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Niacinamide 500 mg

21st Century
4.6
★ ★ ★ ★ ★
(8799 ratings)
Niacin 500 mg
Product Image
Score80
A clear, inexpensive high-dose niacinamide tablet with reasonable skin relevance, but weak cardiovascular fit and more exposure than most people need nutritionally.
How scoring works
Quantity:110 Tablet(s) • (110 servings)
Goals:
Skin Health
Cardiovascular Support

Score 80

A clear, inexpensive high-dose niacinamide tablet with reasonable skin relevance, but weak cardiovascular fit and more exposure than most people need nutritionally.
How scoring works
$5.49($0.04 per serving)
iHerb
$ 5.49
Pure Formulas
$ 6.45
iHerb
$ 5.49
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Analysis

Niacinamide supports vitamin B3 status, cellular energy, and skin-barrier metabolism without the classic niacin flush. The form and amount are clearly disclosed in a simple tablet.

The amount is much higher than routine nutritional needs, while oral skin outcomes are less established than topical niacinamide use. Calcium carbonate adds little to the intended purpose.

It fits users specifically seeking high-dose niacinamide at low cost. It is a poor choice for cholesterol management because niacinamide does not act like nicotinic acid on blood lipids.

Who is it for
  • Adults specifically seeking non-flushing niacinamide
  • Value-focused B3 users
  • People wanting a simple oral skin-support nutrient
Best for
  • Niacinamide supplementation
  • Skin-barrier nutrient support
  • Cellular energy metabolism

Pros

  • Clearly identified niacinamide
  • Very low serving cost
  • Non-flushing form

Cons

  • Amount exceeds routine nutrition needs
  • Calcium adds little to the purpose
  • Does not support lipid management

Warnings

  • Long-term high intake may affect liver enzymes or glucose control in susceptible users
  • The large amount may cause nausea or digestive discomfort
  • Do not treat niacinamide as interchangeable with lipid-active nicotinic acid

Nutrient quality

71 High impact

Niacinamide is a usable non-flushing vitamin B3 form supplied well above nutritional requirements. Its heart-health fit is limited, and the elevated amount reduces balance for routine use.

Ingredient transparency

88 Highest impact

The active amount and serving size are clear, with no proprietary blend hiding the formula. Non-active ingredients and complete usage directions are not supplied.

Customer satisfaction

72 High impact

The average rating is strong, with a very large review count supporting the signal. No detailed reviews are supplied to assess repeated complaints or intended-use experiences.

Value for money

89 Highest impact

The long supply and simple formula provide strong serving value. Added calcium contributes little, while the elevated niacinamide amount limits broad suitability.

Report analysis

Goals

Skin Health
Skin Health
Impact
High effect
B Goal FitA- Strength of SupportC CoverageA- Formula Quality

Niacinamide directly supports skin-barrier lipids and cellular energy, giving it better skin alignment than unspecified niacin. Evidence is more established for topical use, but oral niacinamide also has a plausible barrier-support role.

The 500 mg amount is clearly disclosed and falls within established systemic use. The non-flushing form avoids the acute redness expected from nicotinic acid.

Study evidence
Niacin Supportive 61 studies
Cardiovascular Support
Cardiovascular Support
Impact
Moderate effect
F Goal FitB Strength of SupportF CoverageB Formula Quality
Niacin · 500 mg

Niacinamide supports vitamin B3 status but does not produce the lipid effects associated with nicotinic acid. Its cardiovascular alignment is therefore weak despite the high listed amount.

The form and amount are clearly disclosed, yet calcium adds little to the stated purpose. High long-term niacinamide intake may affect liver enzymes or glucose control in susceptible users.

Study evidence
Niacin Supportive 136 studies

Ingredients

IngredientAmount per serving
Niacinamide
500 mg
Calcium (Calcium Carbonate)
 160 mg
Gluten Free Adults 18–50
Report overview
Niacin · 500 mg OverallScore86
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value

Clearly identified niacinamide and an established amount support general or skin-focused use. The ordinary tablet has no special release technology, while the label does not explicitly describe the form as non-flushing. Very low serving cost and a large supply make the value strong.

View ingredientView products
Loading alternative details
81 Performance

Niacinamide 500 mg

Nature's Way
<p>A focused niacinamide capsule provides transparent non-flushing vitamin B3 with useful skin-oriented coverage. Compared with the original, it keeps a non-flushing vitamin B3 emphasis while improving dose clarity or everyday practicality; however, the amount is high for routine nutrition and does not substitute for nicotinic acid in lipid-focused use.</p>
80 Performance

Niacinamide

Thorne
<p>Clearly identified niacinamide provides a simple non-flushing option with strong skin-purpose alignment. Compared with the original, it keeps a non-flushing vitamin B3 emphasis while improving dose clarity or everyday practicality; however, the amount is well above basic nutritional needs and is not a direct cardiovascular niacin substitute.</p>
82 Performance

Niacinamide 500 mg

Solaray
<p>Clearly named niacinamide offers a non-flushing form suited more to skin and NAD metabolism than lipid management. Compared with the original, it keeps a non-flushing vitamin B3 emphasis while improving dose clarity or everyday practicality; however, the amount exceeds basic nutritional needs and long-term unsupervised use is less suitable.</p>
86 Budget

Niacinamide B-3 100 mg

Source Naturals
<p>A clearly identified moderate niacinamide tablet offers simple non-flushing vitamin B3 support with excellent serving economics. It is among the lowest-cost supplied choices, although it does not undercut the already inexpensive original, but it does not provide nicotinic acid’s lipid-focused effects and complete excipient details are missing.</p>
80 Budget

Niacinamide 500 mg

Best Naturals
<p>Clearly identified niacinamide provides a non-flushing option with useful skin and NAD-metabolism alignment. It is among the lowest-cost supplied choices, although it does not undercut the already inexpensive original, but the amount is well above basic nutritional needs and is not equivalent to nicotinic acid for lipid-focused use.</p>
82 Budget

Niacinamide 500 mg

NOW
<p>A simple niacinamide capsule provides clearly named non-flushing vitamin B3 with strong skin-goal alignment. It is among the lowest-cost supplied choices, although it does not undercut the already inexpensive original, but the amount remains high for routine nutrition and does not offer nicotinic acid’s lipid-related effects.</p>
85 Value

Niacin 100 mg

Source Naturals
<p>A moderate niacinamide tablet provides clearly identified vitamin B3 without typical nicotinic-acid flushing. Its quality-adjusted serving economics and clearer active design support practical value compared with the original, although the form is intended for nutritional or skin support rather than lipid-focused effects.</p>
82 Value

No Flush Niacin (Inositol Hexanicotinate) 800 mg

Life Extension
<p>Clearly named inositol hexanicotinate provides substantial flush-free niacin exposure with economical serving value. Its quality-adjusted serving economics and clearer active design support practical value compared with the original, although its cardiovascular effects may be less direct and reliable than those of nicotinic acid.</p>
81 Value

B-Complex with Folic Acid plus Vitamin C

Nature's Bounty
<p>A broad B-complex with vitamin C provides practical daily B-vitamin coverage at very low serving cost. Its quality-adjusted serving economics and clearer active design support practical value compared with the original, although several forms are conventional, thiamine entries are duplicated, and it is not a dedicated niacin or performance formula.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  2. Role of Niacin in Current Clinical Practice: A Systematic Review.
    Garg A; Sharma A; Krishnamoorthy P; Garg J; Virmani D; Sharma T; Stefanini G; Kostis JB; Mukherjee D; Sikorskaya E · The American journal of medicine · 2017
    Meta-analysis35,206 participants13 studies pooledHeart Health forNiacin
  3. Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes).
    Guyton JR; Slee AE; Anderson T; Fleg JL; Goldberg RB; Kashyap ML; Marcovina SM; Nash SD; O'Brien KD; Weintraub WS; Xu P; Zhao XQ; Boden WE · Journal of the American College of Cardiology · 2013
    Randomized trial3,414 participantsHeart Health Cardiovascular Support forNiacin
  4. Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.
    D'Andrea E; Hey SP; Ramirez CL; Kesselheim AS · JAMA network open · 2020
    Meta-analysis35,760 participants17 studies pooledHeart Health forNiacin
  5. Exploring the Cardiovascular Impacts of Oral Nicotinamide: A Comprehensive Narrative Review.
    Shoukfeh R; Tisack AM; Lim HW; Mohammad TF · Journal of drugs in dermatology : JDD · 2025
    Narrative reviewHeart Health forNiacin
  6. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  7. Niacinamide: A B vitamin that improves aging facial skin appearance.
    Bissett DL; Oblong JE; Berge CA · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial50 participantsSkin Health forNiacin
  8. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
    Hakozaki T; Minwalla L; Zhuang J; Chhoa M; Matsubara A; Miyamoto K; Greatens A; Hillebrand GG; Bissett DL; Boissy RE · The British journal of dermatology · 2002
    Randomized trial138 participantsSkin Health forNiacin
  9. Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis.
    Mainville L; Smilga AS; Fortin PR · Journal of cutaneous medicine and surgery · 2022
    Meta-analysis3,039 participants29 studies pooledSkin Health forNiacin
  10. Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.
    Allen NC; Martin AJ; Snaidr VA; Eggins R; Chong AH; Fernandéz-Peñas P; Gin D; Sidhu S; Paddon VL; Banney LA; Lim A; Upjohn E; Schaider H; Ganhewa AD; Nguyen J; McKenzie CA; Prakash S; McLean C; Lochhead A; Ibbetson J; Dettrick A; Landgren A; Allnutt KJ; Allison C; Davenport RB; Mumford BP; Wong B; Stagg B; Tedman A; Gribbin H; Edwards HA; De Rosa N; Stewart T; Doolan BJ; Kok Y; Simpson K; Low ZM; Kovitwanichkanont T; Scolyer RA; Dhillon HM; Vardy JL; Chadban SJ; Bowen DG; Chen AC; Damian DL · The New England journal of medicine · 2023
    Randomized trial158 participantsSkin Health forNiacin
  11. Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide.
    Kawada A; Konishi N; Oiso N; Kawara S; Date A · The Journal of dermatology · 2008
    Randomized trial30 participantsSkin Health forNiacin
  12. A Foodborne Outbreak Traced to Niacin Overenrichment.
    Hudson PJ; Vogt RL · Journal of food protection · 2023
    Case-control study21 participantsSkin Health forNiacin
  13. Nicotinamide for Skin Cancer Chemoprevention.
    Breglio KF; Knox KM; Hwang J; Weiss R; Maas K; Zhang S; Yao L; Madden C; Xu Y; Hartman RI; Wheless L · JAMA dermatology · 2025
    Cohort study33,822 participantsSkin Health forNiacin
  14. Chemoprevention of keratinocyte carcinomas and actinic keratoses in adults who were immunocompetent: a systematic review.
    Susanto A; Morgan E; Lindsay D; Collins LG · Clinical and experimental dermatology · 2026
    Systematic review7,355 participants11 studies pooledSkin Health forNiacin
  15. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  16. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  17. Niacin improves lipid profile but not endothelial function in patients with coronary artery disease on high dose statin therapy.
    Philpott AC; Hubacek J; Sun YC; Hillard D; Anderson TJ · Atherosclerosis · 2013
    Randomized trial66 participantsCardiovascular Support forNiacin
  18. Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar.
    Jenkins DJA; Spence JD; Giovannucci EL; Kim YI; Josse RG; Vieth R; Sahye-Pudaruth S; Paquette M; Patel D; Blanco Mejia S; Viguiliouk E; Nishi SK; Kavanagh M; Tsirakis T; Kendall CWC; Pichika SC; Sievenpiper JL · Journal of the American College of Cardiology · 2021
    Meta-analysisCardiovascular Support forNiacin
  19. Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial.
    Elam MB; Hunninghake DB; Davis KB; Garg R; Johnson C; Egan D; Kostis JB; Sheps DS; Brinton EA · JAMA · 2000
    Randomized trial468 participantsCardiovascular Support forNiacin
  20. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group · Atherosclerosis · 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  21. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group.
    Guyton JR; Blazing MA; Hagar J; Kashyap ML; Knopp RH; McKenney JM; Nash DT; Nash SD · Archives of internal medicine · 2000
    Randomized trial173 participantsCardiovascular Support forNiacin
  22. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia.
    Knopp RH; Alagona P; Davidson M; Goldberg AC; Kafonek SD; Kashyap M; Sprecher D; Superko HR; Jenkins S; Marcovina S · Metabolism: clinical and experimental · 1998
    Randomized trial223 participantsCardiovascular Support forNiacin
  23. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.
    Chiu PC; Chan CC; Lin HM; Chiu HC · Journal of cosmetic dermatology · 2008
    Randomized trial52 participantsSkin Health forNiacin
  24. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
    Chen AC; Martin AJ; Choy B; Fernández-Peñas P; Dalziell RA; McKenzie CA; Scolyer RA; Dhillon HM; Vardy JL; Kricker A; St George G; Chinniah N; Halliday GM; Damian DL · The New England journal of medicine · 2015
    Randomized trial386 participantsSkin Health forNiacin