Product Image

GABA L-Theanine Stress B Lozenge Natural Mango Tangerine Flavor

KAL
4.6
★ ★ ★ ★ ★
(3430 ratings)
Theanine 50 mg
Vitamin B12 1000 mcg
Folate 400 mcg
Choline 10 mg
Product Image
Score70
Convenient lozenges provide broad B vitamins with modest GABA and theanine, but low active amounts and confusing duplicate B12 entries weaken the formula.
How scoring works
Quantity:100 Liquid(s) • (50 servings)
Goals:
Energy
Cognitive Support
General Health
Mood Support

Score 70

Convenient lozenges provide broad B vitamins with modest GABA and theanine, but low active amounts and confusing duplicate B12 entries weaken the formula.
How scoring works
$13.19($0.26 per serving)
Vitacost
$ 13.19
iHerb
$ 13.19
Amazon
$ 13.19
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Analysis

GABA and L-theanine provide a calming focus, while B vitamins support normal energy and nervous-system function. The lozenge format may be useful for people who dislike swallowing capsules.

Both GABA and theanine are supplied at 50 mg, which is modest for focused calming use. Choline and inositol are even smaller additions, so much of the long ingredient list adds breadth rather than strong functional depth.

Two different high-dose B12 entries make the label difficult to interpret and may overstate the practical value of the vitamin blend. The flavored delivery is convenient, but users sensitive to calming ingredients should assess drowsiness before daytime use.

Who is it for
  • People who prefer lozenges to pills
  • Adults seeking mild calming support with B vitamins
Best for
  • Portable low-dose calming support
  • B-vitamin supplementation in a flavored format

Pros

  • Convenient lozenge delivery
  • Combines GABA with L-theanine
  • Provides broad B-vitamin coverage

Cons

  • GABA and theanine amounts are modest
  • Duplicate B12 entries complicate the label
  • Choline and inositol are too lightly dosed for focused use

Warnings

  • GABA and L-theanine may cause drowsiness in sensitive users, so assess tolerance before driving or operating machinery

Nutrient quality

61 Moderate impact

Methylcobalamin is included, though folic acid and several conventional B-vitamin forms are also used. GABA and L-theanine are modest, while vitamin B12 is extremely abundant.

Ingredient transparency

79 High impact

All listed active ingredients have explicit amounts. Flavoring and other inactive lozenge ingredients are not disclosed.

Customer satisfaction

71 High impact

The supplied average and volume indicate strong aggregate satisfaction. No detailed experience reports are available to identify repeated complaints or confirm perceived benefits.

Value for money

66 High impact

The accessible cost helps, but the key calming ingredients are lightly dosed. Serving cost appears favorable for a lozenge format.

Report analysis

Goals

Energy
Energy
Impact
Highest effect
A- Goal FitB+ Strength of SupportB- CoverageB- Formula Quality
Vitamin B5 · 10 mgThiamin · 4 mgVitamin B12 · 1000 mcg

B vitamins support metabolic energy, while theanine and GABA shift the formula toward calm focus rather than stimulation. The B12 amount is substantial and the lozenge offers purposeful oral delivery.

Mixed B12 forms, synthetic folic acid, and modest theanine and GABA amounts limit form and stress-pathway depth. The formula covers metabolism and calm focus but does not provide acute energy or an established adaptogen.

Study evidence
Theanine Not classified

No linked studies yet.

Cognitive Support
Cognitive Support
Impact
High effect
B Goal FitB- Strength of SupportB- CoverageB+ Formula Quality
Choline · 10 mgThiamin · 4 mgVitamin B6 · 10 mgFolate · 400 mcgVitamin B12 · 1000 mcgTheanine · 50 mg

L-theanine, GABA, folate, vitamin B12, and vitamin B6 combine calm-focus support with foundational neurological nutrition. The amounts favor nutritional maintenance and mild relaxation rather than a strong acute cognitive effect.

All active amounts are disclosed, although folic acid and part of the B12 use conventional forms. The calming ingredients may cause drowsiness in sensitive users.

Study evidence
Folate Supportive 68 studies
Theanine Supportive 25 studies
Vitamin B12 Disputed 84 studies
Vitamin B6 Supportive 17 studies
General Health
General Health
Impact
High effect
B+ Goal FitB Strength of SupportB- CoverageB- Formula Quality
Folate · 400 mcgVitamin B12 · 1000 mcgVitamin C · 10 mg

High-dose B12 and folate provide a clear nutritional base for energy metabolism and methylation. GABA and L-theanine add a stress-focused angle in a lozenge format.

The formula covers several related functions but uses mixed B12 forms and basic folic acid. Modest calming-ingredient amounts make the stress contribution less convincing than the vitamin support.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Mood Support
Mood Support
Impact
High effect
B- Goal FitD+ Strength of SupportC+ CoverageC+ Formula Quality
Folate · 400 mcgVitamin B6 · 10 mgVitamin B12 · 1000 mcg

L-theanine, GABA, B12, folate, and B6 combine acute calming support with neurotransmitter cofactors. Theanine and GABA amounts are mild, while the B12 amount is high and mixes methylcobalamin with cyanocobalamin.

The lozenge covers more than one mood pathway but provides uneven depth and many general B vitamins. Its broad stress formula is coherent, though oral GABA evidence and low theanine dosing limit the expected calming effect.

Study evidence
Folate Supportive 84 studies
GABA Supportive 12 studies
Theanine Supportive 12 studies
Vitamin B12 Supportive 29 studies
Hair Health
Hair Health
Impact
Moderate effect
C Goal FitB- Strength of SupportD CoverageC- Formula Quality
Vitamin C · 10 mg

High-dose B12 and folate may support hair when deficiency affects blood formation or follicle turnover. GABA and L-theanine target stress but do not turn the lozenge into comprehensive hair support.

The lozenge delivery is practical, though B12 combines methylcobalamin with cyanocobalamin and their shares are unclear. Folic acid is less direct than methylfolate, and most companion ingredients are present at modest amounts.

Study evidence
Folate Mixed 15 studies
Vitamin B12 Disputed 17 studies
Productivity Boost
Productivity Boost
Impact
Moderate effect
D+ Goal FitC Strength of SupportC CoverageC- Formula Quality
Vitamin B12 · 1000 mcgVitamin B12 · 1000 mcgVitamin B6 · 10 mgTheanine · 50 mg

Theanine and GABA may ease tension, while B vitamins support normal energy metabolism when status is low. The focus effect is likely mild because both calming actives are supplied at modest amounts.

The broad lozenge provides many clearly listed nutrients but spreads small quantities across too many pathways. The 1,000 mcg B12 presentation appears repeated across two forms, and the 10 mg B6 amount should be counted alongside other daily supplements.

Study evidence
Theanine Supportive 5 studies

Ingredients

IngredientAmount per serving
Total Carbohydrates
1 Gram(s)
Vitamin C (Ascorbic Acid)
 10 mg
Thiamine (Thiamine Mononitrate, Vitamin B1)
 4 mg
Niacin (Vitamin B3)
 4 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 10 mg
Folate (Folic Acid)
 400 mcg
Vitamin B12 (Cyanocobalamin, Methylcobalamin)
 1000 mcg
Pantothenic Acid (Calcium Pantothenate)
 10 mg
Choline Bitartrate
10 mg
Inositol (Inositol Hexahydroxycyclohexane)
 10 mg
GABA
50 mg
L-Theanine
50 mg
Adults 18–50
Report overview
Theanine · 50 mg OverallScore76
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value

The lozenge uses the active L-isomer and clearly discloses its amount. A 50 mg serving provides mild support rather than the usual full effect range. Cost efficiency is moderate, while GABA and B vitamins broaden the formula without obscuring the theanine dose.

View ingredientView products
Vitamin B12 (Cyanocobalamin, Methylcobalamin) · 1000 mcg OverallScore67
C- Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value
+1

The lozenge format and high B12 dose provide useful delivery and potency for elevated needs. A mixed methylcobalamin and cyanocobalamin source is less desirable than an exclusively bioactive form, and the proportions are unclear. Added GABA and L-theanine shift the formula toward stress support, so it is less focused for someone seeking B12 alone.

View ingredientView products
Folate (Folic Acid) · 400 mcg OverallScore44
F Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyD- Value

The 400 mcg serving uses synthetic folic acid, which requires more conversion than active folate forms. Missing DFE conversion weakens label transparency. A substantial B12 amount provides sensible co-supplementation within the stress-support blend.

View ingredientView products
Loading alternative details
86 Performance

Methyl B-12 Methyl Folate Lonzenge Natural Cherry Flavor

Solaray
<p>Methylcobalamin and branded methylfolate provide a high-quality active-form pairing. The ingredient focus improves on the original’s light GABA and L-theanine amounts plus duplicate high B12 entries, although the concentrated B12 amount is better suited to targeted use than basic maintenance.</p>
86 Performance

B-6 B-12 Methyl Folate Mixed Berry

KAL
<p>Active B6, methylfolate, and methylcobalamin create a focused three-nutrient formula. The ingredient focus improves on the original’s light GABA and L-theanine amounts plus duplicate high B12 entries, although the concentrated B12 amount may exceed basic maintenance needs.</p>
63 Performance

Full Spectrum Curcumin Brain Works

Solgar
<p>Bacopa, choline, methylcobalamin, and curcumin create a sensible cognitive-support combination. The ingredient focus improves on the original’s light GABA and L-theanine amounts plus duplicate high B12 entries, although missing bacopa standardization, unclear choline form, and no usable curcumin amount weaken the expensive formula.</p>
82 Budget

BioActive Vitamin B

Terry Naturally
<p>A higher serving cost means this is not a true cheaper option, although active forms of B6, B12, and folate create a compact formula with broad heart, energy, and cognitive alignment. The B6 amount may be more than many users need over the long term.</p>
77 Budget

Vitamin B12 & Folic Acid Natural Raspberry Flavor

Bluebonnet EarthSweet Chewables
<p>A higher serving cost means this is not a true cheaper option, although meaningful B12 and folate amounts provide convenient chewable coverage. Cyanocobalamin, synthetic folic acid, and the carbohydrate base reduce form quality.</p>
75 Budget

Vitamin B12 With Folic Acid 500 mcg Cherry Flavor

Country Life
<p>A higher serving cost means this is not a true cheaper option, although practical B12 and folate amounts come in an oral-dissolving format. Cyanocobalamin and synthetic folic acid are less preferred than active cobalamins and methylfolate.</p>
79 Value

B-6 B-12 Folic Acid Berry

KAL
<p>Active B12 and B6 pair with a substantial folic acid amount in a coherent formula at a higher serving cost. The quality-to-cost balance may improve on the original’s light GABA and L-theanine amounts plus duplicate high B12 entries, although synthetic folic acid is less preferred than methylfolate.</p>
74 Value

BX3

Pure Vegan
<p>Methylcobalamin, folic acid, B6, and trimethylglycine provide broad B-vitamin coverage in an oral spray at a higher serving cost. The quality-to-cost balance may improve on the original’s light GABA and L-theanine amounts plus duplicate high B12 entries, although basic folate and a very small trimethylglycine amount weaken the supporting formula.</p>
80 Value

B-Complex

Advanced Nutrition by Zahler
<p>Benfotiamine, pantethine, methylcobalamin, riboflavin phosphate, methylfolate, active B6, and choline provide excellent B-complex form quality at a higher serving cost. The quality-to-cost balance may improve on the original’s light GABA and L-theanine amounts plus duplicate high B12 entries, although the premium serving cost is only partly justified despite the coherent moderate dosing.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  2. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
    Zhang W; Yan Y; Wu Y; Yang H; Zhu P; Yan F; Zhao R; Tian P; Wang T; Fan Q; Su Z · Pharmacological research · 2022
    Meta-analysis29 participants29 studies pooledMood Support forTheanine
  3. Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
    Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zöllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM · Alcoholism, clinical and experimental research · 2022
    Randomized trial52 participantsCognitive Support forCholine
  4. Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis.
    Long C; Li Z; Feng H; Jiang Y; Pu Y; Tao J; Yue R · Frontiers in aging neuroscience · 2024
    Meta-analysis82,246 participants9 studies pooledCognitive Support forCholine
  5. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsCognitive Support Brain Health forTheanine
  6. A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood.
    Dodd FL; Kennedy DO; Riby LM; Haskell-Ramsay CF · Psychopharmacology · 2016
    Randomized trial24 participantsCognitive Support forTheanine
  7. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support forTheanine
  8. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health forTheanine
  9. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support forTheanine
  10. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Productivity Boost forTheanine
  11. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  12. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  13. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  14. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  15. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  16. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support forVitamin B12
  17. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  18. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  19. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  20. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  21. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  22. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  23. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  24. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support forVitamin B6
  25. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  26. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China.
    Ma F; Wu T; Zhao J; Han F; Marseglia A; Liu H; Huang G · The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Randomized trial180 participantsCognitive Support forFolate
  27. Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.
    Michelakos T; Kousoulis AA; Katsiardanis K; Dessypris N; Anastasiou A; Katsiardani KP; Kanavidis P; Stefanadis C; Papadopoulos FC; Petridou ET · Journal of aging and health · 2013
    Meta-analysis8,122 participants9 studies pooledCognitive Support forFolate
  28. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.
    Wang Z; Zhu W; Xing Y; Jia J; Tang Y · Nutrition reviews · 2022
    Meta-analysis46,175 participants95 studies pooledCognitive Support forFolate
  29. Homocysteine and folate as risk factors for dementia and Alzheimer disease.
    Ravaglia G; Forti P; Maioli F; Martelli M; Servadei L; Brunetti N; Porcellini E; Licastro F · The American journal of clinical nutrition · 2005
    Cohort study816 participantsCognitive Support forFolate
  30. Folate mediates cognitive impairment of aged people with periodontitis.
    Liu F; Liu Y; Feng Y; Zhao J; Wang M; Ye M; Zhang Y; Gan X; Pan Q; Shen J · Nutritional neuroscience · 2025
    Cross-sectional study1,966 participantsCognitive Support forFolate
  31. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  32. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support forTheanine
  33. Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India.
    Behere RV; Deshmukh AS; Otiv S; Gupte MD; Yajnik CS · Frontiers in endocrinology · 2021
    Systematic review46 studies pooledCognitive Support forVitamin B12
  34. Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial.
    Thomas S; Thomas T; Bosch RJ; Ramthal A; Bellinger DC; Kurpad AV; Duggan CP; Srinivasan K · Maternal and child health journal · 2019
    Randomized trial218 participantsCognitive Support forVitamin B12
  35. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsCognitive Support forVitamin B12
  36. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsCognitive Support forVitamin B12
  37. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsCognitive Support forVitamin B12
  38. Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia.
    Zhuo C; Xu Y; Wang H; Fang T; Chen J; Zhou C; Li Q; Liu J; Xu S; Yao C; Yang W; Yang A; Li B; Chen Y; Tian H; Lin C · Frontiers in psychiatry · 2021
    Randomized trial200 participantsCognitive Support forVitamin B6
  39. Associations between dietary B vitamin intakes and cognitive function among elderly individuals: An observational study.
    Chen Q; Huang J; Shi X; Peng Y; Chen A; Huang L; Zhang Y; Chen X · Nutrition (Burbank, Los Angeles County, Calif.) · 2025
    Cross-sectional study2,716 participantsCognitive Support forVitamin B6
  40. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsCognitive Support forVitamin B6
  41. Lower water-soluble vitamins and higher homocysteine are associated with neurodegenerative diseases.
    Zhang C; Hu Y; Cao X; Deng Y; Wang Y; Guan M; Wu X; Jiang H · Scientific reports · 2025
    Cohort study926 participantsCognitive Support forVitamin B6
  42. Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction.
    Gordon S; Hoey L; McNulty H; Keenan J; Pangilinan F; Brody LC; Ward M; Strain JJ; McAnena L; McCann A; Molloy AM; Cunningham C; McCarroll K; Hughes CF · BMC medicine · 2025
    Observational study4,553 participantsCognitive Support forVitamin B6
  43. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  44. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  45. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  46. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  47. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  48. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  49. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  50. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  51. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  52. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  53. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  54. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  55. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
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  59. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
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    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
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    Systematic review10,951 participants33 studies pooledMood Support forFolate
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    Borges-Vieira JG; Cardoso CKS · Nutritional neuroscience · 2023
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    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
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  69. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
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  72. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
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  73. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
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    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
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  75. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
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  76. Subjective well-being in older adults: folate and vitamin B12 independently predict positive affect.
    Edney LC; Burns NR; Danthiir V · The British journal of nutrition · 2016
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    Systematic review24 studies pooledMood Support forVitamin B12
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    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B12
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    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
  81. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsProductivity Boost forTheanine
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    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  83. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsProductivity Boost forTheanine