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Zinc plus Selenium

Dr. Mercola
4.8
★ ★ ★ ★ ★
(14473 ratings)
Selenium 200 mcg
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Score84
A compact zinc-selenium formula with good zinc form quality and clear amounts. The copper contribution is small, so long-term stacking still deserves attention.
How scoring works
Quantity:90 Capsule(s) • (90 servings)
Goals:
General Health
Immunity

Score 84

A compact zinc-selenium formula with good zinc form quality and clear amounts. The copper contribution is small, so long-term stacking still deserves attention.
How scoring works

Also available as

1 option
30 servings Selenium 200 mcg • 30 Capsule(s) • 30 servings $11.99 ($0.39 per serving)
$19.97($0.22 per serving)
iHerb
$ 21.99
Vitacost
$ 21.99
Amazon
$ 19.97
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Analysis

Zinc bisglycinate at 15 mg and selenium yeast at 200 mcg provide meaningful, clearly disclosed amounts. Copper bisglycinate adds a relevant balancing mineral, but 0.25 mg is modest beside the zinc dose.

The chelated zinc form is a good choice for absorption and tolerance. Selenium yeast is useful, though the label does not identify its exact selenium compounds as precisely as an L-selenomethionine label would.

A single capsule makes the formula easy to use for people specifically targeting zinc and selenium. stronger value from the larger supply improves practicality, while the narrow nutrient scope keeps it from replacing a balanced diet or broad multivitamin.

Who is it for
  • Adults seeking combined zinc and selenium
  • People who prefer chelated trace minerals
Best for
  • Trace-mineral intake
  • Antioxidant-enzyme support
  • Immune-related nutrient coverage

Pros

  • Uses zinc bisglycinate
  • Clearly lists all three mineral amounts
  • Includes copper alongside zinc
  • Provides stronger value from the larger supply

Cons

  • Copper amount is small relative to zinc
  • Exact selenium compounds in the yeast are not identified
  • Limited to three trace minerals

Warnings

  • The 200 mcg selenium amount should not be stacked casually with another selenium supplement.
  • Fifteen milligrams of zinc can cause nausea when taken without food and adds meaningful exposure when combined with a multivitamin.
  • Long-term use alongside other zinc products may still impair copper balance because this formula provides only 0.25 mg copper.

Nutrient quality

91 Highest impact

Chelated zinc and copper are premium forms, while selenium yeast offers a useful food-form source. The amounts are meaningful and remain below adult upper limits.

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Ingredient transparency

81 Highest impact

All three mineral amounts and source categories are disclosed without a proprietary blend. Complete directions and capsule ingredients are not supplied.

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Customer satisfaction

73 High impact

The supplied aggregate rating indicates very strong customer satisfaction. Specific comments are unavailable, so complaint patterns and intended-use fit cannot be verified.

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Value for money

91 Highest impact

Useful chelated minerals, a larger bottle, and a lower serving cost create strong value. The balanced design compares well within the category.

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Report analysis

Goals

General Health
General Health
Impact
Highest effect
A+ Goal FitA Strength of SupportA- CoverageA+ Formula Quality
Selenium · 200 mcgZinc · 15 mg

Zinc, selenium, and copper support immune function, antioxidant defenses, thyroid metabolism, and mineral balance. The chelated zinc and copper forms are paired with a substantial selenium amount and clear labeling.

The formula covers several foundational trace-mineral functions without an unnecessary blend. Selenium at 200 mcg leaves less room for other high-selenium supplements, and chronically excessive total intake can cause hair, nail, or digestive changes.

Study evidence
Selenium Supportive 70 studies
Zinc Supportive 60 studies
Immunity
Immunity
Impact
Highest effect
A Goal FitA Strength of SupportB+ CoverageA+ Formula Quality
Zinc · 15 mgSelenium · 200 mcg

Zinc bisglycinate and selenium yeast provide strong, complementary support for immune-cell function and antioxidant defenses. The 15 mg zinc amount meets the goal target, and 200 mcg of selenium is substantial.

Both primary forms are clearly disclosed, while a small amount of copper helps mineral balance. Selenium intake from other supplements should be considered because the serving already provides a relatively high amount.

Study evidence
Selenium Mixed 37 studies
Zinc Supportive 73 studies

Ingredients

IngredientAmount per serving
Zinc (Zinc Bisglycinate Chelate)
 15 mg
Selenium (Selenium Yeast)
 200 mcg
Copper (Copper Bisglycinate Chelate)
 0.25 mg
Adults 18–50
Report overview
Selenium (Selenium Yeast) · 200 mcg OverallScore88
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

Selenium yeast offers an organic food-form source, though its specific compounds are not identified. The 200 mcg serving aligns with common targeted use and stays below the adult upper intake level. Its low serving cost provides favorable selenium-specific value.

View ingredientView products
Loading alternative details
87 Performance

Se-Methyl L-Selenocysteine 200 mcg

Life Extension
<p>Se-methyl L-selenocysteine is a clearly identified organic selenium form with strong absorption potential. Compared with the original less-specific selenium yeast, the focused source provides clearer selenium quality without adding zinc or copper.</p>
87 Performance

Selenium 200 mcg

Nature's Way
<p>L-selenomethionine provides a precise, well-absorbed organic form in a clean formula. Compared with the original less-specific selenium yeast, the focused source provides clearer selenium quality without adding zinc or copper.</p>
85 Performance

Selenium 200 mcg

Healthy Origins
<p>Branded high-selenium yeast provides a well-disclosed food-form source without unnecessary additions. Compared with the original less-specific selenium yeast, the focused source provides clearer selenium quality without adding zinc or copper.</p>
87 Budget

Selenium 100 mcg

Swanson
<p>Trademarked L-selenomethionine supplies a clearly identified organic form at a maintenance-oriented amount. Compared with the original selenium, zinc, and copper combination, the smaller single-mineral amount leaves more room for dietary selenium and avoids unnecessary stacking.</p>
85 Budget

Selenium 100 mcg

NOW
<p>L-selenomethionine supplies a clearly identified, well-absorbed organic form at a maintenance-oriented amount. Compared with the original selenium, zinc, and copper combination, the smaller single-mineral amount leaves more room for dietary selenium and avoids unnecessary stacking.</p>
84 Budget

Selenium 100 mcg

Source Naturals
<p>Selenium yeast provides a sensible maintenance amount in a focused, long-supply format. Compared with the original selenium, zinc, and copper combination, the smaller single-mineral amount leaves more room for dietary selenium and avoids unnecessary stacking.</p>
87 Value

Selenium 200 mcg

Source Naturals
<p>L-selenomethionine provides precise disclosure in a streamlined, long-supply formula. Compared with the original multi-mineral formula, the precise selenium form and long supply provide better focused value.</p>
86 Value

SeMSC Selenium 200 mcg

Swanson
<p>L-Se-methylselenocysteine offers a clearly identified organic form with good absorption potential. Compared with the original multi-mineral formula, the precise selenium form and long supply provide better focused value.</p>
86 Value

Selenium 200 mcg

Solgar
<p>L-selenomethionine provides a well-absorbed organic form in a focused, long-supply formula. Compared with the original multi-mineral formula, the precise selenium form and long supply provide better focused value.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults.
    Ivory K; Prieto E; Spinks C; Armah CN; Goldson AJ; Dainty JR; Nicoletti C · Clinical nutrition (Edinburgh, Scotland) · 2018
    Randomized trial117 participantsImmunity forSelenium
  2. Selenium and immune function: a systematic review and meta-analysis of experimental human studies.
    Filippini T; Fairweather-Tait S; Vinceti M · The American journal of clinical nutrition · 2023
    Meta-analysis9 studies pooledImmunity forSelenium
  3. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  4. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  5. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  6. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  7. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  8. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledGeneral Health forSelenium
  9. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  10. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  11. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  12. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  13. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  14. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  15. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  16. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  17. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  18. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  19. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  20. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  21. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  22. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc