Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Astaxanthin (AstaReal®) Improved Acute and Chronic Digital Eye Strain in Children: A Randomized Double-Blind Placebo-Controlled Trial.
Hecht KA; Marwah M; Wood V; Nishida Y; Bach AE; Gerson J; Hom MM; Schnackenberg J; Raote S; Srivastava S; Negi P; Caston E · Advances in therapy · 2025
Randomized trial64 participantsflagVision Support forscienceAstaxanthin
- Multinuclear MRS at 7T Uncovers Exercise Driven Differences in Skeletal Muscle Energy Metabolism Between Young and Seniors.
Krumpolec P; Klepochová R; Just I; Tušek Jelenc M; Frollo I; Ukropec J; Ukropcová B; Trattnig S; Krššák M; Valkovič L · Frontiers in physiology · 2021
Cross-sectional studyflagAnti-Aging forscienceCarnosine
- Nutritional Strategies Targeting Glucose Metabolism to Slow Cognitive Aging: A Scoping Review of Human Trials.
Fernando MG; Sullivan K; Simons M; Squillace A; Kiat H; Martins RN · The American journal of clinical nutrition · 2026
Scoping review32 studies pooledflagAnti-Aging forscienceCarnosine
- Sports and Kinetic Visual Acuity.
Sawaki K; Kohmura Y; Aoki K; Nakamura M; Murakami S; Suzuki Y · Juntendo Iji zasshi = Juntendo medical journal · 2024
Narrative reviewflagVision Support forscienceAstaxanthin
- Effects of diet containing astaxanthin on visual function in healthy individuals: a randomized, double-blind, placebo-controlled, parallel study.
Sekikawa T; Kizawa Y; Li Y; Miura N · Journal of clinical biochemistry and nutrition · 2023
Randomized trial60 participantsflagVision Support forscienceAstaxanthin
- Anserine/Carnosine Supplementation Preserves Blood Flow in the Prefrontal Brain of Elderly People Carrying APOE e4.
Ding Q; Tanigawa K; Kaneko J; Totsuka M; Katakura Y; Imabayashi E; Matsuda H; Hisatsune T · Aging and disease · 2020
Randomized trial68 participantsflagAnti-Aging forscienceCarnosine
- Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging.
Babizhayev MA; Deyev AI; Savel'yeva EL; Lankin VZ; Yegorov YE · The Journal of dermatological treatment · 2013
Randomized trial42 participantsflagAnti-Aging forscienceCarnosine
- Benefits and Safety of Astaxanthin in the Treatment of Mild-To-Moderate Dry Eye Disease.
Tian L; Wen Y; Li S; Zhang P; Wang Y; Wang J; Cao K; Du L; Wang N; Jie Y · Frontiers in nutrition · 2022
Single-arm trial60 participantsflagVision Support forscienceAstaxanthin
- Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
Martinez-Perez C; Oliveira AP · Nutrients · 2026
Systematic review9 studies pooledflagVision Support forscienceAstaxanthin
- Telomere Attrition in Human Lens Epithelial Cells Associated with Oxidative Stress Provide a New Therapeutic Target for the Treatment, Dissolving and Prevention of Cataract with N-Acetylcarnosine Lubricant Eye Drops. Kinetic, Pharmacological and Activity-Dependent Separation of Therapeutic Targeting: Transcorneal Penetration and Delivery of L-Carnosine in the Aqueous Humor and Hormone-Like Hypothalamic Antiaging Effects of the Instilled Ophthalmic Drug Through a Safe Eye Medication Technique.
Babizhayev MA; Yegorov YE · Recent patents on drug delivery & formulation · 2017
Narrative reviewflagAnti-Aging forscienceCarnosine
- Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential.
Kidd P · Alternative medicine review : a journal of clinical therapeutic · 2012
Narrative reviewflagVision Support flagAnti-Aging forscienceAstaxanthin
- Markers of Hypoxia and Oxidative Stress in Aging Volunteers Ingesting Lycosomal Formulation of Dark Chocolate Containing Astaxanthin.
Petyaev IM; Klochkov VA; Chalyk NE; Pristensky DV; Chernyshova MP; Kyle NH; Bashmakov YK · The journal of nutrition, health & aging · 2019
Randomized trial32 participantsflagAnti-Aging forscienceAstaxanthin
- The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity.
Phetcharat L; Wongsuphasawat K; Winther K · Clinical interventions in aging · 2016
Randomized trial34 participantsflagAnti-Aging flagSkin Health forscienceAstaxanthin
- Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing.
Zhou X; Cao Q; Orfila C; Zhao J; Zhang L · Nutrients · 2021
Meta-analysis11 studies pooledflagAnti-Aging forscienceAstaxanthin
- Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women.
Chupel MU; Minuzzi LG; Furtado GE; Santos ML; Ferreira JP; Filaire E; Teixeira AM · Amino acids · 2021
Randomized trial48 participantsflagAnti-Aging forscienceTaurine
- Taurine as a possible antiaging therapy: A controlled clinical trial on taurine antioxidant activity in women ages 55 to 70.
Abud GF; De Carvalho FG; Batitucci G; Travieso SG; Bueno Junior CR; Barbosa Junior F; Marchini JS; de Freitas EC · Nutrition (Burbank, Los Angeles County, Calif.) · 2022
Randomized trial24 participantsflagAnti-Aging forscienceTaurine
- Association of taurine intake with changes in physical fitness among community-dwelling middle-aged and older Japanese adults: an 8-year longitudinal study.
Domoto T; Kise K; Oyama Y; Furuya K; Kato Y; Nishita Y; Kozakai R; Otsuka R · Frontiers in nutrition · 2024
Cohort studyflagAnti-Aging forscienceTaurine
- The anti-inflammatory and antioxidant effects of astaxanthin as an adjunctive therapy in community-acquired pneumonia: a randomized controlled trial.
Youssef FM; Ateyya H; Hanna Samy AE; Elmokadem EM · Frontiers in pharmacology · 2025
Randomized trial80 participantsflagAnti-Inflammatory Support forscienceAstaxanthin
- The Role of Astaxanthin as an Antioxidant and Anti-Inflammatory Agent in Human Health: A Systematic Review.
Malcangi G; Inchingolo AM; Casamassima L; Trilli I; Ferrante L; Longo M; Inchingolo F; Marinelli G; Palermo A; Dipalma G; Inchingolo AD · International journal of molecular sciences · 2026
Systematic review15 studies pooledflagAnti-Inflammatory Support forscienceAstaxanthin
- Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial.
Rostami S; Alyasin A; Saedi M; Nekoonam S; Khodarahmian M; Moeini A; Amidi F · Frontiers in endocrinology · 2023
Randomized trial50 participantsflagAnti-Inflammatory Support forscienceAstaxanthin
- Astaxanthin Modulates Inflammation in Type 2 Diabetes via Regulation of microRNAs, Lysophosphatidylcholine, and α-Hydroxybutyrate.
Sharifi-Rigi A; Zal F; Aarabi MH; Dehghani M; Roustaei Rad N; Taghiyar S · International journal of endocrinology · 2025
Randomized trial50 participantsflagAnti-Inflammatory Support forscienceAstaxanthin
- Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes.
Basereh A; Khoramipour K; Hosseini N; HajHosseini M; Khodabakhshi A; Amirkhosravi L; Khoramipour K · Scientific reports · 2025
Randomized trial90 participantsflagAnti-Inflammatory Support forscienceAstaxanthin
- Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study.
Rosa FT; Freitas EC; Deminice R; Jordão AA; Marchini JS · European journal of nutrition · 2015
Randomized trial24 participantsflagAnti-Inflammatory Support forscienceTaurine
- Effect of taurine supplementation on preventing ventilator-associated pneumonia in pediatrics under mechanical ventilation, a randomized controlled double-blind clinical trial.
Shirzad-Yazdi N; Shorafa E; Abootalebi SN; Heidari R; Hojabri K; Doostfatemeh M; Masjedi F; Vazin A; Shafiekhani M · Frontiers in pediatrics · 2025
Randomized trial77 participantsflagAnti-Inflammatory Support forscienceTaurine
- Effect of taurine in muscle damage markers and inflammatory cytokines in running exercise.
Wang Y; Xu T; Zhao H; Gu C; Li Z · Frontiers in physiology · 2022
Non-randomized trial10 participantsflagAnti-Inflammatory Support forscienceTaurine
- Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women.
Chupel MU; Minuzzi LG; Furtado G; Santos ML; Hogervorst E; Filaire E; Teixeira AM · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2018
Randomized trial48 participantsflagAnti-Inflammatory Support forscienceTaurine
- Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure.
Ahmadian M; Roshan VD; Aslani E; Stannard SR · Therapeutic advances in cardiovascular disease · 2017
Randomized trialflagAnti-Inflammatory Support forscienceTaurine
- Astaxanthin, a natural antioxidant, lowers cholesterol and markers of cardiovascular risk in individuals with prediabetes and dyslipidaemia.
Ciaraldi TP; Boeder SC; Mudaliar SR; Giovannetti ER; Henry RR; Pettus JH · Diabetes, obesity & metabolism · 2023
Randomized trial34 participantsflagCardiovascular Support forscienceAstaxanthin
- Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
Wan S; Wu W; Zhang Y; He J; Wang X; An P; Luo J; Zhu Y; Luo Y · Nutrients · 2024
Meta-analysisflagCardiovascular Support forscienceAstaxanthin
- Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia.
Yoshida H; Yanai H; Ito K; Tomono Y; Koikeda T; Tsukahara H; Tada N · Atherosclerosis · 2010
Randomized trial61 participantsflagCardiovascular Support forscienceAstaxanthin
- Effects of Astaxanthin Supplementation on Glycemic Control and Lipid Profile in Patients With Prediabetes and Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials.
Molani-Gol R; Bohlouli Sardroudi S; Rafraf M · Nutrition and metabolic insights · 2026
Meta-analysis403 participants9 studies pooledflagCardiovascular Support forscienceAstaxanthin
- Astaxanthin Supplemented with High-Intensity Functional Training Decreases Adipokines Levels and Cardiovascular Risk Factors in Men with Obesity.
Saeidi A; Nouri-Habashi A; Razi O; Ataeinosrat A; Rahmani H; Mollabashi SS; Bagherzadeh-Rahmani B; Aghdam SM; Khalajzadeh L; Al Kiyumi MH; Hackney AC; Laher I; Heinrich KM; Zouhal H · Nutrients · 2023
Randomized trial68 participantsflagCardiovascular Support forscienceAstaxanthin
- Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study.
Sun Q; Wang B; Li Y; Sun F; Li P; Xia W; Zhou X; Li Q; Wang X; Chen J; Zeng X; Zhao Z; He H; Liu D; Zhu Z · Hypertension (Dallas, Tex. : 1979) · 2016
Randomized trial120 participantsflagCardiovascular Support forscienceTaurine
- Taurine ameliorates blood pressure and vascular function in patients with type 2 diabetes: Randomized, double-blind, placebo-controlled trial.
Li Y; Wang Q; Liu Y; Li Q; Xia W; Lin S; Yang Q; Scholze A; Zhao Z; He H; Zhang H; Yan Z; Tepel M; Mu H; Zhu Z; Liu D · iScience · 2025
Randomized trial165 participantsflagCardiovascular Support forscienceTaurine
- Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.
Tzang CC; Chi LY; Lin LH; Lin TY; Chang KV; Wu WT; Özçakar L · Nutrition & diabetes · 2024
Meta-analysis1,024 participants25 studies pooledflagCardiovascular Support forscienceTaurine
- Effects of Oral Taurine Supplementation on Cardiometabolic Risk Factors: A Meta-analysis and Systematic Review of Randomized Clinical Trials.
Nie Z; Liu Y; Zhang M; Wu C; Cao Q; Xu J; Zheng Y; Min Z; Zhang W; Han S · Nutrition reviews · 2025
Meta-analysis34 studies pooledflagCardiovascular Support forscienceTaurine
- The effects of taurine supplementation on glycemic control and serum lipid profile in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.
Maleki V; Alizadeh M; Esmaeili F; Mahdavi R · Amino acids · 2021
Randomized trial45 participantsflagCardiovascular Support forscienceTaurine
- The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial.
Ito N; Seki S; Ueda F · Nutrients · 2018
Randomized trial23 participantsflagSkin Health forscienceAstaxanthin
- Supplementating with dietary astaxanthin combined with collagen hydrolysate improves facial elasticity and decreases matrix metalloproteinase-1 and -12 expression: a comparative study with placebo.
Yoon HS; Cho HH; Cho S; Lee SR; Shin MH; Chung JH · Journal of medicinal food · 2015
Randomized trial44 participantsflagSkin Health forscienceAstaxanthin
- Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers.
Chalyk NE; Klochkov VA; Bandaletova TY; Kyle NH; Petyaev IM · Nutrition research (New York, N.Y.) · 2018
Single-arm trial31 participantsflagSkin Health forscienceAstaxanthin
- Cosmetic benefits of astaxanthin on humans subjects.
Tominaga K; Hongo N; Karato M; Yamashita E · Acta biochimica Polonica · 2012
Other66 participantsflagSkin Health forscienceAstaxanthin
- Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
Randomized trial23 participantsflagSkin Health forscienceVitamin C
- Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
Randomized trial149 participantsflagSkin Health forscienceVitamin C
- Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
Randomized trial25 participantsflagSkin Health forscienceVitamin C
- Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
Randomized trial16 participantsflagSkin Health forscienceVitamin C
- Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
Cross-sectional study4,025 participantsflagSkin Health forscienceVitamin C
- Effects of taurine supplementation on VDT work induced visual stress.
Zhang M; Bi LF; Ai YD; Yang LP; Wang HB; Liu ZY; Sekine M; Kagamimori S · Amino acids · 2005
Randomized trial25 participantsflagVision Support forscienceTaurine