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Neuro-T

LifeSeasons
4.5
★ ★ ★ ★ ★
(225 ratings)
Theanine 250 mg
Vitamin B12 1000 mcg
Vitamin B6 20 mg
Ginkgo
Bacopa 100 mg
Product Image
Score69
A broad calm-focus blend with useful theanine and caffeine, undermined by kava risk, weak botanical standardization, and a questionable huperzine entry.
How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Energy
Brain Health
Productivity Boost
Stress Relief
Mental Focus

Score 69

A broad calm-focus blend with useful theanine and caffeine, undermined by kava risk, weak botanical standardization, and a questionable huperzine entry.
How scoring works
$42.99($1.43 per serving)
Amazon
$ 42.99
iHerb
$ 42.99
Report prices

Analysis

The formula pairs a moderate caffeine amount with a substantial L-theanine serving, a combination suited to focused alertness. Methylcobalamin, bacopa, ginkgo, and clubmoss add several cognitive-support pathways.

Bacopa is low and lacks a bacoside percentage, while ginkgo marker names are given without percentages. The listed huperzine A amount is unusually large for that active and should not be trusted without checking the current label.

Kava conflicts with the stimulating side of the formula by adding sedation, and it carries a separate liver concern. Premium pricing and several uncertain active yields make this a higher-caution focus blend rather than a dependable daily cognitive formula.

Who is it for
  • Adults seeking a combined calm-focus formula
  • Users who tolerate caffeine
  • People willing to verify the current label
Best for
  • Short-term alertness with theanine
  • Multi-pathway cognitive support
  • Users not taking sedatives or blood thinners

Pros

  • Uses a meaningful L-theanine amount
  • Includes methylcobalamin
  • Combines stimulant and calming ingredients

Cons

  • Bacopa and ginkgo standardization is incomplete
  • Kava conflicts with the stimulating design
  • Premium cost for uncertain botanical potency

Warnings

  • Kava may affect the liver and can compound sedation from alcohol or sedative medicines.
  • Ginkgo may increase bleeding risk with anticoagulant or antiplatelet medicines.
  • Verify the huperzine A amount on the current label because the supplied entry is unusually large.
  • Caffeine may not suit stimulant-sensitive users or late-day use.

Nutrient quality

74 High impact

The combination is broadly aligned with focus and stress resilience. Several modest botanicals add complexity without equal dosing depth.

Ingredient transparency

81 Highest impact

No proprietary blend hides the listed doses. A complete inactive-ingredient list is not supplied.

Customer satisfaction

65 High impact

Feedback volume is adequate but not broad. No complaint text is supplied, so repeated negative themes cannot be assessed.

Value for money

51 Moderate impact

Several meaningful actives support quality, but incomplete standardization weakens the premium price. The serving is costly relative to its uneven dose depth.

Report analysis

Goals

Energy
Energy
Impact
High effect
A- Goal FitA- Strength of SupportB CoverageC- Formula Quality
Vitamin B12 · 1000 mcgCaffeine · 75 mg

Caffeine paired with L-theanine offers a direct route to alertness with a calmer subjective profile. Methylcobalamin is well dosed, while bacopa, ginkgo, holy basil, and huperzine target focus or stress rather than physical stamina.

Kava adds a sedating influence that may counter the stimulant intent and complicate daytime use. Kava can intensify sedation from alcohol or sedative medicines and carries a recognized liver-risk concern.

Study evidence
Caffeine Supportive 68 studies
Theanine Not classified

No linked studies yet.

Vitamin B12 Disputed 14 studies
Brain Health
Brain Health
Impact
High effect
A- Goal FitC+ Strength of SupportB+ CoverageC+ Formula Quality
Vitamin B12 · 1000 mcgVitamin B6 · 20 mgBacopa · 100 mg

L-theanine, caffeine, methylcobalamin, bacopa, ginkgo, huperzine-related clubmoss, and adaptogens provide broad nootropic coverage. Theanine and caffeine create a sensible alertness pairing, while B12 supports neurological metabolism.

Bacopa and ginkgo are below typical clinical targets and lack verified standardization percentages, while kava pulls toward sedation. Kava can compound alcohol or sedative effects, and ginkgo may increase bleeding risk with anticoagulant or antiplatelet medicines.

Study evidence
Bacopa Supportive 17 studies
Ginkgo Supportive 90 studies
Theanine Supportive 17 studies
Vitamin B12 Supportive 74 studies
Productivity Boost
Productivity Boost
Impact
High effect
A- Goal FitC+ Strength of SupportB+ CoverageC Formula Quality
Vitamin B12 · 1000 mcgVitamin B12 · 1000 mcgVitamin B6 · 20 mgTheanine · 250 mgCaffeine · 75 mg

Caffeine and theanine create a direct alertness and calm-focus pairing, while B12, bacopa, ginkgo, and club moss broaden cognitive support. Bacopa and ginkgo are below stronger target amounts, and club moss disclosure does not distinguish extract weight from active huperzine yield.

Kava introduces a conflicting sedating mechanism that may blunt the stimulant strategy. Kava can cause drowsiness and has a rare liver-injury concern, while caffeine may mask perceived sedation without removing impairment.

Study evidence
Bacopa Supportive 12 studies
Caffeine Supportive 108 studies
Ginkgo Supportive 20 studies
Ginkgo Supportive 12 studies
Theanine Supportive 5 studies
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies
Stress Relief
Stress Relief
Impact
High effect
A- Goal FitB Strength of SupportB CoverageD+ Formula Quality
Vitamin B12 · 1000 mcgVitamin B6 · 20 mgTheanine · 250 mg

L-theanine, kava, Bacopa, and holy basil directly target calm and stress response, while caffeine adds alertness. L-theanine and kava have relevant human evidence, but Bacopa and holy basil are less convincing at the listed amounts.

L-theanine reaches the optimal range and kava is substantial, while Bacopa and holy basil are comparatively low. Kavalactone and bacoside percentages are not quantified, and kava may compound sedation with alcohol or sedative medicines and carries a liver-injury concern.

Study evidence
Bacopa Supportive 8 studies
Theanine Supportive 16 studies
Mental Focus
Mental Focus
Impact
High effect
B Goal FitC+ Strength of SupportB CoverageD+ Formula Quality
Vitamin B6 · 20 mgVitamin B12 · 1000 mcgTheanine · 250 mgCaffeine · 75 mg

Caffeine paired with a strong L-theanine amount offers a plausible calm-alertness effect, while B vitamins, bacopa, ginkgo, and clubmoss broaden the cognitive intent. Bacopa and ginkgo appear underdosed or incompletely standardized, and the total stimulant amount is unclear because yerba mate may add caffeine.

Kava and holy basil may soften stimulant effects, but kava also introduces sedation and a product-specific liver-safety concern. Ginkgo may raise bleeding risk with anticoagulant or antiplatelet medicines, and kava should not be combined with alcohol or sedatives.

Study evidence
Bacopa Supportive 13 studies
Caffeine Supportive 128 studies
Ginkgo Supportive 28 studies
Theanine Supportive 19 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
B Goal FitD+ Strength of SupportB CoverageD+ Formula Quality
Vitamin B6 · 20 mgVitamin B12 · 1000 mcgTheanine · 250 mgBacopa · 100 mg

L-theanine with caffeine creates a recognized focus pairing, while bacopa, ginkgo, and clubmoss target memory and circulation. Kava and holy basil add stress-related pathways but also make the stack less predictable for alertness.

Theanine and caffeine are meaningfully dosed, while bacopa and ginkgo are low and huperzine A yield is unclear. Kava may add sedation and liver risk, while ginkgo may increase bleeding risk with anticoagulant or antiplatelet medicines.

Study evidence
Bacopa Supportive 30 studies
Ginkgo Supportive 87 studies
Theanine Supportive 25 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxine Hydrochloride)
 20 mg
Vitamin B12 (Methylcobalamin)
 1000 mcg
L-Theanine
250 mg
Kava Kava root extract (Kavalactones)
 200 mg
Bacopa whole plant extract (Bacosides A&B)
 100 mg
Yerba Mate
100 mg
Caffeine (Coffea arabica)
 75 mg
Holy Basil
75 mg
Ginkgo leaf extract (Flavone Glycosides, Terpene Lactones)
 60 mg
Toothed Clubmoss extract (Huperzine A)
 10 mg
Gluten Free Adults 18–50 Dairy Free Vegetarian
Report overview
Theanine · 250 mg OverallScore82
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

The active L-isomer is clearly identified at the top of the optimal dose range. Generic sourcing provides no added assurance about purity or consistency. Cost per standard amount reflects premium pricing.

View ingredientView products
Vitamin B12 (Methylcobalamin) · 1000 mcg OverallScore79
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Methylcobalamin is a bioactive B12 form and is fully disclosed. The dose reaches the higher-support threshold, while the swallowed capsule format offers no absorption-focused delivery. Cost efficiency remains weak even after considering the active form.

View ingredientView products
Vitamin B6 (Pyridoxine Hydrochloride) · 20 mg OverallScore62
D+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Synthetic pyridoxine is less direct than active P-5-P. The B6 dose is well aligned with targeted metabolic and neurological support. No listed additives create a clear purity concern.

View ingredientView products
Loading alternative details
84 Performance

Activated Homocysteine

Swanson
<p>Active B6, methylfolate, methylcobalamin, and betaine give the nutrient portion stronger forms and clearer purpose than the original pyridoxine-based blend. It does not reproduce the calming botanicals, and the high B6 amount is less suitable for routine long-term use.</p>
86 Performance

Ginkgo+

NS Natural Stacks
<p>Larger bacopa and ginkgo amounts plus Panax ginseng create a more focused cognitive blend than the original broad formula. Missing marker percentages and ginkgo purity details remain limitations, but the formula avoids kava and its related sedation and liver concerns.</p>
80 Performance

ThinkFast

Futurebiotics
<p>Bacopa and substantial ginkgo amounts provide a more concentrated cognitive core than the original modest botanical doses. Proprietary supporting blends reduce transparency, although avoiding kava may simplify use for people concerned about sedation or liver safety.</p>
96 Budget

Focus-R

LifeSeasons
<p>An identical ingredient profile provides the clearest lower-cost substitute, including the same amounts of theanine, methylcobalamin, caffeine, bacopa, ginkgo, and kava. The same kava and ginkgo cautions still apply, but little formulation compromise is required.</p>
77 Budget

Tri-B

Carlson
<p>A very low serving cost makes this a practical way to retain B6, folate, and B12 coverage. The formula is much narrower and uses conventional vitamin forms, so it does not replace the original calming and cognitive botanicals.</p>
75 Budget

Folic Acid B6 & B12

Mason Natural
<p>Low-cost B6, folate, and B12 offer basic nutritional coverage for a small fraction of the original serving cost. Pyridoxine is aggressive and the product lacks theanine, bacopa, ginkgo, and stimulant support, making it a budget nutrient option rather than a close nootropic match.</p>
91 Value

Pure Brainpower

Swanson
<p>A well-sized bacopa amount, complementary ginkgo, and coffee-fruit extract target brain health and focus at a much lower serving cost. Incomplete active-marker disclosure is the main trade-off, but the focused formula offers stronger cognitive depth per serving.</p>
78 Value

Think Support

Zoi Research
<p>Bacopa and substantial ginkgo preserve two central cognitive ingredients while costing less per serving. Hidden blends and incomplete standardization weaken confidence, so the value advantage comes with less label clarity.</p>
79 Value

Homocysteine Modulators

Solgar
<p>Betaine plus B6, folate, and B12 provide inexpensive support for energy and cognitive pathways with strong serving value. Older vitamin forms and a high B6 amount limit long-term appeal, and the formula lacks the original theanine and botanical breadth.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin B12 deficiency and neuropsychiatric symptoms in Lebanon: A cross-sectional study of vegans, vegetarians, and omnivores.
    Al Jassem O; Kheir K; Ismail A; Abou-Abbas L; Masri A; Haddad C; Nasrallah K; El Masry J · PloS one · 2024
    Cross-sectional study483 participantsStress Relief forVitamin B12
  2. Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.
    Bjelland I; Tell GS; Vollset SE; Refsum H; Ueland PM · Archives of general psychiatry · 2003
    Cross-sectional study5,948 participantsStress Relief forVitamin B12
  3. Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.
    Furushima D; Sugiyama I; Nomura Y; Unno K; Yamada H · Journal of nutritional science and vitaminology · 2023
    Randomized trial120 participantsStress Relief forTheanine
  4. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialStress Relief Brain Health forTheanine
  5. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
    Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
    Randomized trial46 participantsStress Relief Sleep Support forTheanine
  6. Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
    White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
    Randomized trial34 participantsStress Relief forTheanine
  7. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsBrain Health forVitamin B12
  8. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledBrain Health Energy forVitamin B12
  9. Cognitive impairment and vitamin B12: a review.
    Moore E; Mander A; Ames D; Carne R; Sanders K; Watters D · International psychogeriatrics · 2014
    Systematic review43 studies pooledCognitive Support Brain Health forVitamin B12
  10. Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis.
    Tan MS; Yu JT; Tan CC; Wang HF; Meng XF; Wang C; Jiang T; Zhu XC; Tan L · Journal of Alzheimer's disease : JAD · 2015
    Meta-analysis2,561 participants9 studies pooledBrain Health Cognitive Support forGinkgo
  11. Ginkgo biloba for cognitive impairment and dementia.
    Wieland LS; Ludeman E; Chi Y; Feinberg TM; Chen IH; Chen KH; Zhu Y; Wolverson E; Amri H · The Cochrane database of systematic reviews · 2026
    Meta-analysis10,613 participants82 studies pooledBrain Health Cognitive Support forGinkgo
  12. Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial.
    van Dongen M; van Rossum E; Kessels A; Sielhorst H; Knipschild P · Journal of clinical epidemiology · 2003
    Randomized trial214 participantsBrain Health forGinkgo
  13. Efficacy of Ginkgo biloba extract EGb 761® in dementia with behavioural and psychological symptoms: A systematic review.
    von Gunten A; Schlaefke S; Überla K · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2017
    Meta-analysis1,628 participants4 studies pooledBrain Health Cognitive Support forGinkgo
  14. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract.
    Kongkeaw C; Dilokthornsakul P; Thanarangsarit P; Limpeanchob N; Norman Scholfield C · Journal of ethnopharmacology · 2014
    Meta-analysis518 participants9 studies pooledBrain Health Mental Focus Productivity Boost forBacopa
  15. The acute effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy normal subjects.
    Nathan PJ; Clarke J; Lloyd J; Hutchison CW; Downey L; Stough C · Human psychopharmacology · 2019
    Randomized trial38 participantsBrain Health Cognitive Support forBacopa
  16. Plant-derived nootropics and human cognition: A systematic review.
    Lorca C; Mulet M; Arévalo-Caro C; Sanchez MÁ; Perez A; Perrino M; Bach-Faig A; Aguilar-Martínez A; Vilella E; Gallart-Palau X; Serra A · Critical reviews in food science and nutrition · 2023
    Systematic review256 studies pooledBrain Health forBacopa
  17. L-theanine improves neurophysiological measures of attention in a dose-dependent manner: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2022
    Randomized trial27 participantsMental Focus forTheanine
  18. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsMental Focus Cognitive Support forTheanine
  19. Promising, but Not Completely Conclusive-The Effect of l-Theanine on Cognitive Performance Based on the Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.
    Mátyus RO; Szikora Z; Bodó D; Vargáné Szabó B; Csupor É; Csupor D; Tóth B · Journal of clinical medicine · 2025
    Meta-analysis148 participants5 studies pooledMental Focus forTheanine
  20. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsProductivity Boost Mental Focus forTheanine
  21. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledProductivity Boost forTheanine
  22. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsCognitive Support Productivity Boost forVitamin B12
  23. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
    Zhang C; Luo J; Yuan C; Ding D · Journal of Alzheimer's disease : JAD · 2021
    Meta-analysis21 studies pooledCognitive Support forVitamin B12
  24. Ginkgo biloba Extract (EGb761), Cholinesterase Inhibitors, and Memantine for the Treatment of Mild-to-Moderate Alzheimer's Disease: A Network Meta-Analysis.
    Thancharoen O; Limwattananon C; Waleekhachonloet O; Rattanachotphanit T; Limwattananon P; Limpawattana P · Drugs & aging · 2019
    Meta-analysisCognitive Support forGinkgo
  25. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials.
    Pase MP; Kean J; Sarris J; Neale C; Scholey AB; Stough C · Journal of alternative and complementary medicine (New York, N.Y.) · 2012
    Systematic review6 studies pooledCognitive Support Productivity Boost forBacopa
  26. Comparative effects of Bacopa monnieri and Ginkgo biloba on cognitive functions: A systematic review and network meta-analysis.
    Tiemtad P; Ingkaninan K; Temkitthawon P; Thimkorn P; Rattanachaisit N; Teaktong T; Dhippayom T · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026
    Meta-analysis2,107 participants29 studies pooledCognitive Support Brain Health Mental Focus forBacopa
  27. Comparative efficacy of Medhya Rasayana,Bacopa monnieri, and Centella asiatica in enhancing memory and IQ of 8-10 year-old healthy boys: A prakriti-based double-blind, randomized controlled trial.
    Verma J; Rathi R; Anamika; Rathi B; Pandey VB · Journal of Ayurveda and integrative medicine · 2025
    Randomized trial180 participantsBrain Health Cognitive Support forBacopa
  28. The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of randomized controlled trials.
    Feng X; Fan S; Wei F · Frontiers in pharmacology · 2026
    Meta-analysis1,861 participants25 studies pooledBrain Health Cognitive Support forBacopa
  29. Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trials.
    Riepe M; Hoerr R; Schlaefke S · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2025
    Meta-analysis782 participants4 studies pooledBrain Health Productivity Boost forGinkgo
  30. Ginkgo biloba extract EGb 761® improves cognition and overall condition after ischemic stroke: Results from a pilot randomized trial.
    Cui M; You T; Zhao Y; Liu R; Guan Y; Liu J; Liu X; Wang X; Dong Q · Frontiers in pharmacology · 2023
    Randomized trial201 participantsBrain Health Productivity Boost forGinkgo
  31. Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg.
    Herrschaft H; Nacu A; Likhachev S; Sholomov I; Hoerr R; Schlaefke S · Journal of psychiatric research · 2012
    Randomized trial410 participantsBrain Health forGinkgo
  32. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  33. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  34. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  35. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  36. Relationship between vitamin B12 levels and motor development: A systematic review.
    Dos Santos MERA; da Silva KG; da Silva Souza AP; da Silva ABJ; da Silva RF; da Silva EHA; de Souza SL; Barros WMA · Clinical nutrition ESPEN · 2024
    Systematic review1,559 participants8 studies pooledBrain Health forVitamin B12
  37. Structural and Functional Brain Changes Associated with Vitamin B12 Deficiency using Magnetic Resonance Imaging: A Systematic Review and Meta-analysis.
    Alghamdi A · Current medical imaging · 2023
    Meta-analysis12 studies pooledBrain Health forVitamin B12
  38. Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.
    Franco L; de Andrade CVF; Margini LV; Sousa N · Frontiers in neuroscience · 2026
    Systematic review22 studies pooledBrain Health forVitamin B12
  39. Higher vitamin B12 from mid- to late life is related to slower rates of cognitive decline.
    Marino FR; Rogers G; Miller JW; Selhub J; Mez J; Crane PK; Mukherjee S; Saykin AJ; Hohman TJ; Trittschuh EH; Au R; Jacques PF; Hwang PH · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Cohort study1,994 participantsBrain Health forVitamin B12
  40. A systematic review of the Ayurvedic medicinal herb Bacopa monnieri in child and adolescent populations.
    Kean JD; Downey LA; Stough C · Complementary therapies in medicine · 2017
    Systematic review5 studies pooledCognitive Support forBacopa
  41. Efficacy of Standardized Extract of Bacopa monnieri (Bacognize®) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial.
    Kumar N; Abichandani LG; Thawani V; Gharpure KJ; Naidu MU; Venkat Ramana G · Evidence-based complementary and alternative medicine : eCAM · 2024
    Randomized trial60 participantsCognitive Support forBacopa
  42. Efficacy of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke: a predefined exploratory analysis of a multicenter, double-blind, randomized controlled trial.
    Tian X; Xu Q; Xia X; Zhang Y; Meng X; Wang A · Journal of neurology · 2024
    Randomized trial3,163 participantsCognitive Support forGinkgo
  43. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group.
    Le Bars PL; Katz MM; Berman N; Itil TM; Freedman AM; Schatzberg AF · JAMA · 1997
    Randomized trial309 participantsCognitive Support Productivity Boost forGinkgo
  44. Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761. Findings from a randomized controlled trial.
    Bachinskaya N; Hoerr R; Ihl R · Neuropsychiatric disease and treatment · 2011
    Randomized trial410 participantsCognitive Support forGinkgo
  45. Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial.
    Ihl R; Bachinskaya N; Korczyn AD; Vakhapova V; Tribanek M; Hoerr R; Napryeyenko O; GOTADAY Study Group · International journal of geriatric psychiatry · 2013
    Randomized trial410 participantsCognitive Support forGinkgo
  46. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  47. Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine.
    Haskell CF; Kennedy DO; Wesnes KA; Scholey AB · Psychopharmacology · 2005
    Randomized trial48 participantsEnergy forCaffeine
  48. Caffeine-containing energy drink improves physical performance of elite rugby players during a simulated match.
    Del Coso J; Ramírez JA; Muñoz G; Portillo J; Gonzalez-Millán C; Muñoz V; Barbero-Álvarez JC; Muñoz-Guerra J · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016
    Randomized trial26 participantsEnergy forCaffeine
  49. Differential cognitive effects of energy drink ingredients: caffeine, taurine, and glucose.
    Giles GE; Mahoney CR; Brunyé TT; Gardony AL; Taylor HA; Kanarek RB · Pharmacology, biochemistry, and behavior · 2013
    Randomized trial48 participantsEnergy forCaffeine
  50. Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A Double-Blind, Placebo-Controlled Study.
    Ozan M; Buzdagli Y; Eyipinar CD; Baygutalp NK; Yüce N; Oget F; Kan E; Baygutalp F · Nutrients · 2022
    Randomized trial20 participantsEnergy forCaffeine
  51. Trait Energy and Fatigue Modify the Effects of Caffeine on Mood, Cognitive and Fine-Motor Task Performance: A Post-Hoc Study.
    Fuller DT; Smith ML; Boolani A · Nutrients · 2021
    Randomized trialEnergy forCaffeine
  52. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  53. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  54. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  55. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  56. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  57. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  58. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  59. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  60. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  61. Evaluating the effects of Bacopa monnieri on cognitive performance and sleep quality of patients with mild cognitive impairment: A triple-blinded, randomized, placebo-controlled trial.
    Delfan M; Kordestani-Moghaddam P; Gholami M; Kazemi K; Mohammadi R · Explore (New York, N.Y.) · 2024
    Randomized trial62 participantsMental Focus forBacopa
  62. Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modafinil: a review and comparison of effect sizes.
    Neale C; Camfield D; Reay J; Stough C; Scholey A · British journal of clinical pharmacology · 2013
    Systematic reviewMental Focus forBacopa
  63. Efficiency of Different Supplements in Alleviating Symptoms of ADHD with or Without the Use of Stimulants: A Systematic Review.
    Al Shahab S; Al Balushi R; Qambar A; Abdulla R; Qader M; Abdulla S; Jahrami H · Nutrients · 2025
    Systematic reviewMental Focus forBacopa
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    Wingelaar-Jagt YQ; Bottenheft C; Riedel WJ; Ramaekers JG · Journal of psychopharmacology (Oxford, England) · 2023
    Randomized trial32 participantsMental Focus forCaffeine
  65. Acute effects of caffeine on attention: a comparison of non-consumers and withdrawn consumers.
    Smith AP; Christopher G; Sutherland D · Journal of psychopharmacology (Oxford, England) · 2013
    Randomized trial70 participantsMental Focus forCaffeine
  66. Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation.
    Wesensten NJ; Killgore WD; Balkin TJ · Journal of sleep research · 2006
    Randomized trial48 participantsMental Focus forCaffeine
  67. Effects of caffeine on mood and performance: a study of realistic consumption.
    Brice CF; Smith AP · Psychopharmacology · 2003
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    Fine BJ; Kobrick JL; Lieberman HR; Marlowe B; Riley RH; Tharion WJ · Psychopharmacology · 1995
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  69. Ginkgo biloba Extract EGb 761 in the Treatment of Patients with Mild Neurocognitive Impairment: A Systematic Review.
    Hort J; Duning T; Hoerr R · Neuropsychiatric disease and treatment · 2023
    Systematic review946 participants9 studies pooledMental Focus forGinkgo
  70. Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia.
    Kanowski S; Herrmann WM; Stephan K; Wierich W; Hörr R · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
    Randomized trial216 participantsMental Focus forGinkgo
  71. Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia.
    Kanowski S; Herrmann WM; Stephan K; Wierich W; Hörr R · Pharmacopsychiatry · 1996
    Randomized trial216 participantsMental Focus forGinkgo
  72. Ginkgo biloba extract improved cognitive and neurological functions of acute ischaemic stroke: a randomised controlled trial.
    Li S; Zhang X; Fang Q; Zhou J; Zhang M; Wang H; Chen Y; Xu B; Wu Y; Qian L; Xu Y · Stroke and vascular neurology · 2021
    Randomized trial348 participantsMental Focus forGinkgo
  73. Ginkgo biloba in the Aging Process: A Narrative Review.
    Barbalho SM; Direito R; Laurindo LF; Marton LT; Guiguer EL; Goulart RA; Tofano RJ; Carvalho ACA; Flato UAP; Capelluppi Tofano VA; Detregiachi CRP; Bueno PCS; Girio RSJ; Araújo AC · Antioxidants (Basel, Switzerland) · 2024
    Narrative review14 studies pooledMental Focus forGinkgo
  74. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Productivity Boost Stress Relief forTheanine
  75. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  76. The Effects of a Bacopa monnieri Extract (Bacumen®) on Cognition, Stress, and Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lopresti AL; Smith SJ · Clinical drug investigation · 2025
    Randomized trial101 participantsMood Support forBacopa
  77. Effects of Bacopa monnieri (CDRI 08®) in a population of males exhibiting inattention and hyperactivity aged 6 to 14 years: A randomized, double-blind, placebo-controlled trial.
    Kean JD; Downey LA; Sarris J; Kaufman J; Zangara A; Stough C · Phytotherapy research : PTR · 2022
    Randomized trial112 participantsMood Support forBacopa
  78. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects.
    Stough C; Lloyd J; Clarke J; Downey LA; Hutchison CW; Rodgers T; Nathan PJ · Psychopharmacology · 2001
    Randomized trial85 participantsMood Support Stress Relief forBacopa
  79. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial.
    Calabrese C; Gregory WL; Leo M; Kraemer D; Bone K; Oken B · Journal of alternative and complementary medicine (New York, N.Y.) · 2009
    Randomized trial54 participantsMood Support Productivity Boost Stress Relief forBacopa
  80. Brahmi for the better? New findings challenging cognition and anti-anxiety effects of Brahmi (Bacopa monniera) in healthy adults.
    Sathyanarayanan V; Thomas T; Einöther SJ; Dobriyal R; Joshi MK; Krishnamachari S · Psychopharmacology · 2013
    Randomized trial72 participantsMood Support forBacopa
  81. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine
  82. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
    Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
    Randomized trial60 participantsMood Support Stress Relief forTheanine
  83. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
    Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
    Systematic review9 studies pooledMood Support forTheanine
  84. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
    Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
    Randomized trial168 participantsMood Support Stress Relief forTheanine
  85. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
    Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
    Randomized trial20 participantsMood Support forTheanine
  86. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial.
    Stough C; Downey LA; Lloyd J; Silber B; Redman S; Hutchison C; Wesnes K; Nathan PJ · Phytotherapy research : PTR · 2009
    Randomized trial107 participantsProductivity Boost forBacopa
  87. An acute, double-blind, placebo-controlled crossover study of 320 mg and 640 mg doses of a special extract of Bacopa monnieri (CDRI 08) on sustained cognitive performance.
    Downey LA; Kean J; Nemeh F; Lau A; Poll A; Gregory R; Murray M; Rourke J; Patak B; Pase MP; Zangara A; Lomas J; Scholey A; Stough C · Phytotherapy research : PTR · 2014
    Randomized trial24 participantsProductivity Boost forBacopa
  88. Effects of caffeine on alertness.
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    Randomized trial24 participantsProductivity Boost forCaffeine
  89. Effects of Different Sources of Low-Dose Caffeine on Mood/Arousal and Cognitive Performance.
    Irwin C; McCartney D; Grant G; Delang N; Bartrim K; Cox GR; Desbrow B · Perceptual and motor skills · 2023
    Randomized trial22 participantsProductivity Boost forCaffeine
  90. Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land.
    Lieberman HR; Tharion WJ; Shukitt-Hale B; Speckman KL; Tulley R · Psychopharmacology · 2003
    Randomized trial68 participantsProductivity Boost forCaffeine
  91. A review of caffeine's effects on cognitive, physical and occupational performance.
    McLellan TM; Caldwell JA; Lieberman HR · Neuroscience and biobehavioral reviews · 2017
    Narrative reviewProductivity Boost forCaffeine
  92. Acute caffeine supplementation as a nutrition-based strategy to mitigate sleep-loss-related cognitive and operational performance impairments in military personnel: a systematic review and meta-analysis.
    Wang R; Wang W; Meng L; Hao G; Gu G · Frontiers in nutrition · 2026
    Meta-analysis7 studies pooledProductivity Boost forCaffeine
  93. [Ginkgo biloba extract EGb 761 in the treatment of dementia: evidence of efficacy and tolerability].
    Kasper S; Schubert H · Fortschritte der Neurologie-Psychiatrie · 2009
    Meta-analysis10 studies pooledProductivity Boost forGinkgo
  94. Dietary Flavonoids and Human Cognition: A Meta-Analysis.
    Cheng N; Bell L; Lamport DJ; Williams CM · Molecular nutrition & food research · 2022
    Meta-analysis5,519 participants80 studies pooledProductivity Boost forGinkgo
  95. Limited cognitive benefits in Stage +2 postmenopausal women after 6 weeks of treatment with Ginkgo biloba.
    Elsabagh S; Hartley DE; File SE · Journal of psychopharmacology (Oxford, England) · 2005
    Randomized trial87 participantsProductivity Boost forGinkgo
  96. Efficacy and safety of Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multi-center trial.
    Gavrilova SI; Preuss UW; Wong JW; Hoerr R; Kaschel R; Bachinskaya N; GIMCIPlus Study Group · International journal of geriatric psychiatry · 2015
    Randomized trial160 participantsProductivity Boost forGinkgo
  97. Modulation of cognitive performance following single doses of 120 mg Ginkgo biloba extract administered to healthy young volunteers.
    Kennedy DO; Jackson PA; Haskell CF; Scholey AB · Human psychopharmacology · 2008
    Randomized trial78 participantsProductivity Boost forGinkgo
  98. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewProductivity Boost forTheanine
  99. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  100. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  101. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  102. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  103. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  104. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsProductivity Boost forVitamin B12
  105. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
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    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12
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    Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
    Randomized trial120 participantsSleep Support forTheanine
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    Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
    Meta-analysis897 participants19 studies pooledSleep Support forTheanine
  109. In Search of a Safe Natural Sleep Aid.
    Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
    Narrative reviewSleep Support forTheanine
  110. Efficacy of Brahmi vati in generalised anxiety disorder - Randomized double blind comparative clinical trial.
    Khot SG; Tubaki BR; Gonugade VB · Journal of Ayurveda and integrative medicine · 2022
    Randomized trial56 participantsStress Relief forBacopa
  111. An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri (CDRI 08) on multitasking stress reactivity and mood.
    Benson S; Downey LA; Stough C; Wetherell M; Zangara A; Scholey A · Phytotherapy research : PTR · 2014
    Randomized trial17 participantsStress Relief forBacopa
  112. Herbal remedies for anxiety - a systematic review of controlled clinical trials.
    Ernst E · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2006
    Systematic review8 studies pooledStress Relief forBacopa