Product Image

Malic Acid 1500 mg with Magnesium

KAL
4.7
★ ★ ★ ★ ★
(738 ratings)
Manganese 10 mg
Magnesium 500 mg
Thiamin 7.5 mg
Product Image
Score74
Magnesium citrate and malic acid provide a substantial core for muscles and cellular energy, with B vitamins and manganese adding related support. The high magnesium amount may cause loose stools or cramping, while the manganese amount sits close to the adult daily upper limit and is poorly suited to stacking.
How scoring works
Quantity:120 Tablet(s) • (30 servings)
Goals:
Energy
General Health
Bone Health
Fitness
Stress Relief
Cardiovascular Support
Heart Health
Digestive Health

Score 74

Magnesium citrate and malic acid provide a substantial core for muscles and cellular energy, with B vitamins and manganese adding related support. The high magnesium amount may cause loose stools or cramping, while the manganese amount sits close to the adult daily upper limit and is poorly suited to stacking.
How scoring works
$15.59($0.51 per serving)
iHerb
$ 15.59
Vitacost
$ 15.59
Vitacost
$ 15.59
Amazon
$ 15.59
Walmart
$ 15.59
Report prices

Analysis

Magnesium citrate and malic acid provide a substantial core for muscles and cellular energy, with B vitamins and manganese adding related support. The active forms and amounts are mostly transparent.

Magnesium citrate, manganese citrate, and malic acid provide a coherent energy and muscle-support combination in useful forms. The high magnesium amount may cause loose stools or cramping, while the manganese amount sits close to the adult daily upper limit and is poorly suited to stacking.

Magnesium and B6 can support normal endocrine function, particularly when intake is inadequate. The formula lacks zinc, vitamin D, boron, or a clinically studied stress adaptogen.

Who is it for
  • Adults seeking Energy support
  • People comfortable with a focused tablet formula
  • Users who can review the ingredient list against medicines and existing supplements
Best for
  • Energy
  • General Health
  • Bone Health

Pros

  • Magnesium citrate and malic acid provide a substantial core for muscles and cellular energy, with B vitamins and manganese adding related support
  • Strongest formulation fit is Energy
  • Main label amounts are disclosed for Thiamine, Vitamin B6, Magnesium
  • Includes a meaningful Manganese component

Cons

  • poorly suited to stacking
  • Weak fit for Testosterone Support
  • Several secondary ingredients add breadth without equally strong dose or form support

Warnings

  • The high magnesium amount may cause loose stools or cramping, while the manganese amount sits close to the adult daily upper limit and is poorly suited to stacking.
  • The supplemental magnesium amount is high and may cause diarrhea or cramping, while the manganese amount is also substantial for routine long-term use.

Nutrient quality

77 High impact

Magnesium and manganese use citrate forms, and malic acid is supplied at a substantial amount. The high manganese dose is a notable concern for repeated use.

.

Ingredient transparency

73 High impact

Named nutrients have stated amounts, but one large blend hides important component doses. Usage directions and non-active ingredients are also absent from the supplied information.

.

Customer satisfaction

68 High impact

The listed average rating is strong and supported by a substantial review count. Specific feedback is unavailable, so repeated complaints and firsthand experience cannot be assessed.

.

Value for money

77 High impact

Meaningful magnesium and malic acid support fair value. High manganese and the vague absorption base modestly reduce category competitiveness.

.
Report analysis

Goals

Energy
Energy
Impact
High effect
B+ Goal FitB Strength of SupportB CoverageB+ Formula Quality
Magnesium · 500 mgThiamin · 7.5 mg

Magnesium citrate and malic acid provide a substantial core for muscles and cellular energy, with B vitamins and manganese adding related support. The active forms and amounts are mostly transparent.

The 500 mg supplemental magnesium dose can cause diarrhea or cramping, and 10 mg manganese sits close to the adult daily upper limit. Routine long-term use is better considered alongside total dietary and supplemental mineral intake.

Study evidence
Magnesium Supportive 4 studies
General Health
General Health
Impact
High effect
B+ Goal FitB+ Strength of SupportB- CoverageB Formula Quality
Magnesium · 500 mg

Magnesium citrate provides a relevant foundational mineral, while malic acid and thiamine add a plausible energy-metabolism theme. The amounts are fully stated, and the main magnesium form is generally more useful than magnesium oxide.

The supplemental magnesium amount is high and may cause diarrhea or cramping, while the manganese amount is also substantial for routine long-term use. A small proprietary absorption blend adds uncertainty without enough detail to show a meaningful contribution.

Study evidence
Magnesium Supportive 114 studies
Bone Health
Bone Health
Impact
High effect
B Goal FitA- Strength of SupportC+ CoverageC Formula Quality
Magnesium · 500 mgManganese · 10 mg

Magnesium citrate and manganese citrate provide meaningful mineral support for bone formation and matrix enzymes. The formula lacks calcium, vitamin D, and vitamin K, so its coverage remains supportive rather than comprehensive.

Both goal-relevant minerals use favorable citrate forms with clearly listed amounts. The 500 mg magnesium amount may cause loose stools, and the 10 mg manganese amount is high for routine unsupervised use.

Study evidence
Magnesium Supportive 48 studies
Manganese Adverse 12 studies
Fitness
Fitness
Impact
High effect
C- Goal FitA- Strength of SupportC+ CoverageA- Formula Quality
Magnesium · 500 mg

Magnesium citrate and malic acid provide a focused combination for muscle function and energy metabolism. Vitamin B6 and thiamine add supporting roles in normal energy production.

Direct performance evidence for malic acid is limited, so the main value is nutritional rather than reliably ergogenic. The high supplemental magnesium amount may cause diarrhea or abdominal cramping.

Study evidence
Magnesium Disputed 29 studies
Stress Relief
Stress Relief
Impact
High effect
B- Goal FitB+ Strength of SupportC+ CoverageB- Formula Quality
Magnesium · 500 mgVitamin B6 · 10 mg

Magnesium citrate supplies a substantial relaxation-support amount, and vitamin B6 and thiamine add metabolic support. Malic acid is more relevant to energy metabolism than to direct stress modulation.

The focused mineral dose gives the blend useful depth despite its narrow mechanism. A 500 mg magnesium citrate serving may cause diarrhea or abdominal discomfort in sensitive users.

Study evidence
Magnesium Supportive 13 studies
Vitamin B6 Supportive 10 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B Goal FitA- Strength of SupportC CoverageC- Formula Quality
Magnesium · 500 mgVitamin B6 · 10 mg

A substantial amount of magnesium citrate may support vascular tone and normal cardiac electrical function. Malic acid and B vitamins add energy-metabolism support, although their direct cardiovascular contribution is less established.

The magnesium dose gives the formula useful depth, while broader lipid and endothelial pathways remain absent. A high manganese amount and a small proprietary botanical base reduce the cardiovascular focus.

Study evidence
Magnesium Supportive 123 studies

Ingredients

IngredientAmount per serving
Total Carbohydrates
2 g
Thiamine (Thiamine Hydrochloride)
 7.5 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 10 mg
Magnesium (Magnesium Citrate)
 500 mg
Manganese (Manganese Citrate)
 10 mg
Malic Acid
1.5 g
ActiSorb Base
10 mg
Adults 18–50
Report overview
Manganese (Manganese Citrate) · 10 mg OverallScore88
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

Manganese is supplied as manganese citrate. The citrate form provides good solubility and absorption potential. The 10 mg amount is high yet remains within the stated safety limit. Cost per serving is reasonable for the formulation.

View ingredientView products
Magnesium (Magnesium Citrate) · 500 mg OverallScore67
D Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyC Value
+1

Uses moderately absorbed magnesium citrate at an unusually high elemental amount that may increase digestive discomfort. Vitamin B6, vitamin D, or boron adds relevant formulation support. Economical serving cost partly offsets the non-premium citrate form.

View ingredientView products
Thiamin (Thiamine Hydrochloride) · 7.5 mg OverallScore56
B- Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyD- Value

Thiamine hydrochloride provides a conventional water-soluble source, while the 7.5 mg amount is low for targeted support. The exact dose is clear, but the standard tablet and missing excipient details do not establish a premium delivery system. Cost efficiency is weak because the active amount is small relative to the product cost.

View ingredientView products
Loading alternative details
82 Performance

Advanced Calcium Complex

Solgar
<p>Citrate, malate, and glycinate forms of magnesium and calcium, supported by vitamin D3 and K2, offer broader and better-specified mineral support. The full serving is mineral-heavy and includes magnesium oxide, while no separate malic acid amount is listed.</p>
75 Performance

Calcium & Magnesium Orange Cream Flavor

Liquid Health
<p>Magnesium citrate and gluconate, several calcium forms, vitamin D3, chelated manganese, and boron create a well-specified liquid mineral formula. It lacks the original's malic acid and includes a broadly named silica blend, but avoids the original's unusually high manganese amount.</p>
70 Performance

Whole Food Multivitamin for Men

NATURELO Premium Supplements
<p>Meaningful magnesium, methylfolate, methylcobalamin, active vitamin B6, and MK-7 provide broader nutrient support with lower manganese. Several small proprietary blends and a men-focused multivitamin design make it less direct than the original magnesium-and-malic-acid formula.</p>
80 Budget

Cal-Mag Caps

NOW
<p>Mixed citrate, malate, and oxide magnesium forms plus vitamin D3 and calcium provide a lower-cost mineral option with less manganese than the original. The formula omits the original's disclosed malic acid amount and includes less consistently absorbed oxide.</p>
64 Budget

Thyroid Complex

The Vitamin Shoppe
<p>A lower serving cost supplies thiamine, magnesium, manganese, and several trace minerals. Magnesium oxide, a modest tyrosine amount, iodine, and an animal glandular complex make it less suitable for general energy or stress support, especially with thyroid concerns.</p>
77 Budget

Pro Edge

Bayer One A Day Men's
<p>Broad vitamins and a stated magnesium amount provide economical daily coverage with much less manganese than the original. Most chemical forms are undisclosed, and the product lacks malic acid, so it is a general multivitamin rather than a close functional substitute.</p>
83 Value

Full Spectrum Mineral Caps

NOW
<p>A low-cost broad mineral profile combines magnesium citrate with several chelated trace minerals and vitamin D3. Magnesium oxide and calcium carbonate reduce form quality, and the formula does not preserve the original's malic acid.</p>
69 Value

Metabolic Advantage

Nature's Way
<p>Magnesium and manganese come with iodine, tyrosine, and plant extracts at favorable serving value. Magnesium oxide and thyroid tissue make it a poor general substitute, particularly for anyone managing thyroid disease or thyroid medication.</p>
76 Value

Arthri-Flex Advantage + Vitamin D3

21st Century
<p>Magnesium glycinate, vitamin D3, glucosamine, MSM, and hyaluronic acid create a more rounded fitness and joint-support option. The serving is not cheaper, and a large proprietary blend hides supporting doses, but the named core ingredients offer practical value for joint-focused users.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  2. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  3. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsFitness Energy forMagnesium
  4. Prospective association between dietary magnesium intake and physical performance in older women and men.
    Arias-Fernández L; Struijk EA; Caballero FF; Ortolá R; García-Esquinas E; Rodríguez-Artalejo F; Lopez-Garcia E; Lana A · European journal of nutrition · 2022
    Cohort study863 participantsFitness forMagnesium
  5. The effect of magnesium supplementation on muscle fitness: a meta-analysis and systematic review.
    Wang R; Chen C; Liu W; Zhou T; Xun P; He K; Chen P · Magnesium research · 2018
    Meta-analysis542 participants14 studies pooledFitness forMagnesium
  6. Short-Term Magnesium Supplementation Has Modest Detrimental Effects on Cycle Ergometer Exercise Performance and Skeletal Muscle Mitochondria and Negligible Effects on the Gut Microbiota: A Randomized Crossover Clinical Trial.
    Bomar MC; Ewell TR; Brown RL; Brown DM; Kwarteng BS; Abbotts KSS; Butterklee HM; Williams NNB; Wrigley SD; Walsh MA; Hamilton KL; Thomson DP; Weir TL; Bell C · Nutrients · 2025
    Randomized trial15 participantsFitness forMagnesium
  7. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
    van der Schoot A; Creedon A; Whelan K; Dimidi E · Neurogastroenterology and motility · 2023
    Meta-analysis787 participants8 studies pooledDigestive Health forMagnesium
  8. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial.
    Kubota M; Ito K; Tomimoto K; Kanazaki M; Tsukiyama K; Kubota A; Kuroki H; Fujita M; Vandenplas Y · Nutrients · 2020
    Randomized trial60 participantsDigestive Health forMagnesium
  9. Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
    Andersen J; Christensen H; Pachler JH; Hallin M; Thaysen HV; Kehlet H · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012
    Randomized trial49 participantsDigestive Health forMagnesium
  10. Diagnosis of magnesium-induced diarrhea.
    Fine KD; Santa Ana CA; Fordtran JS · The New England journal of medicine · 1991
    Clinical trial19 participantsDigestive Health forMagnesium
  11. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  12. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  13. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  14. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  15. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  16. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsBone Health forManganese
  17. The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
    Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
    Narrative reviewBone Health forManganese
  18. Associations of multiple metals with bone mineral density: A population-based study in US adults.
    Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
    Cross-sectional studyBone Health forManganese
  19. Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
    Li H; Li G; Yi M; Zhou J; Deng Y; Huang Y; He S; Meng X; Liu L · Frontiers in public health · 2024
    Cross-sectional study31 participantsBone Health forManganese
  20. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
    Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
    Cross-sectional study9,732 participantsBone Health forManganese
  21. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.
    Del Gobbo LC; Imamura F; Wu JH; de Oliveira Otto MC; Chiuve SE; Mozaffarian D · The American journal of clinical nutrition · 2013
    Meta-analysis313,041 participants16 studies pooledCardiovascular Support forMagnesium
  22. Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies.
    Qu X; Jin F; Hao Y; Li H; Tang T; Wang H; Yan W; Dai K · PloS one · 2013
    Meta-analysis532,979 participants19 studies pooledCardiovascular Support forMagnesium
  23. Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies.
    Zhao L; Hu M; Yang L; Xu H; Song W; Qian Y; Zhao M · Journal of cardiovascular pharmacology · 2020
    Meta-analysis544,581 participants18 studies pooledCardiovascular Support Heart Health forMagnesium
  24. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support Heart Health forMagnesium
  25. Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.
    Xiong J; He T; Wang M; Nie L; Zhang Y; Wang Y; Huang Y; Feng B; Zhang J; Zhao J · Journal of nephrology · 2020
    Meta-analysis200,934 participants20 studies pooledCardiovascular Support forMagnesium
  26. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
    Hassanein SMA; Deifallah SM; Bastawy HA · World journal of pediatrics : WJP · 2021
    Randomized trial100 participantsDigestive Health forMagnesium
  27. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.
    Fan L; Zhu X; Sun S; Yu C; Huang X; Ness R; Dugan LL; Shu L; Seidner DL; Murff HJ; Fodor AA; Azcarate-Peril MA; Shrubsole MJ; Dai Q · Clinical nutrition (Edinburgh, Scotland) · 2022
    Randomized trial240 participantsDigestive Health forMagnesium
  28. The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.
    Benninga MA; MENA Infant Constipation Study Group; Vandenplas Y · Pediatric gastroenterology, hepatology & nutrition · 2022
    Randomized trial286 participantsDigestive Health forMagnesium
  29. A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.
    Mori S; Tomita T; Fujimura K; Asano H; Ogawa T; Yamasaki T; Kondo T; Kono T; Tozawa K; Oshima T; Fukui H; Kimura T; Watari J; Miwa H · Journal of neurogastroenterology and motility · 2022
    Randomized trial34 participantsDigestive Health forMagnesium
  30. Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial.
    Sun E; Zhu X; Ness RM; Murff HJ; Sun S; Yu C; Fan L; Azcarate-Peril MA; Shrubsole MJ; Dai Q · The American journal of clinical nutrition · 2025
    Randomized trial240 participantsDigestive Health forMagnesium
  31. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  32. Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
    Welch AA; Skinner J; Hickson M · Nutrients · 2018
    Cross-sectional study156,575 participantsFitness forMagnesium
  33. Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women.
    Welch AA; Kelaiditi E; Jennings A; Steves CJ; Spector TD; MacGregor A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Cross-sectional study2,570 participantsFitness forMagnesium
  34. Nutritional intake as a determinant of high-speed resistance and multicomponent training efficacy on strength in older women at risk of sarcopenia. A randomized clinical trial.
    Polo-Ferrero L; Recio-Rodriguez JI; González-Manzano S; Martín-Vallejo J; Barbero-Iglesias FJ; Montero-Errasquín B; Cruz-Jentoft AJ; Méndez-Sánchez R · Clinical nutrition (Edinburgh, Scotland) · 2025
    Randomized trial80 participantsFitness forMagnesium
  35. Minerals and Sarcopenia in Older Adults: An Updated Systematic Review.
    van Dronkelaar C; Fultinga M; Hummel M; Kruizenga H; Weijs PJM; Tieland M · Journal of the American Medical Directors Association · 2023
    Systematic review45 studies pooledFitness forMagnesium
  36. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  37. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  38. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  39. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  40. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  41. Effects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.
    Xu L; Li X; Wang X; Xu M · Frontiers in nutrition · 2023
    Meta-analysis1,325 participants24 studies pooledHeart Health forMagnesium
  42. The effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trial.
    Guerrero-Romero F; Rodríguez-Morán M · Journal of human hypertension · 2009
    Randomized trial82 participantsHeart Health forMagnesium
  43. Positive effects of magnesium supplementation in metabolic syndrome.
    Kisters S; Kisters K; Werner T; Vormann J; Tokmak F; Westhoff T; Gröber U; Predel HG; Reuter H · International journal of clinical pharmacology and therapeutics · 2024
    Randomized trial54 participantsHeart Health forMagnesium
  44. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsStress Relief forMagnesium
  45. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  46. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  47. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  48. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forMagnesium Stress Relief forVitamin B6
  49. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsStress Relief forVitamin B6
  50. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  51. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  52. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6
  53. Magnesium and anabolic hormones in older men.
    Maggio M; Ceda GP; Lauretani F; Cattabiani C; Avantaggiato E; Morganti S; Ablondi F; Bandinelli S; Dominguez LJ; Barbagallo M; Paolisso G; Semba RD; Ferrucci L · International journal of andrology · 2012
    Cohort study399 participantsTestosterone Support forMagnesium
  54. Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging.
    Rotter I; Kosik-Bogacka DI; Dołęgowska B; Safranow K; Kuczyńska M; Laszczyńska M · Environmental geochemistry and health · 2017
    Cross-sectional study313 participantsTestosterone Support forMagnesium
  55. Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial.
    Gholizadeh-Moghaddam M; Ghasemi-Tehrani H; Askari G; Jaripur M; Clark CCT; Rouhani MH · Health science reports · 2024
    Randomized trial64 participantsTestosterone Support forMagnesium
  56. The effects of trace element supplementation on glycolipid metabolism in PCOS: a systematic review and meta-analysis.
    Yang L; Gao Y; Zhao W; Qi Y; Duo X; Wang H · Frontiers in nutrition · 2025
    Meta-analysis1,600 participants25 studies pooledTestosterone Support forMagnesium
  57. Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.
    Cinar V; Polat Y; Baltaci AK; Mogulkoc R · Biological trace element research · 2011
    Non-randomized trial20 participantsTestosterone Support forMagnesium