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Super Collagen 6000 mg plus Vitamin C

21st Century
4.7
★ ★ ★ ★ ★
(24373 ratings)
Collagen 6000 mg
Product Image
Score84
A substantial 6 g hydrolyzed collagen serving with vitamin C and strong value, offset by a six-tablet dose and limited source transparency.
How scoring works
Quantity:180 Tablet(s) • (30 servings)
Goals:
Skin Health
Anti-Aging
Joint Health
Nail Health
Bone Health
General Health
Hair Health

Score 84

A substantial 6 g hydrolyzed collagen serving with vitamin C and strong value, offset by a six-tablet dose and limited source transparency.
How scoring works
$15.99($0.53 per serving)
iHerb
$ 15.99
Amazon
$ 15.99
Walmart
$ 17.71
iHerb
$ 15.99
Report prices

Analysis

Hydrolyzed collagen provides 6 g per serving, a useful amount for joint, bone, or general structural support. Vitamin C adds 60 mg in a stable calcium ascorbate form and complements collagen formation.

The animal source, collagen types, protein match, and amino acid profile are not shown. A six-tablet serving is less convenient than powder for delivering the same collagen amount.

The amount per container supports strong cost efficiency. It suits users who want a substantial serving and prefer tablets despite the label-detail gaps.

Who is it for
  • People seeking a substantial collagen serving
  • People who prefer tablets to powder
Best for
  • Joint and structural collagen routines
  • Value-focused higher intake

Pros

  • 6 g of hydrolyzed collagen
  • Includes 60 mg of vitamin C
  • Strong amount-per-container value

Cons

  • Six tablets per serving
  • Animal source and collagen types are missing
  • No protein or amino acid verification

Nutrient quality

93 Highest impact

Hydrolyzed collagen supports digestion, and calcium ascorbate is a buffered vitamin C form. The 6,000 mg collagen amount is substantial, and 60 mg of vitamin C provides a useful synthesis cofactor.

.

Ingredient transparency

77 High impact

Both active ingredients have clearly stated amounts. Serving count is supplied, but complete directions and inactive ingredients are not shown.

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Customer satisfaction

71 High impact

The supplied aggregate average is favorable and comes from a very large response pool. No specific firsthand feedback is provided to assess recurring complaints or whether experience matches the intended use.

.

Value for money

95 Highest impact

A substantial collagen amount is delivered at low serving cost. The efficient two-active design compares favorably with similar products.

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Report analysis

Goals

Skin Health
Skin Health
Impact
Highest effect
A+ Goal FitA+ Strength of SupportB+ CoverageA+ Formula Quality
Vitamin C · 60 mgCollagen · 6000 mg

Hydrolyzed collagen at 6 g provides direct structural support in a commonly studied range. Vitamin C adds a logical cofactor for normal collagen synthesis.

The formula is focused and strong for dermal structure but does not directly target barrier lipids or hydration molecules. Missing animal source, collagen type, and peptide standardization limit transparency rather than the basic skin rationale.

Study evidence
Collagen Supportive 62 studies
Vitamin C Supportive 53 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
A- Goal FitA+ Strength of SupportB CoverageA+ Formula Quality
Collagen · 6000 mg

The formula directly supports skin and connective-tissue structure with a synthesis cofactor. It provides 6 g of hydrolyzed collagen with 60 mg of buffered vitamin C for the stated purpose.

Its scope is structural rather than a broad biological-aging strategy. Its narrow or uncertain scope remains the main practical trade-off.

Study evidence
Collagen Supportive 33 studies
Vitamin C Supportive 30 studies
Joint Health
Joint Health
Impact
Highest effect
A Goal FitA Strength of SupportB- CoverageA+ Formula Quality
Collagen · 6000 mg

Hydrolyzed collagen is supplied in a meaningful multi-gram amount for structural joint support. Vitamin C is logically included to support collagen synthesis, creating a focused and complementary formula.

The product has excellent depth for joint structure but does not directly address inflammatory pathways or lubrication. A six-tablet serving is a practical trade-off, though the active design itself is clean.

Study evidence
Collagen Supportive 49 studies
Vitamin C Disputed 24 studies
Nail Health
Nail Health
Impact
Highest effect
A- Goal FitA Strength of SupportB CoverageA+ Formula Quality
Collagen · 6000 mg

Hydrolyzed collagen supplies a strong amount of structural amino acids, and vitamin C supports collagen formation. That pairing is directly relevant to nail strength and resistance to breakage.

The 6,000 mg collagen serving provides substantial depth, although animal source, collagen type, and amino acid profile are not disclosed. The simple two-active formula lacks biotin or silicon but remains focused and complementary.

Study evidence
Collagen Supportive 4 studies
Vitamin C Supportive 1 study
Bone Health
Bone Health
Impact
Highest effect
A- Goal FitA+ Strength of SupportC CoverageA+ Formula Quality
Vitamin C · 60 mgCollagen · 6000 mg

Six grams of hydrolyzed collagen provide meaningful support for the flexible protein framework of bone. Vitamin C complements the peptides by supporting collagen synthesis.

The focused formula gives excellent depth for the organic matrix but does not supply calcium, magnesium, vitamin D, or vitamin K2. The six-tablet serving is burdensome even though the active amounts are well disclosed.

Study evidence
Collagen Supportive 16 studies
Vitamin C Supportive 46 studies
General Health
General Health
Impact
Highest effect
B+ Goal FitB+ Strength of SupportC+ CoverageA+ Formula Quality
Collagen · 6000 mgVitamin C · 60 mg

A substantial amount of hydrolyzed collagen provides amino-acid building blocks for joints, skin, and other connective tissues. Vitamin C is a logical cofactor for normal collagen synthesis.

The formula has meaningful depth for structural support but does not cover energy, essential fats, or wider micronutrient gaps. Collagen source, type, protein matching, and amino acid profile are not disclosed, limiting quality verification.

Study evidence
Collagen Supportive 31 studies
Vitamin C Supportive 56 studies

Ingredients

IngredientAmount per serving
Calories
25 Calorie(s)
Vitamin C (Calcium Ascorbate)
 60 mg
hydrolyzed Collagen
6000 mg
Gluten Free Adults 18–50
Report overview
Collagen · 6000 mg OverallScore59
D+ Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyA+ Value

Hydrolyzed collagen supports absorption, and the 6,000 mg serving reaches a useful joint and bone support range. Animal source, collagen type, branded standardization, protein matching, and an amino acid profile are not disclosed. The low cost per gram makes it an economical collagen option despite those transparency gaps.

View ingredientView products
Loading alternative details
83 Performance

High Potency Maxi-Collagen 7000

Country Life
<p>Branded Verisol peptides and vitamin C give the formula a clear skin-support rationale. Its 7 g amount provides more collagen than the original's disclosed 6 g, while the named form and substantial peptide amount provide more complete general collagen coverage.</p>
85 Performance

Collagen 6000 mg

youtheory
<p>Hydrolyzed collagen is clearly identified for straightforward peptide delivery. Its 6.09 g amount provides more collagen than the original's disclosed 6 g, while the named form and substantial peptide amount provide more complete general collagen coverage.</p>
87 Performance

Collagen + C 2500 mg

Spring Valley
<p>Branded Verisol peptides and vitamin C give the formula a clear skin-support rationale. Its 2.5 g amount provides less collagen than the original's disclosed 6 g, which matters when total peptide intake is the priority, while the named form and substantial peptide amount provide more complete general collagen coverage.</p>
72 Budget

Super Collagen

RejuviCare
<p>The 500 mg collagen serving comes at a lower serving cost than the original. It provides less collagen than the original's disclosed 6 g, which matters when total peptide intake is the priority, and the collagen amount is directly disclosed, although source and type details remain limited.</p>
73 Budget

Hydrolyzed Fish Collagen Type I 400 mg

Swanson Ultra
<p>The 800 mg collagen serving comes at a lower serving cost than the original. It provides less collagen than the original's disclosed 6 g, which matters when total peptide intake is the priority, and the fish source is identified, making the marine-collagen approach easier to assess.</p>
77 Budget

Advanced Collagen 1500 mg

AN Amazing Nutrition Amazing Formulas
<p>The 1.6 g collagen serving comes at a lower serving cost than the original. It provides less collagen than the original's disclosed 6 g, which matters when total peptide intake is the priority, and named collagen types make the source and intended coverage clearer.</p>
79 Value

Collagen 3000 mg Amino Acid Complex

Bronson
<p>Clear active dosing and a favorable balance of collagen amount and serving economy make this a practical value option. Its 3 g collagen amount provides less collagen than the original's disclosed 6 g, which matters when total peptide intake is the priority.</p>
85 Value

Collagen Skin Renewal

Natrol
<p>Clear active dosing and a favorable balance of collagen amount and serving economy make this a practical value option. Its 2.59 g collagen amount provides less collagen than the original's disclosed 6 g, which matters when total peptide intake is the priority.</p>
83 Value

Marine Collagen 2500 mg

youtheory
<p>Clear active dosing and a favorable balance of collagen amount and serving economy make this a practical value option. Its 2.5 g collagen amount provides less collagen than the original's disclosed 6 g, which matters when total peptide intake is the priority.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Multicenter randomized clinical trial comparing surgery and collagen injections for treatment of female stress urinary incontinence.
    Corcos J; Collet JP; Shapiro S; Herschorn S; Radomski SB; Schick E; Gajewski JB; Benedetti A; MacRamallah E; Hyams B · Urology · 2005
    Randomized trial133 participantsGeneral Health forCollagen
  2. Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI.
    Dam EB; Byrjalsen I; Karsdal MA; Qvist P; Christiansen C · Osteoarthritis and cartilage · 2009
    Cohort study158 participantsJoint Health forCollagen
  3. The Role of Collagen Supplementation in Bone Metabolism and Structure: A Scoping Review.
    Kuhlman NM; Jagim AR; Blesso C; Jones MT; Chun O; Puglisi M; Fields JB · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 2026
    Scoping review15 studies pooledBone Health forCollagen
  4. Circulating levels of a biomarker of collagen metabolism are associated with health-related quality of life in patients with chronic heart failure.
    Chatzikyriakou SV; Tziakas DN; Chalikias GK; Stakos D; Papazoglou D; Lantzouraki A; Thomaidi A; Boudoulas H; Konstantinides S · Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2012
    Cohort study280 participantsGeneral Health forCollagen
  5. Role of collagen hydrolysate in bone and joint disease.
    Moskowitz RW · Seminars in arthritis and rheumatism · 2001
    Narrative reviewJoint Health forCollagen
  6. Efficacy of Cross-Linked Collagen Membranes for Bone Regeneration: In Vitro and Clinical Studies.
    Baek SH; Yang BE; Park SY; On SW; Ahn KM; Byun SH · Bioengineering (Basel, Switzerland) · 2025
    Other57 participantsBone Health forCollagen
  7. Soft Tissue Volume Augmentation at Single Implant Sites Applying Collagen Matrices or Connective Tissue Grafts: 10-Year Follow-Up of a Randomized Controlled Trial.
    Strauss FJ; Liguori MG; Gasser TJW; Naenni N; Jung RE; Thoma DS · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026
    Randomized trial20 participantsGeneral Health forCollagen
  8. Histological and molecular characterization of bone integrity in osteogenesis imperfecta: a case series across genetic subtypes.
    Wu Z; den Haan S; King HE; Nijhuis WH; Weinans H; Spaans AJ; Sakkers R; Warmink K · JBMR plus · 2026
    Case seriesBone Health forCollagen
  9. Function of the normal meniscus and consequences of meniscal resection.
    Aagaard H; Verdonk R · Scandinavian journal of medicine & science in sports · 1999
    Narrative reviewJoint Health forCollagen
  10. Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability.
    Devasia S; Joseph JT; P S S; Koizumi S; Clarke L; V T S; Kailas AP; Madhavan S · Cartilage · 2024
    Randomized trial100 participantsJoint Health General Health forCollagen
  11. Effect of Calcium and Vitamin D Supplementation With and Without Collagen Peptides on Volumetric and Areal Bone Mineral Density, Bone Geometry and Bone Turnover in Postmenopausal Women With Osteopenia.
    Lampropoulou-Adamidou K; Karlafti E; Argyrou C; Makris K; Trovas G; Dontas IA; Tournis S; Triantafyllopoulos IK · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry · 2022
    Randomized trial51 participantsBone Health forCollagen
  12. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis.
    Kumar S; Sugihara F; Suzuki K; Inoue N; Venkateswarathirukumara S · Journal of the science of food and agriculture · 2015
    Randomized trialGeneral Health forCollagen
  13. Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double-blind, placebo-controlled trial.
    Luo C; Su W; Song Y; Srivastava S · Journal of experimental orthopaedics · 2023
    Randomized trial101 participantsJoint Health General Health forCollagen
  14. Bone turnover and bone collagen maturation in osteoporosis: effects of antiresorptive therapies.
    Byrjalsen I; Leeming DJ; Qvist P; Christiansen C; Karsdal MA · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008
    Randomized trialBone Health forCollagen
  15. [Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial].
    Alekseeva LI; Kashevarova NG; Taskina EA; Strebkova EA; Korotkova TA; Sharapova EP; Savushkina NM; Lila AM; Shostak NA; Mazurov VI; Nesterovich II; Dedkova VA; Vasilyuk VB; Egorova NV; Leontyeva MA; Yakupova SP; Vinogradova IB; Sorotskaya VN; Shirokova LY · Terapevticheskii arkhiv · 2024
    Randomized trial212 participantsJoint Health forCollagen
  16. Healing Process, Pain, and Health-Related Quality of Life in Patients with Venous Leg Ulcers Treated with Fish Collagen Gel: A 12-Week Randomized Single-Center Study.
    Mościcka P; Cwajda-Białasik J; Szewczyk MT; Jawień A · International journal of environmental research and public health · 2022
    Randomized trial100 participantsGeneral Health forCollagen
  17. Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia.
    Argyrou C; Karlafti E; Lampropoulou-Adamidou K; Tournis S; Makris K; Trovas G; Dontas I; Triantafyllopoulos IK · Journal of musculoskeletal & neuronal interactions · 2021
    Randomized trial51 participantsBone Health forCollagen
  18. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort.
    Benito-Ruiz P; Camacho-Zambrano MM; Carrillo-Arcentales JN; Mestanza-Peralta MA; Vallejo-Flores CA; Vargas-López SV; Villacís-Tamayo RA; Zurita-Gavilanes LA · International journal of food sciences and nutrition · 2012
    Randomized trial250 participantsJoint Health forCollagen
  19. Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.
    Shiojima Y; Takahashi M; Takahashi R; Maruyama K; Moriyama H; Bagchi D; Bagchi M; Akanuma M · Journal of the American Nutrition Association · 2023
    Randomized trial64 participantsGeneral Health forCollagen
  20. Assessment of Osteoporosis in Lumbar Spine: In Vivo Quantitative MR Imaging of Collagen Bound Water in Trabecular Bone.
    Liu J; Liao JW; Li W; Chen XJ; Feng JX; Yao L; Huang PH; Su ZH; Lu H; Liao YT; Li SL; Ma YJ · Frontiers in endocrinology · 2022
    Methods validation study189 participantsBone Health forCollagen
  21. [Experience with the use of undenatured type II collagen in patients with stage III knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial].
    Alekseeva LI; Kashevarova NG; Taskina EA; Strebkova EA; Korotkova TA; Sharapova EP; Savushkina NM; Lila AM; Shostak NA; Nesterovich II; Dedkova VA; Vasilyuk VB; Egorova NV; Leontyeva MA; Yakupova SP; Vinogradova IB; Sorotskaya VN; Shirokova LI; Rudakova AV · Terapevticheskii arkhiv · 2025
    Randomized trial50 participantsJoint Health forCollagen
  22. The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study.
    Genç AS; Yılmaz AK; Anıl B; Korkmaz Salkılıç E; Akdemir E; Güzel B; Mor A; Yarar HA; Güzel N; Kehribar L · BMC musculoskeletal disorders · 2025
    Randomized trial32 participantsGeneral Health forCollagen
  23. Specific Bioactive Collagen Peptides in Osteopenia and Osteoporosis: Long-Term Observation in Postmenopausal Women.
    Zdzieblik D; Oesser S; König D · Journal of bone metabolism · 2021
    Single-arm trial31 participantsBone Health forCollagen
  24. The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial.
    Zdzieblik D; Brame J; Oesser S; Gollhofer A; König D · Nutrients · 2021
    Randomized trial180 participantsJoint Health forCollagen
  25. Comprehensive assessment of osteoporosis in lumbar spine using compositional MR imaging of trabecular bone.
    Liu J; Chen JD; Li P; Liao JW; Feng JX; Chen ZY; Cai ZY; Li W; Chen XJ; Su ZH; Lu H; Li SL; Ma YJ · European radiology · 2023
    Methods validation study182 participantsBone Health forCollagen
  26. Efficacy and safety of low-molecular-weight collagen peptides in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial.
    Park SY; Lee SH; Kim HT; Park HJ; Kim DU; Kim SU; Heo I · Frontiers in nutrition · 2025
    Randomized trial80 participantsJoint Health forCollagen
  27. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial.
    Bakilan F; Armagan O; Ozgen M; Tascioglu F; Bolluk O; Alatas O · The Eurasian journal of medicine · 2016
    Randomized trial39 participantsGeneral Health forCollagen
  28. Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study.
    König D; Oesser S; Scharla S; Zdzieblik D; Gollhofer A · Nutrients · 2018
    Randomized trial131 participantsBone Health forCollagen
  29. Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
    Lee M; Kim E; Ahn H; Son S; Lee H · Food & function · 2023
    Randomized trial100 participantsAnti-Aging Skin Health forCollagen
  30. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
    de Miranda RB; Weimer P; Rossi RC · International journal of dermatology · 2021
    Meta-analysis1,125 participants19 studies pooledAnti-Aging Skin Health forCollagen
  31. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.
    Proksch E; Segger D; Degwert J; Schunck M; Zague V; Oesser S · Skin pharmacology and physiology · 2014
    Randomized trial69 participantsAnti-Aging forCollagen
  32. Skin Anti-Aging and Moisturizing Effects of Low-Molecular-Weight Collagen Peptide Supplementation in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Lee E; Ahn DK; Kim JH; Lee S; Kim HJ; Lee HK; Shin JH · Journal of microbiology and biotechnology · 2025
    Randomized trial70 participantsAnti-Aging forCollagen
  33. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.
    Proksch E; Schunck M; Zague V; Segger D; Degwert J; Oesser S · Skin pharmacology and physiology · 2014
    Randomized trial114 participantsAnti-Aging forCollagen
  34. Study on the Multiple Efficacies of Vitamin C Serum in Anti-Glycation, Anti-Carbonylation, Antioxidation, and Anti-Inflammation of Human Skin Based on In Vivo Tests.
    Zi Y; Liu J; Liu Q; Pan Y; Jiang X · Journal of cosmetic dermatology · 2026
    Randomized trial66 participantsAnti-Aging forVitamin C
  35. Evaluation of the anti-wrinkle effect of a lipophilic pro-vitamin C derivative, tetra-isopalmitoyl ascorbic acid.
    Yokota M; Yahagi S · Journal of cosmetic dermatology · 2022
    Randomized trial69 participantsAnti-Aging forVitamin C
  36. The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach.
    Crisan D; Roman I; Crisan M; Scharffetter-Kochanek K; Badea R · Clinical, cosmetic and investigational dermatology · 2015
    Clinical trial60 participantsAnti-Aging forVitamin C
  37. In vivo evaluation of topical ascorbic acid application on skin aging by 50 MHz ultrasound.
    Vergilio MM; Aiello LM; Furlan AS; Caritá AC; Azevedo JR; Bolzinger MA; Chevalier Y; Leonardi GR · Journal of cosmetic dermatology · 2022
    Randomized trial25 participantsAnti-Aging forVitamin C
  38. Clinical Applications of Vitamin C in Dermatology: A Systematic Review.
    Boghosian T; Mendez H; Boghosian N; Sayegh M; Beer J; Tosti A · The Journal of clinical and aesthetic dermatology · 2026
    Systematic review44 studies pooledAnti-Aging forVitamin C
  39. Undenatured type II collagen for knee osteoarthritis.
    Gupta A; Maffulli N · Annals of medicine · 2025
    Systematic review12 studies pooledAnti-Inflammatory Support forCollagen
  40. Anti-inflammatory effect of collagen tripeptide in atopic dermatitis.
    Hakuta A; Yamaguchi Y; Okawa T; Yamamoto S; Sakai Y; Aihara M · Journal of dermatological science · 2018
    Randomized trial17 participantsAnti-Inflammatory Support forCollagen
  41. [Points of undenatured type II collagen application in musculoskeletal pain syndromes treatment].
    Shavlovskaya OA; Gromova OA; Torshin IY · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2022
    Narrative reviewAnti-Inflammatory Support forCollagen
  42. Ultrasound Guided Injection of Collagen for Elbow Lateral Epicondylitis - A Pilot Study.
    Porta F; Filippucci E; Barni X; Dinescu SC; Vreju FA · Current health sciences journal · 2026
    Single-arm trial13 participantsAnti-Inflammatory Support forCollagen
  43. Effects of porcine-derived collagen hydrolysates on 24 h blood pressure profiles, markers for endothelial dysfunction and low-grade inflammation and the retinal vasculature in adults with overweight/obesity: a randomized, controlled trial.
    Chavez-Alfaro MA; Mensink RP; Joris PJ; Plat J · Food & function · 2025
    Randomized trial56 participantsAnti-Inflammatory Support forCollagen
  44. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support Joint Health forVitamin C
  45. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  46. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  47. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  48. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  49. A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial.
    Elam ML; Johnson SA; Hooshmand S; Feresin RG; Payton ME; Gu J; Arjmandi BH · Journal of medicinal food · 2015
    Randomized trial39 participantsBone Health forCollagen
  50. Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies.
    Zeng LF; Luo MH; Liang GH; Yang WY; Xiao X; Wei X; Yu J; Guo D; Chen HY; Pan JK; Huang HT; Liu Q; Guan ZT; Han YH; Zhao D; Zhao JL; Hou SR; Wu M; Lin JT; Li JH; Liang WX; Ou AH; Wang Q; Li ZP; Liu J · Frontiers in endocrinology · 2020
    Meta-analysis19,484 participants17 studies pooledBone Health forVitamin C
  51. Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis.
    Sun Y; Liu C; Bo Y; You J; Zhu Y; Duan D; Cui H; Lu Q · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Meta-analysis6 studies pooledBone Health forVitamin C
  52. Smoking, antioxidant vitamins, and the risk of hip fracture.
    Melhus H; Michaëlsson K; Holmberg L; Wolk A; Ljunghall S · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1999
    Cohort study66,651 participantsBone Health forVitamin C
  53. Micronutrients and the risk of hip fracture: Case-control study.
    Torbergsen AC; Watne LO; Wyller TB; Frihagen F; Strømsøe K; Bøhmer T; Mowe M · Clinical nutrition (Edinburgh, Scotland) · 2018
    Case-control study189 participantsBone Health forVitamin C
  54. Favorable effect of dietary vitamin C on bone mineral density in postmenopausal women (KNHANES IV, 2009): discrepancies regarding skeletal sites, age, and vitamin D status.
    Kim YA; Kim KM; Lim S; Choi SH; Moon JH; Kim JH; Kim SW; Jang HC; Shin CS · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Cross-sectional study1,196 participantsBone Health forVitamin C
  55. The use of a collagen matrix in hard-to-heal venous leg ulcers.
    Romanelli M; Mulder G; Paggi B; Macchia M; Panduri S; Dini V · Journal of wound care · 2016
    Randomized trial40 participantsGeneral Health forCollagen
  56. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  57. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  58. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  59. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  60. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  61. Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation.
    Hwang S; Won J; Kim S; Kang W; Park M · Journal of medicinal food · 2026
    Randomized trial114 participantsHair Health forCollagen
  62. Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study.
    Duangjai A; Srivilai J; Nangola S; Amornlerdpison D · Clinics and practice · 2025
    Randomized trialHair Health forCollagen
  63. Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.
    Biełach-Bazyluk A; Jurga M; Flisiak I; Zbroch E · Nutrients · 2026
    Narrative reviewHair Health forCollagen
  64. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  65. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  66. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  67. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  68. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  69. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.
    Lugo JP; Saiyed ZM; Lane NE · Nutrition journal · 2016
    Randomized trial191 participantsJoint Health forCollagen
  70. Effects of Multiple Intravenous Doses of Perioperative Vitamin C on Pain Management Following Total Hip Arthroplasty.
    Han G; Ye Y; Kang P · Drug design, development and therapy · 2025
    Randomized trial100 participantsJoint Health forVitamin C
  71. Osteoarthritis prevalence and modifiable factors: a population study.
    Plotnikoff R; Karunamuni N; Lytvyak E; Penfold C; Schopflocher D; Imayama I; Johnson ST; Raine K · BMC public health · 2016
    Cross-sectional study4,733 participantsJoint Health forVitamin C
  72. Anti-Inflammatory Effect of Vitamin C during the Postoperative Period in Patients Subjected to Total Knee Arthroplasty: A Randomized Controlled Trial.
    Ramón R; Holguín E; Chiriboga JD; Rubio N; Ballesteros C; Ezechieli M · Journal of personalized medicine · 2023
    Randomized trial110 participantsJoint Health forVitamin C
  73. Musculoskeletal manifestations of scurvy.
    Fain O · Joint bone spine · 2005
    Narrative reviewJoint Health forVitamin C
  74. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails.
    Hexsel D; Zague V; Schunck M; Siega C; Camozzato FO; Oesser S · Journal of cosmetic dermatology · 2018
    Single-arm trial25 participantsNail Health forCollagen
  75. Influence of collagen peptide supplementation on visible signs of skin and nail health and -aging in an East Asian population: A double blind, randomized, placebo-controlled trial.
    Vleminckx S; Virgilio N; Asserin J; Prawitt J; Silva CIF · Journal of cosmetic dermatology · 2024
    Randomized trial85 participantsNail Health forCollagen
  76. Nail Supplements: When, How, and Why?
    Zaraa I; Richert B · Skin appendage disorders · 2026
    Narrative reviewNail Health forCollagen
  77. Expanding the COL7A1 mutation database: novel and recurrent mutations and unusual genotype-phenotype constellations in 41 patients with dystrophic epidermolysis bullosa.
    Kern JS; Kohlhase J; Bruckner-Tuderman L; Has C · The Journal of investigative dermatology · 2006
    Observational study41 participantsNail Health forCollagen
  78. Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
    Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
    Other20 participantsNail Health forVitamin C
  79. Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.
    Dewi DAR; Arimuko A; Norawati L; Yenny SW; Setiasih NL; Perdiyana A; Arkania N; Nadhira F; Wiliantari N · Cureus · 2024
    Meta-analysis967 participants14 studies pooledSkin Health forCollagen
  80. Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
    Danessa G; Notario D; Regina R · Indian journal of dermatology, venereology and leprology · 2025
    Meta-analysis646 participants10 studies pooledSkin Health forCollagen
  81. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
    Kim DU; Chung HC; Choi J; Sakai Y; Lee BY · Nutrients · 2018
    Randomized trial64 participantsSkin Health forCollagen
  82. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  83. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  84. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  85. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  86. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C