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Purified & Clear Omega 3 Fish Oil 1000 mg

Doctor's Best
4.8
★ ★ ★ ★ ★
(4630 ratings)
EPA (Eicosapentaenoic Acid) 800 mg
Fish Oil 2000 mg
Omega-3 1400 mg
DHA 400 mg
Product Image
Score86
A clearly dosed, EPA-forward serving offers strong everyday potency at an efficient active cost. Ethyl ester form and missing oxidation and purity details limit the quality case.
How scoring works
Quantity:120 Softgel(s) • (60 servings)
Goals:
Heart Health
Anti-Inflammatory Support
Cardiovascular Support
Skin Health
Joint Health
Vision Support
Metabolism Boost
Mental Focus

Score 86

A clearly dosed, EPA-forward serving offers strong everyday potency at an efficient active cost. Ethyl ester form and missing oxidation and purity details limit the quality case.
How scoring works
$25.99($0.43 per serving)
Pure Formulas
$ 28.62
iHerb
$ 25.99
Vitacost
$ 28.59
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Analysis

Two softgels provide 800 mg of EPA and 400 mg of DHA within 1,400 mg of total omega-3 ethyl esters. The ratio favors EPA while retaining a meaningful DHA contribution for broader support.

Anchovy sourcing is identified, and the active quantities are clearly separated from total fish oil. Ethyl ester form generally depends more on taking the oil with food, while no antioxidant or independent purity verification appears in the supplied details.

The formula offers a useful balance of potency and serving efficiency for adults focused on cardiovascular or inflammatory pathways. It is less compelling for shoppers who specifically prioritize triglyceride form or unusually high DHA.

Who is it for
  • Adults seeking substantial EPA and DHA
  • Users prioritizing cardiovascular support
  • People comfortable taking fish oil with a meal
Best for
  • EPA-forward daily support
  • Efficient high-active dosing
  • Users comfortable with ethyl ester fish oil

Pros

  • Provides 800 mg of EPA
  • Provides 400 mg of DHA
  • Clearly identifies ethyl ester form
  • Anchovy source is named
  • Competitive active efficiency

Cons

  • Ethyl ester form is less preferred by some shoppers
  • No antioxidant protection is listed
  • Independent purity verification is absent
  • Requires two softgels per serving

Warnings

  • Contains fish oil and is not suitable for people with a fish allergy
  • Fish oil may cause fishy aftertaste, reflux, or digestive discomfort in sensitive users
  • The substantial EPA and DHA amount may be relevant for people using anticoagulant or antiplatelet medicines

Nutrient quality

89 Highest impact

Anchovy fish oil in the explicitly disclosed ethyl-ester form gives the formula reasonable ingredient quality. The disclosed amounts are meaningful and the ingredient selection stays focused.

Ingredient transparency

86 Highest impact

The meaningful actives and their amounts are clearly identified. Serving guidance and the complete inactive-ingredient list are not fully supplied.

Customer satisfaction

73 High impact

The aggregate rating is strong and supported by useful review volume. No review excerpts are supplied to assess repeated complaints or purpose-specific experiences.

Value for money

93 Highest impact

Formula quality provides fair value for the category. The effective serving and focused ingredient list compare favorably with similar options.

Report analysis

Goals

Heart Health
Impact
Highest effect
A+ Goal FitA Strength of SupportB- CoverageA+ Formula Quality
EPA (Eicosapentaenoic Acid) · 800 mg

A fully disclosed 800 mg of EPA and 400 mg of DHA provides a concentrated omega-3 serving with strong heart-health relevance. The EPA-forward profile supports triglyceride management and inflammatory balance.

Ethyl esters are less readily absorbed than triglyceride-form oils, but taking the softgels with a fat-containing meal can improve uptake. EPA and DHA may modestly increase bleeding tendency with anticoagulant or antiplatelet medicines, especially alongside other products that affect clotting.

Study evidence
Anti-Inflammatory Support
Impact
Highest effect
A+ Goal FitA Strength of SupportB- CoverageA+ Formula Quality
Fish Oil · 2000 mg

EPA and DHA directly support inflammatory balance through well-established lipid-signaling pathways. The combined active amount is substantial and clearly disclosed.

Ethyl esters may absorb less efficiently than triglyceride-form fish oil unless taken with a fat-containing meal. The focused formula provides strong depth without unrelated oils or lightly dosed extras.

Study evidence
Fish Oil Supportive 68 studies
Cardiovascular Support
Impact
Highest effect
A+ Goal FitA Strength of SupportB CoverageA+ Formula Quality
Fish Oil · 2000 mg

The clearly disclosed EPA and DHA amounts provide strong support for triglyceride management and broader cardiovascular lipid balance. The serving supplies a substantial combined marine omega-3 amount with an anchovy source.

Ethyl esters are less efficiently absorbed than triglyceride-form fish oil unless taken with a fat-containing meal. The formula remains focused and provides excellent depth in its main lipid and inflammation-related pathways.

Study evidence
Fish Oil Supportive 185 studies
Skin Health
Impact
Highest effect
B Goal FitB+ Strength of SupportB- CoverageA Formula Quality
Omega-3 · 1400 mg

EPA and DHA provide meaningful support for inflammatory balance and skin-barrier lipids. The combined amount is substantial enough to make the omega-3 pathway relevant rather than decorative.

Individual EPA and DHA amounts are clear, although ethyl esters are less readily absorbed than triglyceride forms unless taken with food. The anchovy source makes the product unsuitable for people with fish allergy, and concentrated omega-3s can add to bleeding risk with anticoagulants.

Study evidence
Omega-3 Supportive 35 studies
Joint Health
Impact
High effect
B Goal FitB Strength of SupportC CoverageA+ Formula Quality
Omega-3 · 1400 mg

EPA and DHA may support joint comfort by helping regulate inflammatory signaling. The clearly disclosed active omega-3 amount is substantial for daily use.

Ethyl ester delivery may absorb less efficiently than triglyceride oil, and no purity certification or antioxidant protection is stated. The focused fish oil supports inflammation more than cartilage structure or connective-tissue repair.

Study evidence
Omega-3 Supportive 40 studies
Vision Support
Impact
High effect
B- Goal FitB+ Strength of SupportC- CoverageA- Formula Quality
EPA (Eicosapentaenoic Acid) · 800 mg

DHA provides direct structural support for retinal membranes, while EPA may help ocular surface comfort. The substantial and clearly disclosed omega-fat amounts give this formula meaningful vision relevance.

The ethyl ester form is less favored for absorption than triglyceride forms, and no oxidation-protective antioxidant is listed. Macular carotenoids and a broader antioxidant network are also absent.

Study evidence

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Total Fat
2 Gram(s)
Fish Oil
2000 mg
Total Omega-3 Fatty Acids Ethyl Esters
1400 mg
Eicosapentaenoic Acid
800 mg
Docosahexaenoic Acid
400 mg
Gluten Free Adults 18–50
Report overview
F Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value

The explicitly stated ethyl ester form is less favored for absorption, though EPA makes up a substantial share of the omega-3 content. The EPA amount and EPA-to-DHA balance are strongly aligned with an EPA-focused product, and the name indicates purification without independent verification. Cost per EPA amount is especially efficient, but no antioxidant protection is disclosed.

Fish Oil · 2000 mg OverallScore72
D+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyA+ Value

The formula clearly provides 800 mg EPA and 400 mg DHA from anchovy oil, giving a strong active dose and high concentration. It uses the less efficiently absorbed ethyl-ester form, while the purified description lacks a named technical method or independent certification. Excellent cost per active gram offsets some of those quality limitations, but no antioxidant stabilizer is shown.

Omega-3 · 1400 mg OverallScore62
D- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyA+ Value

The clearly disclosed EPA and DHA provide a useful amount of active omega-3s. The ethyl ester form may absorb less efficiently than triglyceride forms, and no purity certification or antioxidant protection is listed. Its active omega-3 yield appears to offer good value.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial.
    Song J; Hu M; Li C; Yang B; Ding Q; Wang C; Mao L · Food & function · 2018
    Randomized trial201 participantsAnti-Inflammatory Support forFish Oil
  2. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.
    Lin YL; Wang CL; Chiang TI · Frontiers in nephrology · 2024
    Randomized trial60 participantsAnti-Inflammatory Support forFish Oil
  3. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.
    Yang B; Ren XL; Li ZH; Shi MQ; Ding F; Su KP; Guo XJ; Li D · Food & function · 2020
    Randomized trial77 participantsAnti-Inflammatory Support forFish Oil
  4. The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.
    Meng Z; Dong Y; Gao H; Yao D; Gong Y; Meng Q; Zheng T; Cui X; Su X; Tian Y · The Journal of international medical research · 2019
    Randomized trial174 participantsAnti-Inflammatory Support forFish Oil
  5. Effects of Omega-3 Fatty Acid Intake in Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Liu R; Jiang J; Fu Z; Liu C; Yao L; Quan H · Journal of the American Nutrition Association · 2022
    Meta-analysis49 studies pooledAnti-Inflammatory Support forFish Oil
  6. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  7. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  8. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  9. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  10. Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
    Meta-analysis6 studies pooledCardiovascular Support forFish Oil
  11. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.
    Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Saito Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Japan EPA lipid intervention study (JELIS) Investigators · Lancet (London, England) · 2007
    Randomized trial18,645 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  12. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS).
    Saito Y; Yokoyama M; Origasa H; Matsuzaki M; Matsuzawa Y; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; JELIS Investigators, Japan · Atherosclerosis · 2008
    Randomized trial14,981 participantsHeart Health forEPA (Eicosapentaenoic Acid)
  13. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis.
    Dinu M; Sofi F; Lotti S; Colombini B; Mattioli AV; Catapano AL; Casula M; Baragetti A; Wong ND; Steg PG; Ambrosio G · European journal of preventive cardiology · 2024
    Meta-analysis134,144 participants18 studies pooledHeart Health forEPA (Eicosapentaenoic Acid)
  14. Incremental effects of eicosapentaenoic acid on cardiovascular events in statin-treated patients with coronary artery disease.
    Matsuzaki M; Yokoyama M; Saito Y; Origasa H; Ishikawa Y; Oikawa S; Sasaki J; Hishida H; Itakura H; Kita T; Kitabatake A; Nakaya N; Sakata T; Shimada K; Shirato K; Matsuzawa Y; JELIS Investigators · Circulation journal : official journal of the Japanese Circulation Society · 2009
    Randomized trialHeart Health forEPA (Eicosapentaenoic Acid)
  15. Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association.
    Skulas-Ray AC; Wilson PWF; Harris WS; Brinton EA; Kris-Etherton PM; Richter CK; Jacobson TA; Engler MB; Miller M; Robinson JG; Blum CB; Rodriguez-Leyva D; de Ferranti SD; Welty FK; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology · Circulation · 2020
    OtherHeart Health forEPA (Eicosapentaenoic Acid)
  16. Supplementation of fish oil and olive oil in patients with rheumatoid arthritis.
    Berbert AA; Kondo CR; Almendra CL; Matsuo T; Dichi I · Nutrition (Burbank, Los Angeles County, Calif.) · 2005
    Randomized trial43 participantsJoint Health forOmega-3
  17. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial.
    Stonehouse W; Benassi-Evans B; Bednarz J; Vincent AD; Hall S; Hill CL · The American journal of clinical nutrition · 2022
    Randomized trial235 participantsJoint Health forOmega-3
  18. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
    Wang W; Xu Y; Zhou J; Zang Y · Clinical rheumatology · 2024
    Meta-analysis1,018 participants18 studies pooledJoint Health forOmega-3
  19. Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis.
    Sigaux J; Mathieu S; Nguyen Y; Sanchez P; Letarouilly JG; Soubrier M; Czernichow S; Flipo RM; Sellam J; Daïen C · Arthritis research & therapy · 2022
    Meta-analysis1,420 participants30 studies pooledJoint Health forOmega-3
  20. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain.
    Goldberg RJ; Katz J · Pain · 2007
    Meta-analysis17 studies pooledJoint Health forOmega-3
  21. The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose-response meta-analysis.
    Suh SW; Lim E; Burm SY; Lee H; Bae JB; Han JW; Kim KW · BMC medicine · 2024
    Meta-analysis9,660 participants24 studies pooledMental Focus forEPA (Eicosapentaenoic Acid)
  22. EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD.
    Gustafsson PA; Birberg-Thornberg U; Duchén K; Landgren M; Malmberg K; Pelling H; Strandvik B; Karlsson T · Acta paediatrica (Oslo, Norway : 1992) · 2011
    Randomized trial92 participantsMental Focus forEPA (Eicosapentaenoic Acid)
  23. Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA)-Should They Be Mandatory Supplements in Pregnancy?
    Amza M; Haj Hamoud B; Sima RM; Dinu MD; Gorecki GP; Popescu M; Gică N; Poenaru MO; Pleș L · Biomedicines · 2024
    Narrative reviewMental Focus forEPA (Eicosapentaenoic Acid)
  24. Supplementation with oil rich in eicosapentaenoic acid, but not in docosahexaenoic acid, improves global cognitive function in healthy, young adults: results from randomized controlled trials.
    Patan MJ; Kennedy DO; Husberg C; Hustvedt SO; Calder PC; Khan J; Forster J; Jackson PA · The American journal of clinical nutrition · 2021
    Randomized trial310 participantsMental Focus forEPA (Eicosapentaenoic Acid)
  25. Dietetic intervention in psoriatic arthritis: the DIETA trial.
    Leite BF; Morimoto MA; Gomes CMF; Klemz BNC; Genaro PS; Shivappa N; Hébert JR; Damasceno NRT; Pinheiro MM · Advances in rheumatology (London, England) · 2022
    Randomized trial97 participantsSkin Health forOmega-3
  26. Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial.
    Miura K; Vail A; Chambers D; Hopkins PM; Ferguson L; Grant M; Rhodes LE; Green AC · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019
    Randomized trial49 participantsSkin Health forOmega-3
  27. Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
    Soleimani Z; Hashemdokht F; Bahmani F; Taghizadeh M; Memarzadeh MR; Asemi Z · Journal of diabetes and its complications · 2018
    Randomized trial60 participantsSkin Health forOmega-3
  28. Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix.
    Lee YJ; Han HJ; Shim HS · Journal of wound care · 2024
    Randomized trial50 participantsSkin Health forOmega-3
  29. Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers.
    Rhodes LE; Shahbakhti H; Azurdia RM; Moison RM; Steenwinkel MJ; Homburg MI; Dean MP; McArdle F; Beijersbergen van Henegouwen GM; Epe B; Vink AA · Carcinogenesis · 2003
    Randomized trial42 participantsSkin Health forOmega-3
  30. Dietary omega-3 LCPUFA intake in the prevention of neovascular age-related macular degeneration: a systematic review and meta-analysis.
    Meng XT; Shi YY; Hong-Yan Z · Nutricion hospitalaria · 2022
    Meta-analysis5 studies pooledVision Support forEPA (Eicosapentaenoic Acid)
  31. Dietary omega-3 polyunsaturated fatty acids and fish intake and risk of age-related macular degeneration.
    Jiang H; Shi X; Fan Y; Wang D; Li B; Zhou J; Pei C; Ma L · Clinical nutrition (Edinburgh, Scotland) · 2022
    Meta-analysis21 studies pooledVision Support forEPA (Eicosapentaenoic Acid)
  32. Dietary fatty acid intake, plasma fatty acid levels, and the risk of age-related macular degeneration (AMD): a dose-response meta-analysis of prospective cohort studies.
    Zhong Y; Wang K; Jiang L; Wang J; Zhang X; Xu J; Yao K · European journal of nutrition · 2021
    Meta-analysis167,581 participants11 studies pooledVision Support forEPA (Eicosapentaenoic Acid)
  33. Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women.
    Christen WG; Schaumberg DA; Glynn RJ; Buring JE · Archives of ophthalmology (Chicago, Ill. : 1960) · 2011
    Cohort study38,022 participantsVision Support forEPA (Eicosapentaenoic Acid)
  34. Can Omega-3 Fatty Acids Serve as a Preventive Strategy for Age-Related Macular Degeneration? A Systematic Review and Meta-Analysis.
    Chen KY; Chan HC; Chan CM · The Journal of nutrition · 2026
    Meta-analysis18 studies pooledVision Support forEPA (Eicosapentaenoic Acid)