Selenium Supplement Ingredient

Impact

Highest effect

Typical dose:55–200 mcg

Without adequate selenium, the body cannot effectively utilize and regenerate its primary antioxidant, glutathione. This mineral is critical for quenching free radicals generated during detoxification and for metabolizing certain heavy metals.

Study evidence

10 studies

Selenium contributes to antioxidant defenses, but the supplied research does not establish that supplements improve general Detoxification. Favorable liver-related findings mainly involve specific illnesses or nutrient-status differences, while excess exposure is associated with adverse liver and other health markers.

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Cardiovascular Support

Impact

High effect

Typical dose:50–200 mcg

Selenium is integral to glutathione peroxidase, one of the body's most important antioxidant enzymes. This enzyme neutralizes harmful free radicals, protecting the heart and blood vessels from oxidative stress. Selenium deficiency is linked to Keshan disease, a form of cardiomyopathy.

Study evidence

107 studies

Selenium supplements have not shown reliable cardiovascular protection in the general population. Low selenium status is associated with poorer outcomes, but this does not prove supplementation prevents disease; higher exposure can also have unfavorable effects, making baseline selenium status important.

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General Health

Impact

High effect

Typical dose:55–200 mcg

Selenium is a required cofactor for the powerful antioxidant enzyme glutathione peroxidase, which protects cells from oxidative damage. It is also crucial for converting thyroid hormone to its active form, thus regulating metabolism, and plays a significant role in a healthy immune response.

Study evidence

70 studies

Selenium is an essential nutrient, but taking extra selenium has not reliably prevented cancer, cardiovascular disease or death in clinical trials. Low selenium status is associated with poorer health, yet that does not prove supplementation helps, and excess intake can cause harm.

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Immunity

Impact

High effect

Typical dose:55–200 mcg

Selenium is a key component of the powerful antioxidant enzyme glutathione peroxidase. It helps regulate inflammation and oxidative stress, preventing tissue damage during an infection. Deficiency is linked to impaired immune function and increased viral virulence.

Study evidence

37 studies

Selenium is essential for normal immune function, but extra selenium does not consistently improve immunity in people with adequate intake. Studies report mixed effects on immune cells and vaccine responses, and the available evidence does not establish reliable protection against everyday infections.

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Skin Health

Impact

High effect

Typical dose:50–200 mcg

Selenium is a core component of glutathione peroxidase, one of the body's most powerful antioxidant enzymes. This enzyme protects skin cells from damage caused by free radicals and UV radiation. Adequate selenium levels support skin elasticity and help prevent premature aging.

Study evidence

22 studies

Selenium supplements have not shown a consistent general skin-health benefit, and have not prevented skin cancer in trials. Some evidence indicates increased risk of a common skin cancer, while benefits from topical selenium treatments or antioxidant combinations cannot be attributed to oral selenium alone.

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Weight Loss

Impact

High effect

Typical dose:50–200 mcg

Selenium is a critical cofactor for the deiodinase enzymes that convert inactive thyroid hormone (T4) into its metabolically active form (T3). Without enough selenium, metabolic rate can be compromised even if iodine levels are sufficient, highlighting its key role in thyroid health.

Study evidence

9 studies

Selenium is not established as a weight-loss supplement. Dietary associations with lower body fat and limited positive clinical findings are offset by inconsistent trials, including no clear weight benefit in several groups; higher Selenium exposure has also been linked to less favorable metabolic outcomes.

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Selenium

Ingredient forms

Study evidence

Study evidence

Study evidence

Study evidence

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Study evidence

Studies

Positive Interactions

Negative Interactions

Selenium 200 mcg

Selenium 200 mcg

Yeast-Free Selenium 100 mcg L-Selenomethionine

Selenium 200 mcg

Selenium 200 mcg

SelenoExcell 200 mcg

SeMSC Selenium 200 mcg

Selenium 100 mcg

Selenium 100 mcg

Selenium 200 mcg

Selenium 100 mcg

Selenium 100 mcg

Selenium 200 mcg

Se-Methyl L-Selenocysteine 200 mcg

Selenium 200 mcg

Selenium 100 mcg

Se Selenium

Ingredient forms

Studies

add_circle_outlinePositive Interactions

remove_circle_outlineNegative Interactions

Selenium 200 mcg

Selenium 200 mcg

Yeast-Free Selenium 100 mcg L-Selenomethionine

Selenium 200 mcg

Selenium 200 mcg

SelenoExcell 200 mcg

SeMSC Selenium 200 mcg

Selenium 100 mcg

Selenium 100 mcg

Selenium 200 mcg

Selenium 100 mcg

Selenium 100 mcg

Selenium 200 mcg

Se-Methyl L-Selenocysteine 200 mcg

Selenium 200 mcg

Selenium 100 mcg

Selenium

Positive Interactions

Negative Interactions