Luteolin

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Luteolin is a naturally occurring flavonoid, a class of plant-derived compounds known for their health benefits. It functions as a powerful antioxidant, helping to neutralize harmful free radicals and reduce oxidative stress throughout the body. Furthermore, luteolin exhibits strong anti-inflammatory effects by modulating various inflammatory pathways. Research also suggests its potential neuroprotective qualities, which may support cognitive function and overall brain health, making it a valuable compound for enhancing cellular resilience and systemic well-being.

Natural sources
CeleryParsleyBroccoliOnion leavesCarrotsPeppersCabbageApple skinsChamomile teaThymeDandelion

Ingredient forms

No public comparison lists found.

Timing & Intake
AnytimeWith foodTake with Meals to optimize absorption and reduce potential mild gastrointestinal upset.
Luteolin's absorption can be enhanced when taken with food due to the presence of dietary fats, which may improve its bioavailability.
Optimal Dosage
Minimum500 mg
Maximum1500 mg
Safety & Toxicity
Toxicity Threshold3000 mg
Toxicity EffectGastrointestinal distress, fatigue
3 safety notes
  • Pregnant or breastfeeding individuals should consult their healthcare provider before using luteolin.
  • Individuals taking anticoagulant (blood-thinning) medications should exercise caution and consult a doctor, as luteolin may possess mild blood-thinning properties.
  • Always discuss with a healthcare professional before starting any new supplement, especially if you have existing medical conditions or are on other medications.
Goals
Sleep Support
Sleep Support
Impact
Moderate effect
Typical dose:50–200 mg
Laboratory findings about luteolin’s antioxidant or nervous-system activity do not show that taking it improves human sleep. Direct clinical evidence is needed to support claims about falling asleep, fewer awakenings, or deeper sleep. Its value as an addition to a sleep blend remains uncertain.

Study evidence

No published studies for this goal yet.

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Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Situational effect
Typical dose:50–200 mg
Luteolin is a powerful bioflavonoid that excels at stabilizing mast cells, reducing the release of histamine and other inflammatory mediators. This makes it particularly effective for allergy-related inflammation and neuroinflammation, offering targeted support beyond general antioxidants.

Study evidence

No published studies for this goal yet.

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Studies

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Interactions

Positive Interactions

Vitamin C
May enhance the overall antioxidant capacity when combined with luteolin, contributing to greater protection against oxidative stress.
Vitamin E
Offers synergistic antioxidant effects with luteolin, leading to enhanced cellular protection from free radicals.
Selenium
Works synergistically with luteolin to bolster the body's antioxidant defense mechanisms.
Curcumin
Both compounds are renowned for their potent anti-inflammatory properties, potentially leading to a more pronounced anti-inflammatory effect when combined.
Green Tea
The catechins in green tea can offer synergistic antioxidant and anti-inflammatory benefits when taken with luteolin.
Coenzyme Q-10
Combined with luteolin, it can provide enhanced antioxidant support crucial for cellular energy production and protection.
Resveratrol
As another powerful polyphenol, resveratrol may synergistically enhance luteolin's antioxidant and anti-inflammatory actions.
Flavonoid
Luteolin itself is a flavonoid, and combining it with other flavonoids can lead to synergistic effects, amplifying overall health benefits.
Astaxanthin
Astaxanthin's powerful antioxidant properties can be complemented by luteolin, resulting in broader spectrum antioxidant protection.
Lycopene
Shows synergistic antioxidant effects with luteolin, particularly in protecting against oxidative stress.
carotenoids
Luteolin can work synergistically with various carotenoids to provide comprehensive antioxidant protection.
Omega-3
Omega-3 fatty acids, known for their anti-inflammatory effects, can synergize with luteolin's anti-inflammatory properties for enhanced benefit.
Fish Oil
The anti-inflammatory effects of fish oil (rich in Omega-3s) can be synergistic with luteolin's inflammatory modulation, offering comprehensive support.

Negative Interactions

Ginkgo
Both Ginkgo and luteolin may possess mild blood-thinning properties. Concurrent use, especially in higher doses or in individuals on anticoagulant medications, could theoretically increase the risk of bleeding. It is advisable to consult a healthcare professional.