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Vitamin D + K2

4.9
★ ★ ★ ★ ★
(32408 ratings)
Vitamin K 200 mcg
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Score89

Practical D3 and K2 amounts in a high-value liquid suit maintenance, though the unspecified K2 subtype leaves a small disclosure gap.

How scoring works
Liquid
Quantity:1 Fluid Ounce(s) • (600 servings)
Goals:
General Health
Bone Health
Anti-Aging
Heart Health
Cardiovascular Support

Score 89

Practical D3 and K2 amounts in a high-value liquid suit maintenance, though the unspecified K2 subtype leaves a small disclosure gap.

How scoring works
$34.00($0.05 per serving)
iHerb
$ 34.00
Vitacost
$ 34.00
Pure Formulas
$ 34.00
Vitacost
$ 34.00
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Analysis

A moderate vitamin D3 amount supports routine calcium absorption, while vitamin K2 complements it through calcium-handling proteins. The amounts are well suited to maintenance rather than aggressive correction.

Liquid delivery supports flexible use and the unusually long supply creates excellent practical value. The label does not state whether K2 is MK-4 or MK-7, so its persistence and exact form quality remain uncertain.

The focused two-active formula avoids unrelated ingredients and excessive vitamin D. Warfarin and other vitamin-K-antagonist medicines remain the main suitability limitation.

Who is it for
  • Adults seeking maintenance D3 and K2
  • People who prefer liquid supplements
  • Users wanting a very long supply
Best for
  • Daily maintenance dosing
  • Flexible liquid use
  • Low-cost combined D3 and K2

Pros

  • Moderate vitamin D3 amount
  • Meaningful vitamin K2 amount
  • Flexible liquid format
  • Exceptional serving value

Cons

  • K2 subtype is not identified
  • Drop measurement requires care
  • No calcium or magnesium

Warnings

  • Vitamin K can oppose warfarin and related vitamin-K-antagonist medicines.
  • Use the dropper consistently because liquid measurement errors can change the intended dose.
  • Follow storage and after-opening instructions carefully because the stated supply is unusually long.

Nutrient quality

87 Highest impact

The focused active formula contains little apparent low-value padding. Form disclosure leaves meaningful uncertainty about expected absorption or persistence.

Ingredient transparency

81 Highest impact

All listed active ingredients have specific amounts. A key active is named too broadly for confident form assessment.

Customer satisfaction

94 Highest impact

The large review count makes the aggregate rating highly reliable. No specific experience details are supplied, but the strong aggregate rating is broadly consistent with satisfaction.

Value for money

98 Highest impact

The supply provides excellent value per meaningful serving. The product compares very favorably with similar vitamin K options.

Report analysis

Goals

General Health
General Health
Impact
Highest effect
A+ Goal FitB+ Strength of SupportB CoverageA+ Formula Quality
Vitamin D · 25 mcgVitamin K · 200 mcg

Vitamin D3 and vitamin K2 form a complementary pair for calcium handling and skeletal maintenance. Both amounts are meaningful and clearly listed.

The vitamin K2 subtype is not identified, which limits assessment of its duration and sourcing quality. People taking warfarin should keep vitamin K intake consistent because changes can affect anticoagulant control.

Study evidence
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Bone Health
Bone Health
Impact
Highest effect
A Goal FitA Strength of SupportB- CoverageA Formula Quality
Vitamin K · 200 mcgVitamin D · 25 mcg

Vitamin D3 supports calcium absorption, while vitamin K2 activates proteins involved in placing calcium into bone. Both amounts are clearly disclosed and provide a well-matched signaling combination.

The focused formula has strong depth for calcium handling but supplies no calcium, magnesium, or protein-matrix support. Vitamin K2 can alter warfarin control, so users of vitamin K antagonist anticoagulants need clinician-guided consistency.

Study evidence
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
A- Goal FitA- Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 200 mcgVitamin D · 25 mcg

Vitamin D3 and K2 form a targeted pair for bone strength and vascular calcium handling during aging. The liquid format makes the small serving easy to adjust, although the K2 subtype is not identified.

Both vitamin amounts are clearly stated and meaningful for daily maintenance. Vitamin K can interfere with warfarin and related vitamin K antagonists, so users need clinician-guided consistency.

Study evidence
Vitamin K Supportive 27 studies
Heart Health
Heart Health
Impact
Highest effect
B+ Goal FitB+ Strength of SupportC CoverageA+ Formula Quality
Vitamin K · 200 mcgVitamin D · 25 mcg

Vitamin D3 and vitamin K2 form a complementary pair for calcium handling and vascular mineral regulation. The formula does not address lipids, blood-pressure minerals, or cardiac cellular energy.

Both vitamin amounts are meaningful and fully listed, though the K2 subtype is not identified. People taking warfarin should keep vitamin K intake consistent because changes can disrupt anticoagulant control.

Study evidence
Vitamin K Mixed 62 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B- Goal FitC+ Strength of SupportD+ CoverageA Formula Quality
Vitamin K · 200 mcgVitamin D · 25 mcg

Vitamin K provides a relevant route to cardiovascular support. Dose or form uncertainty limits confidence in the practical contribution.

The formula remains narrow rather than comprehensive. Vitamin K can oppose warfarin and related vitamin-K-antagonist medicines, so the intake should remain medically coordinated and consistent.

Study evidence
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Vitamin D (Vitamin D3)
 25 mcg
Vitamin K (Vitamin K2)
 200 mcg
Adults 18–50
Report overview
Vitamin K (Vitamin K2) · 200 mcg OverallScore17
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

Vitamin K2 is identified, but the missing menaquinone subtype prevents a confident form-quality assessment. No disclosed MK-7 amount supports the collection’s dosage target. Vitamin D3 adds useful formulation synergy, though the dry or unspecified lipid delivery limits absorption optimization.

View ingredientView products
Loading alternative details
86 Performance

Liquid D-3 & MK-7

NOW
<p>Liquid delivery combines MK-7 with a substantial vitamin D3 amount and provides flexible dosing with strong bone- and heart-goal alignment. Vitamin D intake from other sources still matters, especially for the higher-dose options. Vitamin K requires clinician-directed consistency with warfarin-type medicines.</p>
87 Performance

Vitamin D3 25 mcg (1000 IU) & K2 120 mcg

Natural Factors
<p>Moderate vitamin D3 and MK-7 create a balanced maintenance pairing in a softgel, with only minor ambiguity from duplicate K2 source entries. Vitamin D intake from other sources still matters, especially for the higher-dose options. Vitamin K requires clinician-directed consistency with warfarin-type medicines.</p>
84 Performance

D3 + K2

Nature Made
<p>All-trans MK-7 and vitamin D3 use clearly defined forms in a focused softgel, improving active-form clarity. Vitamin D intake from other sources still matters, especially for the higher-dose options. Vitamin K requires clinician-directed consistency with warfarin-type medicines.</p>
88 Budget

Vitamin K2 MK-7 100 mcg

Nutricost
<p>Despite not being cheaper than the unusually economical original, a clearly stated MK-7 amount creates a simple, easy-to-assess vitamin K2 option, although the dry capsule has no stated lipid carrier. It omits the original vitamin D3, so total vitamin D needs separate consideration. Vitamin K can oppose warfarin-type anticoagulants.</p>
87 Budget

MK-7 Vitamin K-2 100 mcg

NOW
<p>Despite not being cheaper than the unusually economical original, a meaningful long-acting MK-7 amount provides focused vitamin K2 support with a simple active formula. It omits the original vitamin D3, so total vitamin D needs separate consideration. Vitamin K can oppose warfarin-type anticoagulants.</p>
85 Budget

Vitamin K2 MenaQ7 100 mcg

AN Amazing Nutrition Amazing Formulas
<p>Despite not being cheaper than the unusually economical original, natto-derived MenaQ7 provides a clearly identified long-acting vitamin K2 form in a focused formula. It omits the original vitamin D3, so total vitamin D needs separate consideration. Vitamin K can oppose warfarin-type anticoagulants.</p>
86 Value

Vitamin K2 100 mcg + Vitamin D3 125 mcg

Nutricost
<p>MK-7 and vitamin D3 provide a fully disclosed combination at very favorable serving value, but the vitamin D amount is concentrated. The combination remains close to the original purpose, while total vitamin D intake should guide selection. Vitamin K can reduce the effect of warfarin-type anticoagulants.</p>
86 Value

Vitamins D3 2500 IU (62.5 mcg) & K2 120 mcg

NaturesPlus
<p>MK-7 and a substantial vitamin D3 amount provide focused bone and cardiovascular support at a low serving cost, though the dry tablet lacks a lipid carrier. The combination remains close to the original purpose, while total vitamin D intake should guide selection. Vitamin K can reduce the effect of warfarin-type anticoagulants.</p>
86 Value

Natural Vitamin K2 MK-7 with MenaQ7 100 mcg

Doctor's Best
<p>Branded MenaQ7 provides a meaningful long-acting K2 amount with clear active disclosure and good serving value. The combination remains close to the original purpose, while total vitamin D intake should guide selection. Vitamin K can reduce the effect of warfarin-type anticoagulants.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  3. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  4. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  5. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  6. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  7. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  8. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  9. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  10. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  11. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  12. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  13. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  14. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  15. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  16. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  17. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  18. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  19. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  20. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  21. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  22. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  23. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  24. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  25. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  26. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  27. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  28. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  29. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  30. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  31. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K