Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- A phase II trial of huperzine A in mild to moderate Alzheimer disease.
Rafii MS; Walsh S; Little JT; Behan K; Reynolds B; Ward C; Jin S; Thomas R; Aisen PS; Alzheimer's Disease Cooperative Study · Neurology · 2011
Randomized trial210 participantsflagCognitive Support forscienceHuperzine
- Huperzine A for vascular dementia.
Hao Z; Liu M; Liu Z; Lv D · The Cochrane database of systematic reviews · 2009
Systematic review14 participants1 studies pooledflagCognitive Support forscienceHuperzine
- Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis.
Zheng W; Xiang YQ; Li XB; Ungvari GS; Chiu HF; Sun F; D'Arcy C; Meng X; Xiang YT · Human psychopharmacology · 2017
Meta-analysis1,117 participants12 studies pooledflagCognitive Support forscienceHuperzine
- Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis.
Xing SH; Zhu CX; Zhang R; An L · Evidence-based complementary and alternative medicine : eCAM · 2014
Meta-analysis825 participants10 studies pooledflagCognitive Support flagBrain Health forscienceHuperzine
- Huperzine A associated with improved early postoperative cognitive function after neurosurgery under general anesthesia: a randomized clinical trial.
Zhang Z; Shen Y; Li J; Tang Y; Zhou P; Ying T; Mo R; Ru Z; Zhao G; Zhu J; Li S; Zhao H · International journal of surgery (London, England) · 2026
Randomized trial123 participantsflagCognitive Support flagBrain Health forscienceHuperzine
- [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial].
Zhang Z; Wang X; Chen Q; Shu L; Wang J; Shan G · Zhonghua yi xue za zhi · 2002
Randomized trial202 participantsflagCognitive Support flagBrain Health forscienceHuperzine
- Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis.
Wang BS; Wang H; Wei ZH; Song YY; Zhang L; Chen HZ · Journal of neural transmission (Vienna, Austria : 1996) · 2009
Meta-analysis4 studies pooledflagCognitive Support forscienceHuperzine
- Huperzine A for Alzheimer's disease.
Li J; Wu HM; Zhou RL; Liu GJ; Dong BR · The Cochrane database of systematic reviews · 2008
Meta-analysis454 participants6 studies pooledflagCognitive Support forscienceHuperzine
- The treatment of cognitive dysfunction in dementia: a multiple treatments meta-analysis.
Perng CH; Chang YC; Tzang RF · Psychopharmacology · 2019
Meta-analysis44,854 participants235 studies pooledflagCognitive Support forscienceHuperzine
- The effect of anti-dementia drugs on Alzheimer disease-induced cognitive impairment: A network meta-analysis.
Cui CC; Sun Y; Wang XY; Zhang Y; Xing Y · Medicine · 2019
Meta-analysis33 studies pooledflagCognitive Support forscienceHuperzine
- Acetyl-L-carnitine treatment in minimal hepatic encephalopathy.
Malaguarnera M; Gargante MP; Cristaldi E; Vacante M; Risino C; Cammalleri L; Pennisi G; Rampello L · Digestive diseases and sciences · 2008
Randomized trial125 participantsflagBrain Health flagCognitive Support forscienceAcetyl L-Carnitine
- Long-term acetyl-L-carnitine treatment in Alzheimer's disease.
Spagnoli A; Lucca U; Menasce G; Bandera L; Cizza G; Forloni G; Tettamanti M; Frattura L; Tiraboschi P; Comelli M · Neurology · 1991
Randomized trial130 participantsflagBrain Health flagCognitive Support forscienceAcetyl L-Carnitine
- Pharmaco-electroencephalographic and clinical effects of the cholinergic substance--acetyl-L-carnitine--in patients with organic brain syndrome.
Herrmann WM; Dietrich B; Hiersemenzel R · International journal of clinical pharmacology research · 1990
Randomized trialflagBrain Health forscienceAcetyl L-Carnitine
- Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial.
Malaguarnera M; Vacante M; Motta M; Giordano M; Malaguarnera G; Bella R; Nunnari G; Rampello L; Pennisi G · Metabolic brain disease · 2012
Randomized trial61 participantsflagBrain Health flagCognitive Support forscienceAcetyl L-Carnitine
- Acetyl-L-carnitine in the treatment of mildly demented elderly patients.
Passeri M; Cucinotta D; Bonati PA; Iannuccelli M; Parnetti L; Senin U · International journal of clinical pharmacology research · 1990
Randomized trial60 participantsflagBrain Health flagMental Focus forscienceAcetyl L-Carnitine
- Comparative effects of Bacopa monnieri and Ginkgo biloba on cognitive functions: A systematic review and network meta-analysis.
Tiemtad P; Ingkaninan K; Temkitthawon P; Thimkorn P; Rattanachaisit N; Teaktong T; Dhippayom T · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026
Meta-analysis2,107 participants29 studies pooledflagBrain Health flagMental Focus forscienceBacopa
- Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract.
Kongkeaw C; Dilokthornsakul P; Thanarangsarit P; Limpeanchob N; Norman Scholfield C · Journal of ethnopharmacology · 2014
Meta-analysis518 participants9 studies pooledflagBrain Health flagMental Focus flagProductivity Boost forscienceBacopa
- Comparative efficacy of Medhya Rasayana,Bacopa monnieri, and Centella asiatica in enhancing memory and IQ of 8-10 year-old healthy boys: A prakriti-based double-blind, randomized controlled trial.
Verma J; Rathi R; Anamika; Rathi B; Pandey VB · Journal of Ayurveda and integrative medicine · 2025
Randomized trial180 participantsflagBrain Health flagCognitive Support forscienceBacopa
- Plant-derived nootropics and human cognition: A systematic review.
Lorca C; Mulet M; Arévalo-Caro C; Sanchez MÁ; Perez A; Perrino M; Bach-Faig A; Aguilar-Martínez A; Vilella E; Gallart-Palau X; Serra A · Critical reviews in food science and nutrition · 2023
Systematic review256 studies pooledflagBrain Health forscienceBacopa
- The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of randomized controlled trials.
Feng X; Fan S; Wei F · Frontiers in pharmacology · 2026
Meta-analysis1,861 participants25 studies pooledflagBrain Health flagCognitive Support forscienceBacopa
- Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis.
Tan MS; Yu JT; Tan CC; Wang HF; Meng XF; Wang C; Jiang T; Zhu XC; Tan L · Journal of Alzheimer's disease : JAD · 2015
Meta-analysis2,561 participants9 studies pooledflagBrain Health forscienceGinkgo
- Efficacy of Ginkgo biloba extract EGb 761® in dementia with behavioural and psychological symptoms: A systematic review.
von Gunten A; Schlaefke S; Überla K · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2017
Meta-analysis1,628 participants4 studies pooledflagBrain Health flagCognitive Support forscienceGinkgo
- Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trials.
Riepe M; Hoerr R; Schlaefke S · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2025
Meta-analysis782 participants4 studies pooledflagBrain Health flagProductivity Boost forscienceGinkgo
- Ginkgo biloba extract EGb 761® improves cognition and overall condition after ischemic stroke: Results from a pilot randomized trial.
Cui M; You T; Zhao Y; Liu R; Guan Y; Liu J; Liu X; Wang X; Dong Q · Frontiers in pharmacology · 2023
Randomized trial201 participantsflagBrain Health flagProductivity Boost forscienceGinkgo
- Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg.
Herrschaft H; Nacu A; Likhachev S; Sholomov I; Hoerr R; Schlaefke S · Journal of psychiatric research · 2012
Randomized trial410 participantsflagBrain Health forscienceGinkgo
- Treatment with Huperzine A improves cognition in vascular dementia patients.
Xu ZQ; Liang XM; Juan-Wu; Zhang YF; Zhu CX; Jiang XJ · Cell biochemistry and biophysics · 2012
Randomized trial78 participantsflagBrain Health forscienceHuperzine
- Huperzine-A response to cognitive impairment and task switching deficits in patients with Alzheimer's disease.
Gul A; Bakht J; Mehmood F · Journal of the Chinese Medical Association : JCMA · 2019
Randomized trial100 participantsflagBrain Health forscienceHuperzine
- A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys.
Torrioli MG; Vernacotola S; Peruzzi L; Tabolacci E; Mila M; Militerni R; Musumeci S; Ramos FJ; Frontera M; Sorge G; Marzullo E; Romeo G; Vallee L; Veneselli E; Cocchi E; Garbarino E; Moscato U; Chiurazzi P; D'Iddio S; Calvani M; Neri G · American journal of medical genetics. Part A · 2008
Randomized trial63 participantsflagCognitive Support forscienceAcetyl L-Carnitine
- Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue.
Malaguarnera M; Gargante MP; Cristaldi E; Colonna V; Messano M; Koverech A; Neri S; Vacante M; Cammalleri L; Motta M · Archives of gerontology and geriatrics · 2008
Randomized trial96 participantsflagCognitive Support forscienceAcetyl L-Carnitine
- The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials.
Pase MP; Kean J; Sarris J; Neale C; Scholey AB; Stough C · Journal of alternative and complementary medicine (New York, N.Y.) · 2012
Systematic review6 studies pooledflagCognitive Support flagProductivity Boost forscienceBacopa
- A systematic review of the Ayurvedic medicinal herb Bacopa monnieri in child and adolescent populations.
Kean JD; Downey LA; Stough C · Complementary therapies in medicine · 2017
Systematic review5 studies pooledflagCognitive Support forscienceBacopa
- Efficacy of Standardized Extract of Bacopa monnieri (Bacognize®) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial.
Kumar N; Abichandani LG; Thawani V; Gharpure KJ; Naidu MU; Venkat Ramana G · Evidence-based complementary and alternative medicine : eCAM · 2024
Randomized trial60 participantsflagCognitive Support forscienceBacopa
- Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
De Jesus Moreno Moreno M · Clinical therapeutics · 2003
Randomized trial261 participantsflagCognitive Support forscienceCholine
- Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study.
Niu YY; Yan HY; Zhong JF; Diao ZQ; Li J; Li CP; Chen LH; Huang WQ; Xu M; Xu ZT; Liang XF; Li ZH; Liu D · The American journal of clinical nutrition · 2025
Cohort study125,594 participantsflagCognitive Support forscienceCholine
- Choline intake during pregnancy and child cognition at age 7 years.
Boeke CE; Gillman MW; Hughes MD; Rifas-Shiman SL; Villamor E; Oken E · American journal of epidemiology · 2013
Cohort study895 participantsflagCognitive Support forscienceCholine
- Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
Randomized trial36 participantsflagCognitive Support forscienceCholine
- Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zöllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM · Alcoholism, clinical and experimental research · 2022
Randomized trial52 participantsflagCognitive Support forscienceCholine
- Efficacy of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke: a predefined exploratory analysis of a multicenter, double-blind, randomized controlled trial.
Tian X; Xu Q; Xia X; Zhang Y; Meng X; Wang A · Journal of neurology · 2024
Randomized trial3,163 participantsflagCognitive Support forscienceGinkgo
- A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group.
Le Bars PL; Katz MM; Berman N; Itil TM; Freedman AM; Schatzberg AF · JAMA · 1997
Randomized trial309 participantsflagCognitive Support flagProductivity Boost forscienceGinkgo
- Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761. Findings from a randomized controlled trial.
Bachinskaya N; Hoerr R; Ihl R · Neuropsychiatric disease and treatment · 2011
Randomized trial410 participantsflagCognitive Support forscienceGinkgo
- Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial.
Ihl R; Bachinskaya N; Korczyn AD; Vakhapova V; Tribanek M; Hoerr R; Napryeyenko O; GOTADAY Study Group · International journal of geriatric psychiatry · 2013
Randomized trial410 participantsflagCognitive Support forscienceGinkgo
- [Drug evaluation of huperzine A in the treatment of senile memory disorders].
Zhang RW; Tang XC; Han YY; Sang GW; Zhang YD; Ma YX; Zhang CL; Yang RM · Zhongguo yao li xue bao = Acta pharmacologica Sinica · 1992
Randomized trial56 participantsflagCognitive Support forscienceHuperzine
- Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α 2b Plus Ribavirin: Effect on Work Performance; A Randomized Clinical Trial.
Malaguarnera G; Pennisi M; Gagliano C; Vacante M; Malaguarnera M; Salomone S; Drago F; Bertino G; Caraci F; Nunnari G; Malaguarnera M · Hepatitis monthly · 2014
Randomized trial62 participantsflagMental Focus flagProductivity Boost forscienceAcetyl L-Carnitine
- [Psycho-functional changes in attention and learning under the action of L-acetylcarnitine in 17 young subjects. A pilot study of its use in mental deterioration].
Lino A; Boccia MM; Rusconi AC; Bellomonte L; Cocuroccia B · La Clinica terapeutica · 1992
Non-randomized trial17 participantsflagMental Focus forscienceAcetyl L-Carnitine
- Acetyl-L-carnitine (ALC) in attention-deficit/hyperactivity disorder: a multi-site, placebo-controlled pilot trial.
Arnold LE; Amato A; Bozzolo H; Hollway J; Cook A; Ramadan Y; Crowl L; Zhang D; Thompson S; Testa G; Kliewer V; Wigal T; McBurnett K; Manos M · Journal of child and adolescent psychopharmacology · 2008
Randomized trial112 participantsflagMental Focus forscienceAcetyl L-Carnitine
- Acetyl-L-carnitine for patients with hepatic encephalopathy.
Martí-Carvajal AJ; Gluud C; Arevalo-Rodriguez I; Martí-Amarista CE · The Cochrane database of systematic reviews · 2019
Meta-analysis398 participants5 studies pooledflagMental Focus forscienceAcetyl L-Carnitine
- Evaluating the effects of Bacopa monnieri on cognitive performance and sleep quality of patients with mild cognitive impairment: A triple-blinded, randomized, placebo-controlled trial.
Delfan M; Kordestani-Moghaddam P; Gholami M; Kazemi K; Mohammadi R · Explore (New York, N.Y.) · 2024
Randomized trial62 participantsflagMental Focus forscienceBacopa
- Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modafinil: a review and comparison of effect sizes.
Neale C; Camfield D; Reay J; Stough C; Scholey A · British journal of clinical pharmacology · 2013
Systematic reviewflagMental Focus forscienceBacopa
- Efficiency of Different Supplements in Alleviating Symptoms of ADHD with or Without the Use of Stimulants: A Systematic Review.
Al Shahab S; Al Balushi R; Qambar A; Abdulla R; Qader M; Abdulla S; Jahrami H · Nutrients · 2025
Systematic reviewflagMental Focus forscienceBacopa
- Ginkgo biloba Extract EGb 761 in the Treatment of Patients with Mild Neurocognitive Impairment: A Systematic Review.
Hort J; Duning T; Hoerr R · Neuropsychiatric disease and treatment · 2023
Systematic review946 participants9 studies pooledflagMental Focus forscienceGinkgo
- Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia.
Kanowski S; Herrmann WM; Stephan K; Wierich W; Hörr R · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
Randomized trial216 participantsflagMental Focus forscienceGinkgo
- Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia.
Kanowski S; Herrmann WM; Stephan K; Wierich W; Hörr R · Pharmacopsychiatry · 1996
Randomized trial216 participantsflagMental Focus forscienceGinkgo
- Ginkgo biloba extract improved cognitive and neurological functions of acute ischaemic stroke: a randomised controlled trial.
Li S; Zhang X; Fang Q; Zhou J; Zhang M; Wang H; Chen Y; Xu B; Wu Y; Qian L; Xu Y · Stroke and vascular neurology · 2021
Randomized trial348 participantsflagMental Focus forscienceGinkgo
- Ginkgo biloba in the Aging Process: A Narrative Review.
Barbalho SM; Direito R; Laurindo LF; Marton LT; Guiguer EL; Goulart RA; Tofano RJ; Carvalho ACA; Flato UAP; Capelluppi Tofano VA; Detregiachi CRP; Bueno PCS; Girio RSJ; Araújo AC · Antioxidants (Basel, Switzerland) · 2024
Narrative review14 studies pooledflagMental Focus forscienceGinkgo
- Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial.
Calabrese C; Gregory WL; Leo M; Kraemer D; Bone K; Oken B · Journal of alternative and complementary medicine (New York, N.Y.) · 2009
Randomized trial54 participantsflagProductivity Boost forscienceBacopa
- Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial.
Stough C; Downey LA; Lloyd J; Silber B; Redman S; Hutchison C; Wesnes K; Nathan PJ · Phytotherapy research : PTR · 2009
Randomized trial107 participantsflagProductivity Boost forscienceBacopa
- An acute, double-blind, placebo-controlled crossover study of 320 mg and 640 mg doses of a special extract of Bacopa monnieri (CDRI 08) on sustained cognitive performance.
Downey LA; Kean J; Nemeh F; Lau A; Poll A; Gregory R; Murray M; Rourke J; Patak B; Pase MP; Zangara A; Lomas J; Scholey A; Stough C · Phytotherapy research : PTR · 2014
Randomized trial24 participantsflagProductivity Boost forscienceBacopa
- [Ginkgo biloba extract EGb 761 in the treatment of dementia: evidence of efficacy and tolerability].
Kasper S; Schubert H · Fortschritte der Neurologie-Psychiatrie · 2009
Meta-analysis10 studies pooledflagProductivity Boost forscienceGinkgo
- Dietary Flavonoids and Human Cognition: A Meta-Analysis.
Cheng N; Bell L; Lamport DJ; Williams CM · Molecular nutrition & food research · 2022
Meta-analysis5,519 participants80 studies pooledflagProductivity Boost forscienceGinkgo
- Limited cognitive benefits in Stage +2 postmenopausal women after 6 weeks of treatment with Ginkgo biloba.
Elsabagh S; Hartley DE; File SE · Journal of psychopharmacology (Oxford, England) · 2005
Randomized trial87 participantsflagProductivity Boost forscienceGinkgo
- Efficacy and safety of Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multi-center trial.
Gavrilova SI; Preuss UW; Wong JW; Hoerr R; Kaschel R; Bachinskaya N; GIMCIPlus Study Group · International journal of geriatric psychiatry · 2015
Randomized trial160 participantsflagProductivity Boost forscienceGinkgo
- Modulation of cognitive performance following single doses of 120 mg Ginkgo biloba extract administered to healthy young volunteers.
Kennedy DO; Jackson PA; Haskell CF; Scholey AB · Human psychopharmacology · 2008
Randomized trial78 participantsflagProductivity Boost forscienceGinkgo
- Effect of Huperzine A on Cognitive Function and Perception of Effort during Exercise: A Randomized Double-Blind Crossover Trial.
Wessinger CM; Inman CL; Weinstock J; Weiss EP · International journal of exercise science · 2025
Randomized trial15 participantsflagProductivity Boost forscienceHuperzine