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Pro-Resolving Mediators

Thorne
4.8
★ ★ ★ ★ ★
(221 ratings)
Omega-3 500 mg
Fish Oil 650 mg
Product Image
Score58
High omega-3 concentration is promising, but missing mediator, EPA/DHA, and quality data do not support the premium cost.
How scoring works
Quantity:60 Gelcap(s) • (60 servings)
Goals:
Cardiovascular Support
Skin Health

Score 58

High omega-3 concentration is promising, but missing mediator, EPA/DHA, and quality data do not support the premium cost.
How scoring works
$75.00($1.25 per serving)
Pure Formulas
$ 75.00
Vitacost
$ 75.03
iHerb
$ 75.00
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Analysis

Five hundred milligrams of total omega-3 from 650 mg marine lipid concentrate represents a high active concentration. The formula is compact and avoids unrelated vitamins or botanicals.

The supplied label does not quantify specialized pro-resolving mediators despite the product name. It also omits the EPA-to-DHA profile, molecular form, antioxidant system, source species, and independent purity standard.

The very high serving cost is difficult to justify from the disclosed data alone. It fits only someone specifically directed toward this concentrate, not a value-focused fish-oil shopper.

Who is it for
  • Adults specifically directed toward a marine lipid concentrate
  • People comfortable with premium pricing
  • Users who value concentration over full label detail
Best for
  • Compact high-concentration omega-3 use
  • People avoiding large oil servings
  • Clinician-guided specialized routines

Pros

  • High total omega-3 concentration
  • One gelcap serving
  • No unrelated active ingredients

Cons

  • No mediator amounts are disclosed
  • EPA and DHA are not separated
  • Very high serving cost

Warnings

  • People with fish allergy should avoid fish-oil supplements unless their allergy specialist says otherwise.
  • Fish oil can increase bruising or bleeding tendency with anticoagulant or antiplatelet medicines, especially at higher total omega-3 intakes.
  • Fishy aftertaste, reflux, or loose stools can occur; taking the softgel with food may improve tolerance.

Nutrient quality

63 Moderate impact

The focused fish-oil formula avoids low-value extras. Modest active concentration and an unspecified oil form limit dose and absorption confidence.

Ingredient transparency

58 Moderate impact

The label states total omega-3 and serving count. Separate EPA and DHA amounts, other ingredients, full directions, and key sourcing or quality details remain missing.

Customer satisfaction

68 High impact

The aggregate satisfaction signal is strong and supported by the available response volume. No review-text evidence is provided to assess repeated complaints or whether experiences match the intended use.

Value for money

43 Lower impact

A focused marine-lipid formula avoids low-value extras. The premium serving cost is difficult to justify without EPA, DHA, oil-form, purity, or mediator details.

Report analysis

Goals

Cardiovascular Support
Impact
High effect
A- Goal FitD- Strength of SupportD+ CoverageA+ Formula Quality
Fish Oil · 650 mg

Marine omega-3 fats support triglyceride management, inflammatory balance, and endothelial function. The 500 mg total omega-3 amount is suitable for basic intake but below targeted lipid-management dosing.

EPA and DHA are not listed separately, so the most relevant active amounts cannot be verified. The focused gelcap is coherent, but its cardiovascular depth remains uncertain without fatty-acid detail.

Study evidence
Fish Oil Supportive 185 studies
Skin Health
Impact
Moderate effect
C Goal FitD+ Strength of SupportD- CoverageB+ Formula Quality
Omega-3 · 500 mg

Marine omega-3 lipids may support skin barrier function and inflammatory balance. The total omega-3 amount is moderate and not separated into EPA and DHA.

The product does not disclose the molecular form, oxidation protection, or specific mediator content. No collagen, hydration active, or dedicated photo-protective antioxidant is included.

Study evidence
Omega-3 Supportive 35 studies

Ingredients

IngredientAmount per serving
Calories
10 Calorie(s)
Total Fat
1 Gram(s)
Cholesterol
5 mg
Marine Lipid Concentrate (Fish Oil)
650 mg
Total Omega-3 Fatty Acids (Fish Oil)
500 mg
Gluten Free Adults 18–50
Report overview
Omega-3 (Fish Oil) · 500 mg OverallScore32
D- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value
A marine lipid concentrate provides a substantial total omega-3 amount but does not verify a high-absorption form. Separate EPA and DHA amounts, antioxidant protection, and purity certification are absent. The premium serving cost cannot be justified against a disclosed active dose.
Fish Oil · 650 mg OverallScore3
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The fish oil amount is shown, but EPA and DHA are not listed separately, so active dose and concentration cannot be verified. Molecular form, purification, fish species, and independent testing are not stated. No antioxidant stabilizer is listed, and missing active amounts prevent a value calculation.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial.
    Miura K; Vail A; Chambers D; Hopkins PM; Ferguson L; Grant M; Rhodes LE; Green AC · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019
    Randomized trial49 participantsSkin Health forOmega-3
  2. Prenatal Omega-3 Supplementation and Eczema Risk among Offspring at Age 36 Months.
    Berman D; Clinton C; Limb R; Somers EC; Romero V; Mozurkewich E · Insights in allergy, asthma & bronchitis · 2020
    Randomized trial84 participantsSkin Health forOmega-3
  3. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  4. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  5. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  6. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  7. Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
    Meta-analysis6 studies pooledCardiovascular Support forFish Oil
  8. Dietetic intervention in psoriatic arthritis: the DIETA trial.
    Leite BF; Morimoto MA; Gomes CMF; Klemz BNC; Genaro PS; Shivappa N; Hébert JR; Damasceno NRT; Pinheiro MM · Advances in rheumatology (London, England) · 2022
    Randomized trial97 participantsSkin Health forOmega-3
  9. Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
    Soleimani Z; Hashemdokht F; Bahmani F; Taghizadeh M; Memarzadeh MR; Asemi Z · Journal of diabetes and its complications · 2018
    Randomized trial60 participantsSkin Health forOmega-3
  10. Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix.
    Lee YJ; Han HJ; Shim HS · Journal of wound care · 2024
    Randomized trial50 participantsSkin Health forOmega-3
  11. Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers.
    Rhodes LE; Shahbakhti H; Azurdia RM; Moison RM; Steenwinkel MJ; Homburg MI; Dean MP; McArdle F; Beijersbergen van Henegouwen GM; Epe B; Vink AA · Carcinogenesis · 2003
    Randomized trial42 participantsSkin Health forOmega-3