Name: Vitamin D-3 & K-2 1000 IU/45 mcg
Brand: NOW
SKU: 1lAYAkk7
Rating: 479.0 (60984 reviews)

Question 1

What is Vitamin K primarily effective for?

Accepted Answer

Vitamin K is essential for proper blood clotting and plays a significant role in bone metabolism. It helps the body produce proteins necessary for these vital bodily functions.

Question 2

How does Vitamin K contribute to bone health?

Accepted Answer

Vitamin K activates proteins such as osteocalcin, which are crucial for incorporating calcium into the bone matrix. This mechanism supports bone mineralization and helps maintain bone density.

Question 3

What is the difference in effectiveness between Vitamin K1 and K2?

Accepted Answer

Vitamin K1 (phylloquinone) is primarily effective for blood coagulation and is abundant in green leafy vegetables. Vitamin K2 (menaquinones) is more involved in bone and cardiovascular health, found in fermented foods and animal products, and has different bioavailabilities.

Question 4

Is Vitamin K effective for cardiovascular health?

Accepted Answer

Emerging research suggests that Vitamin K, particularly K2, may help prevent arterial calcification by activating matrix Gla protein. This protein helps inhibit calcium deposition in soft tissues, supporting arterial flexibility.

Question 5

How does Vitamin K interact with calcium in the body?

Accepted Answer

Vitamin K works synergistically with calcium by helping to direct calcium to the bones and away from soft tissues like arteries. It activates proteins like osteocalcin for bone binding and matrix Gla protein to inhibit soft tissue calcification.

Question 6

Can Vitamin K supplements improve blood clotting?

Accepted Answer

Yes, Vitamin K is crucial for the synthesis of several blood clotting factors in the liver. Supplementation can help ensure adequate levels for normal coagulation, especially in cases of deficiency.

Question 7

Does Vitamin K help prevent bone fractures?

Accepted Answer

Studies suggest that adequate Vitamin K intake, particularly Vitamin K2, may be associated with a lower risk of fractures. This is due to its role in activating proteins that strengthen bone structure.

Question 8

Is Vitamin K effective in reducing arterial stiffness?

Accepted Answer

Some research indicates that higher Vitamin K intake, particularly K2, may be linked to reduced arterial stiffness. This effect is thought to be mediated by its role in preventing vascular calcification.

Question 9

Can Vitamin K reduce the risk of certain chronic diseases?

Accepted Answer

Evidence suggests that sufficient Vitamin K intake, especially K2, may be associated with a reduced risk of certain age-related chronic diseases like osteoporosis and cardiovascular disease. This is due to its roles in bone and vascular health.

Question 10

Is topical Vitamin K effective for skin conditions like bruising?

Accepted Answer

While often marketed for bruising and dark circles, scientific evidence for the effectiveness of topical Vitamin K for these conditions is limited. Its primary roles are internal, related to blood clotting and bone metabolism.

Question 11

What is the recommended daily dosage for Vitamin K?

Accepted Answer

Recommended dosages for Vitamin K vary by age and form (K1 vs K2). For adults, the Adequate Intake (AI) for Vitamin K is 120 mcg per day for men and 90 mcg per day for women. Specific supplemental dosages may differ depending on individual needs and health goals.

Question 12

Are there different dosages for Vitamin K1 versus Vitamin K2?

Accepted Answer

Yes, dosages can differ between Vitamin K1 and K2 due to their varying potencies and half-lives. While K1 is measured in micrograms (mcg) for general intake, K2 (especially MK-7) may be effective at lower microgram doses due to its longer half-life. It's important to check the specific form and dosage on the supplement label.

Question 13

Should Vitamin K be taken with food?

Accepted Answer

Yes, Vitamin K is a fat-soluble vitamin, meaning it is best absorbed when taken with a meal containing some dietary fat. This helps facilitate its absorption into the body.

Question 14

What are the different forms of Vitamin K available in supplements?

Accepted Answer

The two main forms of Vitamin K found in supplements are Vitamin K1 (phylloquinone) and Vitamin K2 (menaquinone). Vitamin K2 further has various subtypes, with MK-4 and MK-7 being the most common in supplements. Each form may have distinct roles and bioavailability.

Question 15

Is there a maximum safe dose for Vitamin K supplements?

Accepted Answer

There is no established Upper Limit (UL) for Vitamin K from food or supplements, as toxicity is rare. However, high doses of synthetic Vitamin K (menadione, K3) can be toxic, though this form is not typically found in supplements. Always adhere to recommended dosages and consult a healthcare provider if you have concerns.

Question 16

How often should I take Vitamin K supplements?

Accepted Answer

Most Vitamin K supplements are designed for daily use. Always follow the specific dosing instructions provided on the supplement label or by a healthcare professional.

Question 17

When is the best time to take Vitamin K supplements?

Accepted Answer

There is no specific "best" time of day to take Vitamin K. It can be taken at any time that is convenient for you. Consistency in timing may help establish a routine.

Question 18

Does the form of Vitamin K (K1, MK-4, MK-7) affect its absorption?

Accepted Answer

Yes, the absorption and bioavailability of Vitamin K forms can differ. Vitamin K1 is generally absorbed well from food, while certain forms of Vitamin K2, particularly MK-7, are known for their longer half-life and better systemic availability. These differences can influence dosing and effectiveness.

Question 19

How long does it take for Vitamin K supplements to show effects?

Accepted Answer

The timeframe for observing effects from Vitamin K supplements can vary depending on individual factors and the health goal. Some benefits, like improved bone mineralization markers, may take several weeks or months to become apparent. Consistent daily intake is key for long-term benefits.

Question 20

What are the interactions between Vitamin K and anticoagulant medications like warfarin?

Accepted Answer

Vitamin K plays a crucial role in blood clotting, which is the opposite effect of anticoagulant medications such as warfarin. Consuming inconsistent amounts of Vitamin K can alter warfarin's effectiveness, potentially making the blood thinner less effective or increasing bleeding risk. Individuals taking warfarin should maintain a consistent intake of Vitamin K and consult their healthcare provider.

Question 21

Who should exercise caution or avoid taking Vitamin K supplements?

Accepted Answer

Individuals taking anticoagulant medications like warfarin should consult their doctor before taking Vitamin K supplements due to potential interactions. People with certain liver conditions or those with a G6PD deficiency should also seek medical advice before supplementation. Always discuss new supplements with a healthcare provider.

Question 22

Are there any common side effects associated with taking Vitamin K supplements?

Accepted Answer

Vitamin K supplements are generally considered safe for most healthy individuals when taken at recommended dosages. Side effects are uncommon but can include upset stomach, diarrhea, or allergic reactions in sensitive individuals. High doses of synthetic Vitamin K (menadione, K3) can be toxic, but this form is rarely used in supplements.

Question 23

Is it safe to take Vitamin K supplements during pregnancy or while breastfeeding?

Accepted Answer

Vitamin K is essential during pregnancy and breastfeeding, and adequate intake is important for both mother and child. However, supplementation during these periods should only be undertaken under the guidance of a healthcare professional. High doses are generally not recommended without specific medical advice.

Question 24

What is the maximum safe daily intake of Vitamin K?

Accepted Answer

There is currently no established Tolerable Upper Intake Level (UL) for Vitamin K from food or supplements due to its low potential for toxicity. However, excessive intake, especially of synthetic forms, could potentially have adverse effects. It is always best to adhere to recommended dosages on supplement labels or as advised by a healthcare professional.

Question 25

How does Vitamin K interact with liver disease?

Accepted Answer

Individuals with liver disease may have impaired Vitamin K absorption or metabolism, potentially leading to a deficiency and increased bleeding risk. In such cases, Vitamin K supplementation might be recommended by a doctor, often in a specific form or dosage. However, self-supplementation without medical guidance is not advised for liver conditions.

Question 26

Can Vitamin K interact with other vitamins or mineral supplements?

Accepted Answer

Vitamin K generally has few known direct interactions with other common vitamins or minerals at typical supplement dosages. High doses of Vitamin A or E supplements might theoretically interfere with Vitamin K absorption or metabolism, though significant clinical impact is rare. It's always advisable to discuss your full supplement regimen with a healthcare provider.

Question 27

Can antibiotics affect Vitamin K levels or its effectiveness?

Accepted Answer

Broad-spectrum antibiotics can sometimes reduce the population of gut bacteria that produce Vitamin K2, potentially leading to a temporary deficiency. While this effect is usually minor for healthy individuals, prolonged antibiotic use might warrant discussion with a healthcare provider regarding Vitamin K intake. This interaction is generally not significant enough to cause major issues in most people.

Question 28

Can someone have an allergic reaction to Vitamin K supplements?

Accepted Answer

Allergic reactions to Vitamin K are rare but possible, as with any supplement or food. Symptoms could include skin rash, itching, or swelling. If you experience signs of an allergic reaction after taking a Vitamin K supplement, discontinue use and seek immediate medical attention.

Question 29

Does mineral oil interact with Vitamin K absorption?

Accepted Answer

Chronic use of mineral oil, a laxative, can interfere with the absorption of fat-soluble vitamins, including Vitamin K. Mineral oil can bind to these vitamins and prevent their uptake in the digestive tract. It is advisable to avoid taking mineral oil close to the time of consuming Vitamin K or other fat-soluble vitamins.

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Ingredient	Amount per serving
Vitamin C	3 mg
Vitamin D3	25 mcg
Vitamin K2	45 mcg

Vitamin D-3 & K-2 1000 IU/45 mcg
NOW

Vitamin D-3 & K-2 1000 IU/45 mcg

Score 85.0

Analysis

Effectiveness for goals

Dosage, timing & forms

Safety & interactions

Ingredients

Categories

Goals

Recommended Alternatives

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Vitamin D-3 & K-2 1000 IU/45 mcgNOW

Vitamin D-3 & K-2 1000 IU/45 mcg

leaderboard Score 85.0

insightsAnalysiswarningMedical Disclaimer

boltEffectiveness for goals

scheduleDosage, timing & forms

health_and_safetySafety & interactions

Ingredients

Categories

Goals

Recommended Alternatives

Vitamin K2 MK-7 100 mcg

Vitamin K-2 100 mcg

Vitamin K-2 100 mcg

ADK Vitamins

Vitamins D and K with Sea-lodine

Super K

Vitamin K-1 100 mcg

Sentry Adults

Therapeutic-M

Vitamin K2 MK-7 100 mcg

Vitamin K-2 100 mcg

Vitamin K-2 100 mcg

ADK Vitamins

Vitamins D and K with Sea-lodine

Super K

Vitamin D-3 & K-2 1000 IU/45 mcg
NOW

Score 85.0

Analysis

Effectiveness for goals

Dosage, timing & forms

Safety & interactions