Product Image

Prostate Defense 320 mg Saw Palmetto

Applied Nutrition
4.5
★ ★ ★ ★ ★
(203 ratings)
Saw Palmetto 320 mg
Lycopene 10 mg
Selenium 200 mcg
Fish Oil 320 mg
Product Image
Score60
A coherent prostate blend led by saw palmetto, pygeum, beta-sitosterol, pumpkin seed oil, and lycopene. Missing extract standardization and omega-3 details are the main limitations.
How scoring works
Quantity:50 Liquid(s) • (25 servings)
Goals:
Hair Health
Skin Health
Immunity

Score 60

A coherent prostate blend led by saw palmetto, pygeum, beta-sitosterol, pumpkin seed oil, and lycopene. Missing extract standardization and omega-3 details are the main limitations.
How scoring works
$14.99($0.59 per serving)
iHerb
$ 14.99
Report prices

Analysis

Saw palmetto reaches a commonly used extract amount, while pygeum, beta-sitosterol, pumpkin seed oil, and lycopene provide complementary prostate-oriented pathways. Oil-based delivery should also support lycopene absorption.

The saw palmetto fatty-acid content is not standardized, and the fish oil does not disclose EPA or DHA. Several urinary botanicals have no usable individual amounts, making that part of the formula impossible to judge.

The product best fits adult men seeking a combined prostate formula rather than a general multivitamin. Hair-related overlap is plausible, but cardiovascular and immune benefits are secondary and poorly developed.

Who is it for
  • Adult men seeking prostate-focused nutrients
  • Users wanting saw palmetto with beta-sitosterol and pygeum
  • People comfortable with a liquid softgel
Best for
  • Prostate-focused botanical support
  • Saw palmetto intake
  • Lycopene delivered with oils

Pros

  • Saw palmetto reaches 320 mg
  • Includes pygeum and beta-sitosterol
  • Oil matrix supports lycopene absorption

Cons

  • Saw palmetto fatty-acid standardization is missing
  • EPA and DHA are not disclosed
  • Urinary blend lacks individual amounts

Warnings

  • Saw palmetto may be unsuitable during pregnancy or with hormone-sensitive therapy without clinical guidance.
  • Uva-ursi and juniper in the poorly quantified urinary blend make long-term unsupervised use difficult to assess.
  • Fish oil makes the product unsuitable for people with fish allergy.

Nutrient quality

67 High impact

Saw palmetto, pygeum, beta-sitosterol, and lycopene are meaningfully dosed, but fish oil and the urinary complex are difficult to assess. Selenium at 200 mcg is relatively high, while hidden urinary-tract ingredients prevent a full safety check.

Ingredient transparency

44 Lower impact

Most main actives have amounts, but several form-only entries are null and urinary herbs lack doses. The urinary-tract complex hides the amounts of juniper, uva-ursi, buchu, and cranberry.

Customer satisfaction

66 High impact

The strong rating is supported by a moderate review base. No review text is available to assess recurring complaints or firsthand results.

Value for money

68 High impact

Several substantive prostate-support doses provide fair quality for the cost. Serving value is reasonable, though fish-oil and urinary-complex contents remain unclear.

Report analysis

Goals

Hair Health
Impact
High effect
B- Goal FitB- Strength of SupportC+ CoverageB- Formula Quality
Zinc · 10 mg

Saw palmetto extract at 320 mg directly addresses androgen-related follicle signaling, while zinc, selenium, beta-sitosterol, pumpkin seed oil, and lycopene add complementary pathways. The saw palmetto amount is appropriate, although fatty-acid standardization and purity are not fully disclosed.

The formula is designed for prostate health but has a credible overlap with hormonally influenced hair thinning. The urinary-tract blend is unrelated to hair, and saw palmetto may not suit pregnancy or people using hormone-sensitive therapies without clinical guidance.

Study evidence
Saw Palmetto Supportive 5 studies
Selenium Disputed 7 studies
Zinc Supportive 22 studies
Skin Health
Impact
High effect
B- Goal FitB Strength of SupportC+ CoverageD Formula Quality
Zinc · 10 mgSelenium · 200 mcgLycopene · 10 mg

Lycopene reaches a useful amount and is delivered with oils that can support carotenoid absorption. Zinc, selenium, and fish oil add repair, antioxidant, and limited barrier-related support.

The formula is designed for prostate health rather than skin, so its skin pathways are incidental. Saw palmetto and most supporting botanicals do not strengthen the selected goal.

Study evidence
Lycopene Supportive 20 studies
Selenium Supportive 22 studies
Zinc Supportive 66 studies
Immunity
Impact
Moderate effect
D+ Goal FitB- Strength of SupportD- CoverageF Formula Quality
Zinc · 10 mgSelenium · 200 mcg

Zinc citrate and selenium provide a limited immune-related nutrient base. Selenium reaches a meaningful amount, while zinc remains below the rubric’s preferred threshold.

Most of the formula is designed for prostate and urinary support rather than immunity. A partly disclosed urinary blend and several unrelated botanicals therefore weaken goal fit and formulation focus.

Study evidence
Selenium Mixed 37 studies
Zinc Supportive 73 studies

Ingredients

IngredientAmount per serving
Zinc
10 mg
Selenium
200 mcg
Fish Oil
320 mg
Saw Palmetto extract
320 mg
Pygeum extract
100 mg
Beta Sitosterol
60 mg
Pumpkin seed Oil
50 mg
Lycopene
10 mg
Urinary Tract Complex
50 mg
Juniper berry powder
0 NP
Uva-Ursi powder
0 NP
Buchu powder
0 NP
Cranberry (Vaccinium macrocarpon) juice powder
0 NP
Adults 18–50
Report overview
Saw Palmetto · 320 mg OverallScore60
D Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyC Value

The oil-compatible format supports absorption, but extract standardization and purity details are incomplete. The daily amount matches the established extract target. The serving cost is reasonable when the delivery format and broader formula are considered.

Lycopene · 10 mg OverallScore56
D- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value

The lycopene source is unspecified, but liquid softgels with fish and pumpkin seed oils provide an excellent absorption matrix. The amount is well aligned with targeted prostate and antioxidant support. Cost efficiency is weak, although the formula also supplies several prostate-focused ingredients.

Selenium · 200 mcg OverallScore46
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The serving provides the standard 200 mcg selenium amount with a strong safety margin. Its chemical form is completely undisclosed, however, so quality and likely retention cannot be determined.

The combination formula is relatively costly when standardized to selenium alone. Saw palmetto and other actives may be the main reasons to choose it, not selenium form quality.

Loading alternative details
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin D, Marine n-3 Fatty Acids, and Primary Prevention of Cardiovascular Disease Current Evidence.
    Manson JE; Bassuk SS; Cook NR; Lee IM; Mora S; Albert CM; Buring JE; VITAL Research Group · Circulation research · 2020
    Randomized trial25,871 participantsCardiovascular Support forFish Oil
  2. The Safety and Efficacy of a Proprietary Bioactive Fatty Acids Extract From Saw Palmetto (Serenoa repens) for Promoting Hair Growth and Reducing Hair Loss in Adults With Self-Perceived Thinning Hair: 90-Day Results.
    Ablon G · Journal of cosmetic dermatology · 2025
    Randomized trial60 participantsHair Health forSaw Palmetto
  3. Marine n-3 fatty acid treatment for carotid plaques in patients with type 2 diabetes.
    Zhuang P; Liu X; Jia W; Zheng W; Wan X; Chen W; Gu J; Li Y; Lan X; Li H; Tong W; Wu Y; Wu X; Ao Y; Ye H; Wu F; Zhu L; Zhang L; Li Y; Meng D; Tian Y; Wang A; Wu S; Zhu F; Zhang Y; Shi H; Yu X; Zhang F; Zhang Y; Jiao J · Cardiovascular diabetology · 2026
    Randomized trial415 participantsCardiovascular Support forFish Oil
  4. Effects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.
    Zhou L; Zhu W; Chen Y · Frontiers in nutrition · 2026
    Meta-analysis1,658 participants19 studies pooledHair Health forSaw Palmetto
  5. Fish oil, enriched with polyunsaturated fatty acids of the omega-3-type accelerates the nucleation time in healthy subjects.
    Janowitz P; Swobodnik W; Wechsler JG; Janowitz A; Saal D; Ditschuneit H · Klinische Wochenschrift · 1991
    Non-randomized trial24 participantsCardiovascular Support forFish Oil
  6. The Safety and Efficacy of a Novel Saw Palmetto (Serenoa repens) Extract for Promoting Hair Growth in Adults With Self-Perceived Thinning Hair: 180-Day Results.
    Ablon G · Journal of cosmetic dermatology · 2026
    Randomized trial60 participantsHair Health forSaw Palmetto
  7. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  8. Beyond Minoxidil: Off-Label Therapies for Male Androgenetic Alopecia-A Systematic Review with Network Meta-Analyses.
    Gupta AK; Compton SAH; Liddy A; Talukder M; Wang T; Bamimore MA · Medicina (Kaunas, Lithuania) · 2026
    Meta-analysis50 participants23 studies pooledHair Health forSaw Palmetto
  9. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  10. Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study.
    Rossi A; Mari E; Scarno M; Garelli V; Maxia C; Scali E; Iorio A; Carlesimo M · International journal of immunopathology and pharmacology · 2013
    Non-randomized trial100 participantsHair Health forSaw Palmetto
  11. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  12. Associations of habitual fish oil supplementation with cardiovascular outcomes and all cause mortality: evidence from a large population based cohort study.
    Li ZH; Zhong WF; Liu S; Kraus VB; Zhang YJ; Gao X; Lv YB; Shen D; Zhang XR; Zhang PD; Huang QM; Chen Q; Wu XB; Shi XM; Wang D; Mao C · BMJ (Clinical research ed.) · 2020
    Cohort study427,678 participantsCardiovascular Support forFish Oil
  13. Regular use of fish oil supplements and course of cardiovascular diseases: prospective cohort study.
    Chen G; Qian ZM; Zhang J; Zhang S; Zhang Z; Vaughn MG; Aaron HE; Wang C; Lip GY; Lin H · BMJ medicine · 2024
    Cohort study415,737 participantsCardiovascular Support forFish Oil
  14. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  15. Cardiovascular Benefits of Fish-Oil Supplementation Against Fine Particulate Air Pollution in China.
    Lin Z; Chen R; Jiang Y; Xia Y; Niu Y; Wang C; Liu C; Chen C; Ge Y; Wang W; Yin G; Cai J; Clement V; Xu X; Chen B; Chen H; Kan H · Journal of the American College of Cardiology · 2020
    Randomized trial65 participantsCardiovascular Support forFish Oil
  16. Beyond Efficacy: 0.6% Selenium Disulfide Shampoo Matches 2% Ketoconazole for Seborrheic Dermatitis with Superior Cosmesis.
    Farris PK; Barbosa V; Houshman EB; Kovylkina N · Journal of drugs in dermatology : JDD · 2026
    Randomized trial87 participantsHair Health forSelenium
  17. Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis.
    Turcu G; Artenie C; Nowicka D; Arenbergerová M; Lazaridou E; Khobzei K; Ataseven A; Part M; Leclerc-Mercier S · European journal of dermatology : EJD · 2023
    Observational study1,407 participantsHair Health forSelenium
  18. A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.
    Barbosa V; Melo DF; Vañó-Galván S; Lutchmanen-Kolanthan V; Sant'Anna B; Leclerc-Mercier S; Reygagne P · Skin appendage disorders · 2025
    Randomized trial64 participantsHair Health forSelenium
  19. Changes of serum trace elements level in patients with alopecia areata: A meta-analysis.
    Jin W; Zheng H; Shan B; Wu Y · The Journal of dermatology · 2018
    Meta-analysis764 participantsHair Health forSelenium
  20. Scientific opinion on the tolerable upper intake level for selenium.
    EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D; Bohn T; Castenmiller J; de Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Peláez C; Pentieva K; Siani A; Thies F; Tsabouri S; Vinceti M; Aggett P; Crous Bou M; Cubadda F; Ciccolallo L; de Sesmaisons Lecarré A; Fabiani L; Titz A; Naska A · EFSA journal. European Food Safety Authority · 2023
    Systematic reviewHair Health forSelenium
  21. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  22. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  23. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  24. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  25. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  26. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  27. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  28. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  29. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  30. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  31. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  32. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  33. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  34. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  35. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  36. Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study.
    Chernyshova MP; Pristenskiy DV; Lozbiakova MV; Chalyk NE; Bandaletova TY; Petyaev IM · Journal of dairy science · 2019
    Randomized trialSkin Health forLycopene
  37. Topical lycopene emulgel significantly improves biophysical parameters of human skin.
    Sohail M; Muhammad Faran Ashraf Baig M; Akhtar N; Chen Y; Xie B; Li B · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2022
    Clinical trialSkin Health forLycopene
  38. Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema.
    Aust O; Stahl W; Sies H; Tronnier H; Heinrich U · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2005
    Randomized trialSkin Health forLycopene
  39. Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States.
    Kim J; Park MK; Li WQ; Qureshi AA; Cho E · JAMA dermatology · 2024
    Cohort study123,570 participantsSkin Health forLycopene
  40. β-Carotene and other carotenoids in protection from sunlight.
    Stahl W; Sies H · The American journal of clinical nutrition · 2013
    Narrative reviewSkin Health forLycopene
  41. Comparative clinical trial of bifonazole solution versus selenium sulphide shampoo in the treatment of pityriasis versicolor.
    Chu AC · Dermatologica · 1985
    Randomized trial38 participantsSkin Health forSelenium
  42. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial.
    Duffield-Lillico AJ; Slate EH; Reid ME; Turnbull BW; Wilkins PA; Combs GF; Park HK; Gross EG; Graham GF; Stratton MS; Marshall JR; Clark LC; Nutritional Prevention of Cancer Study Group · Journal of the National Cancer Institute · 2003
    Randomized trial1,312 participantsSkin Health forSelenium
  43. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forSelenium Skin Health forZinc
  44. A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh.
    Verret WJ; Chen Y; Ahmed A; Islam T; Parvez F; Kibriya MG; Graziano JH; Ahsan H · Journal of occupational and environmental medicine · 2006
    Randomized trial121 participantsSkin Health forSelenium
  45. The Whitening, Moisturizing, Anti-aging Activities, and Skincare Evaluation of Selenium-Enriched Mung Bean Fermentation Broth.
    Wei K; Guo C; Zhu J; Wei Y; Wu M; Huang X; Zhang M; Li J; Wang X; Wang Y; Wei X · Frontiers in nutrition · 2022
    Clinical trial31 participantsSkin Health forSelenium
  46. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  47. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  48. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  49. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc