Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial.
Žmitek K; Žmitek J; Hristov H; Rogl Butina M; Keršmanc P; Pogačnik T · Nutrients · 2024
Randomized trial87 participantsflagSkin Health forscienceHyaluronic Acid
- Efficacy and Safety of Sodium Hyaluronate Gel for Facial Skin Rejuvenation.
Liao Z; Hong W; Wang S; Hou Y; Lu S; Chen R; Zhang Y; Chen J; Liu Y; Luo S · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
Randomized trial420 participantsflagSkin Health forscienceHyaluronic Acid
- Oral Hyaluronic Acid in Osteoarthritis and Low Back Pain: A Systematic Review.
de Carvalho JF; Davidson J · Mediterranean journal of rheumatology · 2025
Systematic review597 participants11 studies pooledflagJoint Health forscienceHyaluronic Acid
- Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability.
Devasia S; Joseph JT; P S S; Koizumi S; Clarke L; V T S; Kailas AP; Madhavan S · Cartilage · 2024
Randomized trial100 participantsflagJoint Health forscienceCollagen
- The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial.
Zdzieblik D; Brame J; Oesser S; Gollhofer A; König D · Nutrients · 2021
Randomized trial180 participantsflagJoint Health forscienceCollagen
- Efficacy and safety of low-molecular-weight collagen peptides in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial.
Park SY; Lee SH; Kim HT; Park HJ; Kim DU; Kim SU; Heo I · Frontiers in nutrition · 2025
Randomized trial80 participantsflagJoint Health forscienceCollagen
- [Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial].
Alekseeva LI; Kashevarova NG; Taskina EA; Strebkova EA; Korotkova TA; Sharapova EP; Savushkina NM; Lila AM; Shostak NA; Mazurov VI; Nesterovich II; Dedkova VA; Vasilyuk VB; Egorova NV; Leontyeva MA; Yakupova SP; Vinogradova IB; Sorotskaya VN; Shirokova LY · Terapevticheskii arkhiv · 2024
Randomized trial212 participantsflagJoint Health forscienceCollagen
- Anti-aging and filling efficacy of six types hyaluronic acid based dermo-cosmetic treatment: double blind, randomized clinical trial of efficacy and safety.
Nobile V; Buonocore D; Michelotti A; Marzatico F · Journal of cosmetic dermatology · 2015
Randomized trial40 participantsflagSkin Health forscienceHyaluronic Acid
- Role and Effectiveness of Intra-articular Injection of Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Systematic Review.
Chavda S; Rabbani SA; Wadhwa T · Cureus · 2024
Systematic review5,025 participants38 studies pooledflagJoint Health forscienceHyaluronic Acid
- Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double-blind, placebo-controlled trial.
Luo C; Su W; Song Y; Srivastava S · Journal of experimental orthopaedics · 2023
Randomized trial101 participantsflagJoint Health forscienceCollagen
- A Split-Face Study of the Effects of a Stabilized Hyaluronic Acid-Based Gel of Nonanimal Origin for Facial Skin Rejuvenation Using a Stamp-Type Multineedle Injector: A Randomized Clinical Trial.
Roh NK; Kim MJ; Lee YW; Choe YB; Ahn KJ · Plastic and reconstructive surgery · 2016
Randomized trial25 participantsflagSkin Health forscienceHyaluronic Acid
- Intra-Articular Injections of Hyaluronic Acid or Steroids Associated With Better Outcomes Than Platelet-Rich Plasma, Adipose Mesenchymal Stromal Cells, or Placebo in Knee Osteoarthritis: A Network Meta-analysis.
Han SB; Seo IW; Shin YS · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2021
Meta-analysis5,554 participants43 studies pooledflagJoint Health forscienceHyaluronic Acid
- Safety and Efficacy of Hyaluronic Acid-Based Filler for Neck Wrinkles: A Prospective, Multicenter, Randomized, Parallel-Controlled Non-Inferiority Trial.
Jiang M; Cheng H; Li Y; Ai H; Li J; Liang Y; Xu W · Clinical, cosmetic and investigational dermatology · 2026
Randomized trial188 participantsflagSkin Health flagAnti-Aging forscienceHyaluronic Acid
- Effectiveness of 3 Weekly Injections Compared With 5 Weekly Injections of Intra-Articular Sodium Hyaluronate on Pain Relief of Knee Osteoarthritis or 3 Weekly Injections of Other Hyaluronan Products: A Systematic Review and Meta-Analysis.
Stitik TP; Issac SM; Modi S; Nasir S; Kulinets I · Archives of physical medicine and rehabilitation · 2017
Meta-analysis2,168 participants24 studies pooledflagJoint Health forscienceHyaluronic Acid
- Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study.
Hsu TF; Su ZR; Hsieh YH; Wang MF; Oe M; Matsuoka R; Masuda Y · Nutrients · 2021
Randomized trial40 participantsflagSkin Health forscienceHyaluronic Acid
- Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period.
Oe M; Sakai S; Yoshida H; Okado N; Kaneda H; Masuda Y; Urushibata O · Clinical, cosmetic and investigational dermatology · 2020
Randomized trial60 participantsflagSkin Health forscienceHyaluronic Acid
- Function of the normal meniscus and consequences of meniscal resection.
Aagaard H; Verdonk R · Scandinavian journal of medicine & science in sports · 1999
Narrative reviewflagJoint Health forscienceCollagen
- Hyaluronic acid microneedle patch for the improvement of crow's feet wrinkles.
Choi SY; Kwon HJ; Ahn GR; Ko EJ; Yoo KH; Kim BJ; Lee C; Kim D · Dermatologic therapy · 2018
Randomized trial34 participantsflagSkin Health forscienceHyaluronic Acid
- Role of collagen hydrolysate in bone and joint disease.
Moskowitz RW · Seminars in arthritis and rheumatism · 2001
Narrative reviewflagJoint Health forscienceCollagen
- Effects of hyaluronic acid injected using the mesogun injector with stamp-type microneedle on skin hydration.
Choi SY; Ko EJ; Yoo KH; Han HS; Kim BJ · Dermatologic therapy · 2021
Randomized trial60 participantsflagSkin Health forscienceHyaluronic Acid
- Oral intake of a new full-spectrum hyaluronan improves skin profilometry and ageing: a randomized, double-blind, placebo-controlled clinical trial.
Michelotti A; Cestone E; De Ponti I; Pisati M; Sparta E; Tursi F · European journal of dermatology : EJD · 2022
Randomized trial60 participantsflagSkin Health forscienceHyaluronic Acid
- A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort.
Benito-Ruiz P; Camacho-Zambrano MM; Carrillo-Arcentales JN; Mestanza-Peralta MA; Vallejo-Flores CA; Vargas-López SV; Villacís-Tamayo RA; Zurita-Gavilanes LA · International journal of food sciences and nutrition · 2012
Randomized trial250 participantsflagJoint Health forscienceCollagen
- [Experience with the use of undenatured type II collagen in patients with stage III knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial].
Alekseeva LI; Kashevarova NG; Taskina EA; Strebkova EA; Korotkova TA; Sharapova EP; Savushkina NM; Lila AM; Shostak NA; Nesterovich II; Dedkova VA; Vasilyuk VB; Egorova NV; Leontyeva MA; Yakupova SP; Vinogradova IB; Sorotskaya VN; Shirokova LI; Rudakova AV · Terapevticheskii arkhiv · 2025
Randomized trial50 participantsflagJoint Health forscienceCollagen
- Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI.
Dam EB; Byrjalsen I; Karsdal MA; Qvist P; Christiansen C · Osteoarthritis and cartilage · 2009
Cohort study158 participantsflagJoint Health forscienceCollagen
- Knee osteoarthritis, knee joint pain and aging in relation to increasing serum hyaluronan level in the Japanese population.
Inoue R; Ishibashi Y; Tsuda E; Yamamoto Y; Matsuzaka M; Takahashi I; Danjo K; Umeda T; Nakaji S; Toh S · Osteoarthritis and cartilage · 2011
Cross-sectional study616 participantsflagJoint Health forscienceHyaluronic Acid
- Single intra-articular injection of lightly cross-linked hyaluronic acid reduces knee pain in symptomatic knee osteoarthritis: a multicenter, double-blind, randomized, placebo-controlled trial.
Petterson SC; Plancher KD · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019
Randomized trial369 participantsflagJoint Health forscienceHyaluronic Acid
- [Cross-linked hyaluronic acid in the treatment of osteoarthritis of the knee--results of a prospective randomized trial].
Auerbach B; Melzer C · Zentralblatt fur Chirurgie · 2003
Randomized trial111 participantsflagJoint Health forscienceHyaluronic Acid
- High molecular weight sodium hyaluronate (hyalectin) in osteoarthritis of the knee: a 1 year placebo-controlled trial.
Dougados M; Nguyen M; Listrat V; Amor B · Osteoarthritis and cartilage · 1996
Randomized trial110 participantsflagJoint Health forscienceHyaluronic Acid
- Intra-articular hyaluronic acid compared with corticoid injections for the treatment of rhizarthrosis.
Fuchs S; Mönikes R; Wohlmeiner A; Heyse T · Osteoarthritis and cartilage · 2006
Randomized trial56 participantsflagJoint Health forscienceHyaluronic Acid
- [Viscosupplementation with High Molecular Weight Hyaluronic Acid for Hip Osteoarthritis: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials].
Pasqualotto T; Pasqualotto E; Migliardi LS; Lunelli L; Lunelli LO; Martinelli RVR · Revista brasileira de ortopedia · 2026
Meta-analysis823 participants4 studies pooledflagJoint Health forscienceHyaluronic Acid
- Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
Lee M; Kim E; Ahn H; Son S; Lee H · Food & function · 2023
Randomized trial100 participantsflagAnti-Aging flagSkin Health forscienceCollagen
- Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
de Miranda RB; Weimer P; Rossi RC · International journal of dermatology · 2021
Meta-analysis1,125 participants19 studies pooledflagAnti-Aging flagSkin Health forscienceCollagen
- Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.
Proksch E; Segger D; Degwert J; Schunck M; Zague V; Oesser S · Skin pharmacology and physiology · 2014
Randomized trial69 participantsflagAnti-Aging forscienceCollagen
- Skin Anti-Aging and Moisturizing Effects of Low-Molecular-Weight Collagen Peptide Supplementation in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Lee E; Ahn DK; Kim JH; Lee S; Kim HJ; Lee HK; Shin JH · Journal of microbiology and biotechnology · 2025
Randomized trial70 participantsflagAnti-Aging forscienceCollagen
- Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.
Proksch E; Schunck M; Zague V; Segger D; Degwert J; Oesser S · Skin pharmacology and physiology · 2014
Randomized trial114 participantsflagAnti-Aging forscienceCollagen
- Effectiveness and Safety of a Cross-linked Hyaluronic Acid Plus Mannitol Filler for the Correction of Nasolabial Folds in Chinese Subjects: A Randomized, Blinded, Controlled Study.
Wu Y; Ascher B; Yang Z; Bi H; Li L; Zhao H; Wang H; Zhang J; Luo SK · Aesthetic surgery journal · 2026
Randomized trial390 participantsflagAnti-Aging forscienceHyaluronic Acid
- A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study.
Fanian F; Deutsch JJ; Bousquet MT; Boisnic S; Andre P; Catoni I; Beilin G; Lemmel C; Taieb M; Gomel-Toledano M; Issa H; Garcia P · The Journal of dermatological treatment · 2023
Randomized trial146 participantsflagAnti-Aging forscienceHyaluronic Acid
- Safety and Effectiveness of a Crosslinked Hyaluronic Acid Filler in Korean Patients for the Correction of Nasolabial Folds: A Randomized, Patient- and Evaluator-Blinded, Paired Study.
Lee SH; Park E; Won CH · Aesthetic surgery journal · 2026
Randomized trial100 participantsflagAnti-Aging forscienceHyaluronic Acid
- A randomized study showing improved skin quality and aesthetic appearance of dorsal hands after hyaluronic acid gel treatment in a Chinese population.
Wu Y; Tian Y; Xu J; Zhong S; Wang R; Wu W · Journal of cosmetic dermatology · 2021
Randomized trial100 participantsflagAnti-Aging forscienceHyaluronic Acid
- Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.
Lugo JP; Saiyed ZM; Lane NE · Nutrition journal · 2016
Randomized trial191 participantsflagJoint Health forscienceCollagen
- Platelet-rich plasma versus hyaluronic acid injection following arthrocentesis for temporomandibular joint disorders under sedation: a comparative clinical study.
Mahdi MS; Abdulsattar MS · Oral and maxillofacial surgery · 2026
Randomized trial60 participantsflagJoint Health forscienceHyaluronic Acid
- Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.
Dewi DAR; Arimuko A; Norawati L; Yenny SW; Setiasih NL; Perdiyana A; Arkania N; Nadhira F; Wiliantari N · Cureus · 2024
Meta-analysis967 participants14 studies pooledflagSkin Health forscienceCollagen
- Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
Danessa G; Notario D; Regina R · Indian journal of dermatology, venereology and leprology · 2025
Meta-analysis646 participants10 studies pooledflagSkin Health forscienceCollagen
- Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
Kim DU; Chung HC; Choi J; Sakai Y; Lee BY · Nutrients · 2018
Randomized trial64 participantsflagSkin Health forscienceCollagen
- Safety and efficacy of hyaluronic acid injectable filler in the treatment of nasolabial fold wrinkle: a randomized, double-blind, self-controlled clinical trial.
Li XZ; Chiang CF; Lin YH; Chen TM; Wang CH; Tzeng YS; Cui HY · The Journal of dermatological treatment · 2023
Randomized trial95 participantsflagSkin Health forscienceHyaluronic Acid
- Long-term Safety and Effectiveness of Cold-Crosslinked Hyaluronic Acid Fillers: Multicenter, Randomized, Controlled, Double-Blind Study.
Kaminer MS; Avelar RL; Baumann L; Callender V; Dayan SH; Green JB; Grekin SK; Guyon S · Aesthetic surgery journal · 2025
Randomized trial140 participantsflagSkin Health forscienceHyaluronic Acid