B-12 5000 mcg
21st Century
B-12 5000 mcg
4.7
★ ★ ★ ★ ★
(2421 ratings)
Vitamin B12 5000 mcg
Score 75.0
A high-dose (5000 mcg) cyanocobalamin B12 tablet that is very affordable, providing good general support despite using the synthetic B12 form.
Quantity: 110 Tablet(s)Servings size: 1 Tablet(s) (110 servings)
Selected goals:
Other goals:
Energy
Brain Health
Mood Support
Cognitive Support
Metabolism Boost
leaderboard Score 75.0
A high-dose (5000 mcg) cyanocobalamin B12 tablet that is very affordable, providing good general support despite using the synthetic B12 form.
insights Analysis
This 21st Century product offers a very high dose of Vitamin B12 (5000 mcg) at an exceptionally low price, making it a budget-friendly option for those seeking a potent B12 supplement. While the high dosage is certainly advantageous for the stated goals of energy, brain health, and mood support, it uses cyanocobalamin, the synthetic form. Although many people can convert cyanocobalamin effectively, it is not the most bioavailable form and may be less efficient for individuals with methylation issues. Its popularity suggests widespread acceptance despite the form.
- Very high dosage (5000 mcg) provides strong B12 support.
- Extremely affordable price per serving for such a high dose.
- High review count indicates widespread acceptance and effectiveness for many users.
- Uses cyanocobalamin, a synthetic form that requires conversion in the body.
- Tablet form offers standard absorption, not enhanced.
- Individuals with impaired methylation pathways might find methylcobalamin to be a more effective form for optimal utilization.
$8.47($0.07 per serving)
 Pure Formulas | $ 8.47 | |
 iHerb | $ 12.49 | |
 Amazon | $ 12.49 |
bolt Effectiveness for goals
Vitamin B12 is crucial for red blood cell formation, DNA synthesis, and proper neurological function. It helps maintain the health of nerve cells and supports the metabolism of every cell in the human body. Adequate intake is essential for overall health and well-being.
Vitamin B12 is vital for cellular energy production. However, supplementation primarily increases energy in individuals who are deficient in Vitamin B12. For those with adequate levels, there is limited evidence to suggest it provides an additional energy boost.
Vitamin B12 supplementation is highly effective in treating and preventing B12 deficiency. It can reverse many deficiency symptoms, such as anemia and neurological issues, especially when started promptly. The specific form and dosage depend on the individual's condition and the cause of the deficiency.
Vitamin B12 plays an important role in brain health and nerve function. In individuals with a B12 deficiency, supplementation can improve memory and cognitive issues. However, for people with sufficient B12 levels, there is limited evidence that supplements enhance cognitive abilities.
Yes, Vitamin B12 is essential for maintaining the myelin sheath that protects nerves and for synthesizing neurotransmitters. Deficiency can lead to neurological damage, including tingling, numbness, and difficulty with coordination. Supplementation helps prevent or reverse these issues in deficient individuals.
schedule Dosage, timing & forms
The recommended daily allowance (RDA) for adults is 2.4 mcg, but supplemental dosages can vary widely. For addressing deficiencies or maintaining levels in specific populations, daily dosages often range from 250 mcg to 1000 mcg or more. Higher doses are generally well-tolerated due to B12's low toxicity.
Vitamin B12 supplements are commonly available as cyanocobalamin, methylcobalamin, adenosylcobalamin, and hydroxocobalamin. Cyanocobalamin is a synthetic form, while methylcobalamin and adenosylcobalamin are natural, active forms found in the body. The choice of form may depend on individual needs or preferences.
Vitamin B12 is a water-soluble vitamin, meaning that excess amounts are generally excreted in the urine, making toxicity rare. No Upper Tolerable Intake Level (UL) has been established for Vitamin B12 due to its extremely low potential for harm. However, it is always advisable to follow recommended dosages or consult with a healthcare provider for very high doses.
There is no universally 'best' time to take Vitamin B12, as it can be taken effectively at any time of day. Some suggest taking it in the morning on an empty stomach for optimal absorption, while others find taking it with food helps prevent minor stomach upset. Consistency in taking the supplement is generally more important than the specific timing.
Yes, specific populations often have different Vitamin B12 requirements or dosage recommendations. Vegetarians and vegans, for example, typically require supplementation due to the lack of dietary B12 sources. Older adults and individuals with certain gastrointestinal conditions may also need higher doses due to age-related malabsorption or specific medical conditions.
health_and_safety Safety & interactions
Yes, certain medications can interact with Vitamin B12 absorption or metabolism. These include metformin, proton pump inhibitors (PPIs), H2-receptor antagonists, and some antibiotics. Individuals taking such medications should discuss B12 supplementation with their healthcare provider.
Vitamin B12 is generally considered safe, even at higher doses, because it is a water-soluble vitamin. Excess amounts are typically excreted through urine, minimizing accumulation. However, it is always advisable to consult a healthcare professional before starting any new supplement.
Side effects from Vitamin B12 supplementation are rare, especially with oral forms. Mild gastrointestinal upset or skin reactions have been reported in some individuals. Serious adverse effects are highly uncommon.
Vitamin B12 has a low potential for toxicity because it is a water-soluble vitamin. There is no established upper intake level, as excess amounts are generally excreted without adverse effects. However, extremely high doses without medical supervision are not typically recommended.
Adequate Vitamin B12 is crucial for maternal and infant health during pregnancy and breastfeeding. Supplementation is generally considered safe and is often recommended, particularly for individuals with dietary restrictions. Discuss appropriate dosages with a healthcare professional.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B12 | 5000 mcg |
Categories
Vitamin B12 75.0
As a Vitamin B12 product, it offers a very high dose at an attractive price, making it a good option for general supplementation, though the use of cyanocobalamin positions it below products with active B12 forms.
Goals
Metabolism Boost 80.0
The high dose effectively supports metabolic pathways where B12 is needed for energy production, even if it's cyanocobalamin, as the body can still convert a significant amount for metabolic processes.
Energy 78.0
The 5000 mcg dosage is very strong for energy support. However, being cyanocobalamin means it might take longer for the body to convert and utilize compared to methylcobalamin, potentially offering a slightly less immediate or potent 'boost' for some.
Brain Health 78.0
The high dose provides ample B12 for brain processes, but the conversion step required for cyanocobalamin means it's not as directly available as methylcobalamin for optimal neurological support and function.
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