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Pharma GABA 250 mg

Natural Factors Stress-Relax
4.7
★ ★ ★ ★ ★
(2057 ratings)
GABA 250 mg
Product Image
Score85
A focused fermented PharmaGABA product delivering 250 mg in a single capsule. It provides fewer dosing increments than a liquid or powder.
How scoring works
Quantity:60 Capsule(s) • (60 servings)
Goals:
Stress Relief
Sleep Support
Mood Support

Score 85

A focused fermented PharmaGABA product delivering 250 mg in a single capsule. It provides fewer dosing increments than a liquid or powder.
How scoring works

Also available as

1 option
200.00mg • 60 Capsule(s) servings GABA 200 mg • 60 Capsule(s) • 30 servings $19.59 ($0.65 per serving)
$34.97($0.58 per serving)
iHerb
$ 34.97
Amazon
$ 34.97
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Analysis

The single capsule supplies 250 mg of fermented PharmaGABA. The formula also has a simple premium-source formula.

PharmaGABA provides a clearly identified fermented source at a practical calming amount. A branded source improves ingredient confidence, although individual response to oral GABA can still vary.

The main limitation is that it provides fewer dosing increments than a liquid or powder. The product fits adults seeking a moderate verified fermented GABA amount, provided sedative stacking and next-day drowsiness are considered.

Who is it for
  • adults seeking a moderate verified fermented GABA amount
  • people seeking focused relaxation support without a multi-herb blend
Best for
  • evening relaxation
  • supporting a calmer bedtime routine

Pros

  • Clearly states 250 mg of GABA
  • Single capsule is easy to use
  • Uses a named fermented PharmaGABA source

Cons

  • It provides fewer dosing increments than a liquid or powder
  • Oral GABA effects may differ substantially between users
  • Focused formula does not address broader causes of poor sleep or stress

Warnings

  • GABA may cause drowsiness, dizziness, or reduced alertness.
  • Alcohol, sleep medicines, benzodiazepines, antihistamines, or other sedatives may intensify drowsiness when combined with GABA.

Nutrient quality

91 Highest impact

Branded fermented PharmaGABA provides strong source quality in a vegetarian capsule. The GABA amount is meaningful for focused calming support, and the focused formula directly supports relaxation through one calming pathway.

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Ingredient transparency

86 Highest impact

Every listed active has a specific amount and no proprietary blend obscures the formula. Complete intake directions and inactive ingredients are not supplied, leaving part of the label unverified.

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Customer satisfaction

73 High impact

The supplied aggregate satisfaction level is strong. The extensive feedback volume makes the aggregate dependable.

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Value for money

88 Highest impact

Premium source quality reasonably supports the moderate cost. The serving value is good for branded fermented GABA, and the product is competitive within the premium-form category.

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Report analysis

Goals

Stress Relief
Stress Relief
Impact
Highest effect
B Goal FitA Strength of SupportC- CoverageA+ Formula Quality
GABA · 250 mg

Branded PharmaGABA provides a targeted calming ingredient at a meaningful 250 mg amount. A naturally fermented source improves quality confidence compared with generic GABA.

Evidence for oral GABA remains less established than its clear biological rationale because brain delivery is uncertain. The single-ingredient design favors focused acute relaxation over broader stress resilience.

Study evidence
GABA Supportive 6 studies
Sleep Support
Sleep Support
Impact
High effect
C+ Goal FitA- Strength of SupportC- CoverageA+ Formula Quality

A clearly stated Pharma GABA amount is intended to support nervous-system relaxation before bed. The branded form and streamlined design make the product easy to assess.

Human sleep evidence remains limited because oral GABA may not reliably reach the brain. GABA may add to drowsiness from alcohol, sedatives, or other sleep medicines.

Study evidence
GABA Supportive 4 studies
Mood Support
Mood Support
Impact
High effect
C- Goal FitA- Strength of SupportD- CoverageA+ Formula Quality

Oral GABA may promote a calmer state, but its ability to influence persistent mood is uncertain. The fermented PharmaGABA source adds quality assurance, although human mood evidence remains limited.

The 250 mg amount is clearly disclosed and fits standalone calming use. GABA may add to drowsiness from alcohol, sleep aids, or other sedating medicines.

Study evidence
GABA Supportive 12 studies

Ingredients

IngredientAmount per serving
Pharma GABA
250 mg
Gluten Free Adults 18–50 Vegan Dairy Free Sugar Free Vegetarian
Report overview
GABA · 250 mg OverallScore91
A Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB- Value

Branded PharmaGABA provides a strong quality signal from a naturally fermented source. The clearly disclosed amount falls within the preferred standalone range, and the vegetarian capsule offers practical delivery. Cost is moderate but reasonable for the premium source.

View ingredientView products
Loading alternative details
74 Performance

Liposomal GABA

Quicksilver Scientific
<p>240 mg GABA with 100 mg L-theanine and phosphatidylcholine broadens the original's single-ingredient approach and may better support relaxation through complementary pathways. The supplied data do not establish how much the liposomal delivery changes absorption, and the serving cost is high.</p>
84 Performance

Pharma GABA 100 mg

Natural Factors Stress-Relax
<p>200 mg fermented branded GABA provides a more conservative amount than the original, which may suit users who are sensitive to drowsiness. The branded source improves ingredient definition, although oral GABA effects can vary and drowsiness remains possible.</p>
84 Performance

GABA 500 mg

NOW
<p>500 mg GABA with 2 mg vitamin B6 provides a higher targeted amount than the original and may offer greater calming depth. Generic sourcing and uncertain oral brain availability limit confidence, and drowsiness remains possible.</p>
84 Budget

GABA

NOW
<p>Lower serving cost and 500 mg GABA make this a more economical option for the same GABA-focused sleep and stress goals. Generic sourcing and uncertain oral brain availability limit confidence, and drowsiness remains possible.</p>
81 Budget

GABA 750 mg

Source Naturals Serene Science
<p>Lower serving cost and 750 mg GABA make this a more economical option for the same GABA-focused sleep and stress goals. Generic sourcing and uncertain oral brain availability limit confidence, while the high amount may increase drowsiness.</p>
83 Budget

GABA 500 mg

Nutricost
<p>Lower serving cost and 500 mg GABA with 2 mg vitamin B6 make this a more economical option for the same GABA-focused sleep and stress goals. Generic sourcing and uncertain oral brain availability limit confidence, and drowsiness remains possible.</p>
83 Value

GABA 500 mg

NOW
<p>Lower serving cost paired with 500 mg GABA with 2 mg vitamin B6 creates a stronger balance of focused calming support and value than the original. Generic sourcing and uncertain oral brain availability limit confidence, and drowsiness remains possible.</p>
83 Value

GABA 500 mg

Swanson
<p>Lower serving cost paired with 500 mg GABA creates a stronger balance of focused calming support and value than the original. Generic sourcing and uncertain oral brain availability limit confidence, and drowsiness remains possible.</p>
81 Value

GABA Powder

Source Naturals Serene Science
<p>Lower serving cost paired with 750 mg GABA creates a stronger balance of focused calming support and value than the original. Generic sourcing and uncertain oral brain availability limit confidence, while the high amount may increase drowsiness.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks.
    Yoto A; Murao S; Motoki M; Yokoyama Y; Horie N; Takeshima K; Masuda K; Kim M; Yokogoshi H · Amino acids · 2012
    Randomized trial63 participantsStress Relief Mood Support forGABA
  2. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsStress Relief Sleep Support forGABA
  3. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
    Deligiannidis KM; Kroll-Desrosiers AR; Mo S; Nguyen HP; Svenson A; Jaitly N; Hall JE; Barton BA; Rothschild AJ; Shaffer SA · Psychoneuroendocrinology · 2017
    Cohort study56 participantsMood Support forGABA
  4. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.
    Wang J; Liu G; Xu K; Ai K; Huang W; Zhang J · Human brain mapping · 2023
    Case-control study69 participantsMood Support forGABA
  5. Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
    Truong V; Cheng PZ; Lee HC; Lane TJ; Hsu TY; Duncan NW · Psychiatry research. Neuroimaging · 2021
    Observational studyMood Support forGABA
  6. Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
    Vigod SN; Strasburg K; Daskalakis ZJ; Blumberger DM · Archives of women's mental health · 2014
    Systematic review11 studies pooledMood Support forGABA
  7. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  8. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  9. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  10. Relieving occupational fatigue by consumption of a beverage containing γ-amino butyric acid.
    Kanehira T; Nakamura Y; Nakamura K; Horie K; Horie N; Furugori K; Sauchi Y; Yokogoshi H · Journal of nutritional science and vitaminology · 2011
    Clinical trial30 participantsStress Relief forGABA
  11. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
    Meyerhoff DJ; Mon A; Metzler T; Neylan TC · Sleep · 2014
    Case-control study45 participantsStress Relief forGABA
  12. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsStress Relief forGABA