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GI Natural Total Digestive Wellness

NaturesPlus
4.6
★ ★ ★ ★ ★
(1120 ratings)
Zinc 15 mg
Glutamine 1000 mg
Calcium 300 mg
Product Image
Score57
Broad digestive ingredients look useful on paper, but missing probiotic strains, viable counts, and enzyme activities sharply limit confidence.
How scoring works
Quantity:90 Tablet(s) • (30 servings)
Goals:
Immunity
General Health
Skin Health

Score 57

Broad digestive ingredients look useful on paper, but missing probiotic strains, viable counts, and enzyme activities sharply limit confidence.
How scoring works
$25.29($0.84 per serving)
Amazon
$ 75.86
iHerb
$ 25.29
Pure Formulas
$ 25.29
Vitacost
$ 25.29
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Analysis

One gram of glutamine anchors the formula, with vitamin C, natural vitamin E, calcium, zinc, and selenium providing supporting nutrition. A prebiotic blend, probiotics, whole-food ingredients, and enzymes aim to broaden digestive coverage.

The probiotic blend is listed only by weight rather than strains and viable counts, while enzyme activity units are absent. The 25 mg probiotic, whole-food, and enzyme blends are each small and cannot be evaluated for meaningful potency.

Three tablets per serving offer many ingredient categories but limited precision. It best fits users who want a broad all-in-one digestive product and accept that several core components are opaque.

Who is it for
  • Adults seeking a broad digestive-support blend
  • Users wanting glutamine with prebiotics
  • People comfortable with proprietary probiotic and enzyme blends
Best for
  • General digestive nutrition
  • Glutamine intake
  • Multi-category gut support

Pros

  • Provides one gram of glutamine
  • Includes a 400 mg prebiotic blend
  • Adds zinc and selenium
  • Uses natural vitamin E

Cons

  • Probiotic strains and viable counts are absent
  • Enzyme activity units are not disclosed
  • Several blends are only 25 mg
  • Requires three tablets

Warnings

  • The proprietary probiotic blend prevents screening individual strains for suitability
  • Prebiotic ingredients may cause gas or bloating in sensitive users
  • The 200 mg ascorbic acid amount may add stomach irritation for some people

Nutrient quality

67 High impact

Ingredient forms are mixed but generally usable. Weak or opaque additions reduce focus.

.

Ingredient transparency

48 Lower impact

Some active amounts remain hidden inside blends. Opaque blends are the main weakness.

.

Customer satisfaction

65 Moderate impact

The supplied average is generally favorable and rests on a substantial review count. No review text was provided to assess recurring complaints or firsthand experiences.

.

Value for money

52 Moderate impact

Serving efficiency is limited for the disclosed formula. Opaque or low-value additions and high cost weaken competitiveness.

.
Report analysis

Goals

Immunity
Immunity
Impact
High effect
B- Goal FitB Strength of SupportB CoverageB- Formula Quality
Vitamin C · 200 mgZinc · 15 mgSelenium · 35 mcg

Zinc and Glutamine provide relevant support for immunity. Zinc is essential for immune cell development and is a primary ingredient in most effective immune protocols.

Gluconate provides a useful, generally well-tolerated zinc form at a maintenance-focused dose. Cost efficiency is weak for the zinc delivered, so the broader digestive formula must provide the main value.

Study evidence
Glutamine Supportive 36 studies
Zinc Supportive 73 studies
General Health
General Health
Impact
Moderate effect
C+ Goal FitC Strength of SupportC CoverageC+ Formula Quality
Selenium · 35 mcgZinc · 15 mgVitamin C · 200 mg

Antioxidant nutrients, zinc, glutamine, prebiotics, and probiotics connect digestive support with broader immune and nutritional health. Evidence is solid for the essential nutrients, while benefit from the probiotic and enzyme blends cannot be judged without strain or activity details.

Glutamine at 1000 mg is modest for targeted use, and the 400 mg prebiotic blend plus tiny probiotic and enzyme blends provide uncertain depth. Exact nutrient amounts are listed, but probiotic strains, viable counts, enzyme activities, and individual blend doses are absent.

Study evidence
Zinc Supportive 60 studies
Skin Health
Skin Health
Impact
Moderate effect
D+ Goal FitC Strength of SupportC CoverageD- Formula Quality
Zinc · 15 mgVitamin C · 200 mgSelenium · 35 mcgVitamin E · 67 mg

Vitamin C, vitamin E, and zinc offer modest collagen-cofactor, antioxidant, and repair support. The digestive formula lacks direct structural or hydration actives.

Core nutrient amounts are clear and zinc gluconate is acceptable. Probiotic and enzyme blends are hidden and mainly serve digestion, weakening skin-specific focus.

Study evidence
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Zinc Supportive 66 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 200 mg
Vitamin E (D-Alpha-Tocopheryl Succinate)
 67 mg
Calcium (Calcium Carbonate, Calcium Phosphate)
 300 mg
Zinc (Zinc Gluconate)
 15 mg
Selenium (Selenomethionine)
 35 mcg
L-Glutamine
1000 mg
Short-Chain Fatty-Acid–Promoting Prebiotic Blend
400 mg
Proprietary Probiotic Blend
25 mg
Enzyme-Rich Whole Food Blend
25 mg
Live Enzyme Blend
25 mg
Gluten Free Adults 18–50 Dairy Free Vegetarian
Report overview
Zinc (Zinc Gluconate) · 15 mg OverallScore72
B Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
Gluconate provides a useful, generally well-tolerated zinc form at a maintenance-focused dose. The pressed-tablet format is conventional, but it may require more binders than a capsule. Cost efficiency is weak for the zinc delivered, so the broader digestive formula must provide the main value.
View ingredientView products
Glutamine · 1000 mg OverallScore70
B- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB Value

The clearly disclosed L-glutamine amount is moderate and below the level commonly used for focused gut support. Reaching a practical daily target requires many tablets, which may make consistent use harder. Standard ingredient quality is acceptable, while the broader digestive formula partly offsets weak value from glutamine alone.

View ingredientView products
Calcium (Calcium Carbonate, Calcium Phosphate) · 300 mg OverallScore63
C+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value

Calcium carbonate is a common form that is best taken with food and is less adaptable to low stomach acid. The 300 mg serving provides useful supplementation but may require another daily dose for higher needs. Cost per serving provides poor value for the calcium delivered.

View ingredientView products
Loading alternative details
81 Performance

Magnesium & Calcium

NOW
<p>Calcium, magnesium, and zinc provide a clearly measured mineral formula with stronger disclosure than the original blend-heavy product. Magnesium is listed at an unusually high amount and the formula offers no glutamine or assessable probiotic support.</p>
83 Performance

Calcium Magnesium plus Zinc

Solgar
<p>Citrate and gluconate improve a well-dosed calcium, magnesium, and zinc profile with clear active amounts. Carbonate and magnesium oxide remain, while the lack of glutamine and defined probiotic organisms means the benefit is mineral support rather than digestive targeting.</p>
82 Performance

Calcium Magnesium Zinc + D3

21st Century
<p>Calcium, magnesium, zinc, and vitamin D3 provide broad mineral coverage with better active disclosure than the original opaque blends. Basic carbonate and oxide forms limit quality, and no direct glutamine, prebiotic, probiotic, or enzyme support is present.</p>
73 Budget

Masonatal

Mason Natural
<p>Vitamin C, zinc, selenium, and broad nutrients provide much cheaper general and immune coverage than the original digestive formula. High iron may be unnecessary and the product lacks the original glutamine, prebiotic, probiotic, and enzyme components, so it is not a direct digestive substitute.</p>
72 Budget

Calcium Magnesium & Zinc

Sundown
<p>Meaningful calcium, magnesium, and zinc provide inexpensive mineral coverage with a much clearer active list than the original opaque blends. Carbonate and oxide forms are basic, and no glutamine or defined probiotic count is supplied.</p>
74 Budget

Chelated Calcium Magnesium Zinc

American Health
<p>Substantial calcium, magnesium, and zinc come at a much lower serving cost and avoid hidden digestive blends. Carbonate and oxide reduce absorption quality, while glutamine, prebiotics, probiotics, and enzymes are absent.</p>
82 Value

Calcium Magnesium Zinc + Vitamin D3

Best Naturals
<p>A broad mineral formula with vitamin D3 provides economical general and immune-related nutrient coverage. Citrate and gluconate improve part of the blend, but oxide forms remain and the product does not replace the original glutamine or digestive blends.</p>
80 Value

Natural Calcium Magnesium & Zinc with Vitamin D3

Spring Valley
<p>Substantial calcium, magnesium, zinc, and vitamin D3 deliver very low-cost basic coverage. Mineral forms are not identified and digestive-specific ingredients are absent, but the straightforward formula offers stronger value for general mineral needs.</p>
78 Value

Calcium Magnesium Zinc With L-Glutamic Acid 1000 mg : 500 mg : 50 mg

Country Life
<p>Calcium, magnesium, zinc, and glutamic acid provide a lower-cost mineral alternative with fully visible headline actives. Carbonate, oxide, and aggressive mineral amounts are drawbacks, and glutamic acid does not replace the original glutamine and poorly quantified probiotic blend.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  2. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  3. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  4. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  5. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  6. Meta-analysis of Glutamine on Immune Function and Post-Operative Complications of Patients With Colorectal Cancer.
    Yang T; Yan X; Cao Y; Bao T; Li G; Gu S; Xiong K; Xiao T · Frontiers in nutrition · 2021
    Meta-analysis2,201 participants31 studies pooledImmunity forGlutamine
  7. Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.
    Dong S; Zhao Z; Li X; Chen Z; Jiang W; Zhou W · Frontiers in nutrition · 2023
    Meta-analysis1,201 participants30 studies pooledImmunity forGlutamine
  8. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: a prospective, controlled, randomized clinical trial.
    Garrel D; Patenaude J; Nedelec B; Samson L; Dorais J; Champoux J; D'Elia M; Bernier J · Critical care medicine · 2003
    Randomized trial45 participantsImmunity forGlutamine
  9. Effect of perioperative glutamine-enriched nutritional support on patients with colorectal cancer: A systematic review and meta-analysis.
    Huang Y; Yang XZ; Qin SH; Zhang T; Xie M; Wang JW · World journal of gastrointestinal surgery · 2026
    Meta-analysis1,643 participants27 studies pooledImmunity forGlutamine
  10. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control.
    Wischmeyer PE; Lynch J; Liedel J; Wolfson R; Riehm J; Gottlieb L; Kahana M · Critical care medicine · 2001
    Randomized trial26 participantsImmunity forGlutamine
  11. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  12. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  13. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  14. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  15. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  16. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  17. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  18. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  19. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  20. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  21. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
    Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
    Randomized trial45 participantsSkin Health forVitamin E
  22. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
    Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
    Meta-analysis20 studies pooledSkin Health forVitamin E
  23. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forVitamin E Skin Health forZinc
  24. Effects of tocotrienol on aging skin: A systematic review.
    Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
    Systematic reviewSkin Health forVitamin E
  25. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
    Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
    Randomized trialSkin Health forVitamin E
  26. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  27. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  28. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  29. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc