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Niacinamide 500 mg

Solaray
4.6
★ ★ ★ ★ ★
(5042 ratings)
Niacin 500 mg
Product Image
Score82
A clearly labeled, good-value niacinamide supplement for focused B3 or skin-barrier support, but not a lipid-active niacin product and too high for casual use.
How scoring works
Quantity:100 VegCap(s) • (100 servings)
Goals:
Skin Health
Heart Health

Score 82

A clearly labeled, good-value niacinamide supplement for focused B3 or skin-barrier support, but not a lipid-active niacin product and too high for casual use.
How scoring works
$11.29($0.11 per serving)
Pure Formulas
$ 11.29
iHerb
$ 11.29
Vitacost
$ 11.29
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Analysis

Niacinamide supports cellular energy metabolism and may contribute to normal skin-barrier function. The non-flushing form is clearly named, so its role is easier to judge than an unspecified niacin product.

The amount is far above ordinary nutritional needs and does not provide the lipid effects associated with nicotinic acid. A simple capsule keeps the formula focused, but it offers no broader skin or heart-support ingredients.

It fits adults specifically seeking oral niacinamide and who have a reason for a high amount. People shopping for cholesterol support should choose based on clinical guidance rather than treating niacinamide as interchangeable with nicotinic acid.

Who is it for
  • Adults specifically seeking oral niacinamide
  • People who want a non-flushing B3 form
  • Users needing a simple single-ingredient capsule
Best for
  • Focused niacinamide supplementation
  • Cellular energy metabolism
  • Skin-barrier nutrient support

Pros

  • Chemical form is clearly identified
  • Non-flushing niacin form
  • Strong value per serving

Cons

  • Amount exceeds routine nutritional needs
  • Weak fit for cardiovascular goals
  • No complementary skin-support ingredients

Warnings

  • Long-term high niacinamide intake may raise liver enzymes in susceptible people
  • The large amount may cause nausea or stomach discomfort
  • People with impaired glucose control should seek guidance before regular high-dose use

Nutrient quality

75 High impact

Niacinamide is a usable non-flushing vitamin B3 form supplied well above nutritional requirements. Its heart-health fit is limited, and the elevated amount reduces balance for routine use.

Ingredient transparency

87 Highest impact

The active amount and serving size are clear, with no proprietary blend hiding the formula. Non-active ingredients and complete usage directions are not supplied.

Customer satisfaction

72 High impact

The average rating is strong, with a very large review count supporting the signal. No detailed reviews are supplied to assess repeated complaints or intended-use experiences.

Value for money

92 Highest impact

A simple single-active formula and long supply provide strong routine value. The elevated amount is less attractive for users who only need basic vitamin B3 support.

Report analysis

Goals

Skin Health
Impact
High effect
C- Goal FitB Strength of SupportD CoverageA- Formula Quality

Niacinamide supports skin-barrier metabolism, but oral niacinamide alone does not provide comprehensive skin nutrition. Skin evidence is stronger for topical niacinamide than for high-dose oral use in generally healthy people.

The amount is substantial, though it exceeds ordinary nutritional needs and may cause nausea or other adverse effects in sensitive users. Niacinamide is clearly identified in a simple capsule.

Study evidence
Niacin Supportive 61 studies
Heart Health
Impact
Moderate effect
F Goal FitB- Strength of SupportF CoverageA Formula Quality

Niacinamide supports general cellular metabolism but does not provide the lipid-lowering action associated with prescription-dose nicotinic acid. Its heart-health fit is therefore limited despite the large and clearly stated amount.

The single ingredient is transparent and focused but covers no major vascular, lipid, or cardiac-energy pathway well. A high niacinamide amount may cause nausea or liver-enzyme elevations with prolonged use in susceptible people.

Study evidence
Niacin Supportive 105 studies

Ingredients

IngredientAmount per serving
Niacinamide
500 mg
Adults 18–50
Report overview
Niacin · 500 mg OverallScore90
B+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value

Niacinamide provides a well-defined, high-dose form suited to general or skin-focused use. The capsule has no special release technology, but the ingredient form and amount are clearly disclosed. Value is strong, while the label does not explicitly help shoppers identify it as non-flushing.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  2. Role of Niacin in Current Clinical Practice: A Systematic Review.
    Garg A; Sharma A; Krishnamoorthy P; Garg J; Virmani D; Sharma T; Stefanini G; Kostis JB; Mukherjee D; Sikorskaya E · The American journal of medicine · 2017
    Meta-analysis35,206 participants13 studies pooledHeart Health forNiacin
  3. Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes).
    Guyton JR; Slee AE; Anderson T; Fleg JL; Goldberg RB; Kashyap ML; Marcovina SM; Nash SD; O'Brien KD; Weintraub WS; Xu P; Zhao XQ; Boden WE · Journal of the American College of Cardiology · 2013
    Randomized trial3,414 participantsHeart Health forNiacin
  4. Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.
    D'Andrea E; Hey SP; Ramirez CL; Kesselheim AS · JAMA network open · 2020
    Meta-analysis35,760 participants17 studies pooledHeart Health forNiacin
  5. Exploring the Cardiovascular Impacts of Oral Nicotinamide: A Comprehensive Narrative Review.
    Shoukfeh R; Tisack AM; Lim HW; Mohammad TF · Journal of drugs in dermatology : JDD · 2025
    Narrative reviewHeart Health forNiacin
  6. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  7. Niacinamide: A B vitamin that improves aging facial skin appearance.
    Bissett DL; Oblong JE; Berge CA · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial50 participantsSkin Health forNiacin
  8. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
    Hakozaki T; Minwalla L; Zhuang J; Chhoa M; Matsubara A; Miyamoto K; Greatens A; Hillebrand GG; Bissett DL; Boissy RE · The British journal of dermatology · 2002
    Randomized trial138 participantsSkin Health forNiacin
  9. Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis.
    Mainville L; Smilga AS; Fortin PR · Journal of cutaneous medicine and surgery · 2022
    Meta-analysis3,039 participants29 studies pooledSkin Health forNiacin
  10. Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.
    Allen NC; Martin AJ; Snaidr VA; Eggins R; Chong AH; Fernandéz-Peñas P; Gin D; Sidhu S; Paddon VL; Banney LA; Lim A; Upjohn E; Schaider H; Ganhewa AD; Nguyen J; McKenzie CA; Prakash S; McLean C; Lochhead A; Ibbetson J; Dettrick A; Landgren A; Allnutt KJ; Allison C; Davenport RB; Mumford BP; Wong B; Stagg B; Tedman A; Gribbin H; Edwards HA; De Rosa N; Stewart T; Doolan BJ; Kok Y; Simpson K; Low ZM; Kovitwanichkanont T; Scolyer RA; Dhillon HM; Vardy JL; Chadban SJ; Bowen DG; Chen AC; Damian DL · The New England journal of medicine · 2023
    Randomized trial158 participantsSkin Health forNiacin
  11. Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide.
    Kawada A; Konishi N; Oiso N; Kawara S; Date A · The Journal of dermatology · 2008
    Randomized trial30 participantsSkin Health forNiacin
  12. A Foodborne Outbreak Traced to Niacin Overenrichment.
    Hudson PJ; Vogt RL · Journal of food protection · 2023
    Case-control study21 participantsSkin Health forNiacin
  13. Nicotinamide for Skin Cancer Chemoprevention.
    Breglio KF; Knox KM; Hwang J; Weiss R; Maas K; Zhang S; Yao L; Madden C; Xu Y; Hartman RI; Wheless L · JAMA dermatology · 2025
    Cohort study33,822 participantsSkin Health forNiacin
  14. Chemoprevention of keratinocyte carcinomas and actinic keratoses in adults who were immunocompetent: a systematic review.
    Susanto A; Morgan E; Lindsay D; Collins LG · Clinical and experimental dermatology · 2026
    Systematic review7,355 participants11 studies pooledSkin Health forNiacin
  15. Differential effect of two nicotinic acid preparations on low-density lipoprotein subclass distribution in patients classified as low-density lipoprotein pattern A, B, or I.
    Superko HR; McGovern ME; Raul E; Garrett B · The American journal of cardiology · 2004
    Randomized trial180 participantsHeart Health forNiacin
  16. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
    Thoenes M; Oguchi A; Nagamia S; Vaccari CS; Hammoud R; Umpierrez GE; Khan BV · International journal of clinical practice · 2008
    Randomized trial50 participantsHeart Health forNiacin
  17. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials.
    Sahebkar A · Vascular medicine (London, England) · 2014
    Meta-analysis441 participants7 studies pooledHeart Health forNiacin
  18. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.
    Chiu PC; Chan CC; Lin HM; Chiu HC · Journal of cosmetic dermatology · 2008
    Randomized trial52 participantsSkin Health forNiacin
  19. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
    Chen AC; Martin AJ; Choy B; Fernández-Peñas P; Dalziell RA; McKenzie CA; Scolyer RA; Dhillon HM; Vardy JL; Kricker A; St George G; Chinniah N; Halliday GM; Damian DL · The New England journal of medicine · 2015
    Randomized trial386 participantsSkin Health forNiacin