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Vitamin D3 5000 IU & Zinc

4.8
★ ★ ★ ★ ★
(223 ratings)
Zinc 22 mg
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Score62
A sensible D3, zinc, and quercetin core is weakened by a high vitamin D amount and minor poorly detailed additions. Regular use should be tied to an intentional D3 plan.
How scoring works
Tablet
Quantity:30 Tablet(s) • (30 servings)
Goals:
Immunity
Testosterone Support
General Health

Score 62

A sensible D3, zinc, and quercetin core is weakened by a high vitamin D amount and minor poorly detailed additions. Regular use should be tied to an intentional D3 plan.
How scoring works
$13.29($0.44 per serving)
iHerb
$ 13.29
Pure Formulas
$ 13.29
Walmart
$ 13.29
Vitacost
$ 13.29
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Analysis

The tablet provides 5,000 IU of vitamin D3, 22 mg of zinc, and 85 mg of quercetin. Those amounts create a focused vitamin D, zinc, and flavonoid formula rather than a broad multivitamin.

The vitamin D amount is above routine maintenance for many adults and should match measured need and total intake. Zinc is listed as zinc quercetin, a less familiar form than picolinate or bisglycinate.

A 25 mg fruit blend and 5 mg Bacillus subtilis entry lack enough detail to judge their contribution. It fits adults seeking a short, immune-oriented formula who have a clear reason for higher-dose D3.

Who is it for
  • Adults seeking combined D3, zinc, and quercetin
  • Users with a defined higher-dose vitamin D plan
  • People who prefer one tablet
Best for
  • Combined immune-nutrient support
  • Short-term D3 and zinc intake
  • One-tablet convenience

Pros

  • Provides 5,000 IU of vitamin D3
  • Includes 22 mg of zinc
  • Supplies 85 mg of quercetin
  • Clearly states the main active amounts

Cons

  • Vitamin D is high for routine unsupervised use
  • Zinc-quercetin has limited comparative form guidance
  • Fruit and probiotic additions are small or poorly detailed

Warnings

  • Daily 5,000 IU D3 exceeds the common adult upper intake level and should be tied to measured need
  • Long-term zinc intake should account for copper status and other zinc products
  • People with high calcium levels or increased vitamin D sensitivity need medical guidance

Nutrient quality

66 High impact

Zinc, vitamin D3, and quercetin provide meaningful immune-focused support. A high vitamin D3 amount and several small extras weaken balance.

Ingredient transparency

61 Moderate impact

The main nutrient amounts are visible and no blend hides the core doses. Accessory blend composition, directions, and inactive ingredients remain incomplete.

Customer satisfaction

69 High impact

The aggregate rating is very strong and the evidence base is adequate. Specific experience details are unavailable, so complaint patterns and purpose fit remain uncertain.

Value for money

54 Moderate impact

Useful core nutrients provide moderate formula value. A relatively high recurring cost and low-value extras weaken competitiveness.

Report analysis

Goals

Immunity
Impact
Highest effect
A+ Goal FitB+ Strength of SupportB+ CoverageA- Formula Quality
Zinc · 22 mgVitamin D · 125 mcg

Vitamin D3, zinc, and quercetin directly support immune regulation and antioxidant defense. Vitamin D and zinc have strong human evidence, while quercetin's immune evidence is less established.

Zinc exceeds the preferred threshold, but the vitamin D3 amount is high for routine use without an established need. Amounts are clear, although zinc quercetin is less established than common chelates and the small blends lack detail.

Study evidence
Vitamin D Supportive 85 studies
Zinc Supportive 73 studies
Testosterone Support
Impact
Highest effect
A Goal FitA- Strength of SupportB CoverageB- Formula Quality
Zinc · 22 mgVitamin D · 125 mcg

Vitamin D3 and zinc directly support endocrine function, while quercetin adds a secondary signaling angle. Human evidence is strongest for correcting vitamin D or zinc deficiency, with less direct support for the small accessory blend.

Vitamin D3 at 125 mcg and zinc at 22 mg provide substantial goal-relevant amounts. Vitamin D3 and zinc forms are identified, though the zinc-quercetin description and fruit blend reduce clarity. The 125 mcg vitamin D3 amount is a high daily dose and may raise calcium excessively during prolonged use in susceptible users.

Study evidence
Vitamin D Supportive 56 studies
Zinc Disputed 7 studies
General Health
Impact
Highest effect
A+ Goal FitB Strength of SupportB CoverageB- Formula Quality
Vitamin D · 125 mcgZinc · 22 mg

Vitamin D3 and zinc address two foundational nutrient needs tied to immune, skeletal, and metabolic function. Quercetin adds antioxidant support, while the other small additions have less certain practical impact.

The vitamin D amount is high for routine maintenance and is better matched to a confirmed need. Zinc is provided at a practical amount, but its quercetin complex has less established absorption guidance than common premium chelates.

Study evidence
Vitamin D Supportive 115 studies
Zinc Supportive 60 studies
Hair Health
Impact
Moderate effect
C- Goal FitB Strength of SupportC- CoverageC Formula Quality
Vitamin D · 125 mcgZinc · 22 mg

Vitamin D and zinc may support normal follicle function when either nutrient is inadequate, while quercetin adds antioxidant support. The formula is more broadly nutritional than directly hair focused.

Benefits are unlikely to be dependable when vitamin D and zinc status are already adequate. Vitamin D reaches the usual adult daily upper limit, and long-term 22 mg zinc use may reduce copper status because no copper is included.

Study evidence
Vitamin D Disputed 34 studies
Zinc Supportive 22 studies
Skin Health
Impact
Moderate effect
C- Goal FitC Strength of SupportC CoverageD+ Formula Quality
Zinc · 22 mg

Zinc and quercetin offer some antioxidant and repair support, but the formula is built mainly around high-potency vitamin D and immune ingredients. It lacks collagen, ceramides, or a dedicated hydration active.

The zinc complex and quercetin are disclosed, while the fruit blend remains opaque. Vitamin D3 exceeds the adult daily upper intake level, so prolonged use should be guided by measured need and clinical advice.

Study evidence
Zinc Supportive 66 studies

Ingredients

IngredientAmount per serving
Vitamin D (D3)
125 mcg
Zinc (Zinc Quercetin)
22 mg
PhytoSure (Quercetin)
85 mg
Organic Fruit Blend
25 mg
Bacillus subtilis DE111
5 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
D+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value

The moderate zinc dose supports daily maintenance, but zinc quercetin has less established absorption guidance than the preferred forms. A pressed tablet and limited source detail reduce formulation confidence. The serving cost is relatively high for the zinc supplied.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Dietary Zinc Intake and All-Cause and Cardiovascular Mortality in Korean Middle-Aged and Older Adults.
    Kwon YJ; Lee HS; Park G; Yang J; Kim HM; Lee JW · Nutrients · 2023
    Cohort study143,050 participantsGeneral Health forZinc
  2. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  3. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  4. Zinc for infection prevention in children with sickle cell anemia: a randomized double-blind placebo-controlled trial.
    Namazzi R; Opoka R; Conroy AL; Datta D; Tagoola A; Bond C; Goings MJ; Ryu MS; Cusick SE; Krebs NF; Jang JH; Tu W; Ware RE; John CC · Blood advances · 2023
    Randomized trial252 participantsImmunity forZinc
  5. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  6. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  7. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  8. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  9. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  10. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  11. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  12. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  13. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  14. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  15. Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis.
    Lee S; Kim BJ; Lee CH; Lee WS · Journal of the European Academy of Dermatology and Venereology : JEADV · 2018
    Meta-analysis2,039 participants14 studies pooledHair Health forVitamin D
  16. Intralesional vitamin D3 in treatment of alopecia areata: A randomized controlled clinical trial.
    Rashad AF; Elgamal E; Fouda I · Journal of cosmetic dermatology · 2022
    Randomized trial60 participantsHair Health forVitamin D
  17. Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis.
    Alsaati AA; Kaliyadan F; Alsaadoun D; Alzakry LM; Alzabadin RA; Hakami TH; Rubaian NFB · Indian dermatology online journal · 2025
    Meta-analysisHair Health forVitamin D
  18. Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial.
    El Taieb MA; Hegazy EM; Ibrahim HM; Osman AB; Abualhamd M · Archives of dermatological research · 2020
    Randomized trial60 participantsHair Health forVitamin D
  19. Serum 25 hydroxyvitamin D in non-scarring alopecia: A systematic review and meta-analysis.
    Chen Y; Dong X; Wang Y; Li Y; Xiong L; Li L · Journal of cosmetic dermatology · 2024
    Meta-analysis10,670 participants23 studies pooledHair Health forVitamin D
  20. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  21. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  22. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  23. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  24. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  25. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
    Martineau AR; Jolliffe DA; Greenberg L; Aloia JF; Bergman P; Dubnov-Raz G; Esposito S; Ganmaa D; Ginde AA; Goodall EC; Grant CC; Janssens W; Jensen ME; Kerley CP; Laaksi I; Manaseki-Holland S; Mauger D; Murdoch DR; Neale R; Rees JR; Simpson S; Stelmach I; Trilok Kumar G; Urashima M; Camargo CA; Griffiths CJ; Hooper RL · Health technology assessment (Winchester, England) · 2020
    Meta-analysis11,321 participants25 studies pooledImmunity forVitamin D
  26. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
    Zhu Z; Zhu X; Gu L; Zhan Y; Chen L; Li X · Frontiers in nutrition · 2022
    Meta-analysis4,859 participants10 studies pooledImmunity forVitamin D
  27. Vitamin D3 and deconvoluting a rash.
    Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
    Randomized trial28 participantsImmunity forVitamin D
  28. Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.
    Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
    Randomized trial110 participantsImmunity forVitamin D
  29. Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication guidelines for overcoming the unpublished data.
    Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
    Meta-analysis50,554 participants65 studies pooledImmunity forVitamin D
  30. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  31. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  32. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc
  33. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  34. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  35. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  36. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc
  37. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forZinc
  38. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
    Jamilian M; Foroozanfard F; Rahmani E; Talebi M; Bahmani F; Asemi Z · Nutrients · 2018
    Randomized trial90 participantsTestosterone Support forVitamin D
  39. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial.
    Al-Bayyari N; Al-Domi H; Zayed F; Hailat R; Eaton A · Clinical nutrition (Edinburgh, Scotland) · 2021
    Randomized trial60 participantsTestosterone Support forVitamin D
  40. Association between plasma 25-OH vitamin D and testosterone levels in men.
    Nimptsch K; Platz EA; Willett WC; Giovannucci E · Clinical endocrinology · 2012
    Case-control study1,362 participantsTestosterone Support forVitamin D
  41. Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis.
    Chen C; Zhai H; Cheng J; Weng P; Chen Y; Li Q; Wang C; Xia F; Wang N; Lu Y · The Journal of clinical endocrinology and metabolism · 2020
    Other4,254 participantsTestosterone Support forVitamin D
  42. Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
    Rafiq R; van Schoor NM; Sohl E; Zillikens MC; Oosterwerff MM; Schaap L; Lips P; de Jongh RT · The Journal of steroid biochemistry and molecular biology · 2017
    Cohort study643 participantsTestosterone Support forVitamin D
  43. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
    Meeker JD; Rossano MG; Protas B; Padmanahban V; Diamond MP; Puscheck E; Daly D; Paneth N; Wirth JJ · Fertility and sterility · 2010
    Cross-sectional study219 participantsTestosterone Support forZinc
  44. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review.
    Santos HO; Cadegiani FA; Forbes SC · Clinical therapeutics · 2022
    Scoping reviewTestosterone Support forZinc
  45. Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men's Health, Germination, Sperm Quality, and Fertilization.
    Fallah A; Mohammad-Hasani A; Colagar AH · Journal of reproduction & infertility · 2020
    Narrative reviewTestosterone Support forZinc
  46. Clinical, endocrinological and biochemical effects of zinc deficiency.
    Prasad AS · Clinics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc
  47. Clinical, endocrinologic, and biochemical effects of zinc deficiency.
    Prasad AS · Special topics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc