NiaCel 400
Thorne
NiaCel 400
4.6
★ ★ ★ ★ ★
(1150 ratings)
Niacin 415 mg
Betaine Anhydrous 85 mg
Score 85.0
Thorne NiaCel 400 effectively combines a substantial dose of Nicotinamide Riboside with Betaine Anhydrous to support cellular energy, metabolism, and cardiovascular health. It's a high-quality, reputable product that, while still premium, offers good value for its specific formulation within the NAD+ precursor market.
Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Heart Health
Skin Health
Energy
Metabolism Boost
Fitness
leaderboard Score 85.0
Thorne NiaCel 400 effectively combines a substantial dose of Nicotinamide Riboside with Betaine Anhydrous to support cellular energy, metabolism, and cardiovascular health. It's a high-quality, reputable product that, while still premium, offers good value for its specific formulation within the NAD+ precursor market.
insights Analysis
Thorne's NiaCel 400 is a highly regarded supplement featuring Nicotinamide Riboside Hydrogen Malate (NRH) at a robust 415mg per serving, complemented by 85mg of Betaine Anhydrous (TMG). This formulation is designed to significantly boost NAD+ levels, which are critical for cellular energy production, metabolic efficiency, and DNA repair, making it effective for a range of goals including energy, metabolism, and cardiovascular support. The inclusion of TMG further supports methylation and homocysteine metabolism, adding to its cardiovascular benefits. Thorne's reputation for quality ensures ingredient purity and efficacy. While a premium product, its price per serving is considerably more favorable than some of its Thorne counterparts like Brain Factors, making it a better value for long-term use and a strong contender for those seeking high-quality NAD+ support.
- High and effective dosage of Nicotinamide Riboside (415mg).
- Includes Betaine Anhydrous for complementary methylation and cardiovascular support.
- Thorne is a highly trusted brand known for quality and purity.
- Better price per serving compared to Thorne's Brain Factors, offering more value.
- Strong review count indicates consumer satisfaction and trust.
- Still a relatively high price point compared to basic Niacin supplements.
- The Betaine Anhydrous dosage, while complementary, is not high enough for direct muscle gain or significant athletic performance benefits often associated with TMG.
- While effective, the specific benefits of NR over other forms of Niacin (especially Niacinamide) are still a topic of ongoing research and debate among some experts.
$63.00($1.05 per serving)
 iHerb | $ 63.00 | |
 Pure Formulas | $ 70.00 | |
 Vitacost | $ 70.00 |
bolt Effectiveness for goals
Niacin, also known as Vitamin B3, is primarily recognized for its role in maintaining healthy cholesterol levels, particularly increasing HDL (good) cholesterol and lowering triglycerides. It also plays a vital role in energy metabolism and DNA repair, contributing to overall cellular function.
Niacin, or Vitamin B3, is essential for energy metabolism and DNA repair. High doses of a specific form, nicotinic acid, are sometimes used under medical supervision to help manage cholesterol levels. Niacinamide, another form, is often found in skin care products.
Niacin can help improve cholesterol profiles by significantly raising high-density lipoprotein (HDL) cholesterol and lowering triglycerides and low-density lipoprotein (LDL) cholesterol. These actions are considered beneficial for supporting overall cardiovascular health, particularly in individuals with dyslipidemia.
Betaine Anhydrous, also known as Trimethylglycine (TMG), is primarily recognized for its role in homocysteine metabolism, helping to convert it to methionine. This action supports cardiovascular health and liver function. It is also explored for its potential to enhance athletic performance and body composition.
Nicotinic acid, a form of niacin, can significantly lower LDL ("bad") cholesterol and triglycerides while raising HDL ("good") cholesterol. This effect contributes to cardiovascular health, especially when medically monitored for lipid management. Its role in primary prevention of cardiovascular events is still debated.
schedule Dosage, timing & forms
The main forms are nicotinic acid, niacinamide (nicotinamide), and inositol hexanicotinate. Nicotinic acid is primarily used for cholesterol management and can cause a 'flush,' while niacinamide does not cause a flush and is often used for skin health. Inositol hexanicotinate is marketed as 'flush-free' but its efficacy for cholesterol lowering is less established.
To minimize the 'niacin flush,' nicotinic acid is often recommended to be taken with meals, especially with a low-fat snack, and with a glass of water. Starting with a low dose and gradually increasing it can also help the body adjust. Some individuals may take aspirin 30 minutes before their dose, but this should be discussed with a healthcare professional.
For general dietary purposes, the recommended daily allowance (RDA) for niacin is 16 mg for adult men and 14 mg for adult women. Therapeutic doses for specific conditions, such as cholesterol management, are often much higher and should be determined and monitored by a healthcare professional.
Yes, niacinamide (nicotinamide) generally does not cause the 'flush' associated with nicotinic acid, so it doesn't require the same precautions regarding food or gradual titration. Nicotinic acid is often taken with food to buffer its effects. Dosage recommendations also differ, as niacinamide is typically used for general vitamin B3 support, while nicotinic acid is sometimes used for specific lipid management under supervision.
Niacin supplements are typically available in several forms, including immediate-release niacin (nicotinic acid), extended-release niacin, and no-flush niacin (inositol hexanicotinate or niacinamide). Each form has different absorption rates, metabolic pathways, and potential side effects.
health_and_safety Safety & interactions
Yes, Niacin can interact with several medications. It may enhance the effects of blood pressure-lowering drugs, potentially leading to low blood pressure. Niacin can also interact with statins, possibly increasing the risk of muscle problems or liver issues in some individuals. Individuals taking medications for diabetes should be aware that niacin might affect blood sugar levels.
The most common side effect of nicotinic acid is the 'niacin flush,' characterized by redness, itching, and warmth of the skin. Other potential side effects at higher doses include stomach upset, elevated liver enzymes, and increased blood sugar. Niacinamide generally does not cause the flush.
Niacin, especially in its nicotinic acid form, can commonly cause a 'niacin flush,' which involves skin redness, warmth, itching, and tingling. Other potential side effects include gastrointestinal upset like nausea, vomiting, or diarrhea. These effects are often dose-dependent and can sometimes be mitigated by taking niacin with food or using a sustained-release form.
Yes, niacin can interact with various medications, including statins, blood pressure medications, and blood thinners. It can also affect blood sugar levels, which is important for individuals with diabetes. It's crucial to consult a healthcare provider before taking niacin, especially if you are on other medications.
Some research indicates that Betaine Anhydrous, particularly at higher doses, may lead to an increase in total cholesterol and LDL ('bad') cholesterol levels in certain individuals. This effect is not universally observed but should be considered, especially for those with existing cardiovascular risk factors. Regular monitoring of lipid panels is recommended if you are concerned.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Nicotinamide Riboside Hydrogen Malate | 415 mg |
Betaine Anhydrous | 85 mg |
Categories
Niacin 95.0
Contains a substantial and effective dose of Nicotinamide Riboside, a premium form of Niacin, which excels at boosting NAD+ levels for comprehensive cellular benefits without the typical 'flush' associated with nicotinic acid.
Betaine Anhydrous 85.0
The inclusion of 85mg of Betaine Anhydrous provides valuable support for methylation and homocysteine metabolism, effectively complementing the Nicotinamide Riboside for overall cellular health.
Goals
Energy 95.0
Nicotinamide Riboside is highly effective at boosting NAD+ levels, which directly fuels cellular energy production (ATP), leading to noticeable improvements in vitality and reduced fatigue.
Metabolism Boost 95.0
By significantly increasing NAD+, this product plays a central role in optimizing metabolic processes, including nutrient utilization and fat oxidation, thereby effectively supporting a metabolism boost.
Heart Health 85.0
The combination of Nicotinamide Riboside supporting endothelial function and Betaine Anhydrous aiding in homocysteine reduction provides strong, complementary support for overall cardiovascular health.
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