Niacinamide 1500 mg
Source Naturals
Niacinamide 1500 mg
4.5
★ ★ ★ ★ ★
(1021 ratings)
Niacin 1500 mg
Score 78.0
Ultra-high dose, non-flush Niacinamide, excellent for intense skin/metabolic support, but overkill for general use and not for cholesterol management.
Quantity: 100 Tablet(s)Servings size: 1 Tablet(s) (100 servings)
Selected goals:
Other goals:
Heart Health
Skin Health
Energy
Metabolism Boost
leaderboard Score 78.0
Ultra-high dose, non-flush Niacinamide, excellent for intense skin/metabolic support, but overkill for general use and not for cholesterol management.
insights Analysis
This Source Naturals product delivers a potent 1500mg dose of Niacinamide, the form of Niacin that does not cause the 'flush.' This high concentration is particularly noteworthy for its potential benefits in intensive skin support and robust metabolic pathway assistance, aligning with some advanced nutritional protocols. However, for average daily needs, this dosage is significantly higher than recommended, and for individuals primarily seeking to manage cholesterol levels, this form of Niacin is not the most effective. Online reviews are positive, often from users seeking higher doses for specific conditions, confirming its potency without the flush. Nutritionists might recommend this dose only for targeted therapeutic applications.
- Very high 1500mg dosage, suitable for specific high-dose therapeutic applications.
- Niacinamide form completely avoids the uncomfortable 'niacin flush'.
- Strong potential for skin health benefits and intensive metabolic support.
- Dosage is often excessively high for general daily supplementation.
- Lacks the proven efficacy of nicotinic acid for significant cholesterol lowering.
- Higher cost per dose compared to lower concentration Niacinamide products.
$10.57($0.10 per serving)
 iHerb | $ 10.57 | |
 Vitacost | $ 10.89 |
bolt Effectiveness for goals
Niacin is known as one of the most effective agents for increasing high-density lipoprotein (HDL) cholesterol levels. It can significantly raise HDL, which is often considered beneficial for cardiovascular health. However, studies have shown that this increase in HDL does not always translate to a reduction in cardiovascular events.
While Niacin can contribute to lowering LDL cholesterol, its primary effect on lipids is typically a more significant reduction in triglycerides and an increase in HDL cholesterol. For LDL reduction, it is generally considered less potent than statins and often used in conjunction with other lipid-lowering therapies if prescribed.
Yes, Niacin is highly effective at reducing elevated triglyceride levels. It achieves this by decreasing the liver's production of very low-density lipoprotein (VLDL), which is a precursor to triglycerides and LDL cholesterol. This makes it a common consideration for individuals with hypertriglyceridemia.
Niacin, also known as vitamin B3, is primarily recognized for its role in preventing and treating pellagra, a deficiency disease. In supplement form, it has been extensively studied for its effects on cholesterol and triglyceride levels. Its physiological functions include energy metabolism and DNA repair.
Niacin can be used in combination with statins to further improve lipid profiles, particularly to increase HDL and lower triglycerides. However, some studies have shown that adding Niacin to statin therapy does not consistently provide additional cardiovascular benefits and may increase the risk of side effects such as myopathy (muscle pain) when taken with certain statins. Medical supervision is essential for this combination.
schedule Dosage, timing & forms
Nicotinic acid is the form most commonly associated with the 'niacin flush' and is often used at higher doses for specific health support under medical supervision. Niacinamide (nicotinamide) generally does not cause flushing and is often preferred for general vitamin B3 supplementation, though it has different metabolic effects compared to nicotinic acid. Their applications can differ significantly.
'Flush-free' niacin, often inositol hexanicotinate, is a form where niacin is chemically bound to inositol, a sugar-like compound. This bond leads to a slow, gradual release of niacin in the body, significantly reducing or eliminating the rapid vasodilation that causes the common flushing sensation. It's often chosen by individuals sensitive to the flush.
To minimize the niacin flush from immediate-release nicotinic acid, individuals can start with a very low dose and gradually increase it over time. Taking it with a non-fatty meal, avoiding hot beverages or alcohol around the time of dosing, and potentially taking aspirin 30 minutes beforehand (if medically appropriate and advised) can also help. Slow and steady increases in dosage are key.
Immediate-release niacin (nicotinic acid) is absorbed quickly, leading to a rapid peak effect and often a pronounced, but temporary, flush. Extended-release forms are designed to release niacin slowly over several hours, which can help reduce the intensity and duration of the flush and may allow for less frequent dosing. The slower release aims to improve tolerance.
Niacin is available in several forms, including nicotinic acid (immediate-release and extended-release), niacinamide (nicotinamide), and inositol hexanicotinate (often marketed as 'no-flush' niacin). Each form has distinct properties and effects within the body. The choice of form can influence how it is absorbed and its potential side effects.
health_and_safety Safety & interactions
The niacin flush is a common side effect characterized by redness, itching, warmth, and tingling, primarily on the face, neck, and chest. It is caused by the release of prostaglandins, which dilate blood vessels. Taking niacin with food, starting with a low dose and gradually increasing it, or taking a low-dose aspirin before niacin may help reduce the flush.
High doses of niacin, particularly sustained-release forms, have been associated with elevated liver enzymes and, in rare cases, liver toxicity. Regular monitoring of liver function by a healthcare professional is often recommended when taking high-dose niacin. Individuals with pre-existing liver conditions should avoid niacin unless specifically advised by a doctor.
Yes, niacin can interact with several medications. It may enhance the effects of blood pressure-lowering drugs, potentially causing hypotension, and can increase the risk of myopathy when taken with statins. Niacin might also interact with blood thinners, antidiabetic medications, and gout medications. Consulting a healthcare provider about all current medications before starting niacin is important.
Individuals with active liver disease, severe hypotension, active peptic ulcer disease, or active bleeding should generally avoid niacin supplements. Those with a history of gout, diabetes, or gallbladder disease should also use niacin with caution and under medical supervision. Consultation with a healthcare provider is essential to determine suitability.
High doses of niacin, particularly nicotinic acid, can sometimes increase blood glucose levels. This effect is more pronounced in individuals with diabetes or prediabetes. People managing their blood sugar should monitor their levels closely if taking niacin and discuss its use with a healthcare provider.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Niacinamide | 1500 mg |
Categories
Niacin 78.0
This product offers a highly potent Niacinamide dose, providing significant non-flush B3 benefits. Its niche high dosage and lack of cholesterol-lowering efficacy temper its overall score within the broader Niacin category.
Goals
Skin Health 95.0
The very high dose of Niacinamide is exceptionally beneficial for skin health, supporting barrier function, reducing inflammation, and potentially aiding in various dermatological concerns, aligning with specialist recommendations for high-dose niacinamide.
Energy 90.0
As a critical precursor to NAD+, this very high dose strongly supports cellular energy production pathways throughout the body.
Metabolism Boost 90.0
The substantial Niacinamide content provides robust support for numerous enzymatic reactions vital for the metabolism of macronutrients, effectively boosting metabolic processes.
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