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Calcium Magnesium Citrate

4.8
★ ★ ★ ★ ★
(3456 ratings)
Calcium 1000 mg
Magnesium 500 mg
Product Image
Score71
The larger package offers better value for meaningful citrate minerals, but magnesium oxide and a five-tablet serving still limit ease of use.
How scoring works
Tablet
Quantity:250 Tablet(s) • (50 servings)
Goals:
Bone Health
General Health
Energy
Digestive Health
Heart Health

Score 71

The larger package offers better value for meaningful citrate minerals, but magnesium oxide and a five-tablet serving still limit ease of use.
How scoring works
$22.40($0.44 per serving)
iHerb
$ 22.40
Vitacost
$ 24.13
Daily Vita
$ 26.40
Amazon
$ 47.98
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Analysis

One gram of calcium citrate provides meaningful bone-mineral support, with magnesium citrate adding a complementary form. The larger bottle materially improves serving value over the smaller size.

Magnesium oxide is part of the formula and is less absorbable than citrate. Repeated magnesium quantities make the proportion from each form unclear.

Five tablets are required for the full serving, so dividing them across the day may be more comfortable. High mineral exposure should be matched to actual dietary needs rather than taken automatically.

Who is it for
  • Regular users needing substantial calcium and magnesium
  • Value-focused buyers comfortable with tablets
Best for
  • Longer-term high-dose mineral support
  • Divided calcium-citrate supplementation

Pros

  • Provides one gram of calcium citrate
  • Includes magnesium citrate
  • Larger bottle improves value

Cons

  • Includes magnesium oxide
  • Five-tablet serving
  • Magnesium form proportions are unclear

Warnings

  • Substantial magnesium may cause loose stools or cramping
  • Check the one-gram calcium amount against food and other supplements
  • Separate calcium from thyroid hormone, bisphosphonates, and some antibiotics

Nutrient quality

66 High impact

Calcium citrate is a useful form, but magnesium oxide weakens the otherwise citrate-based mineral blend, and the 1,000 mg calcium amount is too concentrated for one sitting, and 500 mg magnesium is also aggressive for some users. The concentrated calcium and magnesium amounts may reduce absorption efficiency and digestive comfort, while calcium and magnesium form a coherent mineral-support combination without mismatched actives.

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Ingredient transparency

71 High impact

Total mineral amounts are shown, but repeated amounts across forms make each form contribution unclear, and no proprietary blend hides the amount of a listed core mineral. Serving count is supplied, but complete daily-use directions are not provided, while inactive ingredients and excipients are not included in the supplied label details.

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Customer satisfaction

75 High impact

The supplied average rating is strong, and substantial review volume gives the average rating useful credibility. Specific review themes are unavailable, so repeated negatives and real-world fit remain uncertain.

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Value for money

74 High impact

Mixed mineral forms and dosing trade-offs weaken formula value, and the moderate serving cost is reasonable for the disclosed minerals. The listed formula is focused and does not appear padded with low-value active ingredients, while the product is reasonably competitive but lacks a clear quality or value advantage.

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Goals

Bone Health
Impact
Highest effect
A Goal FitB+ Strength of SupportB CoverageB+ Formula Quality
Magnesium · 500 mgCalcium · 1000 mg

Calcium and magnesium are supplied at meaningful amounts for bone mineral support. Citrate improves the blend, but magnesium oxide lowers expected absorption compared with a fully chelated formula.

The two-mineral design is coherent and more useful than a single-mineral product. Missing vitamin D, vitamin K, and protein-matrix ingredients limit its pathway coverage.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
General Health
Impact
High effect
A Goal FitB- Strength of SupportC+ CoverageB Formula Quality
Magnesium · 500 mg

Calcium and magnesium provide well-established foundational support for muscle, nerve, bone, and energy-related functions. The clearly stated mineral amounts make the formula easier to assess for a known dietary gap.

Magnesium citrate offers moderate absorption, but the included oxide lowers the quality of the blend. The high mineral serving may also cause digestive upset in sensitive users and is more appropriate when the intake need is clear.

Study evidence
Magnesium Supportive 114 studies
Energy
Impact
High effect
A Goal FitB- Strength of SupportC CoverageB+ Formula Quality
Magnesium · 500 mg

Calcium and magnesium provide substantial support for skeletal, muscular, and metabolic functions. Citrate improves absorption potential, but magnesium oxide lowers the quality of the magnesium blend.

The mineral amounts are clearly stated and the calcium-to-magnesium balance is reasonable. A large tablet serving and the high magnesium amount may reduce convenience or cause gastrointestinal discomfort for some users.

Study evidence
Magnesium Supportive 4 studies
Digestive Health
Impact
High effect
B+ Goal FitC+ Strength of SupportD+ CoverageB- Formula Quality
Magnesium · 500 mg

Magnesium directly supports intestinal motility, while calcium is less relevant to digestive comfort. Magnesium citrate has established osmotic and smooth-muscle effects, though oxide is less useful for predictable absorption.

The 500 mg magnesium amount is substantial and may promote stool softening, but it exceeds a moderate supplemental intake. Citrate is a useful form, while magnesium oxide lowers form quality despite clear label amounts. A 500 mg supplemental magnesium serving may cause diarrhea or abdominal cramping, especially in sensitive users.

Study evidence
Magnesium Supportive 50 studies
Heart Health
Impact
High effect
B- Goal FitB Strength of SupportC- CoverageC+ Formula Quality
Magnesium · 500 mg

Magnesium provides relevant support for heart rhythm, vascular tone, and blood-pressure regulation. The 500 mg amount is substantial, but part of it comes from magnesium oxide and the form-specific shares are not clear.

A 1,000 mg calcium amount makes this more of a bone-mineral formula than a focused cardiovascular product. The five-tablet serving is burdensome, and the magnesium amount may cause loose stools or abdominal discomfort in sensitive users.

Study evidence
Magnesium Supportive 158 studies
Stress Relief
Impact
Moderate effect
C+ Goal FitC+ Strength of SupportD+ CoverageC Formula Quality
Magnesium · 500 mg

Magnesium provides relevant foundational support for nervous-system regulation and may help with stress-related tension. The disclosed amount appears substantial enough to contribute meaningfully.

Citrate offers moderate absorption, while included oxide weakens the mineral blend. Added calcium contributes little direct stress support and makes the formula less focused.

Study evidence
Magnesium Supportive 13 studies

Ingredients

IngredientAmount per serving
Calcium (Calcium Citrate)
1000 mg
Magnesium (Magnesium Citrate, Magnesium Oxide)
500 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Vegetarian
Report overview
A- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB+ Value

A citrate source supports reliable absorption, but the 1,000 mg serving is too high for optimal one-time uptake. Five tablets make dose splitting possible but reduce convenience. Cost efficiency is good for the form.

F Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

The label clearly states magnesium, but the blend combines moderately absorbed citrate with poorly absorbed oxide. The elemental amount is just above the preferred range, and the calcium level stays at the stated competition threshold. Value remains limited because the mixed source does not provide premium chelation.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta-analysis.
    Tihtonen K; Korhonen P; Isojärvi J; Ojala R; Ashorn U; Ashorn P; Tammela O · Annals of the New York Academy of Sciences · 2022
    Meta-analysis1,566 participants7 studies pooledBone Health forCalcium
  2. Calcium supplementation and bone mineral density in postmenopausal women using estrogen replacement therapy.
    Haines CJ; Chung TK; Leung PC; Hsu SY; Leung DH · Bone · 1995
    Randomized trialBone Health forCalcium
  3. Bone turnover and the response to alendronate treatment in postmenopausal osteoporosis.
    Gonnelli S; Cepollaro C; Pondrelli C; Martini S; Montagnani A; Monaco R; Gennari C · Calcified tissue international · 1999
    Randomized trial100 participantsBone Health forCalcium
  4. Associations of dietary calcium intake with metabolic syndrome and bone mineral density among the Korean population: KNHANES 2008-2011.
    Kim MK; Chon SJ; Noe EB; Roh YH; Yun BH; Cho S; Choi YS; Lee BS; Seo SK · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Cross-sectional study14,705 participantsBone Health forCalcium
  5. Treatment with alendronate plus calcium, alendronate alone, or calcium alone for postmenopausal low bone mineral density.
    Bonnick S; Broy S; Kaiser F; Teutsch C; Rosenberg E; DeLucca P; Melton M · Current medical research and opinion · 2007
    Randomized trial701 participantsBone Health forCalcium
  6. Calcium and osteoporosis.
    Nordin BE · Nutrition (Burbank, Los Angeles County, Calif.) · 1998
    Meta-analysis20 studies pooledBone Health forCalcium
  7. Dietary calcium intake protects women consuming oral contraceptives from spine and hip bone loss.
    Teegarden D; Legowski P; Gunther CW; McCabe GP; Peacock M; Lyle RM · The Journal of clinical endocrinology and metabolism · 2005
    Randomized trial154 participantsBone Health forCalcium
  8. Relationship between bone mineral density changes and risk of fractures among patients receiving calcium with or without vitamin D supplementation: a meta-regression.
    Rabenda V; Bruyère O; Reginster JY · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011
    Meta-analysis47,365 participants15 studies pooledBone Health forCalcium
  9. Calcium supplementation provides an extended window of opportunity for bone mass accretion after menarche.
    Rozen GS; Rennert G; Dodiuk-Gad RP; Rennert HS; Ish-Shalom N; Diab G; Raz B; Ish-Shalom S · The American journal of clinical nutrition · 2003
    Randomized trial100 participantsBone Health forCalcium
  10. Effect of milk and calcium supplementation on bone density and bone turnover in pregnant Chinese women: a randomized controlled trail.
    Liu Z; Qiu L; Chen YM; Su YX · Archives of gynecology and obstetrics · 2011
    Randomized trial36 participantsBone Health forCalcium
  11. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  12. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  13. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  14. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  15. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  16. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  17. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  18. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  19. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  20. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  21. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  22. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  23. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  24. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  25. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  26. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  27. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  28. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  29. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  30. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  31. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  32. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  33. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  34. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  35. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  36. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  37. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  38. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  39. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  40. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  41. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  42. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  43. Predictive Model of Nail Consistency Using Scanning Electron Microscopy with Energy-Dispersive X-Ray.
    Mingorance Álvarez E; Martínez Quintana R; Pérez Pico AM; Mayordomo R · Biology · 2021
    Cross-sectional study57 participantsNail Health forCalcium
  44. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  45. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  46. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  47. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  48. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium