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Chelated Calcium Magnesium

4.7
★ ★ ★ ★ ★
(2543 ratings)
Calcium 500 mg
Magnesium 200 mg
Product Image
Score79
500 mg calcium and 200 mg magnesium in a focused tablet formula. bisglycinate gives both minerals strong absorption potential and the amounts are practical, but magnesium oxide weakens the blend and the serving value is poor.
How scoring works
Tablet
Quantity:120 Tablet(s) • (40 servings)
Goals:
General Health
Bone Health
Stress Relief
Heart Health
Energy

Score 79

500 mg calcium and 200 mg magnesium in a focused tablet formula. bisglycinate gives both minerals strong absorption potential and the amounts are practical, but magnesium oxide weakens the blend and the serving value is poor.
How scoring works
$31.16($0.77 per serving)
iHerb
$ 31.16
Vitacost
$ 31.16
Daily Vita
$ 31.16
Vitacost
$ 31.16
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Analysis

The chelated tablet formula supplies 500 mg calcium and 200 mg magnesium. The combination supports normal bone mineralization, muscle function, and nerve signaling when dietary intake is insufficient.

bisglycinate gives both minerals strong absorption potential and the amounts are practical. magnesium oxide weakens the blend and the serving value is poor.

It fits adults who need both minerals and prefer a tablet format. Dosing should be matched to dietary intake, tolerance, kidney function, and medications rather than assuming more mineral is always better.

Who is it for
  • Adults with a demonstrated calcium and magnesium gap
  • Users who prefer tablet supplements
  • People seeking combined bone-mineral support
Best for
  • Calcium and magnesium supplementation
  • Bone-mineral support
  • Muscle and nerve nutrient support

Pros

  • Uses calcium bisglycinate and magnesium bisglycinate alongside magnesium oxide
  • bisglycinate gives both minerals strong absorption potential and the amounts are practical
  • Clearly stated mineral amounts

Cons

  • magnesium oxide weakens the blend and the serving value is poor
  • Does not replace dietary mineral assessment
  • Complete inactive ingredients or directions are not supplied

Warnings

  • Calcium and magnesium can reduce absorption of levothyroxine, tetracycline or quinolone antibiotics, and bisphosphonates when taken together
  • Supplemental magnesium may cause diarrhea or abdominal cramping
  • The oxide portion may loosen stools, especially if the whole serving is taken at once

Nutrient quality

88 Highest impact

Well-regarded mineral forms support strong ingredient quality. The core ingredients remain coherent for the intended use.

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Ingredient transparency

84 Highest impact

Active amounts are fully disclosed without a hidden blend. Missing full directions and inactive ingredients keep the supplied label information incomplete.

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Customer satisfaction

68 High impact

The supplied average is generally favorable and rests on a substantial review count. No review text was provided to assess repeated complaints or specific user experiences.

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Value for money

71 High impact

Serving efficiency is limited for the disclosed mineral profile. A focused active list supports value.

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Report analysis

Goals

Impact
Highest effect
A Goal FitB+ Strength of SupportB CoverageA- Formula Quality
Magnesium · 200 mg

Calcium and magnesium provide foundational structural, muscular, nervous-system, and metabolic support. The amounts are substantial, and bisglycinate improves the quality of both minerals.

A meaningful share of the magnesium also comes from less absorbable oxide, while the calcium-heavy ratio may create absorption competition. Magnesium oxide can increase digestive upset in sensitive users, and the three-caplet serving is less streamlined than a focused magnesium product.

Study evidence
Magnesium Supportive 114 studies
Bone Health
Impact
High effect
B+ Goal FitB+ Strength of SupportC CoverageB+ Formula Quality
Magnesium · 200 mgCalcium · 500 mg

Chelated calcium and magnesium provide a focused structural mineral combination. Bisglycinate forms support absorption, although part of the magnesium also comes from oxide.

The amounts are useful for bone support and fit a practical mineral ratio. Vitamin D, vitamin K, and collagen are absent, so mineral regulation and matrix coverage remain incomplete.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Impact
High effect
A- Goal FitB- Strength of SupportC CoverageA- Formula Quality
Magnesium · 200 mg

Magnesium provides direct nervous-system and muscle support at a meaningful but moderate amount. Its role in correcting inadequate magnesium intake is well established, though direct stress-relief effects vary by baseline status.

Magnesium bisglycinate improves form quality, while magnesium oxide lowers expected absorption. Calcium adds mineral nutrition but little direct stress-modulating breadth.

Study evidence
Magnesium Supportive 13 studies
Impact
High effect
B+ Goal FitC+ Strength of SupportC CoverageA- Formula Quality
Magnesium · 200 mg

Magnesium supports normal vascular tone, cardiac rhythm, and cellular energy at a meaningful but moderate amount. Its cardiovascular role is well established, especially when intake is inadequate.

Bisglycinate improves form quality, while magnesium oxide lowers expected absorption and calcium shifts the focus toward bone health. The mineral pairing is coherent but does not address lipids, nitric oxide, or cardiac energy.

Study evidence
Magnesium Supportive 158 studies
Energy
Impact
High effect
B Goal FitB- Strength of SupportD- CoverageB+ Formula Quality
Magnesium · 200 mg

Magnesium reaches the 200 mg energy-support threshold and serves as a direct ATP cofactor. Bisglycinate improves part of the mineral’s absorption profile.

Magnesium oxide lowers overall quality, while the larger calcium amount may compete for absorption. The formula addresses one mineral pathway and is designed mainly for structural support.

Study evidence
Magnesium Supportive 4 studies
Impact
Moderate effect
C+ Goal FitC+ Strength of SupportD- CoverageC Formula Quality
Magnesium · 200 mg

Magnesium provides relevant support for vascular tone and normal rhythm, but the mineral pairing is not optimized for that purpose. Magnesium oxide lowers absorption quality, while calcium substantially exceeds magnesium.

The elemental magnesium amount is useful, though competition from calcium may reduce effective delivery. The formula is coherent for combined mineral supplementation but less compelling as focused cardiovascular support.

Study evidence
Magnesium Supportive 123 studies
Impact
Moderate effect
D+ Goal FitC+ Strength of SupportD- CoverageB- Formula Quality
Magnesium · 200 mg

Two hundred milligrams of magnesium provides a meaningful amount of a nutrient linked to free-testosterone regulation, especially when magnesium status is low. The formula does not address stress regulation, zinc status, boron, or other major endocrine pathways.

The bisglycinate component is useful, but oxide and competing calcium reduce confidence in absorption. Without vitamin D, zinc, or an adaptogen, the product remains a narrow mineral option rather than a complete testosterone formula.

Study evidence
Magnesium Disputed 5 studies

Ingredients

IngredientAmount per serving
Calcium (Calcium Bisglycinate Chelate)
500 mg
Magnesium (Magnesium Bisglycinate Chelate, Magnesium Oxide)
200 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Vegetarian
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Calcium bisglycinate offers strong absorption potential, and the listed serving provides an efficient calcium amount. The mineral amount and form are clearly identified, while no problematic additives appear in the supplied ingredient data. Value is limited because the cost per serving sits above the collection's typical range.

D- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value

Bisglycinate improves the blend, but magnesium oxide lowers absorption quality despite a well-aligned elemental amount. Calcium exceeds magnesium by more than two to one, creating direct competition for absorption. The costly serving offers weak value, and the oxide component may increase digestive upset.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Calcium supplementation provides an extended window of opportunity for bone mass accretion after menarche.
    Rozen GS; Rennert G; Dodiuk-Gad RP; Rennert HS; Ish-Shalom N; Diab G; Raz B; Ish-Shalom S · The American journal of clinical nutrition · 2003
    Randomized trial100 participantsBone Health forCalcium
  2. Calcium supplementation and bone mineral density in postmenopausal women using estrogen replacement therapy.
    Haines CJ; Chung TK; Leung PC; Hsu SY; Leung DH · Bone · 1995
    Randomized trialBone Health forCalcium
  3. Relationship between bone mineral density changes and risk of fractures among patients receiving calcium with or without vitamin D supplementation: a meta-regression.
    Rabenda V; Bruyère O; Reginster JY · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011
    Meta-analysis47,365 participants15 studies pooledBone Health forCalcium
  4. Bone turnover and the response to alendronate treatment in postmenopausal osteoporosis.
    Gonnelli S; Cepollaro C; Pondrelli C; Martini S; Montagnani A; Monaco R; Gennari C · Calcified tissue international · 1999
    Randomized trial100 participantsBone Health forCalcium
  5. Calcium and osteoporosis.
    Nordin BE · Nutrition (Burbank, Los Angeles County, Calif.) · 1998
    Meta-analysis20 studies pooledBone Health forCalcium
  6. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  7. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.
    Orchard TS; Larson JC; Alghothani N; Bout-Tabaku S; Cauley JA; Chen Z; LaCroix AZ; Wactawski-Wende J; Jackson RD · The American journal of clinical nutrition · 2014
    Cohort study73,684 participantsBone Health forMagnesium
  8. Dialysate Magnesium and Coronary Artery Calcification, Bone Mineral Density, and Cramping in Maintenance Hemodialysis: A Quasi-experimental Study.
    Srisuwarn P; Sethakarun S; Nongnuch A; Jongjirasiri S; Sritara C; Klyprayong P; Disthabanchong S · Kidney medicine · 2022
    Non-randomized trial40 participantsBone Health forMagnesium
  9. Association between magnesium deficiency scores and hip bone health in adults: a population-based study.
    Li S; Chang W; Wu G; Wang K; Sun X; Sun H; Zhou J · Magnesium research · 2025
    Cross-sectional study13,259 participantsBone Health forMagnesium
  10. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  11. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  12. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  13. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  14. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  15. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  16. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  17. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  18. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  19. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  20. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  21. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  22. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  23. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  24. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  25. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  26. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  27. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  28. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  29. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  30. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  31. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  32. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  33. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  34. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  35. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  36. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  37. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  38. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  39. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  40. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium
  41. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  42. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  43. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  44. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  45. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium