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Liver Fractions

4.5
★ ★ ★ ★ ★
(588 ratings)
Vitamin B12 1000 mcg
Folate 200 mcg
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Score65
Active folate and B12 forms are clear strengths. Undisclosed heme-iron content makes the liver fraction difficult to assess safely.
How scoring works
Quantity:90 Capsule(s) • (45 servings)
Goals:
General Health
Energy
Productivity Boost
Hair Health

Score 65

Active folate and B12 forms are clear strengths. Undisclosed heme-iron content makes the liver fraction difficult to assess safely.
How scoring works
$39.96($0.88 per serving)
iHerb
$ 39.96
Vitacost
$ 39.96
Daily Vita
$ 39.96
Amazon
$ 39.96
Pure Formulas
$ 45.95
Vitacost
$ 39.96
Report prices

Analysis

Methylfolate at 200 mcg and methylcobalamin at 1,000 mcg provide a clear, focused B-vitamin base. The active forms suit users who specifically want folate and B12 without a full B complex.

A 1,300 mg liver fraction is identified as a natural heme-iron source. The label does not state how much iron that fraction supplies, so its nutritional contribution and stacking risk cannot be quantified.

The formula may fit adults seeking organ-derived nutrients alongside active B vitamins. People with iron-related conditions or substantial dietary iron need a product with explicit elemental iron disclosure.

Who is it for
  • Adults seeking active folate and B12
  • Users specifically comfortable with an animal-derived liver ingredient
Best for
  • Targeted folate and B12 supplementation
  • People who want an organ-based formula

Pros

  • Uses methylfolate
  • Uses methylcobalamin
  • Simple three-active design
  • Liver fraction amount is disclosed

Cons

  • Elemental iron amount is not disclosed
  • Animal-derived ingredient limits suitability
  • Narrow nutrient coverage
  • Two-capsule serving may be less convenient

Warnings

  • People with hemochromatosis or other iron-overload disorders should avoid an unquantified heme-iron source.
  • The undisclosed iron yield makes it difficult to combine safely with iron supplements or iron-containing multivitamins.
  • Methylcobalamin at 1,000 mcg is far above basic nutritional needs and may be unnecessary without a defined reason.

Nutrient quality

80 Highest impact

Bioactive B12 and folate are meaningful strengths. Liver fractions are less transparent because the elemental iron contribution is not stated.

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Ingredient transparency

66 High impact

Most active amounts are stated, but the split across forms leaves some ambiguity. Complete intake directions and a full inactive-ingredient list are not included in the supplied data.

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Customer satisfaction

67 High impact

Supplied satisfaction metrics indicate a strong result with a meaningful response pool. Detailed experience themes are absent, so recurring complaints and real-world purpose fit remain uncertain.

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Value for money

46 Lower impact

Serving value appears weak relative to the disclosed form and amount. Convenience ingredients or minor additions reduce the share of value coming from the core active.

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Report analysis

Goals

General Health
General Health
Impact
Highest effect
B+ Goal FitB+ Strength of SupportB CoverageB+ Formula Quality
Folate · 200 mcgVitamin B12 · 1000 mcg

Active methylfolate and methylcobalamin support methylation, red blood cell formation, nerve function, and cellular energy. The B12 amount is strong, while the folate amount is more modest for daily support.

Liver fractions add a natural heme iron source, but the actual iron yield is not disclosed. The combination is coherent for nutrient repletion, although it covers fewer general-health needs than a broad foundational formula.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Energy
Energy
Impact
High effect
B+ Goal FitB- Strength of SupportC+ CoverageB Formula Quality
Vitamin B12 · 1000 mcg

Methylcobalamin, methylfolate, and liver-derived heme iron components form a related blood and energy-support combination. The 1,000 mcg B12 amount is substantial and uses a bioactive form.

The liver fraction does not disclose its iron yield or other component amounts, which limits dose assessment. Anyone with iron-overload risk should use caution because the liver fraction supplies natural heme iron without a stated elemental amount.

Study evidence
Vitamin B12 Disputed 14 studies
Productivity Boost
Productivity Boost
Impact
High effect
B- Goal FitC+ Strength of SupportC CoverageB+ Formula Quality
Vitamin B12 · 1000 mcgVitamin B12 · 1000 mcg

Methylcobalamin, methylfolate, and natural heme iron may support energy and cognition when status is low. The formula is not an acute nootropic, and benefit should be expected mainly in users with a relevant deficiency.

The active B-vitamin forms are strong, but the liver-fraction label does not reveal the exact iron yield. The ingredients form a coherent blood-cell and energy-support formula with limited dose precision.

Study evidence
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies
Hair Health
Hair Health
Impact
Moderate effect
C Goal FitC Strength of SupportD- CoverageB+ Formula Quality

Methylfolate, methylcobalamin, and liver fractions may support hair when nutrient deficiency contributes to shedding. The label does not state the amount of heme iron delivered by the liver fraction, which limits assessment of the main hair-relevant claim.

Active B-vitamin forms are a strength, but folate is modest and the liver source is not characterized in detail. The formula remains narrow and does not directly address hair structure, hormonal pathways, or scalp circulation.

Study evidence
Folate Mixed 15 studies
Vitamin B12 Disputed 17 studies

Ingredients

IngredientAmount per serving
Folate ((6S)-5-Methylfolate)
 200 mcg
Vitamin B12 (Methylcobalamin)
 1000 mcg
Liver Fractions (natural heme Iron)
 1300 mg
Gluten Free Adults 18–50 Sugar Free
Report overview
Vitamin B12 (Methylcobalamin) · 1000 mcg OverallScore79
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The bioactive methylcobalamin form and high amount support people with greater B12 needs. Standard capsules are practical but do not provide the mucosal delivery of a sublingual or liquid format. B12-focused value is weak because the serving cost is high relative to the active amount.

View ingredientView products
Folate ((6S)-5-Methylfolate) · 200 mcg OverallScore74
A+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyD- Value

The explicit (6S)-5-methylfolate form is body-ready and clearly identifies the active isomer. The estimated dietary folate equivalent is below the preferred daily support range. Vitamin B12 supports the safety logic, while the serving cost offers moderate value for the folate form provided.

View ingredientView products
Loading alternative details
90 Performance

Methyl B-12 Methyl Folate Lonzenge Natural Cherry Flavor

Solaray
<p>The ingredient profile is well aligned with the original’s vitamin B12 and folate focus, supplying 2000 mcg of vitamin B12 as Methylcobalamin and 800 mcg of folate as Quatrefolic (6S)-5-Methyltetrahydrofolate Glucosamine Salt. Both the vitamin B12 and folate amounts match or exceed the original’s disclosed amounts.</p>
88 Performance

B-6 B-12 Folic Acid Drop Ins Natural Mixed Berry Flavor

KAL
<p>The ingredient profile is well aligned with the original’s vitamin B12 and folate focus, supplying 2500 mcg of vitamin B12 as Methylcobalamin and 680 mcg of folate as (6S)-5-Methyltetrahydrofolate. Both the vitamin B12 and folate amounts match or exceed the original’s disclosed amounts.</p>
85 Performance

BioActive Vitamin B

Terry Naturally
<p>The ingredient profile is well aligned with the original’s vitamin B12 and folate focus, supplying 1000 mcg of vitamin B12 as Methylcobalamin and 800 mcg of folate as (6S)-5-Methylfolate. Both the vitamin B12 and folate amounts match or exceed the original’s disclosed amounts.</p>
88 Budget

MegaFolinic 800 mcg

Source Naturals
<p>A lower cost per serving makes this a practical budget alternative, while it supplies 800 mcg of folate as Calcium Folinate. The candidate does not disclose both vitamin B12 and folate, so it is not a like-for-like replacement.</p>
86 Budget

Quick Dissolve B-12 Methylcobalamin 2500 mcg

Nature's Bounty
<p>A lower cost per serving makes this a practical budget alternative, while it supplies 2500 mcg of vitamin B12 as Methylcobalamin. The candidate does not disclose both vitamin B12 and folate, so it is not a like-for-like replacement.</p>
89 Budget

Methyl B-12 1000 mcg & Methyl Folate 400 mcg plus P-5-P Lemon Flavor

Jarrow Formulas
<p>A lower cost per serving makes this a practical budget alternative, while it supplies 1000 mcg of vitamin B12 as Methylcobalamin and 680 mcg of folate. Both the vitamin B12 and folate amounts match or exceed the original’s disclosed amounts.</p>
89 Value

B-6 B-12 Methyl Folate Mixed Berry

KAL
<p>Strong serving value is paired with 2500 mcg of vitamin B12 as Methylcobalamin and 400 mcg of folate as 5-MTHF. Both the vitamin B12 and folate amounts match or exceed the original’s disclosed amounts. The label also identifies at least one methylated nutrient form.</p>
85 Value

B12 Energizer+ Natural Cherry Flavor

Advanced Nutrition by Zahler
<p>Strong serving value is paired with 5000 mcg of vitamin B12 as Methylcobalamin. The candidate does not disclose both vitamin B12 and folate, so it is not a like-for-like replacement. The label also identifies at least one methylated nutrient form.</p>
84 Value

Methyl B-12 Natural Cherry Flavor

ZHOU
<p>Strong serving value is paired with 5000 mcg of vitamin B12 as Methylcobalamin. The candidate does not disclose both vitamin B12 and folate, so it is not a like-for-like replacement. The label also identifies at least one methylated nutrient form.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  2. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  3. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  4. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  5. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  6. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  7. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  8. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  9. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  10. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  11. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  12. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  13. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  14. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  15. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  16. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  17. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  18. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  19. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  20. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  21. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  22. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  23. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  24. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  25. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsProductivity Boost forVitamin B12
  26. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  27. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  28. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  29. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  30. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  31. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsProductivity Boost forVitamin B12
  32. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  33. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12