Product Image

BioActive Complete B-Complex

Life Extension
4.8
★ ★ ★ ★ ★
(112921 ratings)
Thiamin 100 mg
PABA 50 mg
Vitamin B5 500 mg
Riboflavin 75 mg
Vitamin B6 100 mg
Biotin 1000 mcg
Vitamin B12 300 mcg
Product Image
Score74
Excellent active forms and disclosure, held back by unusually aggressive B6 and pantothenic acid dosing.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Energy
Heart Health
General Health
Cardiovascular Support

Score 74

Excellent active forms and disclosure, held back by unusually aggressive B6 and pantothenic acid dosing.
How scoring works
$9.00($0.30 per serving)
iHerb
$ 9.00
Pure Formulas
$ 9.00
Vitacost
$ 9.79
Report prices

Analysis

The formula uses several preferred coenzyme or methylated B-vitamin forms and covers the full B-complex pathway. Methylfolate, methylcobalamin, active B6, and active riboflavin are meaningful upgrades over basic forms.

Potency is aggressive rather than merely complete, especially for vitamin B6 and pantothenic acid. Inositol and PABA add breadth but do not offset the lack of minerals, vitamin D, or other foundational nutrients.

The capsule suits a defined high-potency B-vitamin need better than casual daily wellness use. Users should account for B vitamins in other supplements because stacking can push already high amounts further upward.

Who is it for
  • Adults seeking active B-vitamin forms
  • Users with a defined need for high-potency B support
  • People prioritizing methylfolate and methylcobalamin
Best for
  • High-potency B-complex supplementation
  • Normal energy metabolism
  • Methylation cofactor support

Pros

  • Uses methylfolate and methylcobalamin
  • Includes active B6 and riboflavin forms
  • Clearly lists every active amount
  • Provides broad B-vitamin coverage

Cons

  • Vitamin B6 is extremely high
  • Pantothenic acid is far above routine needs
  • Does not provide broad mineral or fat-soluble vitamin coverage
  • PABA and inositol add limited practical value

Warnings

  • The 100 mg vitamin B6 amount can increase the risk of tingling, numbness, or peripheral nerve injury with prolonged use, especially when stacked with other B6 products.
  • High niacin and pantothenic acid amounts may cause stomach upset or loose stools in sensitive users.

Nutrient quality

71 High impact

Active riboflavin, vitamin B6, methylfolate, and methylcobalamin provide strong form quality. Several B vitamins are supplied at excessive levels that reduce long-term suitability.

Ingredient transparency

74 High impact

All core nutrients are quantified, but several totals repeat across multiple forms. Daily directions and a complete inactive-ingredient list are not supplied.

Customer satisfaction

73 High impact

The aggregate rating is very strong and supported by exceptional volume. No detailed experience reports are supplied, so recurring complaints and purpose fit remain uncertain.

Value for money

79 High impact

Active forms and broad coverage are offered at a very low cost. Excessive dosing reduces practical value because much of the formula exceeds routine needs.

Report analysis

Goals

Energy
Energy
Impact
Highest effect
A- Goal FitA- Strength of SupportC+ CoverageA- Formula Quality
Vitamin B5 · 500 mgRiboflavin · 75 mgThiamin · 100 mgVitamin B12 · 300 mcg

A concentrated B-complex directly supports the cofactor needs of cellular energy metabolism. High thiamin, riboflavin, pantothenate, and bioactive methylcobalamin provide substantial metabolic coverage.

Vitamin B12 remains below the stated higher target, and the formula offers no acute alertness or adaptogen pathway. The very high vitamin B6 amount makes prolonged daily use a concern because excessive supplemental intake can harm nerves.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
Heart Health
Heart Health
Impact
Highest effect
B- Goal FitA Strength of SupportC CoverageA Formula Quality
Vitamin B12 · 300 mcgVitamin B6 · 100 mgFolate · 680 mcg DFE

Methylfolate, active B6, and methylcobalamin provide focused support for homocysteine metabolism, a cardiovascular risk marker. The formula does not address omega-3 status, vascular tone, magnesium, or cardiac energy.

Bioactive forms and exact amounts make the narrow pathway easy to evaluate. The very high vitamin B6 amount creates a neuropathy concern with prolonged daily use.

Study evidence
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
General Health
General Health
Impact
Highest effect
B+ Goal FitB+ Strength of SupportC+ CoverageB+ Formula Quality
Folate · 680 mcg DFEVitamin B12 · 300 mcg

The active B-vitamin forms provide focused support for energy metabolism and common nutrient gaps. Methylcobalamin, methylfolate, and pyridoxal phosphate strengthen the formula's nutritional quality.

The formula is narrower than a full foundational multivitamin and omits minerals, vitamin D, and essential fats. The high vitamin B6 amount may raise the risk of tingling or numbness with prolonged daily use.

Study evidence
Vitamin B12 Adverse 66 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
C- Goal FitB- Strength of SupportD CoverageB Formula Quality
Vitamin B12 · 300 mcgVitamin B6 · 100 mgFolate · 680 mcg DFENiacin · 100 mg NE

Methylfolate, methylcobalamin, and P-5-P create a focused homocysteine-support pathway. The formula does not address lipids, vascular tone, endothelial function, or cardiac energy, so its cardiovascular role remains narrow.

The active forms are clearly disclosed and supplied in substantial amounts. The B6 amount reaches a long-term safety boundary, and regular use with other B6 sources may increase the risk of tingling, numbness, or other nerve symptoms.

Study evidence
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies
Metabolism Boost
Metabolism Boost
Impact
Moderate effect
D+ Goal FitB Strength of SupportD+ CoverageB Formula Quality
Biotin · 1000 mcgNiacin · 100 mg NEVitamin B12 · 300 mcgRiboflavin · 75 mgThiamin · 100 mgVitamin B5 · 500 mgVitamin B6 · 100 mg

High-potency B vitamins support normal conversion of food into cellular energy. Several active coenzyme forms improve metabolic readiness.

The formula does not directly influence thermogenesis, fat oxidation, thyroid function, or insulin sensitivity. Vitamin B6 reaches the adult daily safety ceiling and may raise nerve-symptom risk with prolonged use.

Study evidence
Riboflavin Mixed 5 studies
Vitamin B6 Supportive 16 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
D Goal FitC+ Strength of SupportC- CoverageB Formula Quality
Thiamin · 100 mgVitamin B6 · 100 mgFolate · 680 mcg DFEVitamin B12 · 300 mcg

A full set of B vitamins supports brain energy, methylation, and neurotransmitter production when intake is inadequate. P5P, methylfolate, methylcobalamin, and riboflavin phosphate provide better form quality than a basic B complex.

No choline, omega-3 fat, adaptogen, or blood-flow ingredient directly targets memory or attention. The vitamin B6 amount reaches a level that deserves caution for long-term daily use because excess B6 can contribute to nerve symptoms.

Study evidence
Vitamin B12 Disputed 84 studies
Vitamin B6 Supportive 17 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Hydrochloride, Vitamin B1)
 100 mg
Riboflavin (Riboflavin 5-Phosphate)
 75 mg
Niacin (Niacinamide)
 100 mg NE
Vitamin B6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride)
 100 mg
Folate (L-5-Methyltetrahydrofolate, Calcium Salt)
 680 mcg DFE
Vitamin B12 (Methylcobalamin)
 300 mcg
Biotin
1000 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 500 mg
Calcium (Calcium D-Pantothenate, Dicalcium Phosphate)
 90 mg
Inositol
100 mg
PABA
50 mg
Gluten Free Adults 18–50
Report overview
Thiamin (Thiamine Hydrochloride, Vitamin B1) · 100 mg OverallScore88
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Thiamine hydrochloride is a standard water-soluble form, and the 100 mg amount reaches a high-potency range. The exact thiamin amount is clear, but the standard capsule has no advanced delivery feature. The 100 mg vitamin B6 amount may raise the risk of nerve symptoms with prolonged daily use.

View ingredientView products
PABA · 50 mg OverallScore82
A Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

The clearly identified PABA amount fits a standard high-potency B-complex range. Standard immediate release is appropriate at this amount. The serving offers weak cost efficiency for the active amount delivered.

View ingredientView products
Vitamin B5 (D-Calcium Pantothenate) · 500 mg OverallScore81
B Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

D-calcium pantothenate provides a stable and well-absorbed source of vitamin B5. The high-potency amount may support more intensive use. Source disclosure is clear, but the missing other-ingredients list leaves purity uncertain while normalized cost sits in the middle band.

View ingredientView products
Loading alternative details
81 Performance

Activated B-Complex High Bioavailability

Swanson
<p>Its label clearly provides 25 mg of Riboflavin as Riboflavin 5-Phosphate, making it a more clearly defined vitamin b12 and thiamin and vitamin b6 and riboflavin and vitamin b5 and paba option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s biotin coverage.</p>
81 Performance

Coenzyme B-Complex Caps

Country Life
<p>Its label clearly provides 50 mg of Thiamin as Thiamine Cocarboxylase Chloride, making it a more clearly defined vitamin b12 and thiamin and vitamin b6 and riboflavin and vitamin b5 and paba option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s biotin coverage.</p>
81 Performance

Fully Active B Complex with Quatrefolic

Doctor's Best
<p>Its label clearly provides 40 mg of Vitamin C as Ascorbic Acid, making it a more clearly defined vitamin b12 and thiamin and vitamin b6 and biotin and riboflavin and vitamin b5 option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s paba coverage.</p>
80 Budget

CellularActive Coenzyme B-Complex

Bluebonnet
<p>Its label clearly provides 25 mg of Thiamin as Cocarboxylase, preserving relevant vitamin b12 and thiamin and vitamin b6 and biotin and riboflavin and vitamin b5 and paba coverage. Compared with the original, it lowers the serving cost, although the input does not provide independent testing or absorption evidence.</p>
76 Budget

B-100

NOW
<p>Its label clearly provides 100 mg of Thiamine as Thiamine Hydrochloride, preserving relevant vitamin b12 and thiamin and vitamin b6 and riboflavin and vitamin b5 and paba coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s biotin coverage.</p>
78 Budget

Super Stress B-Complex with Vitamin C

Swanson
<p>Its label clearly provides 500 mg of Vitamin C as Ascorbic Acid, preserving relevant vitamin b12 and thiamin and vitamin b6 and riboflavin and vitamin b5 and paba coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s biotin coverage.</p>
81 Value

CellularActive Coenzyme B-Complex

Bluebonnet
<p>Its label clearly provides 25 mg of Thiamine as Cocarboxylase, keeping the formula relevant to vitamin b12 and thiamin and vitamin b6 and biotin and riboflavin and vitamin b5 and paba. Compared with the original, the somewhat higher serving cost and ingredient detail create a useful quality-to-cost balance, although the input does not provide independent testing or absorption evidence.</p>
80 Value

Coenzyme B-Complex Caps

Country Life
<p>Its label clearly provides 50 mg of Thiamin as Thiamine Cocarboxylase Chloride, keeping the formula relevant to vitamin b12 and thiamin and vitamin b6 and riboflavin and vitamin b5 and paba. Compared with the original, the somewhat higher serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s biotin coverage.</p>
73 Value

B-Complex 50

The Vitamin Shoppe
<p>Its label clearly provides 50 mg of Thiamine as Thiamine Mononitrate, keeping the formula relevant to thiamin and vitamin b6 and biotin and riboflavin and vitamin b5 and paba. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s vitamin b12 coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  2. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  3. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  4. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  5. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  6. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  7. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  8. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  9. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  10. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  11. Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India.
    Behere RV; Deshmukh AS; Otiv S; Gupte MD; Yajnik CS · Frontiers in endocrinology · 2021
    Systematic review46 studies pooledCognitive Support forVitamin B12
  12. Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial.
    Thomas S; Thomas T; Bosch RJ; Ramthal A; Bellinger DC; Kurpad AV; Duggan CP; Srinivasan K · Maternal and child health journal · 2019
    Randomized trial218 participantsCognitive Support forVitamin B12
  13. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsCognitive Support forVitamin B12
  14. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsCognitive Support forVitamin B12
  15. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsCognitive Support forVitamin B12
  16. Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia.
    Zhuo C; Xu Y; Wang H; Fang T; Chen J; Zhou C; Li Q; Liu J; Xu S; Yao C; Yang W; Yang A; Li B; Chen Y; Tian H; Lin C · Frontiers in psychiatry · 2021
    Randomized trial200 participantsCognitive Support forVitamin B6
  17. Associations between dietary B vitamin intakes and cognitive function among elderly individuals: An observational study.
    Chen Q; Huang J; Shi X; Peng Y; Chen A; Huang L; Zhang Y; Chen X · Nutrition (Burbank, Los Angeles County, Calif.) · 2025
    Cross-sectional study2,716 participantsCognitive Support forVitamin B6
  18. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsCognitive Support forVitamin B6
  19. Lower water-soluble vitamins and higher homocysteine are associated with neurodegenerative diseases.
    Zhang C; Hu Y; Cao X; Deng Y; Wang Y; Guan M; Wu X; Jiang H · Scientific reports · 2025
    Cohort study926 participantsCognitive Support forVitamin B6
  20. Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction.
    Gordon S; Hoey L; McNulty H; Keenan J; Pangilinan F; Brody LC; Ward M; Strain JJ; McAnena L; McCann A; Molloy AM; Cunningham C; McCarroll K; Hughes CF · BMC medicine · 2025
    Observational study4,553 participantsCognitive Support forVitamin B6
  21. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  22. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  23. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  24. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  25. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Boost forRiboflavin
  26. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  27. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  28. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  29. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  30. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  31. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  32. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  33. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  34. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  35. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  36. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  37. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  38. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  39. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  40. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  41. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  42. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  43. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  44. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  45. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forVitamin B12
  46. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  47. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  48. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  49. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  50. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  51. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  52. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  53. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  54. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forVitamin B6
  55. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  56. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  57. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  58. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  59. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  60. Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects.
    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A · The American journal of the medical sciences · 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
  61. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  62. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  63. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  64. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  65. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  66. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6
  67. Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials.
    Borges-Vieira JG; Cardoso CKS · Nutritional neuroscience · 2023
    Systematic review2,256 participants20 studies pooledMood Support forVitamin B12
  68. Subjective well-being in older adults: folate and vitamin B12 independently predict positive affect.
    Edney LC; Burns NR; Danthiir V · The British journal of nutrition · 2016
    Cohort study391 participantsMood Support forVitamin B12
  69. Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Arija V · Journal of reproductive and infant psychology · 2025
    Cohort study336 participantsMood Support forVitamin B12
  70. The biological relationship among depression, vitamins B9, B12, and D, and genetic variants: a systematic review.
    Soriano-Gonzalez R; Ramirez-Olea H; Gonzalez-Soltero R; Chavez-Santoscoy RA · Frontiers in nutrition · 2025
    Systematic review24 studies pooledMood Support forVitamin B12
  71. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B12 Mood Support forVitamin B6
  72. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  73. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support forVitamin B6
  74. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  75. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6