D3 10000 + K

D3 10000 + K

Metagenics4.8 (334 ratings)
Format:Softgel Quantity: 60 Softgel(s) · 60 servings
Goals
$31.95 $0.53 per serving
Pure FormulasLowest$31.95 Buy
iHerb$32.95 Buy

About this product

MK-7 and vitamin D3 form a coherent calcium-management pair, while vitamin K1 adds normal clotting support. Softgel delivery suits all three fat-soluble nutrients.

The MK-7 amount is practical, but the vitamin D3 amount is far above typical daily maintenance. No calcium or magnesium is included, so the formula focuses on regulators rather than structural bone material.

The product fits only adults with a clinician-supported reason for very high vitamin D3. It should not be treated as an ordinary daily D3 and K supplement.

Who is it for
  • Adults with a monitored high-vitamin-D plan
  • Users wanting MK-7 in a softgel
  • People needing combined K1 and K2
Best for
  • Clinician-guided vitamin D repletion
  • Calcium-regulation cofactors
  • Focused bone-support protocols

Pros

  • Meaningful MK-7 amount
  • Softgel supports absorption
  • K1 and K2 are separately disclosed

Cons

  • Vitamin D3 is far above routine maintenance
  • No structural minerals
  • Generic MK-7 source

Warnings

  • Very high vitamin D3 can cause excessive blood calcium and kidney problems with prolonged unsupervised use
  • Use regularly only with appropriate vitamin D and calcium monitoring
  • K1 and MK-7 can oppose warfarin and related vitamin K antagonist medicines
  • Account for vitamin D from every other supplement

Product analysis

70 out of 100
A well-delivered K1, MK-7, and D3 formula whose very high vitamin D amount requires documented need and monitoring.

AI assessment of the formula, label and price. How scoring works

Nutrient quality75

Vitamin D3, vitamin K1, and menaquinone-7 are clearly identified usable forms, and vitamin K is meaningful, while vitamin D3 is far above a routine maintenance amount. Vitamin D3 exceeds the adult upper limit and may raise calcium levels with sustained use, while the focused formula avoids low-value active extras.

Ingredient transparency81

Specific amounts are listed for every supplied active ingredient. No proprietary blend hides active doses, while capsule, softgel, or tablet excipients are not included in the supplied details.

Customer satisfaction69

The supplied aggregate satisfaction metric is very strong, and the feedback volume is sufficient for a reasonably stable aggregate metric. No review excerpts were provided, so recurring complaints and purpose-specific experiences cannot be checked.

Value for money48

Useful forms are offset by a vitamin D amount that is too aggressive for routine use. The serving is moderately costly and supplies more vitamin D than most users need, while the formula avoids unnecessary extras.

Format
Softgel
Container
60 Softgel(s)
Per serving
$0.53
Customer rating
4.8 · 334 ratings
Report analysis

Goals

Heart Health
Heart Health
Impact
Highest effect
B+ Goal FitA Strength of SupportC CoverageA Formula Quality
Vitamin K · 90 mcgVitamin D · 250 mcg

Vitamin K2 as MK-7 and vitamin D3 create a strong calcium-management pairing relevant to arterial health. The 90 mcg MK-7 amount is meaningful, but the 250 mcg vitamin D amount is unusually high for routine daily use.

Added vitamin K1 supports clotting rather than broadening cardiovascular mechanisms substantially. Long-term use of the high vitamin D3 amount can raise calcium levels, while both K1 and MK-7 directly oppose warfarin and related vitamin K antagonists.

Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
Bone Health
Bone Health
Impact
High effect
B+ Goal FitB+ Strength of SupportC- CoverageA+ Formula Quality
Vitamin K · 90 mcgVitamin D · 250 mcg

Vitamin D3 and MK-7 support calcium absorption and bone-directed calcium proteins, giving the formula strong regulator coverage. It does not supply calcium, magnesium, or protein-matrix material.

The 10,000 IU D3 amount is too high for routine long-term use without documented need and monitoring because it may cause excessive calcium and kidney problems. MK-7 can also oppose warfarin and other vitamin-K-antagonist anticoagulants.

Study evidence
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B Goal FitC Strength of SupportD+ CoverageA Formula Quality
Vitamin K · 90 mcgVitamin D · 250 mcg

Vitamin D3 and MK-7 form a coherent calcium-management pair with plausible relevance to arterial health. Vitamin K1 adds clotting support but does not strengthen the arterial rationale as much as more K2 would.

The softgel supports absorption and the 90 mcg MK-7 amount is meaningful, while 250 mcg vitamin D3 is far above the usual adult daily upper intake level. The high vitamin D3 amount can raise calcium levels with prolonged unsupervised use, and both K forms can alter warfarin response.

Study evidence
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per servingScore
Vitamin D (Cholecalciferol)
 250 mcg —
Vitamin K (Phytonadione)
 20 mcg 91
Menaquinone-7
90 mcg 91
Gluten Free Adults 18–50
Report overview
Vitamin K (Phytonadione) · 20 mcg OverallScore91
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

The combination provides a clinically aligned MK-7 amount alongside clearly separated vitamin K1 and vitamin D3. Softgel delivery supports absorption of these fat-soluble vitamins. The dose and cost are well balanced, although no branded or all-trans MK-7 source is named.

View ingredientView products
Loading alternative details
86 Performance

Vitamin K2 100 mcg + Vitamin D3 125 mcg

Nutricost
Compared with 250 mcg of vitamin D3 with 90 mcg of MK-7 vitamin K2, the alternative provides 125 mcg of vitamin D3 with 100 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger overall quality. Vitamin K2 can interfere with warfarin-type anticoagulants.
80 Performance

Vitamin D3 + K2

SportsResearch
Compared with 250 mcg of vitamin D3 with 90 mcg of MK-7 vitamin K2, the alternative provides 125 mcg of vitamin D3 with 100 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Vitamin K2 can interfere with warfarin-type anticoagulants.
87 Performance

Vitamin D3 25 mcg (1000 IU) & K2 120 mcg

Natural Factors
Compared with 250 mcg of vitamin D3 with 90 mcg of MK-7 vitamin K2, the alternative provides 25 mcg of vitamin D3 with 120 mcg of MK-7 vitamin K2, and the supplied analysis indicates stronger alignment with the Vitamin K collection. Duplicate K2 source entries create minor label ambiguity, though the softgel and strong value are practical strengths.
88 Budget

Vitamin K2 MK-7 100 mcg

Nutricost
The supplied serving cost is lower, while the formula provides 100 mcg of MK-7 vitamin K2. Vitamin K2 can interfere with warfarin-type anticoagulants.
89 Budget

Mega D-3 5000 IU & MK-7 180 mcg

NOW
The supplied serving cost is lower, while the formula provides 125 mcg of vitamin D3 with 180 mcg of MK-7 vitamin K2. High vitamin D remains the main dosing limitation, while the dry capsule lacks stated fat-intake guidance.
85 Budget

Vitamin K2 MenaQ7 100 mcg

AN Amazing Nutrition Amazing Formulas
The supplied serving cost is lower, while the formula provides vitamin k2. Its vitamin K can counteract warfarin and related vitamin K antagonists, so people using those medicines need clinician-directed intake.
86 Value

Vitamins D3 2500 IU (62.5 mcg) & K2 120 mcg

NaturesPlus
62.5 mcg of vitamin D3 with 120 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Its dry tablet lacks a lipid carrier, and MK-7 requires consistent intake for people using warfarin.
88 Value

D3 + K2 Green Apple

EZ Melts
125 mcg of vitamin D3 with 120 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. High vitamin D and absent fat-based delivery guidance are the main limitations, while value is favorable.
87 Value

MK-7 Vitamin K-2 100 mcg

NOW
100 mcg of MK-7 vitamin K2 offers a practical value trade-off because the supplied serving cost is lower and the value analysis is stronger. Its vitamin K can oppose warfarin and related vitamin-K-antagonist anticoagulants, so the product is not suitable for unsupervised use with those medicines.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  3. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  4. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  5. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  6. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  7. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  8. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  9. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  10. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  11. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  12. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  13. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  14. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  15. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  16. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  17. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  18. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsHeart Health forVitamin D
  19. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  20. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  21. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forVitamin D
  22. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K