Vitamin E is a fat-soluble vitamin, meaning its absorption is significantly enhanced when taken with dietary fat. Taking it alongside a meal or snack that contains some fat is recommended. This helps ensure optimal bioavailability.
The tolerable upper intake level (UL) for alpha-tocopherol in adults from supplements and fortified foods is 1,000 mg per day. This translates to approximately 1,500 IU of natural d-alpha-tocopherol or 1,100 IU of synthetic dl-alpha-tocopherol. Consistently exceeding this level may increase the risk of adverse effects.
health_and_safety Safety & interactions
Yes, high doses of Vitamin E can significantly increase the risk of bleeding when taken with anticoagulant medications like warfarin or antiplatelet drugs. This interaction enhances the effects of these medications. Individuals on such medications must consult a healthcare professional before taking Vitamin E.
At typical supplemental doses, Vitamin E is generally well-tolerated. High doses (above 1,000 mg/day) may lead to nausea, diarrhea, stomach cramps, fatigue, and weakness. A more serious risk at very high doses is an increased tendency to bleed.
Both Vitamin E, particularly in high doses, and aspirin can have antiplatelet effects, increasing the risk of bleeding. Taking them together may amplify this risk. Individuals taking aspirin, especially daily low-dose, should consult a healthcare professional.
The Tolerable Upper Intake Level (UL) for alpha-tocopherol in adults is 1,000 mg (1,500 IU) per day from supplements. Consistently exceeding this limit may increase the risk of adverse effects, including hemorrhagic stroke. It is important to adhere to recommended dosages or consult a healthcare provider.
Individuals taking anticoagulant medications, those with a history of hemorrhagic stroke, or people undergoing surgery should use Vitamin E with caution. Pregnant or breastfeeding women and individuals with certain medical conditions should consult a healthcare provider before supplementation.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin E | 400 IU |
Categories
Vitamin E 90.0
As a highly concentrated and natural source of the primary Vitamin E form, this product is an excellent and popular choice within the Vitamin E supplement category.
Goals
Anti-Aging 85.0
D-Alpha-Tocopherol is a potent antioxidant that combats cellular damage, a key aspect of anti-aging, though mixed tocopherols could offer even broader protection.
Skin Health 85.0
As the most active form, D-Alpha-Tocopherol effectively protects skin from oxidative stress and supports its barrier function, contributing to healthier and more resilient skin.
Heart Health 85.0
D-Alpha-Tocopherol helps protect LDL cholesterol from oxidation, which is crucial for maintaining cardiovascular health and reducing risk factors for heart disease.
Recommended Alternatives
75 Value 
Water Dispersible E Supplement 1000 IU
Spring Valley
4.8
★★★★★
(436 ratings)
Despite an unknown form, its significantly higher dosage (1000 IU) and low price per serving (14 cents) offer potentially great value for those seeking a higher potency Vitamin E, assuming good bioavailability.
85 Value 
UNIQUE E
A.C. Grace Company
4.7
★★★★★
(1820 ratings)
This alternative offers the same high-quality natural D-Alpha-Tocopherol from A.C. Grace Company, providing excellent Vitamin E benefits for its cost, maintaining a strong balance of potency and purity.
80 Value 
Max For Men Iron Free
Country Life
4.7
★★★★★
(1694 ratings)
While a multivitamin, this product provides a substantial 400 IU of natural D-Alpha-Tocopherol Succinate, making it a very good value for receiving a full dose of quality Vitamin E alongside other beneficial nutrients.
92 Performance 
Mixed Vitamin E 400 IU
Natural Factors
4.8
★★★★★
(2141 ratings)
This alternative is superior due to its inclusion of mixed tocopherols, providing a more comprehensive spectrum of Vitamin E forms that offer synergistic benefits beyond just alpha-tocopherol for broader antioxidant protection.
90 Performance 
UNIQUE E
A.C. Grace Company
4.7
★★★★★
(1841 ratings)
This product delivers 400 IU of natural D-Alpha-Tocopherol in its free form, which is often considered highly bioavailable, and comes from a brand specifically dedicated to Vitamin E purity.
88 Performance 
Liquid Multi Gels
NOW
4.7
★★★★★
(725 ratings)
Offering natural D-Alpha-Tocopherol in an easily absorbable liquid gel form, this alternative provides excellent bioavailability and efficacy for those prioritizing the primary form of Vitamin E.
50 Budget 
Complete Multivitamin Adults 50+
Equate
4.8
★★★★★
(1670 ratings)
With a price of just 3 cents per serving, this multivitamin offers the absolute cheapest way to obtain some Vitamin E, though its 50 IU content is significantly lower than the analyzed product.
45 Budget 
Complete Multivitamin
Equate
4.7
★★★★★
(1278 ratings)
At 4 cents per serving, this alternative is very inexpensive, providing 30 IU of synthetic Vitamin E as part of a multivitamin, offering a budget-friendly option for minimal Vitamin E intake.
48 Budget 
Complete Multivitamin
Equate
4.8
★★★★★
(2528 ratings)
This multivitamin offers 50 IU of synthetic Vitamin E for only 4 cents per serving, making it a very economical choice for those seeking any form of Vitamin E at the lowest possible cost.
75 Value
Water Dispersible E Supplement 1000 IU
Spring Valley
4.8
★★★★★
(436 ratings)
Despite an unknown form, its significantly higher dosage (1000 IU) and low price per serving (14 cents) offer potentially great value for those seeking a higher potency Vitamin E, assuming good bioavailability.
85 Value
UNIQUE E
A.C. Grace Company
4.7
★★★★★
(1820 ratings)
This alternative offers the same high-quality natural D-Alpha-Tocopherol from A.C. Grace Company, providing excellent Vitamin E benefits for its cost, maintaining a strong balance of potency and purity.
80 Value
Max For Men Iron Free
Country Life
4.7
★★★★★
(1694 ratings)
While a multivitamin, this product provides a substantial 400 IU of natural D-Alpha-Tocopherol Succinate, making it a very good value for receiving a full dose of quality Vitamin E alongside other beneficial nutrients.
92 Performance
Mixed Vitamin E 400 IU
Natural Factors
4.8
★★★★★
(2141 ratings)
This alternative is superior due to its inclusion of mixed tocopherols, providing a more comprehensive spectrum of Vitamin E forms that offer synergistic benefits beyond just alpha-tocopherol for broader antioxidant protection.
90 Performance
UNIQUE E
A.C. Grace Company
4.7
★★★★★
(1841 ratings)
This product delivers 400 IU of natural D-Alpha-Tocopherol in its free form, which is often considered highly bioavailable, and comes from a brand specifically dedicated to Vitamin E purity.
88 Performance
Liquid Multi Gels
NOW
4.7
★★★★★
(725 ratings)
Offering natural D-Alpha-Tocopherol in an easily absorbable liquid gel form, this alternative provides excellent bioavailability and efficacy for those prioritizing the primary form of Vitamin E.