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Ortho Thyroid

Protocol For Life Balance
4.7
★ ★ ★ ★ ★
(696 ratings)
Iodine 225 mcg
Zinc 25 mg
Copper 1 mg
Ashwagandha 50 mg
Product Image
Score81
A well-disclosed thyroid cofactor formula that needs clinician-aware use because several ingredients may alter thyroid activity.
How scoring works
Quantity:90 Capsule(s) • (45 servings)
Goals:
Metabolism Boost
Hair Health
General Health
Immunity
Fitness

Score 81

A well-disclosed thyroid cofactor formula that needs clinician-aware use because several ingredients may alter thyroid activity.
How scoring works
$23.00($0.51 per serving)
iHerb
$ 23.00
Vitacost
$ 23.00
Amazon
$ 23.00
Pure Formulas
$ 23.00
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Analysis

The formula provides potassium iodide, one gram of tyrosine, L-OptiZinc, selenomethionine, copper, and methylcobalamin. Those forms support several thyroid-hormone production and metabolism steps.

Guggul and ashwagandha add standardized botanicals that may influence thyroid activity. Their effects make the product less suitable as a general energy supplement for someone without a defined thyroid need.

Two capsules and moderate value are reasonable for the ingredient quality. People with thyroid disease should coordinate use with testing and medication management.

Who is it for
  • Adults with a clinician-guided thyroid nutrient plan
  • People seeking iodine with tyrosine
  • Users wanting zinc, selenium, and copper together
Best for
  • Thyroid-oriented nutrient support
  • Iodine and tyrosine intake
  • Metabolism-related cofactor coverage

Pros

  • Uses potassium iodide
  • Includes methylcobalamin and selenomethionine
  • Provides substantial tyrosine

Cons

  • Requires thyroid-specific suitability
  • Ashwagandha amount is modest
  • Folate form is unspecified

Warnings

  • Iodine, guggul, and ashwagandha may change thyroid function or medication needs
  • Separate mineral supplements from levothyroxine as directed by a prescriber
  • Avoid stacking with another iodine or high-zinc product

Nutrient quality

83 Highest impact

Tyrosine, iodine, zinc, selenium, copper, methylcobalamin, guggul, and ashwagandha use useful forms and relevant doses. Iodine and zinc are comparatively high, and the broad goal list extends beyond what this thyroid-focused formula directly covers.

Ingredient transparency

83 Highest impact

Every active has a specific amount and no proprietary blend hides the doses. Complete intake directions and inactive capsule ingredients are not supplied.

Customer satisfaction

71 High impact

The aggregate rating is favorable and supported by a useful number of reviews. No specific review comments were supplied, so repeated complaints and purpose-related experiences cannot be verified.

Value for money

84 Highest impact

Strong forms, clear doses, and a focused profile support very good value. The formula is most competitive for thyroid-focused use rather than the many broader goals listed.

Report analysis

Goals

Metabolism Boost
Metabolism Boost
Impact
Highest effect
B+ Goal FitA Strength of SupportB+ CoverageA Formula Quality
Vitamin B12 · 60 mcgVitamin B6 · 2 mgZinc · 25 mg

Ortho Thyroid has a direct metabolism fit through its disclosed thermogenic, thyroid, mitochondrial, or glycemic-support ingredients.

Dose quality and formula structure support a strong contribution, while evidence context and formula complexity remain the main constraints.

Study evidence
Iodine Mixed 17 studies
Selenium Mixed 28 studies
Hair Health
Hair Health
Impact
Highest effect
B Goal FitA- Strength of SupportB CoverageB+ Formula Quality
Zinc · 25 mg

Ortho Thyroid supplies 25 mg L-OptiZinc with 1 mg copper, 680 mcg DFE folate, 60 mcg methylcobalamin, 225 mcg iodine, and 50 mg standardized ashwagandha for broad deficiency-related hair context.

Supplied reviews average 4.72 stars from 687 customers and the brand reports GMP manufacturing, while thyroid conditions and medications require clinician review.

Study evidence
Ashwagandha Supportive 2 studies
Copper Adverse 4 studies
Folate Mixed 15 studies
Iodine No effect 1 study
Zinc Supportive 22 studies
General Health
General Health
Impact
High effect
B- Goal FitB Strength of SupportB- CoverageB Formula Quality
Folate · 680 mcg DFEVitamin B12 · 60 mcgSelenium · 50 mcgAshwagandha · 50 mgZinc · 25 mg

Ortho Thyroid appears reasonably aligned with general health through thyroid-oriented nutrients and adaptogens with some broader nutritional support.

The supplied customer feedback averages 4.72 from 687 reviews, while the main limitation is its narrow thyroid emphasis.

Study evidence
Ashwagandha Supportive 31 studies
Selenium Supportive 70 studies
Zinc Supportive 60 studies
Immunity
Immunity
Impact
High effect
C Goal FitB- Strength of SupportC CoverageB Formula Quality
Zinc · 25 mgSelenium · 50 mcg

L-OptiZinc at 25 mg and 50 mcg L-selenomethionine provide direct immune cofactors in a thyroid-focused product.

Well-formed and well-dosed zinc is the clear strength, while narrow coverage keeps immunity support incomplete.

Study evidence
Selenium Mixed 37 studies
Zinc Supportive 73 studies
Fitness
Fitness
Impact
High effect
C- Goal FitB- Strength of SupportC- CoverageB- Formula Quality
Ashwagandha · 50 mg

Ortho Thyroid provides 25 mg L-OptiZinc with copper and 1 g tyrosine, but its 50 mg ashwagandha dose is too small to make recovery support a major strength.

Supplied satisfaction is high at 4.72 from 687 reviews and the brand reports GMP controls, while the thyroid-focused iodine, guggul, and ashwagandha combination warrants clinician review for thyroid conditions or medication use.

Study evidence
Ashwagandha Supportive 23 studies
Zinc Supportive 7 studies
Skin Health
Skin Health
Impact
Moderate effect
D+ Goal FitA- Strength of SupportC- CoverageD+ Formula Quality
Zinc · 25 mgCopper · 1 mgSelenium · 50 mcg

Ortho Thyroid supplies 25 mg L-OptiZinc with copper and may support skin repair, but it remains a narrow thyroid-oriented formula without structural or hydration actives.

Customer feedback averages 4.72 from 687 reviews and the brand reports A-rated GMP manufacturing, while thyroid conditions and relevant medication use warrant review.

Study evidence
Copper Supportive 16 studies
Zinc Supportive 66 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxine Hydrochloride)
 2 mg
Folate
680 mcg DFE
Vitamin B12 (Methylcobalamin)
 60 mcg
Iodine (Potassium Iodide)
 225 mcg
Zinc (L-OptiZinc Zinc L-Methionine Complex)
 25 mg
Selenium (L-Selenomethionine)
 50 mcg
Copper (Copper Amino Acid Chelate)
 1 mg
L-Tyrosine
1 Gram(s)
Guggul (Commiphora mukul) (gum resin) standardized extract (Guggulsterones)
 75 mg
Ashwagandha Root Extract (Withanolides)
 50 mg
Gluten Free Adults 18–50 Dairy Free Women
Report overview
Iodine (Potassium Iodide) · 225 mcg OverallScore93
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC+ Value

Ortho Thyroid provides 225 mcg of iodine as potassium iodide, with exact disclosure and a dose inside the preferred daily-maintenance range. At $0.51 per serving, iodine-specific value is moderate, while the presence of 50 mcg selenium and 1,000 mg L-tyrosine improves the higher-price value case. Customer feedback averages 4.72 across 687 reviews; current retailer labeling clearly identifies the iodine, selenium, and tyrosine amounts plus non-GMO and allergen-related positioning, and anyone using thyroid-related medication should review supplemental iodine with a healthcare professional.

View ingredientView products
Zinc (L-OptiZinc Zinc L-Methionine Complex) · 25 mg OverallScore84
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Ortho Thyroid supplies 25 mg zinc as L-OptiZinc zinc L-methionine complex, with customer feedback of 4.72 stars from 687 reviews. Protocol for Life Balance describes itself as an A-rated GMP manufacturer and public labels confirm the L-OptiZinc dose, and 1 mg copper provides sensible mineral balance alongside 25 mg zinc.

View ingredientView products
Copper (Copper Amino Acid Chelate) · 1 mg OverallScore67
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD+ Value

generic copper amino acid chelate provides acceptable form quality with some limitations. The elemental amount suits daily maintenance and remains comfortably safe. Its zinc-to-copper ratio is outside the preferred band, and copper-specific value is mixed.

View ingredientView products
Loading alternative details
81 Performance

Thyroid Energy

NOW
<p>Meaningful tyrosine, well-specified minerals, and standardized guggul and ashwagandha create a coherent thyroid-support formula. It offers a similarly targeted or complementary approach, but the supplied data do not show a decisive quality advantage over Ortho Thyroid; iodine, tyrosine, guggul, and ashwagandha can complicate thyroid conditions or thyroid-medicine management, so affected users should seek individualized guidance.</p>
77 Performance

Essential Thyroid Nutrition

NutriCology
<p>Strong iodine, zinc, selenium, and vitamin B12 forms support a compact thyroid formula, but tyrosine and ashwagandha are modest and botanical standardization is incomplete. It offers a similarly targeted or complementary approach, but the supplied data do not show a decisive quality advantage over Ortho Thyroid; the serving cost is reasonable for the targeted design.</p>
79 Performance

Ferodrox

Kaged Muscle
<p>Branded ashwagandha, zinc, tongkat ali, shilajit, and piperine create a focused, well-dosed performance formula with strong active disclosure. It offers a similarly targeted or complementary approach, but the supplied data do not show a decisive quality advantage over Ortho Thyroid; regular use warrants attention to the copper-free zinc amount and possible piperine interactions, while the serving cost remains moderate for the ingredient quality; the fitness and testosterone positioning is not a direct thyroid substitute.</p>
82 Budget

Thyroid Energy

NOW
<p>Meaningful tyrosine, well-specified minerals, and standardized guggul and ashwagandha create a coherent thyroid-support formula. The lower recurring cost makes it more economical than Ortho Thyroid; iodine, tyrosine, guggul, and ashwagandha can complicate thyroid conditions or thyroid-medicine management, so affected users should seek individualized guidance.</p>
83 Budget

Zinc 30 mg

Nature's Life
<p>Zinc picolinate with copper provides a coherent, economical mineral-balance formula. The lower recurring cost makes it more economical than Ortho Thyroid; the zinc amount is substantial, and repeated copper entries make the total less clear than it should be; the narrower zinc-and-copper profile does not replace a complete thyroid-support formula.</p>
78 Budget

Zinc Copper Amino Acid Chelate with Kelp & Pumpkin Seed

Solaray
<p>Amino acid chelates and included copper support absorption and mineral balance at excellent serving value. The lower recurring cost makes it more economical than Ortho Thyroid; the 50 mg zinc amount exceeds the adult upper intake level and remains poorly balanced against only 2 mg copper; the narrower zinc-and-copper profile does not replace a complete thyroid-support formula.</p>
84 Value

Zinc-Copper Balance

AOR Advanced Orthomolecular Research Premium
<p>A practical zinc amount and well-matched copper use favorable citrate and picolinate forms. The lower recurring cost and stated ingredient strengths create a more favorable quality-to-cost balance than Ortho Thyroid; repeated zinc quantities do not show how the total is divided between forms, while full directions and inactive ingredients are missing; the narrower zinc-and-copper profile does not replace a complete thyroid-support formula.</p>
81 Value

Zinc Plus 25 mg

Nature's Answer
<p>Favorable zinc forms and active vitamin B6 support a well-focused formula at a low serving cost. The lower recurring cost and stated ingredient strengths create a more favorable quality-to-cost balance than Ortho Thyroid; repeated zinc entries obscure the form split, while the copper amount provides only modest balance against substantial zinc; the narrower zinc-and-copper profile does not replace a complete thyroid-support formula.</p>
78 Value

Prenatal Multivitamin/Multimineral with Folate

Spring Valley
<p>Folate, iron, iodine, zinc, and key vitamins are supplied at amounts consistent with prenatal use and excellent serving efficiency. The lower recurring cost and stated ingredient strengths create a more favorable quality-to-cost balance than Ortho Thyroid; most forms are unspecified or basic, and iron may cause nausea or constipation, so the product is better judged by dose coverage than ingredient form quality; the prenatal positioning does not fit routine thyroid support.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study.
    Kale S; Lopresti A; Suri R; Garg N; Langade D · Journal of psychoactive drugs · 2026
    Randomized trial120 participantsEnergy forAshwagandha
  2. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males.
    Lopresti AL; Drummond PD; Smith SJ · American journal of men's health · 2020
    Randomized trial57 participantsEnergy forAshwagandha
  3. Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study.
    McKinney E; Stewart J; Kewalramani R; Singh S · Trials · 2026
    Randomized trial186 participantsEnergy forAshwagandha
  4. Efficacy and Safety of Low-Dose Ashwagandha Supplementation on Exercise Endurance: A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial.
    Prajapati H; Satia M; Shah D; Basera I; Shah T · Phytotherapy research : PTR · 2026
    Randomized trialEnergy forAshwagandha
  5. Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.
    Leonard M; Dickerson B; Estes L; Gonzalez DE; Jenkins V; Johnson S; Xing D; Yoo C; Ko J; Purpura M; Jäger R; Faries M; Kephart W; Sowinski R; Rasmussen CJ; Kreider RB · Nutrients · 2024
    Randomized trial59 participantsEnergy forAshwagandha
  6. Enhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits.
    Vittal M; Vinciguerra M · Biogerontology · 2025
    Narrative reviewEnergy forAshwagandha
  7. Association of radioactive iodine treatment with survivorship symptoms and primary care utilisation in women of reproductive age with thyroid cancer: a retrospective cohort study.
    Devanarayan P; Hartman M; Partin M · Family medicine and community health · 2026
    Cohort study10,882 participantsEnergy forIodine
  8. Energy level and fatigue after surgery for thyroid cancer: A population-based study of patient-reported outcomes.
    Hughes DT; Reyes-Gastelum D; Kovatch KJ; Hamilton AS; Ward KC; Haymart MR · Surgery · 2020
    Cohort study2,584 participantsEnergy forIodine
  9. Health-Related Quality of Life in Differentiated Thyroid Cancer Survivors: A Cross-Sectional Study From Turkey.
    Gültekin A; Kahraman MY; Şengöz T; Şimşek FS · Head & neck · 2026
    Cross-sectional study202 participantsEnergy forIodine
  10. Effects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR Trial.
    Ziegenfuss TN; Kedia AW; Sandrock JE; Raub BJ; Kerksick CM; Lopez HL · Nutrients · 2019
    Randomized trial38 participantsFitness forAshwagandha
  11. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults.
    Choudhary B; Shetty A; Langade DG · Ayu · 2016
    Randomized trial50 participantsFitness General Health forAshwagandha
  12. Effects of Ashwagandha ( Withania somnifera) standardized root extract on physical endurance and VO 2max in healthy adults performing resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study.
    Verma N; Gupta SK; Patil S; Tiwari S; Mishra AK · F1000Research · 2024
    Randomized trial80 participantsFitness General Health forAshwagandha
  13. Effects of Withania somnifera (L.) Dunal (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
    Zhu X; Zeng Q; Lei Y; Xu D · Frontiers in pharmacology · 2026
    Meta-analysis1,249 participants20 studies pooledFitness Testosterone Support forAshwagandha
  14. Effects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclists.
    Shenoy S; Chaskar U; Sandhu JS; Paadhi MM · Journal of Ayurveda and integrative medicine · 2013
    Randomized trial40 participantsFitness forAshwagandha
  15. Association between composite dietary antioxidant index and handgrip strength in American adults: Data from National Health and Nutrition Examination Survey (NHANES, 2011-2014).
    Wu D; Wang H; Wang W; Qing C; Zhang W; Gao X; Shi Y; Li Y; Zheng Z · Frontiers in nutrition · 2024
    Cross-sectional study6,019 participantsFitness forZinc
  16. Serum essential elements and muscle health in Chinese adults: a community-based study.
    Ye H; Wang D; Liu S; Yao N; Gui Z; Huang Z; Zeng Y; Liu L; Wan H; Shen J · Nutrition & metabolism · 2025
    Cross-sectional study5,389 participantsFitness forZinc
  17. [Survey of the dietary status and physical activity level and fitness of college freshmen in Chengdu].
    Han H; Lv X; Wang D · Wei sheng yan jiu = Journal of hygiene research · 2010
    Cross-sectional study1,200 participantsFitness forZinc
  18. A comprehensive review of the physiology and evidence base to guide the use of ergogenic and medical supplements for enhanced cycling performance.
    Rowland A; Edwards S; Prieto-Bellver G; Menz B; Rowland A; Cornelisse E; Karapetis CS; Wallen MP; Hopkins AM · Journal of the International Society of Sports Nutrition · 2026
    Narrative reviewFitness forZinc
  19. Minerals and Sarcopenia in Older Adults: An Updated Systematic Review.
    van Dronkelaar C; Fultinga M; Hummel M; Kruizenga H; Weijs PJM; Tieland M · Journal of the American Medical Directors Association · 2023
    Systematic review45 studies pooledFitness forZinc
  20. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
    Deshpande A; Irani N; Balkrishnan R; Benny IR · Sleep medicine · 2021
    Randomized trial150 participantsGeneral Health forAshwagandha
  21. Withania somnifera (L.) Dunal as Add-On Therapy for COPD Patients: A Randomized, Placebo-Controlled, Double-Blind Study.
    Singh P; Salman KA; Shameem M; Warsi MS · Frontiers in pharmacology · 2022
    Randomized trial150 participantsGeneral Health forAshwagandha
  22. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.
    Cheah KL; Norhayati MN; Husniati Yaacob L; Abdul Rahman R · PloS one · 2021
    Meta-analysis400 participants5 studies pooledGeneral Health forAshwagandha
  23. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  24. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  25. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  26. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  27. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledGeneral Health forSelenium
  28. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  29. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  30. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  31. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  32. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  33. Effects of Withania somnifera root extract serum application on hair health in healthy adults: A prospective, double-blind, randomized, parallel, placebo-controlled study.
    Yerram C; Jillella A; Reddy V · Journal of Ayurveda and integrative medicine · 2023
    Randomized trial61 participantsHair Health forAshwagandha
  34. A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Study of Efficacy and Safety of Ashwagandha Root Extract Capsule on Skin and Hair Health in Healthy Adults.
    Jillella A; Keerthi N; Venkateswar Reddy J · Phytotherapy research : PTR · 2026
    Randomized trialHair Health forAshwagandha
  35. Menkes disease and response to copper histidine: An Indian case series.
    Yoganathan S; Sudhakar SV; Arunachal G; Thomas M; Subramanian A; George R; Danda S · Annals of Indian Academy of Neurology · 2022
    Case series4 participantsHair Health forCopper
  36. Trace element levels in alopecia areata.
    Bhat YJ; Manzoor S; Khan AR; Qayoom S · Indian journal of dermatology, venereology and leprology · 2009
    Case-control study100 participantsHair Health forCopper
  37. UV damage to hair and the effect of antioxidants and metal chelators.
    Millington KR; Marsh JM · International journal of cosmetic science · 2021
    In vitro / ex vivo studyHair Health forCopper
  38. Preserving fibre health: reducing oxidative stress throughout the life of the hair fibre.
    Marsh JM; Davis MG; Lucas RL; Reilman R; Styczynski PB; Li C; Mamak M; McComb DW; Williams RE; Godfrey S; Navqi KR; Chechik V · International journal of cosmetic science · 2016
    In vitro / ex vivo studyHair Health forCopper
  39. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  40. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate
  41. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  42. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  43. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  44. [Evaluation of the role of dietary intake in the occurrence of alopecia].
    El Fékih N; Kamoun H; Fazaa B; El Ati J; Zouari B; Kamoun MR; Gaigi S · Revue medicale de Liege · 2010
    Case-control study272 participantsHair Health forIodine
  45. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  46. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  47. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  48. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  49. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  50. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  51. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  52. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  53. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  54. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  55. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  56. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  57. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  58. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  59. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  60. Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial.
    Herter-Aeberli I; Cherkaoui M; El Ansari N; Rohner R; Stinca S; Chabaa L; von Eckardstein A; Aboussad A; Zimmermann MB · The Journal of nutrition · 2015
    Randomized trial163 participantsMetabolism Boost forIodine
  61. Effect of oral iodized oil on thyroid size and thyroid hormone metabolism in children with concurrent selenium and iodine deficiency.
    Zimmermann MB; Adou P; Torresani T; Zeder C; Hurrell RF · European journal of clinical nutrition · 2000
    Single-arm trial51 participantsMetabolism Boost forIodine
  62. Serum Iodine Concentration as a Biomarker for Individual Iodine Nutrition and Thyroid Function in Pregnant Women: A Cross-Sectional Study in Hubei Province.
    Xu M; Dai X; Wang Z; Guo C; Zhang B; Guo H · Public health nutrition · 2026
    Cross-sectional study1,197 participantsMetabolism Boost forIodine
  63. Iron status influences the efficacy of iodine prophylaxis in goitrous children in Côte d'Ivoire.
    Zimmermann MB · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2002
    OtherMetabolism Boost forIodine
  64. Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in Côte d'Ivoire.
    Zimmermann M; Adou P; Torresani T; Zeder C; Hurrell R · The American journal of clinical nutrition · 2000
    Non-randomized trial109 participantsMetabolism Boost forIodine
  65. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial.
    Asemi Z; Jamilian M; Mesdaghinia E; Esmaillzadeh A · Nutrition (Burbank, Los Angeles County, Calif.) · 2016
    Randomized trial70 participantsMetabolism Boost forSelenium
  66. Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
    Jamilian M; Razavi M; Fakhrie Kashan Z; Ghandi Y; Bagherian T; Asemi Z · Clinical endocrinology · 2016
    Randomized trial70 participantsMetabolism Boost forSelenium
  67. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
    Meta-analysis2,362 participants41 studies pooledMetabolism Boost forSelenium
  68. The Effects of Selenium Supplementation on Gene Expression Related to Insulin and Lipid Metabolism, and Pregnancy Outcomes in Patients with Gestational Diabetes Mellitus: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Karamali M; Dastyar F; Badakhsh MH; Aghadavood E; Amirani E; Asemi Z · Biological trace element research · 2021
    Randomized trial36 participantsMetabolism Boost forSelenium
  69. Glycemic and lipid responses to selenium-enriched vs. zeaxanthin-enriched eggs in patients with type 2 diabetes: a 12-week randomized controlled trial.
    Niu X; Zhang Y; Liu Y; Zhu Y; Fang B; Hu C; Xu X; Wang R; Sang Y; Zhang Q; Guo J · Frontiers in nutrition · 2026
    Randomized trial58 participantsMetabolism Boost forSelenium
  70. Noninferiority of Copper Dressings Than Negative Pressure Wound Therapy in Healing Diabetic Wounds: A Randomized Clinical Trial.
    Melamed E; Dabbah J; Israel T; Kan I; Pinzur MS; Roth T; Borkow G · Advances in wound care · 2026
    Randomized trialSkin Health forCopper
  71. Improvement of facial skin characteristics using copper oxide containing pillowcases: a double-blind, placebo-controlled, parallel, randomized study.
    Borkow G; Gabbay J; Lyakhovitsky A; Huszar M · International journal of cosmetic science · 2010
    Randomized trial57 participantsSkin Health forCopper
  72. Radially Electrospun Fibrous Membrane Incorporated with Copper Peroxide Nanodots Capable of Self-Catalyzed Chemodynamic Therapy for Angiogenesis and Healing Acceleration of Diabetic Wounds.
    Huang Y; Qi L; Liu Z; Jiang Y; Wang J; Liu L; Li Y; Zhang L; Feng G · ACS applied materials & interfaces · 2023
    Animal experimentSkin Health forCopper
  73. Engineering copper nanoparticle/polysaccharide-immobilized cotton gauze for accelerated healing of Staphylococcus aureus-infected dermal wounds.
    Sahoo M; Banerjee T; Virkar S; Das S; Biswas S; Mitra D · Journal of materials chemistry. B · 2026
    Animal experimentSkin Health forCopper
  74. Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings.
    Melamed E; Rovitsky A; Roth T; Assa L; Borkow G · Medicina (Kaunas, Lithuania) · 2021
    Single-arm trialSkin Health forCopper
  75. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  76. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  77. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  78. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc
  79. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forZinc
  80. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: A randomized controlled trial.
    Chauhan S; Srivastava MK; Pathak AK · Health science reports · 2024
    Randomized trial50 participantsTestosterone Support forAshwagandha
  81. Examining the Effects of Herbs on Testosterone Concentrations in Men: A Systematic Review.
    Smith SJ; Lopresti AL; Teo SYM; Fairchild TJ · Advances in nutrition (Bethesda, Md.) · 2021
    Systematic review32 studies pooledTestosterone Support forAshwagandha
  82. Do "testosterone boosters" really increase serum total testosterone? A systematic review.
    Morgado A; Tsampoukas G; Sokolakis I; Schoentgen N; Urkmez A; Sarikaya S · International journal of impotence research · 2024
    Systematic review3 studies pooledTestosterone Support forAshwagandha
  83. Safety and Tolerability of Withania somnifera Root Extract in Healthy Male Participants: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Vaidya N; Agarwal R; Kshirsagar P; Ganu G; Nagore D; Mehta A; Vora A; Nair S · Food science & nutrition · 2025
    Randomized trial40 participantsTestosterone Support forAshwagandha
  84. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
    Meeker JD; Rossano MG; Protas B; Padmanahban V; Diamond MP; Puscheck E; Daly D; Paneth N; Wirth JJ · Fertility and sterility · 2010
    Cross-sectional study219 participantsTestosterone Support forZinc
  85. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review.
    Santos HO; Cadegiani FA; Forbes SC · Clinical therapeutics · 2022
    Scoping reviewTestosterone Support forZinc
  86. Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men's Health, Germination, Sperm Quality, and Fertilization.
    Fallah A; Mohammad-Hasani A; Colagar AH · Journal of reproduction & infertility · 2020
    Narrative reviewTestosterone Support forZinc
  87. Clinical, endocrinological and biochemical effects of zinc deficiency.
    Prasad AS · Clinics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc
  88. Clinical, endocrinologic, and biochemical effects of zinc deficiency.
    Prasad AS · Special topics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc