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GABA 500 mg

Nutricost
4.8
★ ★ ★ ★ ★
(1251 ratings)
GABA 500 mg
Product Image
Score83
The clearly disclosed 500 mg serving is focused and practical, though ordinary oral GABA has inconsistent real-world effects.
How scoring works
Quantity:240 Capsule(s) • (240 servings)
Goals:
Stress Relief
Sleep Support

Score 83

The clearly disclosed 500 mg serving is focused and practical, though ordinary oral GABA has inconsistent real-world effects.
How scoring works
$16.95($0.07 per serving)
iHerb
$ 16.95
iHerb
$ 16.95
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Analysis

500 mg sits within a practical standalone range for a product aimed at relaxation, stress, or sleep support. Oral GABA targets an inhibitory pathway, but its ability to reach the brain reliably remains uncertain.

Capsule delivery is simple and provides a fixed serving. A small vitamin B6 amount adds a relevant neurotransmitter cofactor without distracting from the main active.

Very low serving cost and a generous supply support economical regular use. The formula is better suited to situational calming than to broad mood support or circadian sleep timing.

Who is it for
  • Adults seeking a simple calming supplement
  • Users who prefer capsule delivery
Best for
  • Situational relaxation support
  • A focused single-pathway formula

Pros

  • Clearly disclosed 500 mg amount
  • Includes a small vitamin B6 cofactor
  • Very large two-hundred-forty-serving supply

Cons

  • Ordinary oral GABA has uncertain brain delivery
  • No branded fermented source
  • Does not address circadian timing

Warnings

  • GABA may cause drowsiness; do not drive or operate machinery until its effects are known.
  • Alcohol, sleep medicines, sedating antihistamines, and other sedatives may intensify impaired alertness.
  • GABA may lower blood pressure in some users; monitor for dizziness when using blood-pressure medicine.

Nutrient quality

81 Highest impact

Conventional oral delivery does not overcome the main uncertainty about how much ordinary GABA reaches the brain. well-centered falls within a practical standalone range.

Ingredient transparency

81 Highest impact

GABA and its supporting nutrient have individual amounts. Excipients and daily directions are absent from the supplied data, which leaves some label details uncertain.

Customer satisfaction

72 High impact

The aggregate satisfaction average is exceptionally strong, though no detailed feedback is supplied. The large volume provides a stable aggregate satisfaction signal.

Value for money

99 Highest impact

A clear, practical amount supports good formula value despite generic sourcing. The serving cost is exceptionally low for the GABA amount.

Report analysis

Goals

Stress Relief
Stress Relief
Impact
Highest effect
B Goal FitA- Strength of SupportB- CoverageA Formula Quality
GABA · 500 mgVitamin B6 · 2 mg

GABA directly targets an inhibitory neurotransmitter pathway associated with calm. Oral GABA evidence is less consistent than evidence for theanine, and the formula does not add an adaptogen or mineral pathway.

The GABA amount is clear and substantial, while vitamin B6 provides a small compatible cofactor. The amount may cause drowsiness in some people, so it warrants care before driving.

Study evidence
GABA Supportive 6 studies
Vitamin B6 Supportive 10 studies
Sleep Support
Sleep Support
Impact
High effect
C- Goal FitB Strength of SupportC CoverageB+ Formula Quality

GABA is directly associated with inhibitory signaling, but oral GABA has uncertain access to the brain. The formula may support relaxation for some users, yet evidence for reliable sleep improvement remains limited.

The 500 mg amount is clearly disclosed, and the small B6 dose is a logical neurotransmitter cofactor. GABA may cause drowsiness, so users should avoid driving or operating machinery until they know how the dose affects them.

Study evidence
GABA Supportive 4 studies
Vitamin B6 Disputed 7 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxine Hydrochloride)
 2 mg
Gamma Aminobutyric Acid
500 mg
Gluten Free Adults 18–50 Vegetarian
Report overview
GABA · 500 mg OverallScore90
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The clearly disclosed GABA dose is well aligned with standalone use, while the capsule offers a practical delivery method. Its source is not identified as a branded fermented form, which limits confidence in premium ingredient quality. The low cost per serving adds strong value, though the GABA dose may cause drowsiness in some people and warrants care before driving.

View ingredientView products
Loading alternative details
85 Performance

Pharma GABA 250 mg

Natural Factors Stress-Relax
<p>A meaningful amount of fermented branded GABA provides well-defined, focused relaxation support. Compared with the original, the fermented branded source provides clearer source definition; the defined source improves quality confidence, although individual response to oral GABA may still vary.</p>
79 Performance

PharmaGABA Chewables

Designs for Health
<p>Branded fermented GABA and a well-targeted amount provide focused relaxation support. Compared with the original, the fermented branded source provides clearer source definition; the defined source improves quality confidence, although individual response to oral GABA may still vary.</p>
77 Performance

Liposomal GABA

Quicksilver Scientific
<p>Liposomal delivery plus L-theanine creates a technically strong and coherent calming formula. Compared with the original, liposomal delivery and L-theanine provide a broader calming design; the supplied feedback and high serving cost still weaken value confidence.</p>
86 Budget

GABA

NOW
<p>A substantial GABA amount in flexible liquid form provides highly economical relaxation support. The lower serving cost improves value compared with the original; its comparable disclosed amount preserves the same basic intensity, while ordinary oral GABA still has uncertain brain availability.</p>
81 Budget

GABA 750 mg

Source Naturals Serene Science
<p>A clearly disclosed upper-range GABA amount provides focused calming support in a simple formula, but ordinary oral GABA has uncertain access to the brain and human effects vary. The lower serving cost improves value compared with the original; its higher amount may increase drowsiness, while ordinary oral GABA still has uncertain brain availability.</p>
81 Budget

GABA 750 mg

Best Naturals
<p>A clearly disclosed upper-range GABA amount provides focused calming support in a simple formula, but ordinary oral GABA has uncertain access to the brain and human effects vary. It is among the least-cost eligible fallbacks, but the supplied data do not show it costing less than the original; its higher amount may increase drowsiness, while ordinary oral GABA still has uncertain brain availability.</p>
89 Value

GABA Powder

Source Naturals Serene Science
<p>The combination of a flexible 750 mg GABA serving and an economical serving creates better practical value than the original. The larger amount may cause drowsiness, especially alongside alcohol or other sedating products.</p>
88 Value

GABA 500 mg

Swanson
<p>The combination of clearly disclosed 500 mg GABA and an economical serving creates better practical value than the original. Ordinary oral GABA has uncertain access to the brain, so individual effects may vary.</p>
87 Value

GABA 750 mg

NOW
<p>The combination of clearly disclosed 750 mg GABA and an economical serving creates better practical value than the original. The larger amount may cause drowsiness, especially alongside alcohol or other sedating products.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  2. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  3. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief forGABA
  4. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  5. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support Stress Relief forGABA
  6. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  7. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  8. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  9. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  10. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  11. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  12. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  13. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forGABA
  14. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forVitamin B6
  15. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsStress Relief forVitamin B6
  16. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  17. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  18. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6