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Adrenogen

Metagenics
4.8
ā˜… ā˜… ā˜… ā˜… ā˜…
(74 ratings)
PABA 25 mg
Vitamin B5 50 mg
Vitamin B6 25 mg
Riboflavin 10 mg
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Score59
Basic B vitamins offer some nutritional support, but the poorly characterized bovine adrenal concentrate dominates the product's identity. Transparency and goal alignment are weak.
How scoring works
Quantity:90 Tablet(s) ā€¢ (90 servings)
Goals:
Energy

Score 59

Basic B vitamins offer some nutritional support, but the poorly characterized bovine adrenal concentrate dominates the product's identity. Transparency and goal alignment are weak.
How scoring works
$28.95($0.32 per serving)
Pure Formulas
$ 28.95
iHerb
$ 28.95
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Analysis

Riboflavin, 25 mg vitamin B6, and 50 mg pantothenic acid can support normal energy metabolism when intake is inadequate. PABA is a minor addition without a clear role in the stated goal.

The bovine adrenal concentrate lacks information about its composition, processing, or active constituents. That makes its contribution impossible to judge and leaves the product less transparent than a standard B-complex.

The one-tablet serving is convenient, but the formula is difficult to recommend for general energy use. A conventional, clearly labeled B-complex would provide a more predictable nutritional approach.

Who is it for
  • Adults specifically seeking a bovine glandular product
  • Users who accept animal-derived ingredients
  • People willing to verify sourcing and processing details
Best for
  • One-tablet convenience
  • Basic B2, B6, and B5 coverage
  • A narrowly selected glandular regimen

Pros

  • One-tablet serving
  • Provides riboflavin and pantothenic acid
  • Ingredient amounts are disclosed

Cons

  • Bovine adrenal concentrate is poorly characterized
  • Weak evidence for general energy use
  • Uses conventional pyridoxine
  • Not suitable for vegetarians
  • PABA adds little practical value

Warnings

  • Bovine adrenal concentrate makes the product unsuitable for vegetarian or vegan diets
  • Vitamin B6 at 25 mg adds materially to long-term intake when combined with other supplements
  • People avoiding bovine glandular ingredients for religious, dietary, or sourcing reasons should not use this product

Nutrient quality

54 Moderate impact

Calcium pantothenate is a useful vitamin B5 form, while the bovine adrenal concentrate is not standardized. Vitamin B5 and vitamin B6 are substantial, but the functional dose of the glandular material cannot be established.

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Ingredient transparency

72 High impact

Amounts are listed, but the bovine adrenal concentrate lacks compositional and standardization details. Complete non-active ingredient details are not included in the supplied label data.

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Customer satisfaction

65 Moderate impact

The supplied average rating provides limited high-level context. Detailed firsthand feedback is unavailable, so recurring complaints and purpose fit cannot be assessed.

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Value for money

43 Lower impact

The moderate serving cost is not strongly justified by an unstandardized glandular ingredient. B-vitamin doses are clear, but effective glandular value remains uncertain.

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Goals

Energy
Essential Energy Nutrients
Energy
Impact
Moderate effect
C- Goal FitC- Strength of SupportC- CoverageC Formula Quality
Vitamin B5 Ā· 50 mgRiboflavin Ā· 10 mg

Several B vitamins support basic energy metabolism, but the formula centers on bovine adrenal concentrate rather than a well-supported energy active. It offers no caffeine, creatine, or standardized adaptogen.

Pantothenic acid and vitamin B6 have clear amounts, while the riboflavin form and adrenal material composition are not detailed. People seeking fatigue support would get a more predictable formula from clearly defined nutrients or clinically studied adaptogens.

Study evidence
Riboflavin Mixed 6 studies

Ingredients

IngredientAmount per serving
Riboflavin
10 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 25 mg
Pantothenic Acid (Calcium D-Pantothenate)
 50 mg
Raw Adrenal concentrate (Bovine)
 80 mg
Para-Aminobenzoic Acid
25 mg
Gluten Free Adults 18ā€“50
Report overview
PABA Ā· 25 mg OverallScore78
A Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD- Value

Para-aminobenzoic acid is named directly at a standard B-complex amount. Immediate release is appropriate at this amount, although no pharmaceutical-grade or high-purity designation is provided. The broader adrenal-support formula may add utility, but PABA delivery remains costly for the amount supplied.

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Vitamin B5 (Calcium D-Pantothenate) Ā· 50 mg OverallScore69
A- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Calcium pantothenate provides a stable, well-absorbed Vitamin B5 source, while the 50 mg serving reaches the general maintenance and metabolic-support range. The source and active amount are clear, but no controversial additive is shown, although the full other-ingredient list is not supplied. A very high standardized cost makes it poor value for someone primarily seeking Vitamin B5.

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Vitamin B6 (Pyridoxine Hydrochloride) Ā· 25 mg OverallScore68
D+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

pyridoxine hydrochloride with riboflavin support is less metabolically ready than pure pyridoxal 5-phosphate but has some conversion support or phosphorylation. The 25 mg serving sits within the preferred range and below the chronic neuropathy ceiling. Value is modest for a synthetic B6 form at this serving cost.

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Loading alternative details
81 Performance

Activated B-Complex High Bioavailability

Swanson
<p>Active B-vitamin forms, benfotiamine, and pantethine create a high-quality energy-metabolism formula with better-defined actives than the original. Vitamin B6 remains high for long-term use, but the focused nutrient approach avoids uncertain glandular composition.</p>
78 Performance

Methylfolate B Complex

Codeage
<p>Active riboflavin, B6, methylfolate, and methylcobalamin provide strong form quality and broad energy-related coverage. Concentrated folate and B12 favor targeted use, but the ingredient design is more evidence-aligned and transparent than bovine adrenal concentrate.</p>
77 Performance

Nu-Thera Multivitamin with P5P

Kirkman
<p>Activated riboflavin and B6, folinate, bisglycinate magnesium, and citrate minerals provide a well-formed nutritional base. Vitamin B6 is too high and vitamin D is low, but the disclosed nutrients are easier to evaluate than the originalā€™s unstandardized adrenal tissue.</p>
77 Budget

B-50

NOW
<p>It sharply lowers serving cost while providing broad, clearly dosed B vitamins for normal energy metabolism. Basic forms and high vitamin B6 remain concerns, but it avoids the originalā€™s unstandardized bovine adrenal tissue.</p>
77 Budget

B-50 Complex 50 mg

Source Naturals
<p>A broad B-complex provides low-cost metabolic support without relying on animal glandular material. High folate and vitamin B6 reduce balance, yet the active amounts are easier to assess than the originalā€™s uncertain adrenal concentrate.</p>
76 Budget

Hi Potency B Complex

Natural Factors
<p>Complete B-vitamin coverage offers much lower-cost energy support with clearly stated nutrient amounts. Folate and vitamin B6 are unnecessarily high, but the formula avoids the originalā€™s poorly characterized bovine adrenal concentrate.</p>
71 Value

B Complex

NATURELO Premium Supplements
<p>Active vitamin B6, methylfolate, methylcobalamin, and moderate B-vitamin amounts provide balanced energy support at lower serving cost. A hidden fruit-and-vegetable blend adds little, but the core nutrient profile offers better assessable value than the original glandular formula.</p>
75 Value

Stress B-Complex Caps

Twinlab
<p>Vitamin C and broad B-vitamin coverage provide stress-oriented nutritional support at slightly lower serving cost. Conventional forms and elevated pyridoxine limit prolonged use, but the formula avoids uncertain animal-tissue actives.</p>
74 Value

BioActive Complete B-Complex

Life Extension
<p>Active B-vitamin forms and complete coverage come at a similar serving cost with much clearer active identity. Vitamin B6, niacin, and pantothenic acid are excessively high, but the formula still offers more assessable value than unstandardized bovine adrenal concentrate.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A Ā· Heliyon Ā· 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S Ā· Journal of the Royal Society of Medicine Ā· 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF Ā· Molecular medicine (Cambridge, Mass.) Ā· 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E Ā· Proceedings of the National Academy of Sciences of the United States of America Ā· 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch Ā· Journal of Inherited Metabolic Disease Ā· 2026
    Systematic review381 studies pooledEnergy forRiboflavin